Article
Biochemistry & Molecular Biology
Xenia Puig-Bosch, Markus Ballmann, Stefan Bieletzki, Bernd Antkowiak, Uwe Rudolph, Hanns Ulrich Zeilhofer, Gerhard Rammes
Summary: Neurosteroids and benzodiazepines are GABA(A) receptor modulators with anxiolytic effects. This study aimed to investigate the effects of neurosteroids and their synthesis using a synthetic compound called XBD173, which promotes neurosteroidogenesis by binding to the translocator protein 18 kDa (TSPO). The results showed that XBD173 induced neurosteroidogenesis and the application of potentially synthesized neurosteroids did not impair hippocampal CA1-LTP, which is important for learning and memory. Therefore, TSPO ligands could be promising candidates for post-ischemic recovery with neuroprotection and without detrimental effects on synaptic plasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Natalia Siwinska, Izabela Janus, Agnieszka Zak-Bochenek, Agnieszka Noszczyk-Nowak
Summary: Obesity is a global problem in both humans and companion animals, including horses. This study analyzed the microscopic changes in heart and vessels structure in obese horses and found significant architecture changes, similar to those observed in humans, which may indicate subclinical dysfunction and lead to severe disease.
Article
Multidisciplinary Sciences
Su Hwan Cho, Minseol Jang, Hyorim Ju, Min Ju Kang, Jae Moon Yun, Jae Won Yun
Summary: This large population-based study found a significant inverse relationship between late-life body mass index (BMI) and the risk of Alzheimer's disease (AD), especially in the underweight population. The results suggest that actively screening for AD and improving weight status among the underweight population may help reduce the burden of AD.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Milan Obradovic, Emina Sudar-Milovanovic, Sanja Soskic, Magbubah Essack, Swati Arya, Alan J. Stewart, Takashi Gojobori, Esma R. Isenovic
Summary: Leptin, a peptide hormone, regulates food intake, body mass, and reproductive function, playing a crucial role in fetal growth, immune responses, angiogenesis, and lipolysis. Leptin resistance can lead to reduced satiety, overconsumption of nutrients, and increased body mass, potentially causing obesity. Combining leptin therapies with sensitizers may help overcome resistance and treat obesity effectively.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Caroline Kroll, Dayana Rodrigues Farias, Gilberto Kac, Paulo Henrique Condeixa de Franca, Marco Fabio Mastroeni
Summary: This study found that the TG or GG genotypes of the ADIPOQ-rs2241766 gene are associated with an increased risk of excess body weight in children in the first 6 years of life, especially in girls. In contrast, the LEP-rs7799039 genetic variant showed no association with body weight trajectory.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Medicine, General & Internal
Hassiba Benbaibeche, Abdenour Bounihi, Elhadj Ahmed Koceir
Summary: The study found that obese and overweight subjects exhibited uncontrolled eating behavior, which was related to leptin and insulin sensitivity. High leptin levels may serve as a potential biomarker for uncontrolled eating.
IRISH JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Endocrinology & Metabolism
Kenny Mendoza-Herrera, Andrea A. Florio, Maggie Moore, Abrania Marrero, Martha Tamez, Shilpa N. Bhupathiraju, Josiemer Mattei
Summary: This review focuses on the relationship between diet and leptin, suggesting that addressing leptin resistance through dietary interventions can counteract obesity. High-fat, high-carbohydrate, fructose, and sucrose diets, low in protein, contribute to leptin resistance, while energy-restricted diets can reduce leptin levels and potentially reverse resistance. Further research on reliable methods to measure resistance and alternative approaches like leptin sensitizers and genetically individualized diets is needed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mei Yu, Mengxian Ju, Penghua Fang, Zhenwen Zhang
Summary: Consumption of a high calorie diet with irregular eating and sedentary behavior habits is typical of the current suboptimal lifestyle, contributing to the development of metabolic diseases such as obesity and type 2 diabetes mellitus. The adipokines spexin and leptin play important roles in regulating adipogenesis and glucose metabolism. Their levels and interaction in patients with obesity and diabetes also affect the development of these diseases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maciej Wojcik, Agata Krawczynska, Dorota Anna Zieba, Hanna Antushevich, Andrzej Przemyslaw Herman
Summary: This study aimed to determine the influence of leptin on the activity of the hypothalamic-pituitary-somatotropic (HPS) axis. The research showed that the photoperiod and leptin sensitivity play important roles in regulating HPS axis activity in seasonal ewes. Leptin influences the release of growth hormone in a season-dependent manner, with its effect targeted at the posttranscriptional stages of GH secretion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Ricardo Augusto Leoni De Sousa, Leticia Gomes Santos, Paulo Mauricio Lopes, Bruno Raphael Ribeiro Cavalcante, Alex Cleber Improta-Caria, Ricardo Cardoso Cassilhas
Summary: Exercise, regardless of intensity, has positive effects on memory in both obese patients and animal models, making it an excellent intervention to prevent and inhibit cognitive impairment and memory loss.
Review
Biochemistry & Molecular Biology
Juan Antonio Flores-Cordero, Antonio Perez-Perez, Carlos Jimenez-Cortegana, Gonzalo Alba, Alfonso Flores-Barragan, Victor Sanchez-Margalet
Summary: Obesity is a global health problem and leptin resistance, a mechanism of obesity, is associated with the development of Alzheimer's Disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Juan P. Frias, Srikanth Deenadayalan, Lars Erichsen, Filip K. Knop, Ildiko Lingvay, Stanislava Macura, Chantal Mathieu, Sue Pedersen, Melanie Davies
Summary: This study assessed the efficacy and safety of co-administered semaglutide with cagrilintide in participants with type 2 diabetes. The results showed that the combination treatment resulted in clinically relevant improvements in glycemic control and weight loss compared to cagrilintide alone, and it was well tolerated.
Review
Pharmacology & Pharmacy
Shilpa Kumari, Rahul Deshmukh
Summary: Alzheimer's disease is a multifactorial disorder with accumulation of A beta and neurofibrillary tangles. Although new drug targets are being explored, the lengthy and expensive drug development process hinders fast translation of therapeutic outcomes. Repurposing existing drugs is considered a better approach for faster therapeutic information translation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Jens Andersen, Arne Schousboe, Alexei Verkhratsky
Summary: Astrocytes play a significant role in the development of Alzheimer's disease. They collaborate closely with neurons through neurotransmitter recycling, which is essential for neurotransmission. The metabolic changes in astrocytes during Alzheimer's disease can have a profound impact on neurotransmitter recycling and deprive neurons of metabolic support, leading to synaptic dysfunction and neurodegeneration.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Youchao Xiao, Wentao Wu, Kefan Cai, Lu Jin, Yanfei Jia, Ning Qiao, Fangzheng Liu, Siming Ru, Lei Cao, Songbai Gui
Summary: Craniopharyngioma (CP) is a benign tumor associated with obesity and recurrence. The role of leptin/leptin receptors axis in CP and its association with weight-related outcomes and prognosis were studied. High plasma leptin level and leptin receptor overexpression were found in CP patients, which were independent risk factors for weight gain and poor progression-free survival (PFS). Leptin/leptin receptors axis may be a potential therapeutic target for obesity in CP patients.
Article
Biochemistry & Molecular Biology
Ana Lloret, Paloma Monllor, Tanja Fuchsberger, Esther Giraldo, Marzia Perluigi, Jose Vina
FREE RADICAL RESEARCH
(2020)
Article
Public, Environmental & Occupational Health
Paloma Monllor, Zhenyu Su, Laura Gabrielli, Paloma Taltavull de la Paz
FRONTIERS IN PUBLIC HEALTH
(2020)
Article
Neurosciences
Paloma Monllor, Esther Giraldo, Mari-Carmen Badia, Jose Garcia de la Asuncion, Maria-Dolores Alonso, Ana Lloret, Jose Vina
Summary: This study aimed to evaluate three serum proteins as potential biomarkers in Alzheimer's disease (AD) patients. Serum clusterin, PKR, and RAGE levels were found to be significantly different in the AD group compared to controls, and showed a significant correlation with CSF A beta(42). These proteins were selected to generate an AD detection model with high sensitivity and specificity.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Esteban Merino, Danae Raya-Salom, Vicent Teruel-Marti, Albert Adell, Ana Cervera-Ferri, Joana Martinez-Ricos
Summary: Displaying a stress response to threatening stimuli is crucial for survival, but must be adaptive to prevent mental illnesses. Recent research focuses on characterizing brain activity in response to stress, aiming to enhance understanding of this phenomenon.
Article
Acoustics
Rebeca Miron Mombiela, Jelena Vucetic, Paloma Monllor, Jenny S. Cardenas-Herran, Paloma Taltavull de la Paz, Consuelo Borras
Summary: The study found a correlation between muscle fractal dimension and echo intensity, with different patterns observed according to frailty phenotype. Echo intensity was found to outperform fractal dimension as a potential diagnostic tool for frailty.
ULTRASONIC IMAGING
(2021)
Article
Multidisciplinary Sciences
Maria Villafranca-Faus, Manuel Esteban Vila-Martin, Daniel Esteve, Esteban Merino, Anna Teruel-Sanchis, Ana Cervera-Ferri, Joana Martinez-Ricos, Ana Lloret, Enrique Lanuza, Vicent Teruel-Marti
Summary: The study demonstrates the importance of incorporating vomeronasal signals into the hippocampal cognitive map for the learning of territorial spatial structures in mice, highlighting the critical role of such information in territorial behavior. Navigating a virtual environment induces synchronic activity between the vomeronasal amygdala and the dorsal CA1 of the hippocampus in mice, indicating the influence of vomeronasal information on hippocampal learning.
NATURE COMMUNICATIONS
(2021)
Review
Physiology
Ana Lloret, Daniel Esteve, Maria Angeles Lloret, Paloma Monllor, Begona Lopez, Jose Luis Leon, Ana Cervera-Ferri
Summary: Oxidative stress plays a crucial role in the early development of Alzheimer's disease and is associated with cerebral small vessel disease. Endothelial cells are involved in oxidative stress and affect oligodendrocytes which are susceptible to oxidation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hanna Vila-Merkle, Alicia Gonzalez-Martinez, Rut Campos-Jimenez, Joana Martinez-Ricos, Vicent Teruel-Marti, Arantxa Blasco-Serra, Ana Lloret, Pau Celada, Ana Cervera-Ferri
Summary: The study investigated the neural oscillations in an anxiety model and the therapeutic effects of infralimbic deep brain stimulation in mood disorders. It was found that the anxiogenic drug altered the oscillatory profile in the neural network, while deep brain stimulation could reverse these effects.
Review
Biochemistry & Molecular Biology
Paloma Monllor, Ana Cervera-Ferri, Maria-Angeles Lloret, Daniel Esteve, Begona Lopez, Jose-Luis Leon, Ana Lloret
Summary: Biomarkers for disease diagnosis and prognosis should be objective, quantifiable, reproducible, and allow repeated measurements over time. This review focuses on the usefulness and limitations of electroencephalography (EEG) as a potential source for Alzheimer's disease (AD) biomarkers, emphasizing the need for new non-invasive biomarkers in addition to traditional ones.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Anatomy & Morphology
Cecilia Pardo-Bellver, Manuel E. Vila-Martin, Sergio Martinez-Bellver, Maria Villafranca-Faus, Anna Teruel-Sanchis, Camila A. Savarelli-Balsamo, Sylwia M. Drabik, Joana Martinez-Ricos, Ana Cervera-Ferri, Fernando Martinez-Garcia, Enrique Lanuza, Vicent Teruel-Marti
Summary: This study investigates the integration of chemosensory information in rodents, specifically the olfactory and vomeronasal systems. The results suggest that the amygdala plays a crucial role in controlling the activity of the olfactory bulbs, highlighting its active involvement in the integration of chemosensory information.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Behavioral Sciences
Hanna Vila-Merkle, Alicia Gonzalez-Martinez, Rut Campos-Jimenez, Joana Martinez-Ricos, Vicent Teruel-Marti, Ana Lloret, Arantxa Blasco-Serra, Ana Cervera-Ferri
Summary: This study explores the neurobiological sex differences in depression and anxiety disorders. Surprisingly, in response to an anxiogenic drug, female rats showed fewer changes compared to males, which contradicts the higher prevalence of anxiety in women. These findings raise compelling questions about sex differences in the neurobiology of anxiety and depression.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
