Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies

Systemic AAV vectors for widespread and targeted gene delivery in rodents

(2019) Rosemary C. Challis et al.   Nature Protocols

Sudden Heart Rate Reduction Upon Optogenetic Release of Acetylcholine From Cardiac Parasympathetic Neurons in Perfused Hearts

(2019) Angel Moreno et al.   Frontiers in Physiology

Viral Strategies for Targeting the Central and Peripheral Nervous Systems

(2018) Claire N. Bedbrook et al.   Annual Review of Neuroscience

Electrophysiological effects of nicotinic and electrical stimulation of intrinsic cardiac ganglia in the absence of extrinsic autonomic nerves in the rabbit heart

(2018) Emily Allen et al.   HEART RHYTHM

Dynamics of neuroeffector coupling at cardiac sympathetic synapses

(2018) Valentina Prando et al.   JOURNAL OF PHYSIOLOGY-LONDON

Transcriptomic and neurochemical analysis of the stellate ganglia in mice highlights sex differences

(2018) R. G. Bayles et al.   Scientific Reports

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

(2017) Ken Y Chan et al.   NATURE NEUROSCIENCE

Quantification of sympathetic hyperinnervation and denervation after myocardial infarction by three-dimensional assessment of the cardiac sympathetic network in cleared transparent murine hearts

(2017) Teruki Yokoyama et al.   PLoS One

Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow

(2017) Alon Greenbaum et al.   Science Translational Medicine

Communication in Neural Circuits: Tools, Opportunities, and Challenges

(2016) Talia N. Lerner et al.   CELL

Sensory Neurons that Detect Stretch and Nutrients in the Digestive System

(2016) Erika K. Williams et al.   CELL

Extracting structural and functional features of widely distributed biological circuits with single cell resolution via tissue clearing and delivery vectors

(2016) Jennifer Brooke Treweek et al.   CURRENT OPINION IN BIOTECHNOLOGY

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

(2016) Benjamin E Deverman et al.   NATURE BIOTECHNOLOGY

Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control

(2016) Alessandro Furlan et al.   NATURE NEUROSCIENCE

Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis

(2016) Frieda A. Koopman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3D imaging in CUBIC-cleared mouse heart tissue: going deeper

(2016) Imke Nehrhoff et al.   Biomedical Optics Express

Central-peripheral neural network interactions evoked by vagus nerve stimulation: functional consequences on control of cardiac function

(2015) Jeffrey L. Ardell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Vagal nerve stimulation activates vagal afferent fibers that reduce cardiac efferent parasympathetic effects

(2015) Kentaro Yamakawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Vagal Sensory Neuron Subtypes that Differentially Control Breathing

(2015) Rui B. Chang et al.   CELL

Clarifying Tissue Clearing

(2015) Douglas S. Richardson et al.   CELL

Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping

(2015) Jennifer B Treweek et al.   Nature Protocols

Optogenetic release of norepinephrine from cardiac sympathetic neurons alters mechanical and electrical function

(2014) Anastasia M. Wengrowski et al.   CARDIOVASCULAR RESEARCH

Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing

(2014) Bin Yang et al.   CELL

iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging

(2014) Nicolas Renier et al.   CELL

Focal myocardial infarction induces global remodeling of cardiac sympathetic innervation: neural remodeling in a spatial context

(2013) Olujimi A. Ajijola et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nerves projecting from the intrinsic cardiac ganglia of the pulmonary veins modulate sinoatrial node pacemaker function

(2013) Manuel Zarzoso et al.   CARDIOVASCULAR RESEARCH

High-resolution measurement of electrically-evoked vagus nerve activity in the anesthetized dog

(2013) Paul B Yoo et al.   Journal of Neural Engineering

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

(2012) Linda Madisen et al.   NATURE NEUROSCIENCE

Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

(2011) Jari Rossi et al.   Cell Metabolism

Immunohistochemical characterization of the intrinsic cardiac neural plexus in whole-mount mouse heart preparations

(2011) Kristina Rysevaite et al.   HEART RHYTHM

Quantitative analysis of parasympathetic innervation of the porcine heart

(2010) Joseph S. Ulphani et al.   HEART RHYTHM

Orderly recruitment of motor units under optical control in vivo

(2010) Michael E Llewellyn et al.   NATURE MEDICINE

High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency

(2009) E Ayuso et al.   GENE THERAPY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

The anatomy of the cardiac conduction system

(2008) Robert H. Anderson et al.   CLINICAL ANATOMY

Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75

(2008) J.L. Hoard et al.   NEUROSCIENCE