Article
Cell Biology
Han Yan, Qi Li, Mengying Li, Xiuqun Zou, Ningning Bai, Zichao Yu, Jie Zhang, Dan Zhang, Qun Zhang, Jiamin Wang, Hao Jia, Yingjie Wu, Zhaoyuan Hou
Summary: The study shows that depletion of Ajuba in 3T3-L1 cells reduces the expression of PPARγ and C/EBPα, impairing adipocyte differentiation, while overexpression increases their expression and promotes differentiation. Restoring C/EBPα or PPARγ expression in Ajuba-deficient cells improves impaired lipid accumulation. Ajuba interacts with C/EBPβ and recruits CBP to enhance binding to the promoter regions of PPARγ and C/EBPα, leading to increased gene expression.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Wan Xu, Jingjing Zhang, Jing Xiao
Summary: The selective PDE4 inhibitor Roflumilast was found to suppress adipogenesis and promote lipolysis, showing therapeutic potential in obesity-related diseases in cell culture and mouse models.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Food Science & Technology
Xiaohong Lin, Weiye Xu, Liu Liu, Shiyi Ou, Xichun Peng
Summary: The metabolites of flaxseed polysaccharide fermented by fecal bacteria were found to inhibit glucose intake and lipid accumulation, which might be a weight-loss mechanism of flaxseed polysaccharide through regulating intestinal microbiota.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Chaiwat Monmai, Jin-Suk Kim, Hyun Bo Sim, Doh-Won Yun, Sung-Dug Oh, Eui-Shik Rha, Jong-Jin Kim, So-Hyeon Baek
Summary: This study evaluated the effects of extracts from transgenic rice on inhibiting adipogenesis and anti-inflammatory activity. The results showed that the extracts significantly reduced lipid accumulation in cells and inhibited the expression of adipogenesis-related mRNA and inflammation-related factors. Therefore, transgenic rice may have potential as an obesity-reducing and/or -preventing agent.
Article
Cell & Tissue Engineering
Ping Duan, Hanyu Wang, Xinzeyu Yi, Hao Zhang, Hui Chen, Zhenyu Pan
Summary: This study investigated the epigenetic mechanism of intramedullary fat accumulation and continuous osteonecrosis in steroid-induced avascular necrosis of the femoral head (SANFH). The results showed that C/EBP alpha regulated PPAR gamma expression by acetylating histones and played a crucial role in the differentiation of BMSCs, leading to the development of SANFH.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Pharmacology & Pharmacy
Jinhai Luo, Zhiling Yu, Juscelino Tovar, Anne Nilsson, Baojun Xu
Summary: Phytochemicals inhibit adipogenesis and lipid accumulation by activating the Wnt/β-catenin signaling pathway, potentially serving as anti-obesity drugs.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biology
Amir Roshanzadeh, Anil Kumar Yadav, Sai-Prasad Pydi, Takefumi Kimura, Byeong-Churl Jang
Summary: This study demonstrates that the expression of beta 3-adrenergic receptor (beta 3-AR) is up-regulated during differentiation of 3T3-L1 cells in a p38 MAPK and PKC-dependent manner, and plays a crucial role in lipid accumulation.
Article
Biochemistry & Molecular Biology
Mirko Marino, Samuele Venturi, Cristian Del Bo', Peter Moller, Patrizia Riso, Marisa Porrini
Summary: The biologically active form of vitamin D, calcitriol (VD3), has been found to reduce fatty acid accumulation in macrophages and may have a protective effect against atherosclerosis by regulating proteins involved in lipid transport and clearance.
Article
Cell Biology
Jiaqi Guo, Linglin Qian, Jingjing Ji, Zhenjun Ji, Yu Jiang, Ya Wu, Ziwei Yang, Genshan Ma, Yuyu Yao
Summary: Serpina3c promotes adipogenesis and maintains normal fat function by inhibiting the Wnt/beta-catenin pathway. Serpina3c knockout mice exhibit reduced body weight and white adipose tissue weight, and increased lipid depositions in the liver and muscles. In addition, knockout mice show severe insulin resistance.
CELLULAR SIGNALLING
(2022)
Article
Pharmacology & Pharmacy
Amir Hossein Faghfouri, Yaser Khajebishak, Laleh Payahoo, Elnaz Faghfuri, Mohammadreza Alivand
Summary: Autophagy pathways are involved in the pathogenesis of some obesity related health problems. PPAR-gamma as the main modulator of adipogenesis process can be effective in regulating obesity related phenotypes. The effects of PPAR-gamma and its agonists on autophagy modulation in obesity have been investigated in a limited number of studies.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Abhijit B. Shinde, Elizabeth R. Nunn, Genesis A. Wilson, Mathew T. Chvasta, Julia A. Pinette, Jacob W. Myers, Sun H. Peck, Jessica B. Spinelli, Elma Zaganjor
Summary: Energy balance and nutrient availability play important roles in cellular decisions of quiescence, proliferation, and differentiation. However, how metabolic rewiring and nucleotide metabolism regulate cell fate decisions remains unclear. Using adipogenesis as a model, this study identified metabolic signatures associated with differentiation and revealed the requirement of nucleotide biosynthesis for adipocyte differentiation. Moreover, purines were found to regulate transcriptional activators of adipogenesis to promote differentiation, independent of mechanistic target of rapamycin complex 1 signaling.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hyo-Shin Kwon, Gil-Saeng Jeong, Byeong-Churl Jang
Summary: CTXA from Cudrania tricuspidata Bureau exhibits strong anti-adipogenic and anti-inflammatory effects on 3T3-L1 cells by regulating the expression and phosphorylation levels of C/EBP-alpha, PPAR-gamma, FAS, ACC, perilipin A, STAT-3/5, AMPK, and iNOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Junjie Yue, Caiting Sun, Jinyuan Tang, Qiyuan Zhang, Mengjie Lou, Hongwen Sun, Lianying Zhang
Summary: 2-Ethylhexyl diphenyl phosphate (EHDPP), a commonly used flame retardant and food packaging material, exhibits high lipophilicity and bioaccumulation properties, primarily targeting adipocytes. The toxicity of EHDPP on preadipocytes and the underlying mechanism have not been fully understood. This study identified 7 differentially expressed miRNAs in 3T3-L1 preadipocytes exposed to EHDPP, with miR-155-5p being the most significantly down-regulated miRNA. Inhibition of miR-155-5p promoted adipocyte differentiation, while its overexpression counteracted EHDPP-induced adipogenesis.
Article
Biochemistry & Molecular Biology
Sasikumar Jalajakumari Soumya, Chandran Sheela Abhinand, Arya Saseendran Nair, Priji Sathyan Sonu, Govindapillai Mohanadasan Nair, Appukuttan Nair Gangaprasad, Achuthsankar S. Nair, Ananthakrishnan Jayakumaran Nair
Summary: Chrysin inhibits adipogenesis by modulating the key adipogenic transcription factor PPAR-γ, which may provide potential therapeutic interventions for controlling adiposity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Endocrinology & Metabolism
Dongliang Fang, Xinyi Shi, Xiaowei Jia, Chun Yang, Lulu Wang, Baopu Du, Tao Lu, Lin Shan, Yan Gao
Summary: The research reveals that FSTL1 promotes adipogenesis through the integrin/FAK/ERK signaling pathway, with glycosylated modification at the N142 site playing a key role. Lack of FSTL1 inhibits preadipocyte differentiation and obesity development.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Young-Kwon Park, Limin Wang, Anne Giampietro, Binbin Lai, Ji-Eun Lee, Kai Ge
MOLECULAR AND CELLULAR BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Young-Kwon Park, Kai Ge
MOLECULAR AND CELLULAR BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Ji-Eun Lee, Young-Kwon Park, Sarah Park, Younghoon Jang, Nicholas Waring, Anup Dey, Keiko Ozato, Binbin Lai, Weiqun Peng, Kai Ge
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Lenan Zhuang, Younghoon Jang, Young-Kwon Park, Ji-Eun Lee, Shalini Jain, Eugene Froimchuk, Aaron Broun, Chengyu Liu, Oksana Gavrilova, Kai Ge
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Young-Kwon Park, Hyunsung Park
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Correction
Biochemistry & Molecular Biology
Young-Kwon Park, Hyunsung Park
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Young-Kwon Park, Bongju Park, Seongyeol Lee, Kang Choi, Yunwon Moon, Hyunsung Park
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Ho-Youl Lee, Kang Choi, Hookeun Oh, Young-Kwon Park, Hyunsung Park
MOLECULES AND CELLS
(2014)
Article
Biochemistry & Molecular Biology
Younghoon Jang, Aaron Broun, Chaochen Wang, Young-Kwon Park, Lenan Zhuang, Ji-Eun Lee, Eugene Froimchuk, Chengyu Liu, Kai Ge
NUCLEIC ACIDS RESEARCH
(2019)
Article
Multidisciplinary Sciences
Young-Kwon Park, Ji-Eun Lee, Zhijiang Yan, Kaitlin McKernan, Tommy O'Haren, Weidong Wang, Weiqun Peng, Kai Ge
Summary: The study reveals that BAF and MLL4 are interdependent in promoting enhancer activation by lineage-determining transcription factors during adipogenesis, providing a positive feedback mechanism for the activation of cell type-specific enhancers.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Younghoon Jang, Young-Kwon Park, Ji-Eun Lee, Danyang Wan, Nhien Tran, Oksana Gavrilova, Kai Ge
Summary: Our study reveals that MED1 is not generally required for transcription during adipogenesis, but plays a crucial role in postnatal adipose expansion and induction of lipid synthesis genes after diet switch.
GENES & DEVELOPMENT
(2021)
Article
Oncology
Haobin Chen, Lisa Gesumaria, Young-Kwon Park, Trudy G. Oliver, Dinah S. Singer, Kai Ge, David S. Schrump
Summary: Small-cell lung cancer (SCLC) is a difficult-to-treat malignancy. BET proteins have been found to interact with NEUROD1 and function as transcriptional coactivators in SCLC. Blocking BET proteins with inhibitors suppresses NEUROD1-target genes, inhibiting SCLC growth in vitro and in vivo. LSAMP, a membrane protein, is identified as one of the NEUROD1-target genes mediating BET inhibitor sensitivity in SCLC. These findings highlight the essential role of BET proteins and their potential as targets in SCLC-N subtype tumors.
MOLECULAR CANCER RESEARCH
(2023)
Article
Genetics & Heredity
Guojia Xie, Ji-Eun Lee, Anna D. Senft, Young-Kwon Park, Younghoon Jang, Shreeta Chakraborty, Joyce J. J. Thompson, Kaitlin McKernan, Chengyu Liu, Todd S. S. Macfarlan, Pedro P. P. Rocha, Weiqun Peng, Kai Ge
Summary: The enzymatic activities of MLL3 and MLL4 are critical for embryonic development and embryonic stem cell differentiation.
Article
Oncology
Wonchung Lim, Yeomyung Park, Jungyoon Cho, Choa Park, Joonwoo Park, Young-Kwon Park, Hyunsung Park, YoungJoo Lee
BREAST CANCER RESEARCH
(2011)