Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development

Published 2019 View Full Article

Authors

Keywords

pluripotent stem cells, endoderm, single-cell RNA-seq, CRISPRi, human development, chromatin accessibility, hepatic endoderm, dCas9-KRAB, stem cell differentiation, perturbation screen

Journal

Cell Reports

Volume 27, Issue 3, Pages 708-718.e10

Publisher

Elsevier BV

Online

2019-04-16

DOI

10.1016/j.celrep.2019.03.076

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