Applications of Manganese-Enhanced Magnetic Resonance Imaging in Ophthalmology and Visual Neuroscience

Sensing intracellular calcium ions using a manganese-based MRI contrast agent

(2019) Ali Barandov et al.   Nature Communications

Astrocytes usurp neurons as a disease focus

(2019) Shane A. Liddelow et al.   NATURE NEUROSCIENCE

Manganese-enhanced magnetic resonance imaging in the whole visual pathway: chemical identification and neurotoxic changes

(2019) Zebin Xiao et al.   ACTA RADIOLOGICA

Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain

(2018) Juan Sanchez-Ramos et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

White Matter Tract Integrity: An Indicator of Axonal Pathology after Mild Traumatic Brain Injury

(2018) Sohae Chung et al.   JOURNAL OF NEUROTRAUMA

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Continuous manganese delivery via osmotic pumps for manganese-enhanced mouse MRI does not impair spatial learning but leads to skin ulceration

(2018) Dulcie A. Vousden et al.   NEUROIMAGE

Mn 2+ dynamics in manganese-enhanced MRI (MEMRI): Ca v 1.2 channel-mediated uptake and preferential accumulation in projection terminals

(2018) Benedikt T. Bedenk et al.   NEUROIMAGE

In vivo manganese tract tracing of frontal eye fields in rhesus macaques with ultra-high field MRI: Comparison with DWI tractography

(2018) David J. Schaeffer et al.   NEUROIMAGE

In Vivo Visualization of Active Polysynaptic Circuits With Longitudinal Manganese-Enhanced MRI (MEMRI)

(2018) Suellen Almeida-Corrêa et al.   Frontiers in Neural Circuits

Mouse MRI shows brain areas relatively larger in males emerge before those larger in females

(2018) Lily R. Qiu et al.   Nature Communications

Age-related Changes in Eye, Brain and Visuomotor Behavior in the DBA/2J Mouse Model of Chronic Glaucoma

(2018) Xiao-Ling Yang et al.   Scientific Reports

Evaluation and review of body fluids saliva, sweat and tear compared to biochemical hydration assessment markers within blood and urine

(2017) M Villiger et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Manganese-enhanced MR imaging (MEMRI) combined with electrophysiology in the study of cross-modal plasticity in binocularly blind rats

(2017) Zuohua Tang et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Genetically heterogeneous mice show age-related vision deficits not related to increased rod cell L-type calcium channel function in vivo

(2017) Bruce A. Berkowitz et al.   NEUROBIOLOGY OF AGING

Continuous infusion of manganese improves contrast and reduces side effects in manganese-enhanced magnetic resonance imaging studies

(2017) Dana S. Poole et al.   NEUROIMAGE

Transcranial manganese delivery for neuronal tract tracing using MEMRI

(2017) Tatjana Atanasijevic et al.   NEUROIMAGE

Brain activation induced by chronic psychosocial stress in mice

(2017) Mikaela A Laine et al.   Scientific Reports

Manganese-enhanced magnetic resonance imaging combined with electrophysiology in the evaluation of visual pathway in experimental rat models with monocular blindness

(2017) Zuohua Tang et al.   Brain and Behavior

Pre- and Postnatal Development of the Eye: A Species Comparison

(2017) Steven Van Cruchten et al.   Birth Defects Research

Longitudinal Assessments of Normal and Perilesional Tissues in Focal Brain Ischemia and Partial Optic Nerve Injury with Manganese-enhanced MRI

(2017) Kevin C. Chan et al.   Scientific Reports

T1 mapping of the mouse brain following fractionated manganese administration using MP2RAGE

(2016) Luc Driencourt et al.   Brain Structure & Function

Ability of Mn2+to Permeate the Eye and Availability of Manganese-enhanced Magnetic Resonance Imaging for Visual Pathway Imaging via Topical Administration

(2016) Zhi-Zhong Ma et al.   CHINESE MEDICAL JOURNAL

L-type voltage-operated calcium channels contribute to astrocyte activationIn vitro

(2016) Veronica T. Cheli et al.   GLIA

Semiquantitative assessment of optic nerve injury using manganese-enhanced MRI

(2016) Jun Yang et al.   JAPANESE JOURNAL OF RADIOLOGY

Combining systemic and stereotactic MEMRI to detect the correlation between gliosis and neuronal connective pathway at the chronic stage after stroke

(2016) Xiao-zhu Hao et al.   Journal of Neuroinflammation

Dose response and time course of manganese-enhanced magnetic resonance imaging for visual pathway tracing in vivo

(2016) Xiao-dong Sun et al.   Neural Regeneration Research

Activity-induced manganese-dependent MRI (AIM-MRI) and functional MRI in awake rabbits during somatosensory stimulation

(2016) Matthew P. Schroeder et al.   NEUROIMAGE

Semiquantitative assessment of optic nerve injury using manganese-enhanced MRI

(2016) Jun Yang et al.   Japanese Journal of Radiology

In Vivo Evaluation of the Visual Pathway in Streptozotocin-Induced Diabetes by Diffusion Tensor MRI and Contrast Enhanced MRI

(2016) Swarupa Kancherla et al.   PLoS One

Differentiation and quantification of inflammation, demyelination and axon injury or loss in multiple sclerosis

(2015) Yong Wang et al.   BRAIN

Calmangafodipir [Ca4Mn(DPDP)5], mangafodipir (MnDPDP) and MnPLED with special reference to their SOD mimetic and therapeutic properties

(2015) Jan Olof G. Karlsson et al.   DRUG DISCOVERY TODAY

Oxidative Stress and Light-Evoked Responses of the Posterior Segment in a Mouse Model of Diabetic Retinopathy

(2015) B. A. Berkowitz et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Manganese-Enhanced Magnetic Resonance Imaging of Traumatic Brain Injury

(2015) Lora Talley Watts et al.   JOURNAL OF NEUROTRAUMA

Repeated exposure to chlorpyrifos leads to prolonged impairments of axonal transport in the living rodent brain

(2015) Caterina M. Hernandez et al.   NEUROTOXICOLOGY

Manganese-Enhanced MRI Reflects Both Activity-Independent and Activity-Dependent Uptake within the Rat Habenulomesencephalic Pathway

(2015) Leiming Wang et al.   PLoS One

Divergence of dim-light vision among bats (order: Chiroptera) as estimated by molecular and electrophysiological methods

(2015) He-Qun Liu et al.   Scientific Reports

Diagnostic accuracy of calculated serum osmolarity to predict dehydration in older people: adding value to pathology laboratory reports

(2015) Lee Hooper et al.   BMJ Open

Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy

(2014) Fiona C Mansergh et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Long-Term Effects of Neonatal Hypoxia-Ischemia on Structural and Physiological Integrity of the Eye and Visual Pathway by Multimodal MRI

(2014) K. C. Chan et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Manganese-enhanced magnetic resonance imaging investigation of the interferon-α model of depression in rats

(2014) Alessandro Daducci et al.   MAGNETIC RESONANCE IMAGING

Confirming a prediction of the calcium hypothesis of photoreceptor aging in mice

(2014) Bruce A. Berkowitz et al.   NEUROBIOLOGY OF AGING

In vivo visuotopic brain mapping with manganese-enhanced MRI and resting-state functional connectivity MRI

(2014) Kevin C. Chan et al.   NEUROIMAGE

Axonal transport rate decreased at the onset of optic neuritis in EAE mice

(2014) Tsen-Hsuan Lin et al.   NEUROIMAGE

Manganese-enhanced MRI (MEMRI) via topical loading of Mn2+significantly impairs mouse visual acuity: a comparison with intravitreal injection

(2014) Tsen-Hsuan Lin et al.   NMR IN BIOMEDICINE

Response of the Primary Auditory and Non-Auditory Cortices to Acoustic Stimulation: A Manganese-Enhanced MRI Study

(2014) Hyungjun Kim et al.   PLoS One

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

(2014) Stefanie Fischer et al.   Jove-Journal of Visualized Experiments

In vivo axonal transport deficits in a mouse model of fronto-temporal dementia

(2014) Tabassum Majid et al.   NeuroImage-Clinical

Intravitreal Injection of Normal Saline Induces Retinal Degeneration in the C57BL/6J Mouse

(2014) Jose R. Hombrebueno et al.   Translational Vision Science & Technology

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Improved Visualization of Neuronal Injury Following Glial Activation by Manganese Enhanced MRI

(2013) Aditya N. Bade et al.   Journal of Neuroimmune Pharmacology

Calcium Influx and Calpain Activation Mediate Preclinical Retinal Neurodegeneration in Autoimmune Optic Neuritis

(2013) Dorit B. Hoffmann et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Ocular integrity following manganese labeling of the visual system for MRI

(2013) James D. Lindsey et al.   MAGNETIC RESONANCE IMAGING

Top-down influences on visual processing

(2013) Charles D. Gilbert et al.   NATURE REVIEWS NEUROSCIENCE

Diminished Vision in Healthy Aging Is Associated with Increased Retinal L-Type Voltage Gated Calcium Channel Ion Influx

(2013) David Bissig et al.   PLoS One

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

(2013) Bridgette D. Semple et al.   PROGRESS IN NEUROBIOLOGY

Mn-alginate gels as a novel system for controlled release of Mn2+in manganese-enhanced MRI

(2012) Ýrr A. Mørch et al.   Contrast Media & Molecular Imaging

Loss of Caveolin-1 Impairs Retinal Function Due to Disturbance of Subretinal Microenvironment

(2012) Xiaoman Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dose dependence and temporal evolution of theT1relaxation time and MRI contrast in the rat brain after subcutaneous injection of manganese chloride

(2012) Mohammed Salman Shazeeb et al.   MAGNETIC RESONANCE IN MEDICINE

Enhanced tissue differentiation in the developing mouse brain using magnetic resonance micro-histology

(2012) Francesca C. Norris et al.   MAGNETIC RESONANCE IN MEDICINE

Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI

(2012) Joseph J. Gallagher et al.   NEUROIMAGE

Manganese transport via the transferrin mechanism

(2012) Thomas E. Gunter et al.   NEUROTOXICOLOGY

Manganese-enhanced MRI optic nerve tracking: effect of intravitreal manganese dose on retinal toxicity

(2012) Lisha Luo et al.   NMR IN BIOMEDICINE

Longitudinal diffusion tensor and manganese-enhanced MRI detect delayed cerebral gray and white matter injury after hypoxia–ischemia and hyperoxia

(2012) Tora Sund Morken et al.   PEDIATRIC RESEARCH

Visualizing Non-Gaussian Diffusion: Clinical Application of q-Space Imaging and Diffusional Kurtosis Imaging of the Brain and Spine

(2012) Masaaki HORI et al.   Magnetic Resonance in Medical Sciences

Effects of temporarily disrupting BBB on activity-induced manganese-dependent functional MRI

(2011) Zhiqiang Fa et al.   Brain Imaging and Behavior

Infusion-based manganese-enhanced MRI: a new imaging technique to visualize the mouse brain

(2011) Stephanie I. Mok et al.   Brain Structure & Function

Manganese-enhanced MRI reveals multiple cellular and vascular layers in normal and degenerated retinas

(2011) Govind Nair et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Axonal tracing of the normal and regenerating visual pathway of mouse, rat, frog, and fish using manganese-enhanced MRI (MEMRI)

(2011) Axel Sandvig et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Body Fluid Dynamics: Back to the Future

(2011) G. Bhave et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

In vivo chromium-enhanced MRI of the retina

(2011) Kevin C. Chan et al.   MAGNETIC RESONANCE IN MEDICINE

Longitudinal Manganese-Enhanced Magnetic Resonance Imaging of Delayed Brain Damage after Hypoxic-Ischemic Injury in the Neonatal Rat

(2011) Marius Widerøe et al.   Neonatology

Same-session functional assessment of rat retina and brain with manganese-enhanced MRI

(2011) David Bissig et al.   NEUROIMAGE

In vivo evaluation of retinal and callosal projections in early postnatal development and plasticity using manganese-enhanced MRI and diffusion tensor imaging

(2011) Kevin C. Chan et al.   NEUROIMAGE

Magnetic resonance imaging of the mouse visual pathway for in vivo studies of degeneration and regeneration in the CNS

(2011) Ronny Haenold et al.   NEUROIMAGE

Quantitative assessment of central nervous system disorder induced by prenatal X-ray exposure using diffusion and manganese-enhanced MRI

(2011) Shigeyoshi Saito et al.   NMR IN BIOMEDICINE

In vivo MRI of olfactory ensheathing cell grafts and regenerating axons in transplant mediated repair of the adult rat optic nerve

(2011) Ioanna Sandvig et al.   NMR IN BIOMEDICINE

Manganese-enhanced MRI predicts the histological grade of hepatocellular carcinoma in potential surgical candidates

(2010) R.P. Sutcliffe et al.   CLINICAL RADIOLOGY

Manganese transport in the rat optic nerve evaluated with spatial- and time-resolved magnetic resonance imaging

(2010) Øystein Olsen et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

CNS regeneration after chronic injury using a self-assembled nanomaterial and MEMRI for real-time in vivo monitoring

(2010) Yu-Xiang Liang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Retrograde axonal tracing using manganese enhanced magnetic resonance imaging

(2010) Ken Matsuda et al.   NEUROIMAGE

In vivo retinotopic mapping of superior colliculus using manganese-enhanced magnetic resonance imaging

(2010) Kevin C. Chan et al.   NEUROIMAGE

Activity-induced manganese-dependent functional MRI of the rat visual cortex following intranasal manganese chloride administration

(2010) Zhiqiang Fa et al.   NEUROSCIENCE LETTERS

Fractionated manganese injections: effects on MRI contrast enhancement and physiological measures in C57BL/6 mice

(2010) Barbara Grünecker et al.   NMR IN BIOMEDICINE

Role of n-type voltage-dependent calcium channels in autoimmune optic neuritis

(2009) Ivana Gadjanski et al.   ANNALS OF NEUROLOGY

Development of a Dendritic Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Contrast Agent: Synthesis, Toxicity (in Vitro) and Relaxivity (in Vitro, in Vivo) Studies

(2009) Annabelle Bertin et al.   BIOCONJUGATE CHEMISTRY

Toward clinical application of manganese-enhanced MRI of retinal function

(2009) Paul S. Tofts et al.   BRAIN RESEARCH BULLETIN

Experimental protocol for activation-induced manganese-enhanced MRI (AIM-MRI) based on quantitative determination of Mn content in rat brain by fastT1mapping

(2009) S. Tambalo et al.   MAGNETIC RESONANCE IN MEDICINE

Temporal changes in theT1andT2relaxation rates (ΔR1and ΔR2) in the rat brain are consistent with the tissue-clearance rates of elemental manganese

(2009) Kai-Hsiang Chuang et al.   MAGNETIC RESONANCE IN MEDICINE

In vivo detection of individual glomeruli in the rodent olfactory bulb using manganese enhanced MRI

(2009) Kai-Hsiang Chuang et al.   NEUROIMAGE

In vivo visualization of reactive gliosis using manganese-enhanced magnetic resonance imaging

(2009) Yuko Kawai et al.   NEUROIMAGE

Manganese-enhanced MRI visualizes V1 in the non-human primate visual cortex

(2009) Nicholas A. Bock et al.   NMR IN BIOMEDICINE

In vivo imaging of axonal transport using MRI: aging and Alzheimer’s disease

(2008) Satoshi Minoshima et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

GD-DTPA enhanced MRI of ocular transport in a rat model of chronic glaucoma

(2008) Kevin C. Chan et al.   EXPERIMENTAL EYE RESEARCH

Manganese-enhanced MRI of the rat visual pathway: Acute neural toxicity, contrast enhancement, axon resolution, axonal transport, and clearance of Mn2+

(2008) Marte Thuen et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Combination of Mn2+-enhanced and diffusion tensor MR imaging gives complementary information about injury and regeneration in the adult rat optic nerve

(2008) Marte Thuen et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Real-time animal functional magnetic resonance imaging and its application to neuropharmacological studies

(2008) Hanbing Lu et al.   MAGNETIC RESONANCE IMAGING

Manganese-enhanced MRI detection of neurodegeneration in neonatal hypoxic-ischemic cerebral injury

(2008) Jian Yang et al.   MAGNETIC RESONANCE IN MEDICINE

Evaluation of the retina and optic nerve in a rat model of chronic glaucoma using in vivo manganese-enhanced magnetic resonance imaging

(2008) Kevin C. Chan et al.   NEUROIMAGE

Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus

(2008) Riikka J. Immonen et al.   NEUROIMAGE

Manganese-enhanced magnetic resonance imaging of hypoxic–ischemic brain injury in the neonatal rat

(2008) Marius Widerøe et al.   NEUROIMAGE

Does diffusion kurtosis imaging lead to better neural tissue characterization? A rodent brain maturation study

(2008) Matthew M. Cheung et al.   NEUROIMAGE

Manganese-enhanced MRI of layer-specific activity in the visual cortex from awake and free-moving rats

(2008) David Bissig et al.   NEUROIMAGE

Diffusion-Tensor Neuronal Fiber Tractography and Manganese-enhanced MR Imaging of Primate Visual Pathway in the Common Marmoset: Preliminary Results

(2008) Masayuki Yamada et al.   RADIOLOGY

Detection of cortical gray matter lesion in the late phase of mild hypoxic–ischemic injury by manganese-enhanced MRI

(2007) Jian Yang et al.   NEUROIMAGE

Fractionated manganese-enhanced MRI

(2007) Nicholas A. Bock et al.   NMR IN BIOMEDICINE