Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs

Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems

(2018) Houfu Liu et al.   DRUG DISCOVERY TODAY

Dimethyl Sulfoxide (DMSO) Decreases Cell Proliferation and TNF-α, IFN-γ, and IL-2 Cytokines Production in Cultures of Peripheral Blood Lymphocytes

(2017) Lucas de Abreu Costa et al.   MOLECULES

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

(2017) Choi-Fong Cho et al.   Nature Communications

Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

(2017) Ryan G. Lim et al.   Cell Reports

Toxic effects of dimethyl sulfoxide on red blood cells, platelets, and vascular endothelial cells in vitro

(2017) Xiaoyang Yi et al.   FEBS Open Bio

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

(2016) Hans C Helms et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Minimum Transendothelial Electrical Resistance Thresholds for the Study of Small and Large Molecule Drug Transport in a Human in Vitro Blood–Brain Barrier Model

(2016) Jennifer L. Mantle et al.   MOLECULAR PHARMACEUTICS

Cryopreservation of Brain Endothelial Cells Derived from Human Induced Pluripotent Stem Cells Is Enhanced by Rho-Associated Coiled Coil-Containing Kinase Inhibition

(2016) Hannah K. Wilson et al.   TISSUE ENGINEERING PART C-METHODS

Human Brain Microvascular Endothelial Cells Derived from the BC1 iPS Cell Line Exhibit a Blood-Brain Barrier Phenotype

(2016) Moriah E. Katt et al.   PLoS One

Temporal expression of transporters and receptors in a rat primary co-culture blood–brain barrier model

(2014) Houfu Liu et al.   XENOBIOTICA

A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources

(2014) Ethan S. Lippmann et al.   Scientific Reports

Retinoic Acid Induces Blood-Brain Barrier Development

(2013) M. R. Mizee et al.   JOURNAL OF NEUROSCIENCE

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

The Human Brain in a Dish: The Promise of iPSC-Derived Neurons

(2011) Ricardo Dolmetsch et al.   CELL

Astrocytes and Pericytes Differentially Modulate Blood—Brain Barrier Characteristics during Development and Hypoxic Insult

(2010) Abraham Al Ahmad et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood-Brain Barrier for A 1-40 Peptides

(2009) H. Xiong et al.   JOURNAL OF NEUROSCIENCE

Analysis of Unstirred Water Layer in In Vitro Permeability Experiments

(2009) Timo Korjamo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Maintaining blood-brain barrier integrity: Pericytes perform better than astrocytes during prolonged oxygen deprivation

(2008) A. Al Ahmad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

(2008) Shinsuke Nakagawa et al.   NEUROCHEMISTRY INTERNATIONAL