Meeting the Challenge of Eliminating Chronic Hepatitis B Infection

Efficacy of hepatitis B virus ribonuclease H inhibitors, a new class of replication antagonists, in FRG human liver chimeric mice

(2018) Kelly R. Long et al.   ANTIVIRAL RESEARCH

Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection

(2018) Klaus Klumpp et al.   GASTROENTEROLOGY

Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype

(2018) Fang Shen et al.   HEPATOLOGY

A research agenda for curing chronic hepatitis B virus infection

(2018) Harvey Alter et al.   HEPATOLOGY

CRISPR/Cas9-mediated knockout of HBsAg inhibits proliferation and tumorigenicity of HBV-positive hepatocellular carcinoma cells

(2018) Jia Song et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hepatitis B splice variants are strongly associated with and are indeed predictive of hepatocellular carcinoma

(2018) M.-H. Pan et al.   JOURNAL OF HEPATOLOGY

96 weeks treatment of tenofovir alafenamide vs . tenofovir disoproxil fumarate for hepatitis B virus infection

(2018) Kosh Agarwal et al.   JOURNAL OF HEPATOLOGY

One-Vector System for Multiplexed CRISPR/Cas9 against Hepatitis B Virus cccDNA Utilizing High-Capacity Adenoviral Vectors

(2018) Maren Schiwon et al.   Molecular Therapy-Nucleic Acids

No Resistance to Tenofovir Alafenamide Detected through 96 Weeks of Treatment in Patients with Chronic Hepatitis B Infection

(2018) Andrea L. Cathcart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Circulating and intrahepatic antiviral B cells are defective in hepatitis B

(2018) Alice R. Burton et al.   JOURNAL OF CLINICAL INVESTIGATION

Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus

(2018) Angela M. Lam et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection

(2018) Emily P. Thi et al.   ACS Infectious Diseases

Hepatitis B cure: From discovery to regulatory approval

(2017) Anna S. Lok et al.   HEPATOLOGY

Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages

(2017) Xiaoming Cheng et al.   HEPATOLOGY

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

(2017) Anthony B El-Khoueiry et al.   LANCET

RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg

(2017) Christine I. Wooddell et al.   Science Translational Medicine

Nucleic Acid Polymers with Accelerated Plasma and Tissue Clearance for Chronic Hepatitis B Therapy

(2017) Ingo Roehl et al.   Molecular Therapy-Nucleic Acids

Deep sequencing shows that HBV basal core promoter and precore variants reduce the likelihood of HBsAg loss following tenofovir disoproxil fumarate therapy in HBeAg-positive chronic hepatitis B

(2016) Julianne Bayliss et al.   GUT

In Vitro Studies Show that Sequence Variability Contributes to Marked Variation in Hepatitis B Virus Replication, Protein Expression, and Function Observed across Genotypes

(2016) Vitina Sozzi et al.   JOURNAL OF VIROLOGY

Global strategies are required to cure and eliminate HBV infection

(2016) Peter Revill et al.   Nature Reviews Gastroenterology & Hepatology

Towards an HBV cure: state-of-the-art and unresolved questions—report of the ANRS workshop on HBV cure

(2015) Mirjam B Zeisel et al.   GUT

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

(2015) Michael Nassal   GUT

High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein

(2015) Klaus Klumpp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genotypes and Genetic Variability of Hepatitis B Virus

(2014) Anna Kramvis   INTERVIROLOGY

Molecular virology of hepatitis B virus, sub-genotype C4 in northern Australian Indigenous populations

(2014) M. Littlejohn et al.   JOURNAL OF MEDICAL VIROLOGY

Kinetics of Intrahepatic Covalently Closed Circular DNA and Serum Hepatitis B Surface Antigen During Antiviral Therapy for Chronic Hepatitis B: Lessons From Experimental and Clinical Studies

(2013) Fabien Zoulim et al.   Clinical Gastroenterology and Hepatology

The molecular epidemiology of hepatitis B in the Indigenous people of northern Australia

(2013) Jane Davies et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hepatitis B virus splicing is enhanced prior to development of hepatocellular carcinoma

(2013) Julianne Bayliss et al.   JOURNAL OF HEPATOLOGY

Inactivation of Hepatitis B Virus Replication in Cultured Cells and In Vivo with Engineered Transcription Activator-Like Effector Nucleases

(2013) Kristie Bloom et al.   MOLECULAR THERAPY

TALENs: a widely applicable technology for targeted genome editing

(2012) J. Keith Joung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Production of hepatitis B defective particles is dependent on liver status

(2012) Francois Redelsperger et al.   VIROLOGY

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

(2012) Huan Yan et al.   eLife

HBV genotypes: relevance to natural history, pathogenesis and treatment of chronic hepatitis B

(2011) Beom Kyung Kim et al.   ANTIVIRAL THERAPY

Hepatitis B Virus Resistance to Nucleos(t)ide Analogues

(2009) Fabien Zoulim et al.   GASTROENTEROLOGY

Expression of Defective Hepatitis B Virus Particles Derived from Singly Spliced RNA Is Related to Liver Disease

(2008) Patrick Soussan et al.   JOURNAL OF INFECTIOUS DISEASES

Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein

(2008) Joerg Petersen et al.   NATURE BIOTECHNOLOGY

Tenofovir Disoproxil Fumarate versus Adefovir Dipivoxil for Chronic Hepatitis B

(2008) Patrick Marcellin et al.   NEW ENGLAND JOURNAL OF MEDICINE