Roles of Primary Cilia in the Developing Brain

TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms

(2018) Thomas Rosengren et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Gli2 Rescues Delays in Brain Development Induced by Kif3a Dysfunction

(2018) Jia-Long Chen et al.   CEREBRAL CORTEX

Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination

(2018) Sang Min Park et al.   NEURON

Autophagy in mammalian neurodevelopment and implications for childhood neurological disorders

(2018) Derek Marsh et al.   NEUROSCIENCE LETTERS

LPA signaling is regulated through the primary cilium: a novel target in glioblastoma

(2018) Yuriy V. Loskutov et al.   ONCOGENE

Mixed signals from the cell's antennae: primary cilia in cancer

(2018) Thibaut Eguether et al.   EMBO REPORTS

APC sets the Wnt tone necessary for cerebral cortical progenitor development

(2017) Naoki Nakagawa et al.   GENES & DEVELOPMENT

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unique spatiotemporal requirements for intraflagellar transport genes during forebrain development

(2017) John Snedeker et al.   PLoS One

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

(2016) Philippe Foerster et al.   DEVELOPMENT

Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain

(2016) Mary Gazea et al.   DEVELOPMENTAL BIOLOGY

Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow

(2016) Idil Orhon et al.   NATURE CELL BIOLOGY

PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide

(2016) Lan B. Hoang-Minh et al.   Translational Oncology

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy

(2016) Junguee Lee et al.   Oncotarget

Adult Neurogenesis: Beyond Learning and Memory

(2015) Heather A. Cameron et al.   Annual Review of Psychology

Primary cilia and autophagic dysfunction in Huntington’s disease

(2015) M Kaliszewski et al.   CELL DEATH AND DIFFERENTIATION

Huntingtin functions as a scaffold for selective macroautophagy

(2015) Yan-Ning Rui et al.   NATURE CELL BIOLOGY

Developmental disruptions underlying brain abnormalities in ciliopathies

(2015) Jiami Guo et al.   Nature Communications

Primary cilium and sonic hedgehog signaling during neural tube patterning: Role of GPCRs and second messengers

(2014) Kasturi Pal et al.   Developmental Neurobiology

The Neurology of mTOR

(2014) Jonathan O. Lipton et al.   NEURON

Hedgehog

(2014) Julien Ferent et al.   NEUROSCIENTIST

Primary cilia are required in a unique subpopulation of neural progenitors

(2014) C. K. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decision making during interneuron migration in the developing cerebral cortex

(2014) Jiami Guo et al.   TRENDS IN CELL BIOLOGY

Aberrant Wnt signalling and cellular over-proliferation in a novel mouse model of Meckel–Gruber syndrome

(2013) Gabrielle Wheway et al.   DEVELOPMENTAL BIOLOGY

Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel–Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and Wnt signalling defects

(2013) Zakia A. Abdelhamed et al.   HUMAN MOLECULAR GENETICS

Functional interaction between autophagy and ciliogenesis

(2013) Olatz Pampliega et al.   NATURE

Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites

(2013) Zaiming Tang et al.   NATURE

Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation

(2013) Holden Higginbotham et al.   NATURE NEUROSCIENCE

Primary cilia in neurodevelopmental disorders

(2013) Enza Maria Valente et al.   Nature Reviews Neurology

Focal malformations of cortical development: New vistas for molecular pathogenesis

(2013) K.-C. Lim et al.   NEUROSCIENCE

Sonic hedgehog promotes autophagy in hippocampal neurons

(2013) R. S. Petralia et al.   Biology Open

Neuronal Autophagy and Neurodevelopmental Disorders

(2013) Kyung-Min Lee et al.   Experimental Neurobiology

Arl13b in Primary Cilia Regulates the Migration and Placement of Interneurons in the Developing Cerebral Cortex

(2012) Holden Higginbotham et al.   DEVELOPMENTAL CELL

The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

(2012) Jeremy F Reiter et al.   EMBO REPORTS

Context-Dependent Regulation of Wnt Signaling through the Primary Cilium

(2012) E. C. Oh et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A role for primary cilia in glutamatergic synaptic integration of adult-born neurons

(2012) Natsuko Kumamoto et al.   NATURE NEUROSCIENCE

Tangentially Migrating Neurons Assemble a Primary Cilium that Promotes Their Reorientation to the Cortical Plate

(2012) Jean-Pierre Baudoin et al.   NEURON

The role of primary cilia in the pathophysiology of neural tube defects

(2012) Timothy W. Vogel et al.   Neurosurgical Focus

Primary cilia and graded Sonic Hedgehog signaling

(2012) Noriaki Sasai et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing

(2011) L. Besse et al.   DEVELOPMENT

Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease

(2011) Guy Keryer et al.   JOURNAL OF CLINICAL INVESTIGATION

Development and distribution of neuronal cilia in mouse neocortex

(2011) Jon I. Arellano et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Primary Cilia Regulate Proliferation of Amplifying Progenitors in Adult Hippocampus: Implications for Learning and Memory

(2011) A. Amador-Arjona et al.   JOURNAL OF NEUROSCIENCE

Ciliopathies

(2011) Friedhelm Hildebrandt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of Sonic Hedgehog During Cell Proliferation in the Human Cerebellum

(2011) Parthiv Haldipur et al.   STEM CELLS AND DEVELOPMENT

The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes

(2010) Jerzy Wegiel et al.   ACTA NEUROPATHOLOGICA

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

(2010) Hanna Tukachinsky et al.   JOURNAL OF CELL BIOLOGY

Primary cilia regulate mTORC1 activity and cell size through Lkb1

(2010) Christopher Boehlke et al.   NATURE CELL BIOLOGY

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

The Primary Cilium as a Complex Signaling Center

(2009) Nicolas F. Berbari et al.   CURRENT BIOLOGY

Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia

(2009) P. Huang et al.   DEVELOPMENT

Towards an integrated view of Wnt signaling in development

(2009) R. van Amerongen et al.   DEVELOPMENT

Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain

(2009) R.W. Stottmann et al.   DEVELOPMENTAL BIOLOGY

Primary Cilia Are Not Required for Normal Canonical Wnt Signaling in the Mouse Embryo

(2009) Polloneal Jymmiel R. Ocbina et al.   PLoS One

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

(2009) Suzie J. Scales et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Hedgehog signaling is involved in development of the neocortex

(2008) M. Komada et al.   DEVELOPMENT

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

(2008) E. Dessaud et al.   DEVELOPMENT

Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool

(2008) N. Spassky et al.   DEVELOPMENTAL BIOLOGY

Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain

(2008) Marat Gorivodsky et al.   DEVELOPMENTAL BIOLOGY

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

(2008) Tiffiney R. Hartman et al.   HUMAN MOLECULAR GENETICS

A Crucial Role for Primary Cilia in Cortical Morphogenesis

(2008) M. A. Willaredt et al.   JOURNAL OF NEUROSCIENCE

THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

(2008) Pamela V Tran et al.   NATURE GENETICS

Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells

(2008) Young-Goo Han et al.   NATURE NEUROSCIENCE

Aβ1–42 stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor

(2008) Areechun Sotthibundhu et al.   NEUROBIOLOGY OF AGING

The stumpy gene is required for mammalian ciliogenesis

(2008) T. Town et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling

(2008) J. J. Breunig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA