Article
Pharmacology & Pharmacy
Haiming Xiao, Xiaohong Sun, Zeyuan Lin, Yan Yang, Meng Zhang, Zhanchi Xu, Peiqing Liu, Zhongqiu Liu, Heqing Huang
Summary: The study found that gentiopicroside (GPS) can activate the PI3K/AKT pathway by promoting DNA-binding protein 2 (DDB2)-mediated degradation of progestin and adipoQ receptor 3 (PAQR3), thereby improving glycolipid metabolism. GPS directly binds to PAQR3 and inhibits the interaction between PAQR3 and the PI3K catalytic subunit (P110a) to restore insulin signaling pathway.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Agriculture, Multidisciplinary
Shuhua Tian, Yunfan Wang, Xiangfei Li, Jie Liu, Jing Wang, Yingjian Lu
Summary: Sulforaphane (SFN) can alleviate obesity complications through various mechanisms, including reducing NAFLD, inflammation, oxidative stress, adipose tissue hypertrophy, and insulin resistance, as well as regulating glucose and lipid metabolism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Ling-Yu Tian, Daniel J. Smit, Manfred Juecker
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths globally. The dysregulation of the PI3K/AKT/mTOR signaling pathway is common in HCC, and understanding its role in regulating cellular metabolism is crucial for developing novel therapies for liver cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Ying-Jun Zhou, Nuo Xu, Xiao-Chen Zhang, Yu-Yan Zhu, Shao-Wei Liu, Ya-Ning Chang
Summary: Chrysin, a natural product with minimal side effects, has been shown to effectively modulate glucose and lipid metabolism by regulating key proteins and signaling pathways, offering potential as a treatment for metabolic syndrome.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xiaojia Zhu, Yu He, Qingyu Zhang, Derui Ma, Hongfeng Zhao
Summary: This study investigated the toxicological effects of lead exposure on hepatic carbohydrate and lipid metabolism in birds. Using the Japanese quail as an animal model, the study found that lead accumulation in the liver was dose-dependent. High dose exposure to lead caused severe histopathological damages and disruption of the PI3K/Akt signaling pathway. Furthermore, lead exposure altered the expression of genes related to glycometabolism, fat synthesis, and oxidation in the liver, leading to liver metabolic disorder.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Pauline Morigny, Jeremie Boucher, Peter Arner, Dominique Langin
Summary: White adipocyte metabolism plays a crucial role in systemic metabolism regulation and is often disrupted in conditions like cancer and type 2 diabetes mellitus. This review provides an overview of lipid metabolism in white adipocytes and discusses how these pathways can serve as therapeutic targets in metabolic disorders.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Gabriela Tavares, Fatima O. Martins, Bernardete F. Melo, Paulo Matafome, Silvia Conde
Summary: Peripheral dopamine plays a role in regulating glucose uptake in insulin-sensitive tissues, with dopamine receptors having differential involvement. Dopamine also affects lipid metabolism in white adipose tissue. The modulation of the dopaminergic system in the periphery could be a potential therapeutic approach for metabolic disorders.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Xu-guang Zhang, Ai-xia Liu, Yu-xin Zhang, Ming-yan Zhou, Xiang-yi Li, Ming-hai Fu, Yi-peng Pan, Jian Xu, Jun-qing Zhang
Summary: The study found that DPH5 can improve insulin resistance and enhance antioxidant capacity, thereby improving oxidative stress and glucose metabolism, accelerating glucose utilization, and enhancing insulin sensitivity. The mechanism of action of DPH5 involves the regulation of the PI3K/AKT-Nrf2-GSK3 beta pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Ran Liu, Shilin Guan, Zhongai Gao, Jingyu Wang, Jie Xu, Zhaohu Hao, Yi Zhang, Shaohua Yang, Zhenhong Guo, Juhong Yang, Hailin Shao, Baocheng Chang
Summary: In the prediabetic stage of IGT, high concentrations of insulin and glucose regulate the secretory function of glomerular endothelial cells in opposite ways by modulating the expression of miRNA-21, potentially leading to renal tubule ischemia.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Medicinal
Nada El-Megiri, Yasser M. Mostafa, Amal Ahmed, Eman T. Mehanna, Mona F. El-Azab, Fatma Alshehri, Hadil Alahdal, Norhan M. El-Sayed
Summary: The present study aimed to investigate the potential neuroprotective effect of Pioglitazone in PTZ kindled seizure in mice. Treatment with Pioglitazone demonstrated a significant decrease in NGF, seizure score, m-TOR, GLUT-1 and GLUT-3 in comparison to the PTZ group, suggesting that Pioglitazone provides its neuroprotective effect through modulating m-TOR signaling, glucose metabolism and NGF levels.
Article
Multidisciplinary Sciences
Tingting Zhao, Qian Xiang, Beifeng Lie, Deqi Chen, Minyi Li, Xi Zhang, Junzheng Yang, Bao He, Wei Zhang, Ruixue Dong, Yadi Liu, Junling Gu, Quan Zhu, Yijing Yao, Tingting Duan, Zhenghai Li, Youhua Xu
Summary: Aim: Diabetic nephropathy (DN) is the primary cause of end-stage renal disease worldwide. Lipid metabolism disorder plays a role in DN, and Yishen Huashi (YSHS) granule has shown potential to inhibit diabetic damage and reduce microalbuminuria (mALB) in DN animals. This study explored the role of YSHS and its mechanism in lipid metabolism under DN settings. Results: YSHS administration reduced levels of TC, TG, and LDL-C, while increasing HDL-C level. It ameliorated histological changes, liver steatosis, intestinal barrier integrity, and dysbacteriosis. Mechanism study revealed that YSHS modulated mitophagy and inhibited mTOR/AMPK/PI3K/AKT signaling pathway. Conclusion: YSHS administration can ameliorate lipid metabolism disorder in DN animals, and its modulation on the intestinal-liver axis is significant.
Article
Food Science & Technology
Song-Zi Xie, Wang-Juan Zhang, Wang Liu, Jin-Bo Bai, Song-Ling Xie, Tongsheng Wang, Guo-Bing Xu, De-Ling Wu
Summary: A polysaccharide called PSPW was isolated from the rhizome of Polygonatum sibiricum, which has the potential to improve type 2 diabetes. Oral administration of PSPW decreased blood glucose, glycosylated serum protein, and insulin levels, while increasing glucagon-like peptide-1 secretion. PSPW also improved glucose tolerance, insulin sensitivity, and hepatic glucose metabolism.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Pharmacology & Pharmacy
Yan-Ling Shi, Yue-Ping Zhang, Huan Luo, Fan Xu, Jian-Mei Gao, Jing-Shan Shi, Qi-Hai Gong
Summary: This study demonstrates that trilobatin (TLB) exhibits an anti-type 2 diabetes effect in KK-Ay mice by activating the Nrf2/ARE signaling pathway and regulating insulin signaling. TLB reduces blood glucose levels and insulin resistance, improves glucose and insulin tolerance, and has antioxidant properties. TLB also regulates abnormal lipid metabolism and improves pancreatic islet morphology and insulin expression.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Huidong Liu, Ye-Guang Chen
Summary: TGF-beta signaling plays a critical role in metabolism and is closely related to the progression of various diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Linda X. Wang, Mark R. Frey, Rohit Kohli
Summary: Bile acids not only play a crucial role in lipid digestion, but also act as signaling molecules in metabolic processes throughout the body. By binding to various receptors, bile acids regulate glucose and lipid metabolism, and promote glycogen synthesis. Recent studies have identified a novel intestinal protein that positively affects bile acid levels, providing a new target for treating metabolic and bile acid-related disorders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhongyao Tang, Yuanyuan Hou, Xueyan Hu, Aina Liu, Leefong Yau, Tiantian Tong, Zhihong Jiang, Gang Bai
Article
Chemistry, Multidisciplinary
Xueyan Hu, Yunbing Shen, Shengnan Yang, Wei Lei, Cheng Luo, Yuanyuan Hou, Gang Bai
Article
Biochemistry & Molecular Biology
Man Zhang, Xiaoyao Ma, Honglei Xu, Wenbo Wu, Xin He, Xiaoying Wang, Min Jiang, Yuanyuan Hou, Gang Bai
Article
Pharmacology & Pharmacy
Yanting Jiao, Fukui Shen, Zhihua Wang, Lili Ye, Man Zhang, Jie Gao, Yuanyuan Hou, Gang Bai
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Food Science & Technology
Chuan-jing Cheng, Xiao-tao Hou, Er-wei Hao, Nut Palachai, Jintanaporn Wattanathorn, Gang Bai, Yuan-yuan Hou
Summary: This study utilized a molecular network-guided HPLC-UV-FLD method to analyze the global antioxidant activity compounds in Camellia nitidissima Chi, successfully screening valuable antioxidant ingredients and establishing connections between them. By integrating the molecular network, the precise locations and relationships of the active ingredients were clarified, leading to the discovery of a new antioxidant ingredient, okicamelliaside, and providing useful guidance for screening trace active ingredients in natural products.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Oncology
Man Zhang, Jing Cui, Fukui Shen, Lili Ye, Chuanjing Cheng, Yang Li, Qiuyang Zhang, Lin Niu, Yuanyuan Hou, Gang Bai
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Plant Sciences
Man Zhang, Wenshuang Wang, Kaixin Liu, Chao Jia, Yuanyuan Hou, Gang Bai
Summary: This study investigated the potential therapeutic target and molecular mechanisms of Astragaloside IV (AST) in improving lung injury and treating COPD-associated pulmonary fibrosis. The results showed that AST protected lung function and inhibited pulmonary fibrosis by inhibiting the RAS/RAF/FoxO signaling pathway.
Article
Plant Sciences
Chuanjing Cheng, Jinling Zhang, Kaixin Liu, Yanyan Xu, Fukui Shen, Yanqi Han, Yuanyuan Hou, Tiejun Zhang, Gang Bai
Summary: The study aims to determine the potential therapeutic targets and molecular mechanisms of Ginsenoside CK in improving oxidative stress injury. It was found that CK improves oxidative damage by regulating the KEAP1-NRF2/ARE pathway, and its target protein is KEAP1. CK binds to KEAP1, disrupting the binding between NRF2 and KEAP1, thereby inhibiting oxidative damage induced by LPS or physical mechanical stress.
