Article
Biochemistry & Molecular Biology
Natalia Mena-Vazquez, Marta Rojas-Gimenez, Clara Fuego-Varela, Aimara Garcia-Studer, Nair Perez-Gomez, Carmen Maria Romero-Barco, Francisco Javier Godoy-Navarrete, Sara Manrique-Arija, Myriam Gandia-Martinez, Jerusalem Calvo-Gutierrez, Pilar Morales-Garrido, Coral Mourino-Rodriguez, Patricia Castro-Perez, Isabel Anon-Onate, Francisco Espildora, Maria Carmen Aguilar-Hurtado, Ana Hidalgo Conde, Rocio Arnedo Diez de los Rios, Eva Cabrera Cesar, Rocio Redondo-Rodriguez, Maria Luisa Velloso-Feijoo, Antonio Fernandez-Nebro
Summary: The study aims to evaluate the safety and efficacy profile of abatacept in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The results showed that abatacept can stabilize pulmonary function and joint inflammation in most patients, and it has a favorable safety profile.
Article
Medicine, General & Internal
Natalia Mena-Vazquez, Marta Rojas-Gimenez, Carmen Maria Romero-Barco, Sara Manrique-Arija, Espildora Francisco, Maria Carmen Aguilar-Hurtado, Isabel Anon-Onate, Lorena Perez-Albaladejo, Rafaela Ortega-Castro, Francisco Javier Godoy-Navarrete, Inmaculada Urena-Garnica, Maria Luisa Velloso-Feijoo, Rocio Redondo-Rodriguez, Francisco Gabriel Jimenez-Nunez, Blanca Panero Lamothe, Maria Isabel Padin-Martin, Antonio Fernandez-Nebro
Summary: This study describes a cohort of patients with RA-ILD and identifies risk factors associated with disease progression and mortality. Most patients with RA-ILD maintained stable lung function while one-third experienced worsening or died. Identifying factors related to worsening in RA-ILD is crucial for clinical management.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Natalia Mena-Vazquez, Marta Rojas-Gimenez, Carmen Maria Romero-Barco, Myriam Gandia-Martinez, Nair Perez-Gomez, Francisco Javier Godoy-Navarrete, Sara Manrique-Arija, Aimara Garcia-Studer, Jerusalem Calvo-Gutierrez, Clara Fuego Varela, Pilar Morales-Garrido, Patricia Castro Perez, Coral Mourino-Rodriguez, Isabel Anon-Onate, Francisco Espildora, Maria Carmen Aguilar-Hurtado, Rocio Redondo, Ana Hidalgo Conde, Rocio Arnedo Diez de los Rios, Eva Cabrera Cesar, Maria Luisa Velloso-Feijoo, Antonio Fernandez-Nebro
Summary: The study aimed to describe comorbid conditions in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and analyze factors associated with multimorbidity. The results showed that comorbid conditions were more frequent in RA-ILD patients compared to those with RA but not ILD. Age, inflammatory markers, and lung function were found to be associated with multimorbidity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Bryant R. England, Megan Campany, Harlan Sayles, Punyasha Roul, Yangyuna Yang, Apar Kishor Ganti, Jeremy Sokolove, William H. Robinson, Andreas M. Reimold, Gail S. Kerr, Grant W. Cannon, Brian C. Sauer, Joshua F. Baker, Geoffrey M. Thiele, Ted R. Mikuls
Summary: Elevated serum cytokine/chemokine concentrations in rheumatoid arthritis (RA) patients are associated with an increased risk of future cancer, particularly lung and lymphoproliferative cancers. These findings suggest that measuring circulating cytokines/chemokines could be informative for cancer risk stratification and future cancer prevention strategies, not only in RA patients but possibly in individuals without RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Rheumatology
Vanessa L. Kronzer, Weixing Huang, Paul F. Dellaripa, Sicong Huang, Vivi Feathers, Bing Lu, Christine K. Iannaccone, Ritu R. Gill, Hiroto Hatabu, Mizuki Nishino, Cynthia S. Crowson, John M. Davis, Michael E. Weinblatt, Nancy A. Shadick, Tracy J. Doyle, Jeffrey A. Sparks
Summary: This study identified obesity, high CRP levels, poor functional status, and extensive smoking as novel risk factors for RA-ILD, which may be helpful for RA-ILD risk assessment and prevention. The overall predictive ability for RA-ILD remains modest.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Immunology
Dylan T. Bergstedt, Wyatt J. Tarter, Ryan A. Peterson, Marie L. Feser, Mark C. Parish, Christopher C. Striebich, M. Kristen Demoruelle, LauraKay Moss, Elizabeth A. Bemis, Jill M. Norris, V. Michael Holers, Jess D. Edison, Geoffrey M. Thiele, Ted R. Mikuls, Kevin D. Deane
Summary: In rheumatoid arthritis (RA), ACPA and RF are predictive markers for future RA. This study found that changes in RF isotypes were associated with an increased risk for developing RA, and SE was associated with an increased risk of RA. These findings are important for counseling individuals at-risk for RA and designing clinical trials for RA prevention.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Natalia Mena-Vazquez, Jose Manuel Lisbona-Montanez, Rocio Redondo-Rodriguez, Arkaitz Mucientes, Sara Manrique-Arija, Jose Rioja, Aimara Garcia-Studer, Fernando Ortiz-Marquez, Laura Cano-Garcia, Antonio Fernandez-Nebro
Summary: Patients with late-onset rheumatoid arthritis (LORA) have poorer control of inflammation after diagnosis and more comorbidities compared to patients with young-onset rheumatoid arthritis (YORA) and healthy controls.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Natalia Mena-Vazquez, Marta Rojas-Gimenez, Carmen Maria Romero-Barco, Sara Manrique-Arija, Ana Hidalgo Conde, Rocio Arnedo Diez de los Rios, Eva Cabrera Cesar, Rafaela Ortega-Castro, Francisco Espildora, Maria Carmen Aguilar-Hurtado, Isabel Anon-Onate, Lorena Perez-Albaladejo, Manuel Abarca-Costalago, Inmaculada Urena-Garnica, Maria Luisa Velloso-Feijoo, Rocio Redondo-Rodriguez, Antonio Fernandez-Nebro
Summary: The study found that about half of patients with interstitial lung disease associated with systemic autoimmune disease stabilize or improve after a median of 5 years, but over one-third of patients die. Rheumatoid arthritis is associated with higher rates of disease progression and hospitalization in ILD, while usual interstitial pneumonia pattern, FVC%, and smoking are independent predictors for worsening of ILD-SAI.
Article
Medicine, General & Internal
Jiaqi Wang, Xiao Wang, Xiaoyan Qi, Zhijian Sun, Tao Zhang, Yi Cui, Qiang Shu
Summary: The combination treatment of pirfenidone (PFD) with immunosuppressant (IS) has shown significant improvement in prognosis for patients with CTD-ILD, especially those with SSc, IIM, and RA.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yerin Kim, Hyung-In Yang, Kyoung-Soo Kim
Summary: This review summarizes and analyzes the etiology and pathogenesis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The incidence of RA-ILD increases with age and is higher in men, and is also associated with lifestyle factors such as smoking and exposure to pollutants. The presence of anti-cyclic citrullinated peptide antibody, high RA disease activity, and rheumatoid factor positivity increase the risk of RA-ILD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
David Bergman, Bjorn Roelstraete, Jiangwei Sun, Fahim Ebrahimi, Johan Askling, Jonas F. Ludvigsson
Summary: A study found that there is an association between microscopic colitis (MC) and rheumatoid arthritis (RA), with MC patients being nearly twice as likely to develop RA compared to the general population. This study is important as it highlights the need for expedited evaluation for RA in MC patients presenting with joint symptoms and/or arthralgia, thus preventing delay in RA diagnosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Rheumatology
Chanakya Kodishala, Cassondra A. Hulshizer, Vanessa L. Kronzer, John M. Davis III, Vijay K. Ramanan, Maria Vassilaki, Michelle M. Mielke, Cynthia S. Crowson, Elena Myasoedova
Summary: This study assessed the risk factors for dementia in patients with rheumatoid arthritis (RA). The findings showed that older age, rheumatoid nodules, hypertension, joint swelling, cardiovascular diseases, and psychological issues were associated with an increased risk of dementia.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Respiratory System
Jake G. Natalini, Joshua F. Baker, Namrata Singh, Tina D. Mahajan, Punyasha Roul, Geoffrey M. Thiele, Brian C. Sauer, Cheilonda R. Johnson, Steven M. Kawut, Ted R. Mikuls, Bryant R. England
Summary: The study found that combined RF/ACPA seropositivity and higher individual autoantibody concentrations were strongly associated with prevalent RA-ILD, but not with incident RA-ILD. Patients with RF concentrations greater than 90 IU/ml were observed to be at higher risk of developing incident RA-ILD.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Rheumatology
Hyoungyoung Kim, Soo-Kyung Cho, Yeo-Jin Song, Juyeon Kang, Seung-A Jeong, Hye Won Kim, Chan-Bum Choi, Tae-Hwan Kim, Jae-Bum Jun, Sang-Cheol Bae, Dae-Hyun Yoo, Hyun Lee, Dong Won Park, Jang Won Sohn, Ho Joo Yoon, Su Jin Hong, Seung-Jin Yoo, Yo Won Choi, Youkyung Lee, Sang Heon Kim, Yoon-Kyoung Sung
Summary: This study established a prospective cohort of rheumatoid arthritis (RA) patients with interstitial lung disease (ILD) and compared their clinical features with RA patients without ILD. The findings showed that factors such as age, gender, and age over 60 years were associated with the presence of ILD in RA patients.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Jill A. Poole, Bryant R. England, Harlan Sayles, Tate M. Johnson, Michael J. Duryee, Carlos D. Hunter, Joshua F. Baker, Gail S. Kerr, Gary Kunkel, Grant W. Cannon, Brian C. Sauer, Katherine D. Wysham, Amy M. Joseph, Beth Wallace, Geoffrey M. Thiele, Ted R. Mikuls
Summary: This study found a significant inverse association between serum IL-33 concentration and the risk of developing incident RA-ILD, but no associations with prevalent ILD. TSLP and IL-25 showed no significant associations with incident ILD.
Article
Rheumatology
Naomi J. Patel, Xiaosong Wang, Xiaoqing Fu, Yumeko Kawano, Claire Cook, Kathleen M. M. Vanni, Grace Qian, Emily Banasiak, Emily Kowalski, Yuqing Zhang, Jeffrey A. Sparks, Zachary S. Wallace
Summary: Rheumatic disease patients on multiple immunomodulators are at a higher risk of breakthrough infection, while recipients of mRNA-1273 vaccine have a lower risk compared to BNT162b2 recipients.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Manuel F. Ugarte-Gil, Graciela S. Alarcon, Andrea M. Seet, Zara Izadi, Anna D. Montgomery, Ali Duarte-Garcia, Emily L. Gilbert, Maria O. Valenzuela-Almada, Leanna Wise, Jeffrey A. Sparks, Tiffany Y. -T. Hsu, Kristin M. D'Silva, Naomi J. Patel, Emily Sirotich, Jean W. Liew, Jonathan S. Hausmann, Paul Sufka, Rebecca Grainger, Suleman Bhana, Zachary Wallace, Lindsay Jacobsohn, Anja Strangfeld, Elsa F. Mateus, Kimme L. Hyrich, Laure Gossec, Loreto Carmona, Saskia Lawson-Tovey, Lianne Kearsley-Fleet, Martin Schaefer, Pedro M. Machado, Philip C. Robinson, Milena Gianfrancesco, Jinoos Yazdany
Summary: A study on individuals with SLE in the US found that Black and Hispanic patients had higher odds of experiencing more severe COVID-19 outcomes compared to White patients, which may be attributed to socioeconomic and health disparities.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Hui Li, Zachary S. Wallace, Jeffrey A. Sparks, Na Lu, Jie Wei, Dongxing Xie, Yilun Wang, Chao Zeng, Guanghua Lei, Yuqing Zhang
Summary: Patients with rheumatoid arthritis (RA) are at higher risks of SARS-CoV-2 infection and severe outcomes even after COVID-19 vaccination. It is necessary to implement booster COVID-19 vaccinations and other preventive strategies for patients with RA.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
May Y. Choi, Susan Malspeis, Jeffrey A. Sparks, Jing Cui, Kazuki Yoshida, Karen H. Costenbader
Summary: Sleep deprivation is associated with increased risk of autoimmune diseases, particularly systemic lupus erythematosus (SLE). This study using Nurses' Health Study data found that chronic low sleep duration was associated with higher risk of SLE, especially for individuals with bodily pain and depression.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Dongxing Xie, Hyon K. Choi, Nicola Dalbeth, Zachary S. Wallace, Jeffrey A. Sparks, Na Lu, Chao Zeng, Xiaoxiao Li, Jie Wei, Guanghua Lei, Yuqing Zhang
Summary: This study found that individuals with gout, especially women, have higher risks of SARS-CoV-2 infection and severe outcomes, even when vaccinated.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Jing Cui, Susan Malspeis, May Y. Choi, Bing Lu, Jeffrey A. Sparks, Kazuki Yoshida, Karen H. Costenbader
Summary: This study developed a risk prediction model for systemic lupus erythematosus (SLE) based on known genetic, lifestyle, environmental, and family history risk factors. The model accurately classified future SLE risk in a cohort of female nurses, incorporating genetic data and easily assessable risk factors.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Anne R. Bass, Eliza Chakravarty, Elie A. Akl, Clifton O. Bingham, Leonard Calabrese, Laura C. Cappelli, Sindhu R. Johnson, Lisa F. Imundo, Kevin L. Winthrop, Reuben J. Arasaratnam, Lindsey R. Baden, Roberta Berard, S. Louis Bridges Jr, Jonathan T. L. Cheah, Jeffrey R. Curtis, Polly J. Ferguson, Ida Hakkarinen, Karen B. Onel, Grayson Schultz, Vidya Sivaraman, Benjamin J. Smith, Jeffrey A. Sparks, Tiphanie P. Vogel, Eleanor Anderson Williams, Cassandra Calabrese, Joanne S. Cunha, Joann Fontanarosa, Miriah C. Gillispie-Taylor, Elena Gkrouzman, Priyanka Iyer, Kimberly S. Lakin, Alexandra Legge, Mindy S. S. Lo, Megan M. Lockwood, Rebecca E. Sadun, Namrata Singh, Nancy Sullivan, Herman Tam, Marat Turgunbaev, Amy S. Turner, James Reston
Summary: This guideline provides evidence-based recommendations on the use of vaccinations in children and adults with rheumatic and musculoskeletal diseases (RMDs). It includes expanded indications for some vaccines in patients with RMDs and addresses the safe use of live attenuated vaccines in patients taking immunosuppressive medications.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Anne R. Bass, Eliza Chakravarty, Elie A. Akl, Clifton O. Bingham, Leonard Calabrese, Laura C. Cappelli, Sindhu R. Johnson, Lisa F. Imundo, Kevin L. Winthrop, Reuben J. Arasaratnam, Lindsey R. Baden, Roberta Berard, S. Louis Bridges, Jonathan T. L. Cheah, Jeffrey R. Curtis, Polly J. Ferguson, Ida Hakkarinen, Karen B. Onel, Grayson Schultz, Vidya Sivaraman, Benjamin J. Smith, Jeffrey A. Sparks, Tiphanie P. Vogel, Eleanor Anderson Williams, Cassandra Calabrese, Joanne S. Cunha, Joann Fontanarosa, Miriah C. Gillispie-Taylor, Elena Gkrouzman, Priyanka Iyer, Kimberly S. Lakin, Alexandra Legge, Mindy S. Lo, Megan M. Lockwood, Rebecca E. Sadun, Namrata Singh, Nancy Sullivan, Herman Tam, Marat Turgunbaev, Amy S. Turner, James Reston
Summary: This study aims to provide evidence-based recommendations on vaccinations for patients with rheumatic and musculoskeletal diseases (RMDs). The research team conducted a systematic literature review and formulated guidelines on issues such as whether vaccinations can be administered during immunosuppressive treatment. Most recommendations have low quality of supporting evidence.
ARTHRITIS & RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Elizabeth R. Volkmann, Jeffrey A. Sparks, Anna-Maria Hoffmann-Vold, Tracy J. Doyle, Paul Emery, Philippe Dieude
LANCET RHEUMATOLOGY
(2023)
Article
Rheumatology
Grace Qian, Xiaosong Wang, Naomi J. Patel, Yumeko Kawano, Xiaoqing Fu, Claire E. Cook, Kathleen M. M. Vanni, Emily N. Kowalski, Emily P. Banasiak, Katarina J. Bade, Shruthi Srivatsan, Zachary K. Williams, Derrick J. Todd, Michael E. Weinblatt, Zachary S. Wallace, Jeffrey A. Sparks
Summary: Outpatient SARS-CoV-2 treatment is associated with lower odds of severe COVID-19 outcomes in patients with systemic autoimmune rheumatic disease and COVID-19 compared with no outpatient treatment.
LANCET RHEUMATOLOGY
(2023)
Article
Rheumatology
Anne R. Bass, Noha Abdel-Wahab, Pankti D. Reid, Jeffrey A. Sparks, Cassandra Calabrese, Deanna P. Jannat-Khah, Nilasha Ghosh, Divya Rajesh, Carlos Andres Aude, Lydia Gedmintas, Lindsey MacFarlane, Senada Arabelovic, Adewunmi Falohun, Komal Mushtaq, Farah Al Haj, Adi Diab, Ami A. Shah, Clifton O. Bingham, Karmela Kim Chan, Laura C. Cappelli
Summary: This study compares the safety and effectiveness of biologic and conventional DMARDs for ICI-IA. The results show that biologic DMARDs can achieve faster arthritis control than MTX, but may be associated with a shorter time to cancer progression.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Jie Wei, Weiya Zhang, Michael Doherty, Zachary S. Wallace, Jeffrey A. Sparks, Na Lu, Xiaoxiao Li, Chao Zeng, Guanghua Lei, Yuqing Zhang
Summary: In a population-based study in the UK, the BNT162b2 vaccine showed higher efficacy than the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection and hospitalization for COVID-19, but there was no significant difference in the risk of death from COVID-19.
Review
Rheumatology
Alessandra Zaccardelli, Zachary S. Wallace, Jeffrey A. Sparks
Summary: This review summarizes the findings of studies on the outcomes of patients with rheumatoid arthritis (RA) and their risk of acute and postacute COVID-19. It is found that patients with RA have a higher risk of COVID-19 infection and severe outcomes, and factors such as immunosuppressive medications and disease severity contribute to the risk. Although COVID-19 vaccination reduces the risk for RA patients, some still experience breakthrough infections. Future studies are needed to investigate postacute sequelae of COVID-19 among RA patients.
CURRENT OPINION IN RHEUMATOLOGY
(2023)
Article
Rheumatology
Xiaofeng Jiang, Jeffrey Sparks, Zachary Wallace, Xinjia Deng, Hui Li, Na Lu, Dongxing Xie, Yilun Wang, Chao Zeng, Guanghua Lei, Jie Wei, Yuqing Zhang
Summary: This study compares the risk of SARS-CoV-2 infection and severe sequelae in patients with systemic lupus erythematosus (SLE) and the general population, based on their COVID-19 vaccination status. It was found that unvaccinated patients with SLE had a higher risk of SARS-CoV-2 infection and severe sequelae compared to the general population. However, no significant differences were observed between vaccinated patients with SLE and the vaccinated general population during the 9-month follow-up.
Article
Rheumatology
Kaitlin R. McCarter, Taylor Wolfgang, Senada Arabelovic, Xiaosong Wang, Kazuki Yoshida, Emily P. Banasiak, Grace Qian, Emily N. Kowalski, Kathleen M. M. Vanni, Nicole R. LeBoeuf, Elizabeth Buchbinder, Lydia Gedmintas, Lindsey A. MacFarlane, Deepak A. Rao, Nancy A. Shadick, Ellen M. Gravallese, Jeffrey A. Sparks
Summary: Patients with pre-existing rheumatoid arthritis initiating immune checkpoint inhibitors had similar risk of mortality and severe immune-related AEs as matched comparators. Although patients with pre-existing rheumatoid arthritis were more likely to have immune-related AEs, this finding was mostly due to mild rheumatoid arthritis flares. These results suggest that this patient population can safely receive immune checkpoint inhibitors for cancer treatment.
LANCET RHEUMATOLOGY
(2023)