Review
Neurosciences
Elisa J. Gonzalez-Rothi, Kun-Ze Lee
Summary: Acute intermittent hypoxia has shown promise as a treatment for respiratory insufficiency in individuals with spinal cord injury, through inducing neuroplasticity and functional recovery. Research in animal models has laid the foundation for the translation of this therapeutic strategy to clinical populations.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Cell & Tissue Engineering
Aeri Shin, Jae Ryun Ryu, Byung Gon Kim, Woong Sun
Summary: Fetal spinal cord ischemia is a serious condition with limited understanding and treatment options. We established a screening system using spinal cord organoids and discovered the mild neuroprotective effects of rapamycin.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jeonghoon Oh, Alexander G. Steele, Blesson Varghese, Catherine A. Martin, Michelle S. Scheffler, Rachel L. Markley, Yi-Kai Lo, Dimitry G. Sayenko
Summary: Transcutaneous spinal stimulation is a promising method for restoring upper limb function in patients with spinal cord injuries. By selectively stimulating different electrode placements, specific groups of upper limb muscles can be activated. This approach may enhance efficacy and help patients recover more diverse motor activities.
Review
Neurosciences
Marissa C. Ciesla, Yasin B. Seven, Latoya L. Allen, Kristin N. Smith, Zachary A. Asa, Alec K. Simon, Ashley E. Holland, Juliet Santiago, Kelsey Stefan, Ashley Ross, Elisa J. Gonzalez-Rothi, Gordon S. Mitchell
Summary: The study found that there is substantial serotonergic reinnervation following cervical spinal cord injury, but intermittent hypoxia does not affect the extent of reinnervation.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Cell Biology
Zhen-Xiao Ren, Jing-Hui Xu, Xing Cheng, Gui-Xing Xu, Hou-Qing Long
Summary: Cervical spondylotic myelopathy is a common cause of non-traumatic spinal cord injury. The main pathological changes involve compression and damage to the microvascular network, leading to ischemia and inflammation. Vascular regeneration and remodeling play a crucial role in neural repair.
NEURAL REGENERATION RESEARCH
(2023)
Review
Neurosciences
Milap S. Sandhu, Monica A. Perez, Martin Oudega, Gordon S. Mitchell, William Z. Rymer
Summary: Acute intermittent hypoxia (AIH) can enhance upper-extremity function in individuals with incomplete SCI. A single AIH session improves bilateral grip and pinch strength, peaking around 3 hours post-intervention, significantly higher than sham AIH.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Medicine, General & Internal
Wenxuan Wang, Chenhui Xue, Xun Ma, Haoyu Feng, Zhuo Ma, Xiaoming Guan, Xu Chen, Xin Zhang
Summary: This study indicates that there are changes in cervical sagittal parameters in patients after surgery, but the use of C2 to 7 laminoplasty can achieve satisfactory clinical results without significantly altering the cervical sagittal parameters.
Article
Orthopedics
Huachuan Wu, Guoliang Chen, Xianlong Li, Zhengya Zhu, Zuofeng Xu, Xizhe Liu, Shaoyu Liu
Summary: This study compares the reliability of two different methods for evaluating the hyperechoic intensity of spinal cord ultrasound in degenerative cervical myelopathy. The images-based GVR-B method demonstrates better reliability and can be used for prognostic prediction and future studies.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Neurosciences
Marissa C. Ciesla, Yasin B. Seven, Latoya L. Allen, Kristin N. Smith, Elisa J. Gonzalez-Rothi, Gordon S. Mitchell
Summary: This study found that daily AIH increased the area of serotonergic immunolabeling in the XII motor nuclei in rats, while CIH protocols did not have the same effect, indicating that different intermittent hypoxia protocols have differential effects on XII serotonergic innervation.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Orthopedics
Moon Soo Park, Young-Su Ju, Seong-Hwan Moon, Young-Woo Kim, Jong Ho Jung, Jung Hyun Oh, Chi Heon Kim, Chun Kee Chung
Summary: This study aimed to compare the reoperation rates of cervical and lumbar fusion surgeries in patients with degenerative spinal diseases. Results showed that the reoperation rate was higher in patients who underwent lumbar fusion surgery compared to cervical fusion surgery, particularly in the late period. Associated comorbidities and hospital type were identified as risk factors for reoperation.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Surgery
Srihari K. Lella, Harold D. Waller, Alaska Pendleton, Christopher A. Latz, Laura T. Boitano, Anahita Dua
Summary: This study reviewed the rates of SCI and strategies for prevention and mitigation during DTA and TAA repairs. A multimodal approach, including institutional protocols, staging of repairs, preservation of collateral blood flow, augmented spinal cord perfusion, selective cerebrospinal fluid drainage, and distal aortic perfusion during open TAA repairs, was found to be important in reducing the risk of SCI.
JOURNAL OF VASCULAR SURGERY
(2022)
Review
Neurosciences
Hyun Woo Kim, Hu Yong, Graham Ka Hon Shea
Summary: Degenerative cervical myelopathy (DCM) is the leading cause of spinal cord dysfunction in the aging population. The disruption of the blood-spinal cord barrier (BSCB) is a critical pathological feature affecting prognosis. This review discusses the pathophysiology of DCM and highlights the importance of BSCB dysfunction in surgical outcomes.
FLUIDS AND BARRIERS OF THE CNS
(2023)
Review
Neurosciences
Breanna M. Arnold, Behzad M. Toosi, Sally Caine, Gordon S. Mitchell, Gillian D. Muir
Summary: This study showed that prolonged repetitive AIH combined with task-specific training improved forelimb reach-to-grasp function in rats with chronic cervical hemisection, without affecting off-target motor tasks. It further supports the idea that daily AIH can enhance limb function when combined with task-specific training.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hatice Kumru, Loreto Garcia-Alen, Aina Ros-Alsina, Sergiu Albu, Margarita Valles, Joan Vidal
Summary: This study aimed to investigate whether transcutaneous spinal cord stimulation (tSCS) could improve respiratory function in individuals with cervical spinal cord injury (cSCI). The results showed that subjects who received tSCS combined with inspiratory muscle training (IMT) experienced significant improvements in breathlessness/dyspnea, hypophonia, maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), and forced vital capacity. Therefore, tSCS may serve as an effective adjunctive therapy for respiratory impairments following SCI.
Article
Neurosciences
Goran Pavic, Patrick Petzsch, Robin Jansen, Katharina Raba, Nicole Rychlik, Ioannis Simiantonakis, Patrick Kuery, Peter Goettle, Karl Koehrer, Hans-Peter Hartung, Sven G. Meuth, Sebastian Jander, Michael Gliem
Summary: This study found that while there are differences in the inflammatory response and repair activity between the brain and spinal cord, the overall inflammatory reaction is comparable between day 1 and day 7 post-ischemia. The cerebral cortex shows a higher capacity for remyelination, which is supported by microglia dominance.
Article
Radiology, Nuclear Medicine & Medical Imaging
J. R. Young, I. Orosz, M. A. Franke, H. J. Kim, D. Woodworth, B. M. Ellingson, N. Salamon, W. B. Pope
CLINICAL RADIOLOGY
(2018)
Article
Oncology
Ararat Chakhoyan, Davis C. Woodworth, Robert J. Harris, Albert Lai, Phioanh L. Nghiemphu, Linda M. Liau, Whitney B. Pope, Timothy F. Cloughesy, Benjamin M. Ellingson
JOURNAL OF NEURO-ONCOLOGY
(2018)
Article
Clinical Neurology
Benjamin M. Ellingson, Noriko Salamon, Davis C. Woodworth, Hajime Yokota, Langston T. Holly
JOURNAL OF NEUROSURGERY-SPINE
(2018)
Article
Oncology
Benjamin M. Ellingson, Dana T. Aftab, Gisela M. Schwab, Colin Hessel, Robert J. Harris, Davis C. Woodworth, Kevin Leu, Ararat Chakhoyan, Catalina Raymond, Jan Drappatz, John de Groot, Michael D. Prados, David A. Reardon, David Schiff, Marc Chamberlain, Tom Mikkelsen, Annick Desjardins, Jaymes Holland, Jerry Ping, Ron Weitzman, Patrick Y. Wen, Timothy F. Cloughesy
Article
Oncology
Benjamin M. Ellingson, Lauren E. Abrey, Josep Garcia, Olivier Chinot, Wolfgang Wick, Frank Saran, Ryo Nishikawa, Roger Henriksson, Warren P. Mason, Robert J. Harris, Kevin Leu, Davis C. Woodworth, Arnav Mehta, Catalina Raymond, Ararat Chakhoyan, Whitney B. Pope, Timothy F. Cloughesy
Article
Clinical Neurology
Davis C. Woodworth, Langston T. Holly, Emeran A. Mayer, Noriko Salamon, Benjamin M. Ellingson
Article
Clinical Neurology
Davis C. Woodworth, Langston T. Holly, Noriko Salamon, Benjamin M. Ellingson
WORLD NEUROSURGERY
(2018)
Article
Multidisciplinary Sciences
Davis C. Woodworth, Adelle Dagher, Adam Curatolo, Monisha Sachdev, Cody Ashe-McNalley, Bruce D. Naliboff, Jennifer S. Labus, J. Richard Landis, Jason J. Kutch, Emeran A. Mayer, Richard S. Lee, Marsha A. Moses, Benjamin M. Ellingson
Article
Geriatrics & Gerontology
Nienke Legdeur, Pieter Jelle Visser, Davis C. Woodworth, Majon Muller, Evan Fletcher, Pauline Maillard, Philip Scheltens, Charles DeCarli, Claudia H. Kawas, Maria M. Corrada
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2019)
Article
Clinical Neurology
Langston T. Holly, Chencai Wang, Davis C. Woodworth, Noriko Salamon, Benjamin M. Ellingson
JOURNAL OF CLINICAL NEUROSCIENCE
(2019)
Article
Clinical Neurology
Davis C. Woodworth, Hannah L. Nguyen, Zainab Khan, Claudia H. Kawas, Maria M. Corrada, S. Ahmad Sajjadi
Summary: The study found that participants with hippocampal sclerosis of aging (HS) showed distinct patterns of hippocampal atrophy on MRI compared to participants without HS but with Alzheimer's disease neuropathology, suggesting that subiculum and CA1 atrophy could be a potential in vivo biomarker for HS.
ALZHEIMERS & DEMENTIA
(2021)
Review
Neurosciences
Davis C. Woodworth, Kiana A. Scambray, Maria M. Corrada, Claudia H. Kawas, S. Ahmad Sajjadi
Summary: Neuroimaging studies in the oldest-old population show that they are more likely to exhibit brain atrophy and white matter lesions compared to younger old individuals, which are associated with dementia or cognitive impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Lorena Sordo, Tianchen Qian, Syed A. Bukhari, Katelynn M. Nguyen, Davis C. Woodworth, Elizabeth Head, Claudia H. Kawas, Maria M. Corrada, Thomas J. Montine, S. Ahmad Sajjadi
Summary: Hippocampal sclerosis of aging (HS-A) is a common age-related neuropathological lesion characterized by neuronal loss and astrogliosis in the subiculum and CA1 subfield of the hippocampus. It is associated with cognitive decline similar to Alzheimer's disease. This study compares the traditional binary diagnosis of HS-A with a novel quantitative measure, revealing associations between HS-A and other neuropathologies and cognitive impairment that were not detected using the traditional approach.
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Davis C. Woodworth, Nasim Sheikh-Bahaei, Kiana A. Scambray, Michael J. Phelan, Mari Perez-Rosendahl, Maria M. Corrada, Claudia H. Kawas, Seyed Ahmad Sajjadi
Summary: The study found that even after accounting for the most common neuropathologies, dementia still had among the strongest associations with atrophy of medial temporal lobe structures.
BRAIN COMMUNICATIONS
(2022)
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)