Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals

The dual role of the glycosaminoglycan chondroitin-6-sulfate in the development, progression and metastasis of cancer

(2019) Adam Pudełko et al.   FEBS Journal

Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease

(2018) Courtney J. Mycroft-West et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Synthesis, physicochemical characterization and biological evaluation of chitosan sulfate as heparan sulfate mimics

(2018) Ernesto Doncel-Pérez et al.   CARBOHYDRATE POLYMERS

Comprehensive analysis of glycosaminoglycans from the edible shellfish

(2018) Yusuke Okamoto et al.   CARBOHYDRATE POLYMERS

Immune-enhancing activities of chondroitin sulfate in murine macrophage RAW 264.7 cells

(2018) Fangfang Wu et al.   CARBOHYDRATE POLYMERS

Purification, characterization of Chondroitinase ABC from Sphingomonas paucimobilis and in vitro cardiocytoprotection of the enzymatically degraded CS-A

(2018) Jingyun Fu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A chondroitin sulfate and hyaluronic acid lyase with poor activity to glucuronyl 4,6-O-disulfatedN-acetylgalactosamine (E-type)–containing structures

(2018) Chune Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spinal Cord Injury Scarring and Inflammation: Therapies Targeting Glial and Inflammatory Responses

(2018) Michael B. Orr et al.   Neurotherapeutics

Hyaluronidases: A Therapeutic Enzyme

(2018) Naqab Khan et al.   PROTEIN AND PEPTIDE LETTERS

A holistic approach to unravelling chondroitin sulfation: Correlations between surface charge, structure and binding to growth factors

(2018) Raúl Benito-Arenas et al.   CARBOHYDRATE POLYMERS

Anticoagulant and Antithrombotic Properties of Three Structurally Correlated Sea Urchin Sulfated Glycans and Their Low-Molecular-Weight Derivatives

(2018) Ariana Vasconcelos et al.   Marine Drugs

Structure and Anti-Inflammatory Activity of a New Unusual Fucosylated Chondroitin Sulfate from Cucumaria djakonovi

(2018) Nadezhda Ustyuzhanina et al.   Marine Drugs

Leishmaniasis and glycosaminoglycans: a future therapeutic strategy?

(2018) Débora Almeida Merida-de-Barros et al.   Parasites & Vectors

Fucosylated chondroitin sulfate oligosaccharides exert anticoagulant activity by targeting at intrinsic tenase complex with low FXII activation: Importance of sulfation pattern and molecular size

(2017) Junhui Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chondroitin sulfates and their binding molecules in the central nervous system

(2017) L Djerbal et al.   GLYCOCONJUGATE JOURNAL

Purification and characterization of chondroitinase ABC from Acinetobacter sp. C26

(2017) Changliang Zhu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Medical application of glycosaminoglycans: a review

(2017) Alexander Köwitsch et al.   Journal of Tissue Engineering and Regenerative Medicine

Neuroprotective effect of chondroitin sulfate on SH-SY5Y cells overexpressing wild-type or A53T mutant α-synuclein

(2017) Chuanxia Ju et al.   Molecular Medicine Reports

Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules

(2017) T.V. Stabler et al.   OSTEOARTHRITIS AND CARTILAGE

Cloning and Expression of Recombinant Chondroitinase ACII and Its Comparison to the Arthrobacter aurescens Enzyme

(2017) Asher Williams et al.   Biotechnology Journal

Sulfation pattern of fucose branches affects the anti-hyperlipidemic activities of fucosylated chondroitin sulfate

(2016) Nian Wu et al.   CARBOHYDRATE POLYMERS

Expression, purification and characterization of GAPDH-ChSase ABC I from Proteus vulgaris in Escherichia coli

(2016) Ye Li et al.   PROTEIN EXPRESSION AND PURIFICATION

Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1

(2016) Marina Ayres Pereira et al.   PLoS Pathogens

A versatile bioink for three-dimensional printing of cellular scaffolds based on thermally and photo-triggered tandem gelation

(2015) Matti Kesti et al.   Acta Biomaterialia

Incorporation of chitosan in biomimetic gelatin/chondroitin-6-sulfate/hyaluronan cryogel for cartilage tissue engineering

(2015) Chang-Yi Kuo et al.   CARBOHYDRATE POLYMERS

Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans

(2015) Gregory M. Miller et al.   EXPERIMENTAL NEUROLOGY

Expression, purification and thermostability of MBP-chondroitinase ABC I from Proteus vulgaris

(2015) Zhenya Chen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Tough and elastic hydrogel of hyaluronic acid and chondroitin sulfate as potential cell scaffold materials

(2015) Yilu Ni et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Perspective on the Use of Sulfated Polysaccharides from Marine Organisms as a Source of New Antithrombotic Drugs

(2015) Paulo Mourão   Marine Drugs

Discrepancies in Composition and Biological Effects of Different Formulations of Chondroitin Sulfate

(2015) Johanne Martel-Pelletier et al.   MOLECULES

Discovery of an intrinsic tenase complex inhibitor: Pure nonasaccharide from fucosylated glycosaminoglycan

(2015) Longyan Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel single-chain antibody GD3A10 defines a chondroitin sulfate biomarker for ovarian cancer

(2014) Myrtille JE Vallen et al.   Biomarkers in Medicine

Chondroitinase: A promising therapeutic enzyme

(2014) Narayanan Kasinathan et al.   CRITICAL REVIEWS IN MICROBIOLOGY

The effects of fucosylated chondroitin sulfate isolated from Isostichopus badionotus on antimetastatic activity via down-regulation of Hif-1α and Hpa

(2014) Min He et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Enhancing the intestinal absorption of low molecular weight chondroitin sulfate by conjugation with α-linolenic acid and the transport mechanism of the conjugates

(2014) Yuliang Xiao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Targeted Disruption of a Ring-infected Erythrocyte Surface Antigen (RESA)-like Export Protein Gene inPlasmodium falciparumConfers Stable Chondroitin 4-Sulfate Cytoadherence Capacity

(2014) Suchi Goel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen–glycosaminoglycan scaffold in vivo

(2013) T.M. McFadden et al.   Acta Biomaterialia

Probing the biofunctionality of biotinylated hyaluronan and chondroitin sulfate by hyaluronidase degradation and aggrecan interaction

(2013) Noomi Altgärde et al.   Acta Biomaterialia

Silk fibroin/chondroitin sulfate/hyaluronic acid ternary scaffolds for dermal tissue reconstruction

(2013) Shuqin Yan et al.   Acta Biomaterialia

A biomimetic extracellular matrix for cartilage tissue engineering centered on photocurable gelatin, hyaluronic acid and chondroitin sulfate

(2013) Peter A. Levett et al.   Acta Biomaterialia

Sulfation pattern of the fucose branch is important for the anticoagulant and antithrombotic activities of fucosylated chondroitin sulfates

(2013) Shiguo Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Approaches for enhancing oral bioavailability of peptides and proteins

(2013) Jwala Renukuntla et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Chondroitin sulfate and sulfated hyaluronan-containing collagen coatings of titanium implants influence peri-implant bone formation in a minipig model

(2013) P. Korn et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca2+

(2013) Carolina R. Córdula et al.   Molecular BioSystems

Holothurian Glycosaminoglycan Inhibits Metastasis and Thrombosis via Targeting of Nuclear Factor-κB/Tissue Factor/Factor Xa Pathway in Melanoma B16F10 Cells

(2013) Yang Zhao et al.   PLoS One

Comparison of five dermal substitutes in full-thickness skin wound healing in a porcine model

(2012) Cécile Philandrianos et al.   BURNS

Highly sulfated hexasaccharide sequences isolated from chondroitin sulfate of shark fin cartilage: Insights into the sugar sequences with bioactivities

(2012) Shuji Mizumoto et al.   GLYCOBIOLOGY

Electrospinning collagen and hyaluronic acid nanofiber meshes

(2012) Rachael L. Fischer et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Sulfated Hyaluronan Containing Collagen Matrices Enhance Cell-Matrix-Interaction, Endocytosis, and Osteogenic Differentiation of Human Mesenchymal Stromal Cells

(2012) Stefanie Kliemt et al.   JOURNAL OF PROTEOME RESEARCH

Chitosan-chondroitin sulphate nanoparticles for controlled delivery of platelet lysates in bone regenerative medicine

(2012) Vítor E. Santo et al.   Journal of Tissue Engineering and Regenerative Medicine

Tyrosinase-mediatedin situforming hydrogels from biodegradable chondroitin sulfate-tyramine conjugates

(2012) Rong Jin et al.   POLYMER INTERNATIONAL

Silk–hyaluronan-based composite hydrogels: A novel, securable vehicle for drug delivery

(2011) Roberto Elia et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

A hierarchical classification of polysaccharide lyases for glycogenomics

(2010) Vincent Lombard et al.   BIOCHEMICAL JOURNAL

Structural and mechanistic classification of uronic acid-containing polysaccharide lyases

(2010) M.-L. Garron et al.   GLYCOBIOLOGY

Variable Effects of 3 Different Chondroitin Sulfate Compounds on Human Osteoarthritic Cartilage/Chondrocytes: Relevance of Purity and Production Process

(2010) S. K. TAT et al.   JOURNAL OF RHEUMATOLOGY

About oral absorption and human pharmacokinetics of chondroitin sulfate

(2010) N. Volpi   OSTEOARTHRITIS AND CARTILAGE

Crystal structures of a family 8 polysaccharide lyase reveal open and highly occluded substrate-binding cleft conformations

(2010) Zainab H. Elmabrouk et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Ultraperformance liquid chromatography with electrospray ionization ion trap mass spectrometry for chondroitin disaccharide analysis

(2009) Kemal Solakyildirim et al.   ANALYTICAL BIOCHEMISTRY

Fucosylated chondroitin sulfate inhibits plasma thrombin generation via targeting of the factor IXa heparin-binding exosite

(2009) Y. Buyue et al.   BLOOD

Type II collagen-chondroitin sulfate-hyaluronan scaffold cross-linked by genipin for cartilage tissue engineering

(2009) Chih-Sheng Ko et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Hyaluronidase in the correction of hyaluronic acid-based fillers: a review and a recommendation for use

(2009) Berthold Rzany et al.   Journal of Cosmetic Dermatology

Specific interactions between human fibroblasts and particular chondroitin sulfate molecules for wound healing

(2008) Xiao Hui Zou et al.   Acta Biomaterialia

Composite active site of chondroitin lyase ABC accepting both epimers of uronic acid

(2008) D. Shaya et al.   GLYCOBIOLOGY

Anti-inflammatory activity of chondroitin sulfate

(2008) M. Iovu et al.   OSTEOARTHRITIS AND CARTILAGE

Serpin-independent anticoagulant activity of a fucosylated chondroitin sulfate

(2008) Bianca F. Glauser et al.   THROMBOSIS AND HAEMOSTASIS