Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease

Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1

(2018) Miriam Toledo et al.   Cell Metabolism

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

(2018) David Højland Ipsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Circadian clock rhythms in different adipose tissue model systems

(2018) Maureen Friedrichs et al.   CHRONOBIOLOGY INTERNATIONAL

Daily cycle in hepatic lipid metabolism in obese mice, Neotomodon alstoni: Sex differences

(2018) Moisés Pérez-Mendoza et al.   CHRONOBIOLOGY INTERNATIONAL

Bmal1-deficient mouse fibroblast cells do not provide premature cellular senescence in vitro

(2018) Yasukazu Nakahata et al.   CHRONOBIOLOGY INTERNATIONAL

Clock genes alterations and endocrine disorders

(2018) Anna Angelousi et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Potential Roles of Dec and Bmal1 Genes in Interconnecting Circadian Clock and Energy Metabolism

(2018) Fuyuki Sato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Epigenetic Regulation of Biological Rhythms: An Evolutionary Ancient Molecular Timer

(2018) Tyler J. Stevenson   TRENDS IN GENETICS

Temporal Control of Metabolic Amplitude by Nocturnin

(2018) Jeremy J. Stubblefield et al.   Cell Reports

BMAL1 functions as a cAMP-responsive coactivator of HDAC5 to regulate hepatic gluconeogenesis

(2018) Jian Li et al.   Protein & Cell

The Biological Clock: A Pivotal Hub in Non-alcoholic Fatty Liver Disease Pathogenesis

(2018) Gianluigi Mazzoccoli et al.   Frontiers in Physiology

Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration

(2018) A.T. Pettersson-Klein et al.   Molecular Metabolism

Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity

(2018) Silvia Sookoian et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Role of the Circadian Clock in the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease

(2018) Akshay Shetty et al.   DIGESTIVE DISEASES AND SCIENCES

Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity

(2017) Songtao Li et al.   HEPATOLOGY

Asia-Pacific Working Party on Non-alcoholic Fatty Liver Disease guidelines 2017-Part 1: Definition, risk factors and assessment

(2017) Vincent Wai-Sun Wong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation

(2017) Amol Chaudhari et al.   MOLECULAR BIOLOGY OF THE CELL

Period23′-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation

(2017) Seung-Hee Yoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian rhythms, nutrition and implications for longevity in urban environments

(2017) O. Froy   PROCEEDINGS OF THE NUTRITION SOCIETY

NPAS2 promotes cell survival of hepatocellular carcinoma by transactivating CDC25A

(2017) Peng Yuan et al.   Cell Death & Disease

RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis

(2017) Yong-Hyun Han et al.   Cell Reports

Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice

(2016) Yu Fujita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

(2016) Nicole M. Kettner et al.   CANCER CELL

Global Epidemiology of Nonalcoholic Fatty Liver Disease and Perspectives on US Minority Populations

(2016) Zaki A. Sherif et al.   DIGESTIVE DISEASES AND SCIENCES

Circadian Clock Control of Liver Metabolic Functions

(2016) Hans Reinke et al.   GASTROENTEROLOGY

Non-invasive diagnosis of hepatic steatosis

(2016) Christiane Stern et al.   Hepatology International

Hepatic rhythmicity of endoplasmic reticulum stress is disrupted in perinatal and adult mice models of high-fat diet-induced obesity

(2016) Junpei Soeda et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Circadian regulation of lipid metabolism

(2016) Joshua J Gooley   PROCEEDINGS OF THE NUTRITION SOCIETY

Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis

(2016) Xiaoyue Pan et al.   Nature Communications

Impact of nutrients on circadian rhythmicity

(2015) Johanneke E. Oosterman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Zonation of hepatic fatty acid metabolism — The diversity of its regulation and the benefit of modeling

(2015) J. Schleicher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The systemic control of circadian gene expression

(2015) A. Gerber et al.   DIABETES OBESITY & METABOLISM

Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study

(2015) Miwa Yamaguchi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism

(2015) Sang Min Lee et al.   HEPATOLOGY

Genome-wide analysis of long noncoding RNA expression profiles in patients with non-alcoholic fatty liver disease

(2015) Chuanzheng Sun et al.   IUBMB LIFE

Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?

(2015) Mohamed Asrih et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Circadian Clock-Deficient Mice as a Tool for Exploring Disease Etiology

(2015) Masao Doi   BIOLOGICAL & PHARMACEUTICAL BULLETIN

RORα Decreases Oxidative Stress Through the Induction of SOD2 and GPx1 Expression and Thereby Protects Against Nonalcoholic Steatohepatitis in Mice

(2014) Yong-Hyun Han et al.   ANTIOXIDANTS & REDOX SIGNALING

Daytime restricted feeding modifies the daily variations of liver gluconeogenesis: Adaptations in biochemical and endocrine regulators

(2014) Moisés Pérez-Mendoza et al.   CHRONOBIOLOGY INTERNATIONAL

Physiological links between circadian rhythms, metabolism and nutrition

(2014) Jonathan D. Johnston   EXPERIMENTAL PHYSIOLOGY

Hepatic PPARγ and LXRα independently regulate lipid accumulation in the livers of genetically obese mice

(2014) Kimihiko Matsusue et al.   FEBS LETTERS

Inhibiting CB1 receptors improves lipogenesis in an in vitro non-alcoholic fatty liver disease model

(2014) Dongmei Shi et al.   Lipids in Health and Disease

Non-alcoholic fatty liver disease: the role of nuclear receptors and circadian rhythmicity

(2014) Gianluigi Mazzoccoli et al.   LIVER INTERNATIONAL

Epigenetic control and the circadian clock: Linking metabolism to neuronal responses

(2014) R. Orozco-Solis et al.   NEUROSCIENCE

Entrainment of the Human Circadian Clock to the Natural Light-Dark Cycle

(2013) Kenneth P. Wright et al.   CURRENT BIOLOGY

Genetic Variation in the NOC Gene Is Associated with Body Mass Index in Chinese Subjects

(2013) Yi-Cheng Chang et al.   PLoS One

Prevalence and factors associated with nonalcoholic fatty liver disease in shanghai work-units

(2012) Xiaona Hu et al.   BMC GASTROENTEROLOGY

CLOCK, PER2 and BMAL1 DNA Methylation: Association with Obesity and Metabolic Syndrome Characteristics and Monounsaturated Fat Intake

(2012) Fermín I. Milagro et al.   CHRONOBIOLOGY INTERNATIONAL

Deletion of clock gene Per2 exacerbates cholestatic liver injury and fibrosis in mice

(2012) Peng Chen et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Differences in circadian rhythmicity in CLOCK 3111T/C genetic variants in moderate obese women as assessed by thermometry, actimetry and body position

(2012) C Bandín et al.   INTERNATIONAL JOURNAL OF OBESITY

Differentiated embryo chondrocyte 1 (DEC1) represses PPARγ2 gene through interacting with CCAAT/enhancer binding protein β (C/EBPβ)

(2012) Young-Kwon Park et al.   MOLECULES AND CELLS

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

(2012) Laura A. Solt et al.   NATURE

Nocturnin: at the crossroads of clocks and metabolism

(2012) Jeremy J. Stubblefield et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cellular DBP and E4BP4 proteins are critical for determining the period length of the circadian oscillator

(2011) Daisuke Yamajuku et al.   FEBS LETTERS

Regulation of metabolism: the circadian clock dictates the time

(2011) Saurabh Sahar et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PER2 Controls Lipid Metabolism by Direct Regulation of PPARγ

(2010) Benedetto Grimaldi et al.   Cell Metabolism

Loss of clock gene mPer2 promotes liver fibrosis induced by carbon tetrachloride

(2010) Peng Chen et al.   HEPATOLOGY RESEARCH

Kruppel-Like Factor KLF10 Is a Link between the Circadian Clock and Metabolism in Liver

(2010) F. Guillaumond et al.   MOLECULAR AND CELLULAR BIOLOGY

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

(2010) Eric E Zhang et al.   NATURE MEDICINE

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population)

(2009) Marta Garaulet et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Clock gene expression in peripheral leucocytes of patients with type 2 diabetes

(2008) H. Ando et al.   DIABETOLOGIA

Redundant Function of REV-ERBα and β and Non-Essential Role for Bmal1 Cycling in Transcriptional Regulation of Intracellular Circadian Rhythms

(2008) Andrew C. Liu et al.   PLoS Genetics