Article
Gastroenterology & Hepatology
Fumitaka Suzuki, Yoshiyuki Suzuki, Yoshiyasu Karino, Yasuhito Tanaka, Masayuki Kurosaki, Hiroshi Yatsuhashi, Tomofumi Atarashi, Masanori Atsukawa, Tsunamasa Watanabe, Masaru Enomoto, Masatoshi Kudo, Naoto Maeda, Hiroshi Kohno, Kouji Joko, Kojiro Michitaka, Koichiro Miki, Kazuhiro Takahashi, Tatsuya Ide, Shigetoshi Fujiyama, Tomoko Kohno, Hiroshi Itoh, Sakiyo Tsukamoto, Yuko Suzuki, Yoshiaki Kawano, Wataru Sugiura, Hiromitsu Kumada
Summary: This study aimed to evaluate the potential of switching from entecavir (ETV) to tenofovir disoproxil fumarate (TDF) for reducing HBsAg levels in HBeAg-positive chronic hepatitis B patients at 48 weeks. Results showed limited HBsAg reduction after switching, with a numerical increase in reduction for participants with higher alanine aminotransferase levels. Further investigation is needed to understand the clinical impact of this switch.
BMC GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Baijun Li, Zhaozhe Liu, Xing Liu, Dongchun Liu, Mingyu Duan, Ye Gu, Qiong Liu, Qiang Ma, Yushi Wei, Yan Wang
Summary: The study demonstrated that both TAF and TDF effectively prevented mother-to-child transmission of hepatitis B. TAF showed superiority in terms of renal safety and breastfeeding compared to TDF.
HEPATOLOGY INTERNATIONAL
(2021)
Review
Gastroenterology & Hepatology
Golasa Samadi Kochaksaraei, Abdel A. Shaheen, Cynthia H. Seow, Herman W. Barkema, Carla S. Coffin
Summary: Hepatitis B virus (HBV) is a global health problem, and vertical transmission is the main route of infection. Traditional immunoprophylaxis methods are effective, but may fail in pregnant women with high viral load. Therefore, pregnant women with high viral load are recommended to receive antiviral treatment in late pregnancy to prevent infant infection. However, maternal immunological reconstitution after childbirth may exacerbate immune responses to viral antigens.
LIVER INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Jinlin Hou, Qin Ning, Zhongping Duan, You Chen, Qing Xie, Fu-Sheng Wang, Lunli Zhang, Shanming Wu, Hong Tang, Jun Li, Feng Lin, Yongfeng Yang, Guozhong Gong, John F. Flaherty, Anuj Gaggar, Shuyuan Mo, Cong Cheng, Gregory Camus, Chengwei Chen, Yan Huang, Jidong Jia, Mingxiang Zhang
Summary: In Chinese patients with chronic hepatitis B, TAF treatment demonstrated efficacy similar to TDF after 3 years, but with improved renal and bone safety.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Chien-Hung Chen, Wen-Juei Jeng, Tsung-Hui Hu, Yen-Chun Liu, Jing-Houng Wang, Chao-Hung Hung, Sheng-Nan Lu, Rong-Nan Chien
Summary: This study compared the relapse patterns in hepatitis B patients who stopped two different antiviral drugs and found that those who stopped TAF had higher rates of virological relapse, but there was no significant difference in clinical relapse pattern and severity compared to those who stopped TDF.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Pharmacology & Pharmacy
Na Yang, Guanlun Zhou, Xiaoliang Cheng, Jun He, Yan Chen, Chao Chen, Meijuan Li, Jiajia Ge, Min Wang, Tianqi Zhang, Weihong Ge, Huaijun Zhu, Guorong Han
Summary: This study found that the concentration of TFV in the breast milk of mothers treated with TAF was significantly higher than in those treated with TDF, indicating a need for further investigation into the distribution of TAF in breast milk.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Ahizechukwu C. Eke, Kensuke Shoji, Brookie M. Best, Jeremiah D. Momper, Alice M. Stek, Tim R. Cressey, Mark Mirochnick, Edmund Capparelli
Summary: The pharmacokinetics of tenofovir in pregnant and postpartum women were affected by changes in apparent oral clearance and volume of distribution at steady state. These changes were primarily associated with increased body weight and enhanced renal function during pregnancy, leading to higher clearance rates compared to postpartum values. Dose adjustment of tenofovir disoproxil fumarate during pregnancy is generally not necessary, but any modifications should be made based on considerations of weight and renal function.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Srijanee Das, Weimin Wang, Murali Ganesan, Franchesca Fonseca-Lanza, Denise A. Cobb, Grace Bybee, Yimin Sun, Lili Guo, Brandon Hanson, Samuel M. Cohen, Howard E. Gendelman, Natalia A. Osna, Benson J. Edagwa, Larisa Y. Poluektova
Summary: The treatment of chronic hepatitis B virus (HBV) requires lifelong daily therapy, but suboptimal adherence has led to the need for ultralong-acting antivirals. A recent study developed a new drug called NM1TFV, which demonstrated monthslong antiviral activities in mice and in laboratory experiments, providing proof of concept for a new therapeutic paradigm for HBV treatment and prevention.
Article
Gastroenterology & Hepatology
Kwan Soo Byun, Jonggi Choi, Ji-Hoon Kim, Yung Sang Lee, Han Chu Lee, Yoon Jun Kim, Byung Chul Yoo, So Young Kwon, Geum-Youn Gwak, Young-Suk Lim
Summary: The study findings suggest that TAF may have better bone and renal safety profiles compared to TDF in patients with multidrug-resistant HBV, without compromising efficacy. However, concerns may arise due to increases in body weight and cholesterol levels with TAF treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jihye Lim, Won-Mook Choi, Ju Hyun Shim, Danbi Lee, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jonggi Choi
Summary: Real-world data suggests that TAF and TDF have comparable efficacies in treating CHB, with similar virological responses and ALT normalization, and no higher risk of HCC.
LIVER INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Hye Yeon Chon, Sang Hoon Ahn, Yoon Jun Kim, Jung-Hwan Yoon, Jeong-Hoon Lee, Dong Hyun Sinn, Seung Up Kim
Summary: The study compared the effects of three antiviral agents on the risk of hepatocellular carcinoma and orthotopic liver transplantation or mortality in patients with chronic hepatitis B. It was found that the outcomes of entecavir, tenofovir disoproxil fumarate, and tenofovir alafenamide were statistically similar in treatment-naive patients with CHB.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Jing Li, Lihong Qu, Xuehua Sun, Yanhong Liu, Qiming Gong, Demin Yu, Donghua Zhang, Jiehong Jiang, Jia Chen, Dong Wei, Yue Han, Yueqiu Gao, Qin Zhang, Weimin She, Liang Chen, Jiming Zhang, Xinxin Zhang
Summary: Several studies have shown that combining peginterferon alpha (Peg-IFNα) with nucleotide analogues has complementary effects in chronic hepatitis B (CHB). This clinical trial aimed to investigate the optimal regimen for HBeAg-positive CHB naive patients. The results suggest that adding Peg-IFNα to TDF treatment may be an effective strategy for achieving HBsAg loss in these patients.
JOURNAL OF VIRAL HEPATITIS
(2021)
Article
Virology
Lilian Yan Liang, Terry Cheuk-Fung Yip, Jimmy Che-To Lai, Amy Shuk-Man Lam, Yee-Kit Tse, Vicki Wing-Ki Hui, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong, Grace Lai-Hung Wong
Summary: This study evaluated the impact of switching to TAF on ALT normalization and renal safety in CHB patients and described the indications for switching to TAF. The results showed that switching to TAF significantly reduced ALT levels and increased ALT normalization rate. TAF was found to be associated with improved ALT levels and better renal safety compared to TDF dominant therapy in CHB patients. The majority of CHB patients switched to TAF due to advanced age, followed by bone disease and renal alteration.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Yoshihito Uchida, Masamitsu Nakao, Shunsuke Yamada, Shohei Tsuji, Hayato Uemura, Jun-ichi Kouyama, Kayoko Naiki, Kayoko Sugawara, Nobuaki Nakayama, Yukinori Imai, Tomoaki Tomiya, Satoshi Mochida
Summary: The long-term efficacy of switching from entecavir (ETV) to tenofovir alafenamide fumarate (TAF) was evaluated in patients with chronic HBV infection. The study showed that TAF treatment resulted in a greater reduction in serum HBsAg levels compared to ETV treatment, suggesting that switching to TAF may be a beneficial option for these patients.
Article
Infectious Diseases
Siying Li, Jie Jin, Yi Jiang, Jinfeng Shi, Xiaoxian Jiang, Nengming Lin, Zhiyuan Ma
Summary: This study investigated the safety of infants whose mothers continued to receive TDF while breastfeeding. The results showed that the concentration of TDF in breast milk is much lower than that from placental transfer and swallowing amniotic fluid, indicating that breastfeeding is safe for infants of HBV-infected mothers who continue to receive TDF through three months postpartum.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Gastroenterology & Hepatology
Josef Wagner, Lilly Yuen, Margaret Littlejohn, Vitina Sozzi, Kathy Jackson, Vithika Suri, Susanna Tan, Becket Feierbach, Anuj Gaggar, Patrick Marcellin, Maria Buti Ferret, Harry L. A. Janssen, Ed Gane, Henry L. Y. Chan, Danni Colledge, Gillian Rosenberg, Julianne Bayliss, Benjamin P. Howden, Stephen A. Locarnini, Darren Wong, Alexander T. Thompson, Peter A. Revill
Summary: The study identified different haplotype populations associated with treatment outcomes and disease progression in chronic hepatitis B infection. Haplotype diversity varied across HBV genotypes and phases of CHB history. Highly conserved sequences in key genes were proposed as potential targets for antiviral therapies and predictors of treatment response.
Review
Biotechnology & Applied Microbiology
Julianne Bayliss, Michael Nissen, Damita Prakash, Peter Richmond, Kyu-Bin Oh, Terry Nolan
Summary: The use of the DTPa-HBV-IPV/Hib combined vaccine in Australia since 2009 has led to increased vaccination coverage rates, decreased incidences of diseases such as diphtheria, tetanus, and poliomyelitis, particularly among Indigenous infants. The safety profile of the vaccine remains acceptable, with additional strategies such as parental cocooning and maternal vaccination further reducing the burden of pertussis during the first six months of life.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Editorial Material
Gastroenterology & Hepatology
Darren Wong, Simon P. L. Travis
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Hui Xu, Stephen Locarnini, Darren Wong, Rachel Hammond, Danni Colledge, Sally Soppe, Thao Huynh, Tim Shaw, Alexander J. Thompson, Peter A. Revill, P. Mark Hogarth, Bruce D. Wines, Renae Walsh, Nadia Warner
Summary: This study identified key anti-HBs profiles associated with either functional cure or failure to achieve functional cure in patients with chronic hepatitis B, suggesting a role for anti-HBs responses in functional cure.
JOURNAL OF HEPATOLOGY
(2022)
Editorial Material
Surgery
Zexi Allan, Darren J. Wong, Thomas Sweeney, David S. Liu
ANZ JOURNAL OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
David S. Liu, Ryan Newbold, Sean Stevens, Enoch Wong, Jonathan Fong, Krinal Mori, Darren J. Wong, Anna Sonia Gill, Sharon Lee, Wael Jamel, Amy Crowe, Tess Howard, Anshini Jain, Pith Soh Beh, Maeve Slevin, Nicola Fleming, Simon Bennet, Chi Chung
Summary: For patients undergoing abdominal visceral resections, initiating chemoprophylaxis postoperatively reduces the risk of bleeding without increasing the risk of clinical VTE compared to early administration.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Surgery
David S. Liu
Summary: This study aimed to investigate the variability in perioperative chemoprophylaxis and assess the impact of timing on bleeding and symptomatic venous thromboembolism in elective major ventral hernia surgery. The findings showed that early initiation of chemoprophylaxis significantly increased the risk of bleeding without providing substantial additional protection against venous thromboembolism. The incidence of symptomatic venous thromboembolism after the surgery was low.
Article
Gastroenterology & Hepatology
Ross Apostolov, Emily Gianatti, Darren Wong, Numan Kutaiba, Paul Gow, Mathis Grossmann, Marie Sinclair
Summary: Testosterone therapy can reduce hepatic steatosis in men with diabetes and low serum testosterone.
WORLD JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Darren Wong, Lawrence Matini, Andrey Kormilitzin, Ramona Kantschuster, Daniel Martin Simadibrata, Sara Lyden, Jean Wilson, Oliver A. Brain, Rebecca Palmer, Tim Ambrose, Jack Satsangi, Matthew South, John Geddes, Keith Bodger, Simon P. L. Travis, Alissa Walsh
Summary: This study reports on the symptoms, quality of life, and ICHOM IBD outcomes of patients with inflammatory bowel disease. The results illustrate the therapeutic deficit in current care, and demonstrate that patient-reported outcome data can be collected continuously with little burden on healthcare professionals.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Penelope Hey, Melissa Chew, Darren Wong, Paul Gow, Adam Testro, Numan Kutaiba, Marie Sinclair
LIVER TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Jennifer R. Reilly, Paul S. Myles, Darren Wong, Stephane R. Heritier, Wendy A. Brown, Toby Richards, Max Bell
Summary: The study assessed the relationships of patient and surgical factors and hospital costs with the number of days alive and at home during the 30 days following surgery. The findings showed a moderate association between days alive and at home and total hospital costs, with a decline in median days alive and at home observed with increasing age, comorbidity score, ASA physical status score, surgical severity, and duration.
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Article
Virology
Jack Wallace, Jacqueline Richmond, Jessica Howell, Behzad Hajarizadeh, Jennifer Power, Carla Treloar, Peter A. Revill, Benjamin Cowie, Su Wang, Mark Stoove, Alisa Pedrana, Margaret Hellard
Summary: Hepatitis B is a global health issue, and it is crucial to ensure that all patients have access to treatment. Eliminating viral hepatitis is vital for public health and requires addressing social and public health implications, as well as addressing current disparities and responding to cultural contexts and patient health needs.
Editorial Material
Gastroenterology & Hepatology
Josef Wagner, Margaret Littlejohn, Peter A. Revill
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Margaret Littlejohn, Lesley-Anne Jaskowski, Ros Edwards, Kathy Jackson, Lilly Yuen, Darrel Crawford, Stephen A. Locarnini, Graham Cooksley
Summary: This study aimed to characterize the hepatitis B virus (HBV) from Indigenous populations in Queensland and the Torres Strait Islands. The HBV isolated from the Torres Strait Islanders was notably different from the HBV/C4 strain isolated from Indigenous people of mainland northern Australia, reflecting the differences in culture and origin between the two.
INTERNAL MEDICINE JOURNAL
(2023)