Article
Multidisciplinary Sciences
Mary C. Peavey, San-Pin Wu, Rong Li, Jian Liu, Olivia M. Emery, Tianyuan Wang, Lecong Zhou, Margeaux Wetendorf, Chandra Yallampalli, William E. Gibbons, John P. Lydon, Francesco J. DeMayo
Summary: The study revealed that overexpression of progesterone receptor PGR-B leads to relaxation of uterine muscles, prolonged gestational length, and increased incidence of labor dystocia, while overexpression of PGR-A increases uterine muscle contraction without affecting gestational length.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Chaolu Chen, Shuaiying Zhu, Long Bai, Meihua Sui, Danqing Chen
Summary: This study analyzed the myometrial transcriptome during parturition and found that the onset of labor was associated with an inflammatory response. Hub genes, including FPR1, were identified as being associated with the onset of labor, with FPR1 playing a novel role as a modulator of myometrial contraction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Obstetrics & Gynecology
Yihong Luo, Long Cui, Lina Chen, Lele Wang, Kaiyuan Ji, Huishu Liu
Summary: This study identified differentially expressed lncRNAs in the human myometrium during labor and non-labor using RNA sequencing and bioinformatic analysis. The enriched analysis showed that these lncRNAs are associated with mRNA splicing, ferroptosis, FGFR, and NOTCH signaling pathways.
REPRODUCTIVE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Kumar Saurabh, Magdaleena Naemi Mbadhi, Kevin K. Prifti, Kaci T. Martin, Antonina Frolova
Summary: Abnormal uterine contractility is a common mechanism for obstetric complications, affecting millions of women annually. The activation of sphingolipid metabolism, specifically sphingosine 1-phosphate (S1P), during human labor may modify the myometrial proinflammatory phenotype. By activating S1P receptor 3 (S1PR3) and downstream ERK1/2 pathways, S1P induces a proinflammatory gene signature and upregulates expression of known inflammatory markers of labor.
Article
Multidisciplinary Sciences
Yosuke Sugita, Yoshimitsu Kuwabara, Akira Katayama, Shigeru Matsuda, Ichiro Manabe, Shunji Suzuki, Yumiko Oishi
Summary: Preterm birth (PTB) is a leading cause of neonatal mortality and reducing the PTB rate is crucial. Cervical insufficiency (CI), a major cause of PTB, is characterized by premature cervical ripening and recurrent pregnancy loss. This study explored the molecular mechanism of CI and found that downregulation of progesterone signaling at the receptor level is responsible for abnormal cervical ripening in CI, providing new insights into the understanding of PTB.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Carolin Jungmann, Sophie-Charlotte Pyzik, Eva-Maria Packeiser, Hanna Koerber, Susanne Hoppe, Gemma Mazzuoli-Weber, Sandra Goericke-Pesch
Summary: Conservative treatment of canine dystocia with oxytocin and denaverine hydrochloride is usually unsuccessful. In this study, we used an in vitro organ bath assay to investigate the potential ecbolic effects of oxytocin and denaverine on pregnant canine myometrium. Our experiments showed different effects on contractility depending on the oxytocin concentrations used and no effect on myometrial contractility with denaverine hydrochloride.
Article
Immunology
Lina Chen, Lele Wang, Yihong Luo, Qian Huang, Kaiyuan Ji, Junjie Bao, Huishu Liu
Summary: This study utilized RNA sequencing and mass spectrometry to uncover that inflammation and hypoxia play a role in differentially expressed proteins and mRNA in the myometrium during labor.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Physiology
Manasi Malik, Michelle Roh, Sarah K. England
Summary: The review provides a summary of studies on uterine excitation and contractions in mice, rats, guinea pigs, and humans, aiming to help new researchers understand the field and provide assistance in experimental design and result interpretation in rodent models.
Article
Reproductive Biology
Nardhy Gomez-Lopez, Roberto Romero, Jose Galaz, Gaurav Bhatti, Bogdan Done, Derek Miller, Corina Ghita, Kenichiro Motomura, Marcelo Farias-Jofre, Eunjung Jung, Roger Pique-Regi, Sonia S. Hassan, Tinnakorn Chaiworapongsa, Adi L. Tarca
Summary: By analyzing the transcriptomic data, it was found that women undergoing term labor exhibit labor-specific gene expression changes in their peripheral blood, which correlate with gene changes in the chorioamniotic membranes, myometrium, and cervix, partially overlapping with changes observed in asymptomatic women prior to preterm birth, potentially serving as a tool for assessing labor status and identifying preterm birth risk.
BIOLOGY OF REPRODUCTION
(2022)
Review
Endocrinology & Metabolism
Melissa L. Kozakiewicz, Chad A. Grotegut, Allyn C. Howlett
Summary: The endocannabinoid system plays a crucial role in early pregnancy success, embryo development, and parturition, influencing uterine activation and maternal-fetal interaction, regulating pregnancy maintenance and timing of labor.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Microbiology
Priya Debisarun, Katharina Goessling, Ozlem Bulut, Gizem Kilic, Martijn Zoodsma, Zhaoli Liu, Marina Oldenburg, Nadine Ruechel, Bowen Zhang, Cheng-Jian Xu, Patrick Struycken, Valerie A. C. M. N. Koeken, Jorge Dominguez-Andres, Simone J. C. F. M. Moorlag, Esther Taks, Philipp Ostermann, Lisa Mueller, Heiner Schaal, Ortwin Adams, Arndt G. Borkhardt, Jaap L. ten Oever, Reinout van Crevel, Yang L. Li, Mihai Netea
Summary: Influenza vaccination has been shown to reduce the risk of COVID-19 infection by decreasing systemic inflammation and reprogramming immune cells to fight against SARS-CoV-2. This suggests potential benefits of influenza vaccination against COVID-19, calling for future randomized trials to test this possibility.
Article
Genetics & Heredity
Vasily V. Stavchansky, Ivan B. Filippenkov, Julia A. Remizova, Alina E. Denisova, Ivan V. Mozgovoy, Leonid V. Gubsky, Nikolay F. Myasoedov, Lyudmila A. Andreeva, Svetlana A. Limborska, Lyudmila V. Dergunova
Summary: Studies have shown that peptides containing PGP can affect gene expression under ischemia-reperfusion conditions, with effects different from Semax, providing new therapeutic strategies for overcoming brain ischemia-reperfusion injury.
Article
Immunology
Anya L. Arthurs, Melanie D. Smith, Mhyles D. Hintural, James Breen, Dylan McCullough, Francesca I. Thornton, Shalem Y. Leemaqz, Gustaaf A. Dekker, Tanja Jankovic-Karasoulos, Claire T. Roberts
Summary: Parturition signals the end of immune tolerance in pregnancy. The activation of placental inflammasome differs in terms of mode of delivery and neonatal sex. Assessing placental inflammasome activation may identify babies who have been exposed to aberrant inflammation at birth.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Reproductive Biology
Mina Takamatu, Shugo Kazama, Takehito Suzuki, Yoko Miyazaki, Kazuaki Tanaka, Makoto Usami, Tatsuya Takizawa
Summary: The expression of desmin, an intermediate filament, in the myometrium and cervix of peripartum rats was investigated. Desmin protein was diffusely present in the myometrium and locally in the cervix epithelium. The protein levels of desmin in the myometrium increased during peripartum, while its levels in the cervix decreased at parturition. The expression of desmin in the cervix seemed to be regulated by estradiol at the translational level.
REPRODUCTIVE BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Yinuo Li, Ross P. McNally, Yue Feng, J. Julie Kim, Jian-Jun Wei
Summary: This study reveals significant differences in Mediator Complex Subunit 12 mutations, transcriptomics, and protein expression between Black and White women in uterine myometrium and leiomyomas.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Marcia Arenas-Hernandez, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Offer Erez, Adi L. Tarca
Summary: The study found that pregnant women with severe PPH had higher median maternal plasma concentrations of IL-16, IL-6, IL-12/IL-23p40, MCP-1, and IL-1 beta than patients without PPH. These cytokines could serve as biomarkers or therapeutic targets.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Doron Kabiri, Dror Raif Nesher, Danielle Luxenbourg, Amihai Rottenstreich, Joshua Rosenbloom, Yosef Ezra, Simcha Yagel, Shay Porat, Roberto Romero
Summary: Vaginal progesterone treatment in women with threatened preterm labor and a short cervix after 24 weeks of pregnancy is associated with lower rates of preterm birth. The treatment also prolongs the time interval from diagnosis to delivery and reduces the frequency of neonatal intensive care unit admission.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Maria Teresa Gervasi, Roberto Romero, Elisa Cainelli, Paola Veronese, Maria Rosa Tran, Eunjung Jung, Manaphat Suksai, Mariachiara Bosco, Francesca Gotsch
Summary: This study suggests that asymptomatic intra-amniotic inflammation in the mid-trimester of pregnancy can increase the risk of neurodevelopmental disorders in children. Early recognition and treatment of maternal immune activation may be a strategy for preventing such disorders in offspring.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Nandor Gabor Than, Roberto Romero, Daniel Gyorffy, Mate Posta, Gaurav Bhatti, Bogdan Done, Piya Chaemsaithong, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Dahiana M. Gallo, Mariachiara Bosco, Bomi Kim, Yeon Mee Kim, Tinnakorn Chaiworapongsa, Simona W. Rossi, Andras Szilagyi, Offer Erez, Adi L. Tarca, Zoltan Papp
Summary: This study identified different molecular subclasses of preeclampsia through longitudinal proteomic profiling, laying the foundation for the development of new diagnostic and personalized tools for prevention.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Tinnakorn Chaiworapongsa, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Dahiana M. Gallo, Eunjung Jung, Arthur Krieger, Piya Chaemsaithong, Offer Erez, Adi L. Tarca
Summary: This study aimed to determine the prevalence, characteristics, and clinical significance of angiogenic/antiangiogenic factor abnormalities in women with preeclampsia stratified according to gestational age at delivery. The results showed that patients with early preeclampsia had an abnormal angiogenic profile in virtually all cases, whereas only 50% of women with preeclampsia at term had such abnormalities. These findings have implications for future clinical care and research.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Obstetrics & Gynecology
Bo Hyun Yoon, Roberto Romero, Kyung Joon Oh, Hyeon Ji Kim, Eunjung Jung, Francesca Gotsch
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Roberto Romero
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Tomi Kanninen, Eunjung Jung, Dahiana M. Gallo, Ramiro Diaz-Primera, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Mariachiara Bosco, Tinnakorn Chaiworapongsa
Summary: Preeclampsia and fetal growth disorders are pregnancy-specific conditions that share common pathophysiological mechanisms. This study suggests that the severity of the maternal inflammatory response is highest in patients with preeclampsia, while patients with an SGA fetus also show elevated inflammatory response.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero
Summary: This review examines the efficacy of vaginal progesterone (VP) in preventing preterm birth (PTB) in different subsets of high-risk women. The evidence suggests that VP is effective in reducing the risk of PTB and improving perinatal outcomes in certain groups, such as singleton gestations with a short cervix. However, further research is needed to determine its efficacy in other high-risk groups.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Francesca Gotsch, Sunil Jaiman, Eunjung Jung, Manaphat Suksai, Carlos Lopez Ramon y Cajal, Bo Hyun Yoon, Tinnakorn Chaiworapongsa
Summary: Green-stained amniotic fluid, also known as meconium-stained amniotic fluid, is a common obstetric hazard. It can be caused by the passage of fetal colonic content or intraamniotic bleeding. Birth with green-stained amniotic fluid is associated with fetal acidemia and potential complications like respiratory distress and seizures. Infection/inflammation inside the amniotic fluid plays a role in the development of meconium-stained amniotic fluid and can lead to clinical chorioamnionitis and neonatal sepsis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero, Anoop Rehal, Maria L. Brizot, Vicente Serra, Eduardo Da Fonseca, Elcin Cetingoz, Argyro Syngelaki, Alfredo Perales, Sonia S. Hassan, Kypros H. Nicolaides
Summary: This study evaluated the efficacy of vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin pregnancies. The results showed that vaginal progesterone did not prevent preterm birth or improve perinatal outcomes in unselected twin pregnancies. However, it appeared to reduce the risk of preterm birth and neonatal morbidity and mortality in twin pregnancies with a sonographic short cervix.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zhengyuan Huang, Pei F. Lai, Alexander T. H. Cocker, Stuart M. Haslam, Anne Dell, Hugh J. M. Brady, Mark R. Johnson
Summary: Protein N-linked glycosylation is a diverse post-translational modification that stores biological information in a larger magnitude than other modifications. It impacts trophoblast functions and their interactions with decidual cells. Understanding N-glycosylation can improve approaches to predicting and diagnosing pregnancy complications related to placental dysfunction.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2023)
Review
Microbiology
Jonathan J. Panzer, Roberto Romero, Jonathan M. Greenberg, Andrew D. Winters, Jose Galaz, Nardhy Gomez-Lopez, Kevin R. Theis
Summary: The existence of a microbiota in the human placenta is still debated. Recent DNA sequencing investigations reported the presence of a microbiota in typical human term placentas, but it could be background DNA or contamination. Re-analysis of publicly available 16S rRNA gene datasets showed that Lactobacillus, a vaginal bacterium, was highly abundant in placentas but disappeared after applying DNA contaminant removal. Furthermore, bacterial profiles of placental samples clustered primarily by study origin and mode of delivery, suggesting that placentas delivered at term are unlikely to be the original source of observed bacterial DNA signals.
Letter
Obstetrics & Gynecology
Piya Chaemsaithong, Piroon Jenjaroenpun, Pisut Pongchaikul, Arunee Singsaneh, Iyarit Thaipisuttikul, Roberto Romero, Thidathip Wongsurawat
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Priya Prasad, Roberto Romero, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Anderson Lo, Jose Galaz, Andreea B. B. Taran, Eunjung Jung, Francesca Gotsch, Nandor Gabor Than, Adi L. L. Tarca
Summary: Approximately 47% of women with preterm labor deliver at term, but their infants are at higher risk for being small for gestational age and having neurodevelopmental disorders. This study tested the involvement of components of the insulin-like growth factor system in preterm labor and found higher levels of certain components in women with a history of preterm labor.
FETAL DIAGNOSIS AND THERAPY
(2023)