Article
Rheumatology
Xiaofeng Jiang, Jeffrey Sparks, Zachary Wallace, Xinjia Deng, Hui Li, Na Lu, Dongxing Xie, Yilun Wang, Chao Zeng, Guanghua Lei, Jie Wei, Yuqing Zhang
Summary: This study compares the risk of SARS-CoV-2 infection and severe sequelae in patients with systemic lupus erythematosus (SLE) and the general population, based on their COVID-19 vaccination status. It was found that unvaccinated patients with SLE had a higher risk of SARS-CoV-2 infection and severe sequelae compared to the general population. However, no significant differences were observed between vaccinated patients with SLE and the vaccinated general population during the 9-month follow-up.
Article
Psychiatry
Md. Dhedharul Alam, Md. Joynal Abedin, Asraful Islam, Md. Mosfeq-Ul-Hasan, Obaydur Rahman, Yi Xu
Summary: This study investigated the psychological effects and associated factors among vaccinated and unvaccinated populations against COVID-19 infection in Bangladesh. The results showed that vaccinated populations had significantly lower prevalence rates of psychological distress, depression, anxiety, stress, post-traumatic stress disorder (PTSD), insomnia, and fear symptoms compared to unvaccinated populations. Factors such as living in nuclear families, experiencing loss due to the pandemic, and residing in the Dhaka division were associated with higher risk of psychological symptoms in vaccinated and unvaccinated populations.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Immunology
Anna Hudson, Peter A. Hall, Sara C. Hitchman, Gang Meng, Geoffrey T. Fong
Summary: Cognitive variables, including future orientation, delay discounting, and executive function, are associated with COVID-19 mitigation behaviors, such as mask wearing, social distancing, hand hygiene, and vaccination. Future orientation is associated with more mitigation behaviors and a higher likelihood of being fully vaccinated, while lower delay discounting and better executive function predict more consistent implementation of mask wearing and being fully vaccinated. Vaccination status does not moderate the effects of cognitive predictors on mitigation behaviors.
Article
Multidisciplinary Sciences
Samar Fatima, Amara Zafar, Haris Afzal, Taymmia Ejaz, Sara N. Shamim, Shayan N. Saleemi, Amna Subhan N. Butt
Summary: Although vaccinated patients may still develop severe and critical COVID-19 infection, the proportion is lower compared to the unvaccinated population. Efforts should be made to vaccinate as many individuals as possible and develop more effective vaccines to reduce the high death toll of COVID-19 infection.
Article
Health Care Sciences & Services
Alicia Martinez-Varea, Elena Satorres, Sandra Florez, Josep Domenech, Julia Desco-Blay, Sagrario Monfort-Pitarch, Maria Hueso, Alfredo Perales-Marin, Vicente Diago-Almela
Summary: This study suggests that COVID-19 vaccination during pregnancy can reduce the risk of hospital admission and severity of COVID-19 infection. Additionally, infection with SARS-CoV-2 during the third trimester of pregnancy was associated with a significantly reduced risk of positive cord-blood SARS-CoV-2 IgG antibodies. Furthermore, pregnant women who received at least two doses of the COVID-19 vaccine did not develop severe COVID-19.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Daniele Colombo, Franca Del Nonno, Luisa Marchioni, Eleonora Lalle, Paola Galli, Francesco Vaia, Laura Falasca
Summary: This study aims to investigate the death of COVID-19-vaccinated patients who acquired infection and developed severe disease, and compare it with fatal COVID-19 in unvaccinated subjects by studying the pathological events triggered by SARS-CoV-2. Results showed that pre-existing pathologies played a major role in the death of vaccinated patients, while unvaccinated patients primarily died from COVID-19. Additionally, a significant reduction in macrophage infiltration was observed in the hearts of vaccinated patients.
Article
Rheumatology
Yilun Wang, Kristin M. D'Silva, April M. Jorge, Xiaoxiao Li, Houchen Lyv, Jie Wei, Chao Zeng, Guanghua Lei, Yuqing Zhang
Summary: This study estimated the risk of COVID-19 in patients with rheumatoid arthritis (RA) and found that they had a higher risk compared to the general population. These findings support the recommendations for booster vaccines and priority access to anti-SARS-CoV-2 monoclonal antibody treatments for RA patients.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Immunology
Erol Demir, Hamad Dheir, Seda Safak, Ayse Serra Artan, Savas Sipahi, Aydin Turkmen
Summary: This study investigates the impact of COVID-19 vaccines on kidney transplant recipients with SARS-CoV-2 infection. The results show that while the vaccines do not prevent death in all kidney transplant recipients, they decrease hospitalization rate and duration. The vaccinated group had lower rates of hospitalization and ICU admission compared to the unvaccinated group.
Article
Immunology
Sandhya Sundar, Ramya Ramadoss, Rajeshkumar Shanmugham, Lakshmi Trivandrum Anandapadmanabhan, Suganya Paneerselvam, Pratibha Ramani, Rumesa Batul, Mohmed Isaqali Karobari
Summary: In this study, SARS-CoV-2 antibodies were assessed in the saliva of vaccinated participants. Female participants showed significantly higher antibody titres than males. Vaccinated individuals had higher total antibody titres compared to unvaccinated participants, and those who completed both doses had higher levels than those who received a single dose. People who had experienced COVID-19 after vaccination had better immunity. The study demonstrates the presence of SARS-CoV-2 spike-specific antibodies in saliva samples, providing insights into vaccine-induced immunity for informed decision-making.
Article
Medicine, General & Internal
Haley Wienkes, Kelley Vilen, Alexandra Lorentz, Daniel Gerlach, Xiong Wang, Amy Saupe, Richard Danila, Ruth Lynfield, Kirk Smith, Carlota Medus
Summary: This cohort study investigated transmission and infection of SARS-CoV-2 among vaccinated and unvaccinated attendees at an indoor wedding reception, identifying a Delta variant outbreak despite a high proportion of vaccinated attendees and finding that vaccination was associated with a reduced risk of infection.
Review
Immunology
Ali A. Rabaan, Muhammed A. Bakhrebah, Abbas Al Mutair, Saad Alhumaid, Jumana M. Al-Jishi, Jehad AlSihati, Hawra Albayat, Ahmed Alsheheri, Mohammed Aljeldah, Mohammed Garout, Wadha A. Alfouzan, Yousef N. Alhashem, Salma AlBahrani, Saleh A. Alshamrani, Sultan Alotaibi, Abdullah A. AlRamadhan, Hanadi N. Albasha, Khalid Hajissa, Mohamad-Hani Temsah
Summary: This article is a systematic review comparing health complications observed in vaccinated and non-vaccinated individuals with COVID-19. The study found a potential association between COVID-19 infection, vaccination, and multiorgan failure, although there is currently insufficient evidence to make conclusive statements about the relationship.
Article
Pharmacology & Pharmacy
O. Papaioannou, T. Karampitsakos, P. Tsiri, V. Sotiropoulou, E. Koulousousa, P. Tasiopoulos, G. Schinas, M. Katsaras, E. Zarkadi, E. Malakounidou, V. Georgiopoulou, F. Sampsonas, A. Spyridonidis, K. Akinosoglou, M. Marangos, A. Tzouvelekis
Summary: This population-based analysis examines the hospitalization risk for COVID-19 in a sample of 98,982 individuals and compares the characteristics of vaccinated and unvaccinated patients. The findings indicate that vaccination significantly reduces the risk of hospitalization and mortality, and booster doses play a crucial role in the era of the Omicron variant.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Infectious Diseases
Sonja H. Brunvoll, Anders B. Nygaard, Morten W. Fagerland, Petter Holland, Merete Ellingjord-Dale, John Arne Dahl, Arne Soraas
Summary: This study aimed to describe the post-acute sequelae of SARS-CoV-2 infection (PASC) related symptoms 3-15 months after a positive test in unvaccinated and vaccinated participants. The results showed no significant differences in PASC symptoms between vaccinated and unvaccinated participants, but vaccinated participants reported fewer memory problems compared to unvaccinated participants.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Psychiatry
Md. Dhedharul Alam, Asraful Islam, Md. Sanwar Hossain, Afsana Hossain, Delara Akhter, Md. Masum Haider, Yi Xu
Summary: This study investigated the mental health outcomes and associated factors among vaccinated and unvaccinated teachers against COVID-19 infection in Bangladesh. Vaccinated teachers had lower prevalence of psychological distress, depression, anxiety, stress, PTSD, insomnia, and fear symptoms compared to unvaccinated teachers. Vulnerable groups, such as teachers with lower education levels, those with children, and those who lost family members or friends due to COVID-19, were more likely to experience mental health issues.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Md. Dhedharul Alam, Sujan Kumer Paul, Mahmuda Momi, Li Ni, Yi Xu
Summary: This study investigated the psychological outcomes and associated factors among vaccinated and unvaccinated healthcare workers (HCWs) against COVID-19 infection in Bangladesh. The results showed that vaccinated HCWs had a significantly lower prevalence of general health problems, depression, post-traumatic stress disorder, insomnia, and loneliness symptoms compared to unvaccinated HCWs. Female HCWs, those living in urban areas, unmarried, working as nurses, frontline workers, and providing direct care to infected patients were more likely to experience psychological issues.
FRONTIERS IN MEDICINE
(2022)
Letter
Rheumatology
Chao Zeng, Zidan Yang, Guanghua Lei, Yuqing Zhang
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Xiurui Zhang, Xiaoxiao Li, Yilin Xiong, Yilun Wang, Jie Wei, Chao Zeng, Tingting Sha, Guanghua Lei
Summary: This study evaluated the efficacy and safety of tramadol for knee and hip osteoarthritis. The results showed that tramadol 300 mg/day had minimal improvement in pain and function, but with increased adverse events compared to placebo. Therefore, the excessive use of tramadol is not recommended for treating knee and hip osteoarthritis.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Sizheng Steven Zhao, Houchen Lyu, Chao Zeng, Guanghua Lei, Jie Wei, Sarah L. Mackie
Summary: Initiation of ARBs is associated with a higher risk of GCA compared with ACEis or other antihypertensives. Mechanistic studies of angiotensin receptor biology will provide further clarity for our findings.
Article
Rheumatology
May Y. Choi, Susan Malspeis, Jeffrey A. Sparks, Jing Cui, Kazuki Yoshida, Karen H. Costenbader
Summary: Sleep deprivation is associated with increased risk of autoimmune diseases, particularly systemic lupus erythematosus (SLE). This study using Nurses' Health Study data found that chronic low sleep duration was associated with higher risk of SLE, especially for individuals with bodily pain and depression.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Dongxing Xie, Hyon K. Choi, Nicola Dalbeth, Zachary S. Wallace, Jeffrey A. Sparks, Na Lu, Chao Zeng, Xiaoxiao Li, Jie Wei, Guanghua Lei, Yuqing Zhang
Summary: This study found that individuals with gout, especially women, have higher risks of SARS-CoV-2 infection and severe outcomes, even when vaccinated.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Zachary S. Wallace, John H. Stone, Xiaoqing Fu, Peter A. Merkel, Eli M. Miloslavsky, Yuqing Zhang, Hyon K. Choi, Emily P. Hyle
Summary: This study developed a simulation model (AAV-Sim) to predict clinical outcomes of fixed and tailored rituximab retreatment strategies in ANCA-associated vasculitis (AAV) patients. The model estimated transition rates, validated internally and externally, and produced consistent results with published data. The AAV-Sim has the potential to inform management guidelines and research priorities.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Anne R. Bass, Eliza Chakravarty, Elie A. Akl, Clifton O. Bingham, Leonard Calabrese, Laura C. Cappelli, Sindhu R. Johnson, Lisa F. Imundo, Kevin L. Winthrop, Reuben J. Arasaratnam, Lindsey R. Baden, Roberta Berard, S. Louis Bridges, Jonathan T. L. Cheah, Jeffrey R. Curtis, Polly J. Ferguson, Ida Hakkarinen, Karen B. Onel, Grayson Schultz, Vidya Sivaraman, Benjamin J. Smith, Jeffrey A. Sparks, Tiphanie P. Vogel, Eleanor Anderson Williams, Cassandra Calabrese, Joanne S. Cunha, Joann Fontanarosa, Miriah C. Gillispie-Taylor, Elena Gkrouzman, Priyanka Iyer, Kimberly S. Lakin, Alexandra Legge, Mindy S. Lo, Megan M. Lockwood, Rebecca E. Sadun, Namrata Singh, Nancy Sullivan, Herman Tam, Marat Turgunbaev, Amy S. Turner, James Reston
Summary: This study aims to provide evidence-based recommendations on vaccinations for patients with rheumatic and musculoskeletal diseases (RMDs). The research team conducted a systematic literature review and formulated guidelines on issues such as whether vaccinations can be administered during immunosuppressive treatment. Most recommendations have low quality of supporting evidence.
ARTHRITIS & RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Elizabeth R. Volkmann, Jeffrey A. Sparks, Anna-Maria Hoffmann-Vold, Tracy J. Doyle, Paul Emery, Philippe Dieude
LANCET RHEUMATOLOGY
(2023)
Article
Rheumatology
Grace Qian, Xiaosong Wang, Naomi J. Patel, Yumeko Kawano, Xiaoqing Fu, Claire E. Cook, Kathleen M. M. Vanni, Emily N. Kowalski, Emily P. Banasiak, Katarina J. Bade, Shruthi Srivatsan, Zachary K. Williams, Derrick J. Todd, Michael E. Weinblatt, Zachary S. Wallace, Jeffrey A. Sparks
Summary: Outpatient SARS-CoV-2 treatment is associated with lower odds of severe COVID-19 outcomes in patients with systemic autoimmune rheumatic disease and COVID-19 compared with no outpatient treatment.
LANCET RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Jie Wei, Weiya Zhang, Michael Doherty, Zachary S. Wallace, Jeffrey A. Sparks, Na Lu, Xiaoxiao Li, Chao Zeng, Guanghua Lei, Yuqing Zhang
Summary: In a population-based study in the UK, the BNT162b2 vaccine showed higher efficacy than the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection and hospitalization for COVID-19, but there was no significant difference in the risk of death from COVID-19.
Review
Rheumatology
Alessandra Zaccardelli, Zachary S. Wallace, Jeffrey A. Sparks
Summary: This review summarizes the findings of studies on the outcomes of patients with rheumatoid arthritis (RA) and their risk of acute and postacute COVID-19. It is found that patients with RA have a higher risk of COVID-19 infection and severe outcomes, and factors such as immunosuppressive medications and disease severity contribute to the risk. Although COVID-19 vaccination reduces the risk for RA patients, some still experience breakthrough infections. Future studies are needed to investigate postacute sequelae of COVID-19 among RA patients.
CURRENT OPINION IN RHEUMATOLOGY
(2023)
Article
Rheumatology
Jie Wei, Hyon K. Choi, Nicola Dalbeth, Nancy E. Lane, Jing Wu, Houchen Lyu, Chao Zeng, Guanghua Lei, Yuqing Zhang
Summary: This study aimed to investigate whether lowering serum urate levels to target values through pharmacotherapy can reduce the risk of fractures in individuals with gout. The study found that lowering serum urate levels to target values was significantly associated with a decreased risk of fractures in individuals with gout.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ziying Wu, Yilun Wang, Yuqing Zhang, Kim L. Bennell, Daniel K. White, Liusong Shen, Wei Ren, Jie Wei, Chao Zeng, Guanghua Lei
Summary: The COVID-19 pandemic has caused a decline in daily steps and physical activity levels. Studies show that over 7000 steps per day is the minimum standard for reducing the risk of all-cause mortality. The confinement period of COVID-19 has led to a significant decrease in daily steps among the general adult population.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Letter
Rheumatology
April M. Jorge, Emma Materne, Baijun Zhou, Karen Costenbader, Yuqing Zhang, Hyon K. Choi
ARTHRITIS & RHEUMATOLOGY
(2023)
