A Cautionary Note on the Effects of Population Stratification Under an Extreme Phenotype Sampling Design

The impact of a fine-scale population stratification on rare variant association test results

(2018) Elodie Persyn et al.   PLoS One

On the substructure controls in rare variant analysis: Principal components or variance components?

(2017) Yiwen Luo et al.   GENETIC EPIDEMIOLOGY

Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models

(2016) Han Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Testing of candidate single nucleotide variants associated with paclitaxel neuropathy in the trial NCCTG N08C1 (Alliance)

(2016) Ganesh K. Boora et al.   Cancer Medicine

Detecting the Common and Individual Effects of Rare Variants on Quantitative Traits by Using Extreme Phenotype Sampling

(2016) Ya-Jing Zhou et al.   Genes

A Nonparametric Regression Approach to Control for Population Stratification in Rare Variant Association Studies

(2016) Qiuying Sha et al.   Scientific Reports

Exome-based case–control association study using extreme phenotype design reveals novel candidates with protective effect in diabetic retinopathy

(2015) Corina Shtir et al.   HUMAN GENETICS

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach

(2014) Jorie Versmissen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Quantitative trait analysis in sequencing studies under trait-dependent sampling

(2013) D.-Y. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Population Stratification on False Positive Rates of Population-Based Association Analyses of Quantitative Traits

(2012) Tanushree Haldar et al.   ANNALS OF HUMAN GENETICS

Detecting Rare Variant Effects Using Extreme Phenotype Sampling in Sequencing Association Studies

(2012) Ian J. Barnett et al.   GENETIC EPIDEMIOLOGY

Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis

(2012) Mary J Emond et al.   NATURE GENETICS

Differential confounding of rare and common variants in spatially structured populations

(2012) Iain Mathieson et al.   NATURE GENETICS

Genome-wide efficient mixed-model analysis for association studies

(2012) Xiang Zhou et al.   NATURE GENETICS

Improved linear mixed models for genome-wide association studies

(2012) Jennifer Listgarten et al.   NATURE METHODS

Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

(2011) Michael C. Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A flexible likelihood framework for detecting associations with secondary phenotypes in genetic studies using selected samples: application to sequence data

(2011) Dajiang J Liu et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants

(2011) Lin T. Guey et al.   GENETIC EPIDEMIOLOGY

FaST linear mixed models for genome-wide association studies

(2011) Christoph Lippert et al.   NATURE METHODS

Variance component model to account for sample structure in genome-wide association studies

(2010) Hyun Min Kang et al.   NATURE GENETICS

Genetic Structure of Europeans: A View from the North–East

(2009) Mari Nelis et al.   PLoS One

Power of deep, all-exon resequencing for discovery of human trait genes

(2009) G. V. Kryukov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genealogical Interpretation of Principal Components Analysis

(2009) Gil McVean   PLoS Genetics

Efficient Control of Population Structure in Model Organism Association Mapping

(2008) H. M. Kang et al.   GENETICS

Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America

(2008) Roman Kosoy et al.   HUMAN MUTATION