Article
Medicine, General & Internal
Talia C. Oughourlian, Chencai Wang, Noriko Salamon, Langston T. Holly, Benjamin M. Ellingson
Summary: In patients with DCM, males have larger gray matter volume (GMV) in motor, language, and vision related brain regions compared to female DCM patients. Males show a significant positive correlation between GMV and mJOA score, with worsening neurological symptoms leading to decreasing GMV primarily in somatosensory and motor related cortical regions. Females exhibit a similar association, involving a broader range of cortical areas including those involved in pain processing. Additionally, female patients consistently show smaller GMV in sensorimotor regions compared with male patients, regardless of mJOA score. Results indicate strong sex-related differences in cortical volume in patients with DCM, potentially reflecting hormonal influence or differing compensation mechanisms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Maksim A. Shlykov, Erica M. Giles, Michael P. Kelly, Shiow J. Lin, Vy T. Pham, Nancy L. Saccone, Elizabeth L. Yanik
Summary: This study aimed to evaluate the associations between genetic and nongenetic factors and degenerative cervical myelopathy (DCM). The study identified age, sex, and relative socioeconomic deprivation as independent risk factors for DCM, while Asian race was inversely associated. Additionally, potential SNP markers were found in the GTPBP1 gene on chromosome 22 and an intergenic region on chromosome 18. These findings contribute to understanding the disease processes, guiding prevention and interventions, and potentially influencing surgical outcomes for DCM.
Article
Clinical Neurology
Edward Goacher, Richard Phillips, Oliver D. Mowforth, Stefan Yordanov, Erlick A. C. Pereira, Adrian Gardner, Nasir A. Quraishi, Antony H. Bateman, Andreas K. Demetriades, Marcel Ivanov, Alexandru Budu, Edward Dyson, Guy Wynne-Jones, Benjamin M. Davies, Mark R. N. Kotter
Summary: The incidence of hospitalization for degenerative cervical myelopathy (DCM) is rising in England. Epidemiological data indicates that DCM primarily affects the working-age population. There is a significant gender difference, with a higher number of male patients than female patients. Early diagnosis and treatment should be strengthened to address the increasing burden of DCM.
ACTA NEUROCHIRURGICA
(2022)
Article
Medicine, General & Internal
Chencai Wang, Benjamin M. Ellingson, Talia C. Oughourlian, Noriko Salamon, Langston T. Holly
Summary: This study investigated the changes in brain functional network at different stages of myelopathy severity in DCM patients and developed a link prediction model to predict the progression of DCM. The results revealed differences in network connectivity in DCM patients at different stages and demonstrated the predictive capability of the link prediction model.
Article
Clinical Neurology
Ricardo Rodrigues-Pinto, Thiago S. Montenegro, Benjamin M. Davies, So Kato, Yoshiharu Kawaguchi, Manabu Ito, Mehmet Zileli, Brian K. Kwon, Michael G. Fehlings, Paul A. Koljonen, Shekar N. Kurpad, James D. Guest, Bizhan Aarabi, Vafa Rahimi-Movaghar, Jefferson R. Wilson, Mark R. N. Kotter, James S. Harrop
Summary: The study introduces individualized surgery as a research priority for Degenerative Cervical Myelopathy. The article summarizes current surgical recommendations and indications, and discusses the impact of prognostic factors on surgical outcomes. It highlights the potential of surgical decompression to improve neurologic function and quality of life for most patients, but acknowledges the uncertainties regarding surgical types and timing.
GLOBAL SPINE JOURNAL
(2022)
Article
Clinical Neurology
Chencai Wang, Benjamin M. Ellingson, Sabah Islam, Azim Laiwalla, Noriko Salamon, Langston T. Holly
Summary: The study aimed to investigate cerebral reorganization in patients with degenerative cervical myelopathy (DCM) after surgical decompression. Functional connectivity (FC) patterns differed significantly between DCM patients and healthy controls, with stronger FC observed between the cerebellum and frontal lobes in DCM patients postoperatively. Increased FC between the cerebellum and primary sensorimotor areas was associated with neurological improvement in DCM patients.
JOURNAL OF NEUROSURGERY-SPINE
(2021)
Article
Surgery
Dougho Park, Jae Man Cho, Joong Won Yang, Donghoon Yang, Mansu Kim, Gayeoul Oh, Heum Dai Kwon
Summary: This study aimed to develop machine learning models for classifying expert-level therapeutic decisions in patients with degenerative cervical myelopathy (DCM). The study utilized various classification methods and machine learning algorithms to construct the models, and evaluated their performance using the area under the receiver operating characteristic curve (AUC-ROC). The results showed that the machine learning models were able to effectively classify DCM therapeutic options and could serve as a basis for establishing generalizable surgical decision models for DCM.
FRONTIERS IN SURGERY
(2022)
Review
Medicine, General & Internal
Melissa Lannon, Edward Kachur
Summary: Degenerative cervical myelopathy (DCM) is a common condition caused by narrowing of the spinal canal, leading to spinal cord compression and neurologic dysfunction. Clinicians should be aware of early signs and symptoms to consider surgical intervention for preventing severe deterioration in neurologic function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Brandon He, Kyle Sheldrick, Abhirup Das, Ashish Diwan
Summary: Degenerative cervical myelopathy (DCM) is a non-traumatic, chronic, and progressive disease, and current diagnostic and prognostic techniques have limitations. This article presents evidence on novel quantitative MRI (qMRI) techniques for assessing spinal cord integrity in DCM and suggests future research directions.
Article
Clinical Neurology
G. Baucher, H. Rasoanandrianina, S. Levy, L. Pini, L. Troude, P-H Roche, V Callot
Summary: This study assessed the potential value of quantitative cervical spinal cord T1 mapping in patients with degenerative cervical myelopathy and found that patients with moderate-to-severe degenerative cervical myelopathy had higher T1 values compared to healthy controls. Patients showed increased T1 values at specific levels, such as C1, C7, and the level of maximal compression. However, patients with mild degenerative cervical myelopathy did not show significant results compared to healthy controls, indicating a need for further multicenter studies.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Clinical Neurology
Max B. Butler, Oliver D. Mowforth, Abdul Badran, Michelle Starkey, Timothy Boerger, Iwan Sadler, Julia Tabrah, Caroline Treanor, Lucy Cameron, Sukhvinder Kalsi-Ryan, Rodney J. Laing, Benjamin M. Davies, Mark R. N. Kotter
Summary: This study investigated the usage and perceptions of nonoperative physiotherapy for degenerative cervical myelopathy (DCM). The results showed that few patients perceived benefit from physiotherapy, but this was more likely in those with mild DCM and shorter symptom durations. This suggests a need for further research on the appropriate role of physiotherapy in the management of DCM.
GLOBAL SPINE JOURNAL
(2022)
Article
Clinical Neurology
Chencai Wang, Langston T. Holly, Talia Oughourlian, Jingwen Yao, Catalina Raymond, Noriko Salamon, Benjamin M. Ellingson
Summary: The study revealed long-term reorganization in the brain of patients with DCM and neurologically asymptomatic spinal cord compression, especially in regions responsible for sensory information perception and integration, motor regulation, and pain modulation.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zi-Wen Yan, Dong-Ya Li, Wang-Yi Jin, Chao-Ran Huang, Sheng Pan, Da-Lin Peng, Xing-Chen Zhang, Yong Pang, Kai-Jin Guo, Xin Zheng
Summary: This study found that incidental thyroid abnormalities are common in patients with degenerative cervical spondylosis (DCS) who undergo cervical spine magnetic resonance imaging (MRI). The prevalence of incidental thyroid abnormalities in this population was 7.5%, with thyroid nodules being the most frequent abnormality. Age and sex were found to have a significant impact on the presence of incidental thyroid abnormalities in DCS patients.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Clinical Neurology
Chencai Wang, Benjamin M. Ellingson, Noriko Salamon, Langston T. Holly
Summary: This study investigated the recovery of microstructural integrity and reorganization of microstructural connectivity in patients with degenerative cervical myelopathy (DCM) after surgical decompression. The results showed that neurological improvement was associated with increased structural connectivity and improved microstructural indices in sensory and motor-related regions.
Review
Geriatrics & Gerontology
Ben Grodzinski, Rory Durham, Oliver Mowforth, Daniel Stubbs, Mark R. N. Kotter, Benjamin M. Davies
Summary: The study found that age is a significant predictor in affecting the clinical presentation, surgical management, and post-operative outcomes of degenerative cervical myelopathy (DCM). Older patients with DCM tend to have worse pre-operative functional status, are more likely to undergo posterior surgery, and have worse post-operative functional status but experience a similar amount of improvement as younger patients. The findings emphasize the importance of considering age when determining the eligibility of older patients for surgery.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jingwen Yao, Chencai Wang, Benjamin M. Ellingson
Summary: The study found that the exchange rates of alpha-amine and hydroxyl protons are highly dependent on pH and phosphate concentrations, while the exchange rates of eta-amine and amide protons depend on pH but are not catalyzed by phosphate. Phosphate, predominantly intracellular, affects the CEST contrast of alpha-amine, showing higher sensitivity to changes in the extracellular microenvironment.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Clinical Neurology
Davis C. Woodworth, Hannah L. Nguyen, Zainab Khan, Claudia H. Kawas, Maria M. Corrada, S. Ahmad Sajjadi
Summary: The study found that participants with hippocampal sclerosis of aging (HS) showed distinct patterns of hippocampal atrophy on MRI compared to participants without HS but with Alzheimer's disease neuropathology, suggesting that subiculum and CA1 atrophy could be a potential in vivo biomarker for HS.
ALZHEIMERS & DEMENTIA
(2021)
Review
Neurosciences
Davis C. Woodworth, Kiana A. Scambray, Maria M. Corrada, Claudia H. Kawas, S. Ahmad Sajjadi
Summary: Neuroimaging studies in the oldest-old population show that they are more likely to exhibit brain atrophy and white matter lesions compared to younger old individuals, which are associated with dementia or cognitive impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Oncology
Benjamin M. Ellingson, Grace Hyun J. Kim, Matt Brown, Jihey Lee, Noriko Salamon, Lori Steelman, Islam Hassan, Shuchi S. Pandya, Saewon Chun, Michael Linetsky, Bryan Yoo, Patrick Y. Wen, Ingo K. Mellinghoff, Jonathan Goldin, Timothy F. Cloughesy
Summary: In IDH-mutant low-grade gliomas, using 3D volumetric measurements is better for determining response assessment, as it provides more stable measures of tumor growth rates, highest inter-reader agreement, and lowest reader discordance rates.
Review
Clinical Neurology
Benjamin M. Ellingson, Victor A. Levin, Timothy F. Cloughesy
Summary: There is an urgent need for drug development in brain tumors. Current radiographic response assessment methods lack the ability to evaluate complex or difficult to measure tumors. A tiered strategy is proposed to increase confidence in identifying therapeutic effects and provide a framework for evaluating combination and sequential treatment schemes.
Article
Clinical Neurology
Nicholas S. Cho, Akifumi Hagiwara, Francesco Sanvito, Benjamin M. Ellingson
Summary: This study investigated the impact of different NAWM normalization methods on nrCBV and nADC values, with results suggesting that CSO methods, particularly CSOs, may be preferred due to time savings, good reader variability, and similar diagnostic performance compared to TUM methods.
Article
Clinical Neurology
Chencai Wang, Jason J. Kutch, Jennifer S. Labus, Claire C. Yang, Richard E. Harris, Emeran A. Mayer, Benjamin M. Ellingson
Summary: This study found that alterations in white matter microstructure may be associated with persistent pain symptoms in urologic chronic pelvic pain syndrome (UCPPS). The results showed consistent aberrations in mean diffusivity (MD) between UCPPS patients and healthy controls, while fractional anisotropy (FA) differences were unique at baseline and 6-month follow-up visits. Furthermore, abnormal microstructural connectivity was observed in specific brain regions involved in sensory processing and pain modulation.
Article
Oncology
John H. Sampson, Achal Singh Achrol, Manish K. Aghi, Krystof Bankiewicz, Martin Bexon, Steven Brem, Andrew Brenner, Chandtip Chandhasin, Sajeel Chowdhary, Melissa Coello, Benjamin M. Ellingson, John R. Floyd, Seunggu Han, Santosh Kesari, Yael Mardor, Fahar Merchant, Nina Merchant, Dina Randazzo, Michael Vogelbaum, Frank Vrionis, Eva Wembacher-Schroeder, Miroslaw Zabek, Nicholas Butowski
Summary: This article introduces the application of MDNA55 in the treatment of recurrent GBM. Through clinical trials, it has been verified that MDNA55 can effectively control tumors and improve the survival rate of patients, showing the best efficacy at high doses.
Article
Oncology
Benjamin M. Ellingson, Patrick Y. Wen, Susan M. Chang, Martin van den Bent, Michael A. Vogelbaum, Gang Li, Shanpeng Li, Jiyoon Kim, Gilbert Youssef, Wolfgang Wick, Andrew B. Lassman, Mark R. Gilbert, John F. de Groot, Michael Weller, Evanthia Galanis, Timothy F. Cloughesy
Summary: This study reviewed past trials in recurrent glioblastoma and identified target objective response rates (ORRs) for different treatments. The study found that ORRs varied depending on the type of therapy, and ORR was significantly correlated with median overall survival (mOS) for chemotherapy, biologic, and immunotherapy trials. Based on this analysis, the study recommends a target ORR >25% and a sample size of >=40 patients for future studies in recurrent glioblastoma.
Letter
Oncology
Benjamin M. Ellingson, Patrick Y. Wen, Timothy F. Cloughesy
Article
Clinical Neurology
Lorena Sordo, Tianchen Qian, Syed A. Bukhari, Katelynn M. Nguyen, Davis C. Woodworth, Elizabeth Head, Claudia H. Kawas, Maria M. Corrada, Thomas J. Montine, S. Ahmad Sajjadi
Summary: Hippocampal sclerosis of aging (HS-A) is a common age-related neuropathological lesion characterized by neuronal loss and astrogliosis in the subiculum and CA1 subfield of the hippocampus. It is associated with cognitive decline similar to Alzheimer's disease. This study compares the traditional binary diagnosis of HS-A with a novel quantitative measure, revealing associations between HS-A and other neuropathologies and cognitive impairment that were not detected using the traditional approach.
ACTA NEUROPATHOLOGICA
(2023)
Article
Oncology
Kunal S. Patel, Jingwen Yao, Nicholas S. Cho, Francesco Sanvito, Kaleab Tessema, Alvaro Alvarado, Lindsey Dudley, Fausto Rodriguez, Richard Everson, Timothy F. Cloughesy, Noriko Salamon, Linda M. Liau, Harley Kornblum, Benjamin M. Ellingson
Summary: This study evaluated the use of amine chemical exchange saturation transfer echo planar imaging (CEST-EPI) for the diagnosis and prognostication of glioblastoma. The results showed that CEST-EPI can visualize non-enhancing (NE) tumor regions and is correlated with tumor cell density, degree of proliferation, and progression-free survival (PFS).
Article
Psychiatry
C. Wang, T. A. Tishler, K. H. Nuechterlein, B. M. Ellingson
Summary: This longitudinal study compared the effects of oral antipsychotics (OAP) and long-acting injectable antipsychotic, paliperidone palmitate (PP), on cortical thickness, gray-to-white matter contrast (GWC), and frontal lobe intracortical myelin (ICM) volume in first-episode schizophrenia (FES) patients. The results showed that OAP treatment resulted in more widespread cortical thickness reduction compared to PP treatment, suggesting that PP treatment may aid in the preservation of brain morphology.
PSYCHIATRY RESEARCH
(2023)
Article
Oncology
Sonoko Oshima, Akifumi Hagiwara, Catalina Raymond, Chencai Wang, Nicholas S. Cho, Jianwen Lu, Blaine S. C. Eldred, Phioanh L. Nghiemphu, Albert Lai, Donatello Telesca, Noriko Salamon, Timothy F. Cloughesy, Benjamin M. Ellingson
Summary: The aim of this study was to evaluate the impact of volumetric TGR alterations on overall survival (OS) in rGBM patients treated with chemotherapy with or without radiation therapy. The results showed that a decrease in TGR, smaller baseline tumor volume, O-6-methylguanine-DNA methyltransferase promoter methylation, and fewer recurrences were significantly associated with longer OS.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Clinical Neurology
Davis C. Woodworth, Nasim Sheikh-Bahaei, Kiana A. Scambray, Michael J. Phelan, Mari Perez-Rosendahl, Maria M. Corrada, Claudia H. Kawas, Seyed Ahmad Sajjadi
Summary: The study found that even after accounting for the most common neuropathologies, dementia still had among the strongest associations with atrophy of medial temporal lobe structures.
BRAIN COMMUNICATIONS
(2022)
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)
