Impact of a patient-derived hepatitis C viral RNA genome with a mutated microRNA binding site

RNA–protein interaction detection in living cells

(2018) Muthukumar Ramanathan et al.   NATURE METHODS

microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site

(2018) Philipp Schult et al.   Nature Communications

Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB

(2018) Janina Bruening et al.   PLoS Pathogens

RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus

(2018) Rodney P. Kincaid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial

(2017) Meike H van der Ree et al.   LANCET

Cellular DEAD-box RNA helicase DDX6 modulates interaction of miR-122 with the 5′ untranslated region of hepatitis C virus RNA

(2017) Jason M. Biegel et al.   VIROLOGY

DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes

(2017) Jennifer H. Lumb et al.   Cell Reports

Characterization of miR-122-independent propagation of HCV

(2017) Chikako Ono et al.   PLoS Pathogens

Hepatitis C Virus RNA Functionally Sequesters miR-122

(2015) Joseph M. Luna et al.   CELL

miR-122 Stimulates Hepatitis C Virus RNA Synthesis by Altering the Balance of Viral RNAs Engaged in Replication versus Translation

(2015) Takahiro Masaki et al.   Cell Host & Microbe

L159F and V321A Sofosbuvir-Associated Hepatitis C Virus NS5B Substitutions

(2015) Evguenia S. Svarovskaia et al.   JOURNAL OF INFECTIOUS DISEASES

SEC14L2 enables pan-genotype HCV replication in cell culture

(2015) Mohsan Saeed et al.   NATURE

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

Viral Determinants of miR-122-Independent Hepatitis C Virus Replication

(2015) Sharon E. Hopcraft et al.   mSphere

In VitroAntiviral Activity and Preclinical and Clinical Resistance Profile of Miravirsen, a Novel Anti-Hepatitis C Virus Therapeutic Targeting the Human Factor miR-122

(2014) Søren Ottosen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The complexity of miRNA-mediated repression

(2014) A Wilczynska et al.   CELL DEATH AND DIFFERENTIATION

Hepatitis C Virus Subverts Liver-Specific miR-122 to Protect the Viral Genome from Exoribonuclease Xrn2

(2014) Cecilia D. Sedano et al.   Cell Host & Microbe

Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation

(2014) Daisuke Yamane et al.   NATURE MEDICINE

Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors

(2014) Benjamin Israelow et al.   Nature Communications

HRas Signal Transduction Promotes Hepatitis C Virus Cell Entry by Triggering Assembly of the Host Tetraspanin Receptor Complex

(2013) Laetitia Zona et al.   Cell Host & Microbe

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure

(2013) Stefanie A. Mortimer et al.   NUCLEIC ACIDS RESEARCH

Modulation of Hepatitis C Virus RNA Accumulation and Translation by DDX6 and miR-122 Are Mediated by Separate Mechanisms

(2013) Adam Huys et al.   PLoS One

Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication

(2012) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of hepatitis C virus RNA abundance and virus release by dispersion of processing bodies and enrichment of stress granules

(2012) Cara T. Pager et al.   VIROLOGY

Nucleotide requirements at positions +1 to +4 for the initiation of hepatitis C virus positive-strand RNA synthesis

(2011) U. Nandasoma et al.   JOURNAL OF GENERAL VIROLOGY

miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components

(2011) Ashley P. E. Roberts et al.   NUCLEIC ACIDS RESEARCH

Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex

(2011) E. S. Machlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protease Inhibitor–Resistant Hepatitis C Virus Mutants With Reduced Fitness From Impaired Production of Infectious Virus

(2010) Tetsuro Shimakami et al.   GASTROENTEROLOGY

Regulation of Hepatitis C Virus Translation and Infectious Virus Production by the MicroRNA miR-122

(2010) R. K. Jangra et al.   JOURNAL OF VIROLOGY

Role of RNA Structures in Genome Terminal Sequences of the Hepatitis C Virus for Replication and Assembly

(2009) P. Friebe et al.   JOURNAL OF VIROLOGY

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Position-Dependent Function for a Tandem MicroRNA miR-122-Binding Site Located in the Hepatitis C Virus RNA Genome

(2008) Catherine L. Jopling et al.   Cell Host & Microbe

microRNA-122 stimulates translation of hepatitis C virus RNA

(2008) Jura Inga Henke et al.   EMBO JOURNAL

Hepatitis C virus infection protein network

(2008) B de Chassey et al.   Molecular Systems Biology

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE