Article
Medicine, General & Internal
R. L. Atmar, K. E. Lyke, M. E. Deming, L. A. Jackson, A. R. Branche, H. M. El Sahly, C. A. Rostad, J. M. Martin, C. Johnston, R. E. Rupp, M. J. Mulligan, R. C. Brady, R. W. Frenck, M. Backer, A. C. Kottkamp, T. M. Babu, K. Rajakumar, S. Edupuganti, D. Dobrzynski, R. N. Coler, C. M. Posavad, J. Archer, S. Crandon, S. U. Nayak, D. Szydlo, J. A. Zemanek, C. P. Dominguez Islas, E. R. Brown, M. S. Suthar, M. J. McElrath, A. B. McDermott, D. C. Montefiori, A. Eaton, K. M. Neuzil, D. S. Stephens, P. C. Roberts, J. H. Beigel
Summary: This study investigated the efficacy of homologous and heterologous booster vaccines in adults who had completed a primary Covid-19 vaccine regimen. The results showed that both types of booster vaccines were safe and immunogenic.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Ophir Freund, Alma Harish, Anna Breslavsky, Ori Wand, Nadav Zacks, Natalya Bilenko, Amir Bar-Shai
Summary: The humoral response to the first two doses of the COVID-19 vaccine can predict the response to the booster vaccine. In this study, low antibody levels 1 month after the second vaccine and a rapid decline in antibodies were independent predictors of low antibody response to the booster vaccine.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Immunology
Chung-Jong Kim, Ji-Yun Bae, Kang-Il Jun, Jihee Kim, Hee-Jung Son, Hae-Sun Chung, Soo-Kyung Kim, Soohyun Kim, Dohsik Minn, Hee-Jung Choi
Summary: This study investigates the efficacy of different COVID-19 booster vaccines and finds that booster vaccination after two prior vaccinations significantly increases serum antibody levels, regardless of the type of vaccine administered.
Review
Psychiatry
Kai G. Kahl, Britta Stapel, Christoph U. Correll
Summary: Patients with mental disorders have an increased risk of developing cardiovascular disease, and comorbidity with adjustment, anxiety, and depressive disorders is common. Cognitive behavioral therapy and internet-based psychological treatments are effective for these patients. Psychopharmacological drugs are commonly used in more severe cases, but their side effects should be considered.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Julia Elina Stocker, Georgia Koppe, Hanna Reich, Saeideh Heshmati, Sarah Kittel-Schneider, Stefan G. Hofmann, Tim Hahn, Han L. J. van der Maas, Lourens Waldorp, Hamidreza Jamalabadi
Summary: Despite the increasing use of network representation in understanding psychological phenomena, the effectiveness of using networks to describe the effects of psychological interventions remains unclear. Network control theory, a recent methodology in engineering studies, offers potential in characterizing and guiding interventions. This paper investigates a psychological intervention experiment and applies network control theory to model and predict its effect. The findings demonstrate the significant potential of network control theory as a tool for studying psychological interventions, and provide insights into the conceptualization, methodology, and future directions of this field.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Wendy De La Rosa, Eesha Sharma, Stephanie M. Tully, Eric Giannella, Gwen Rino
Summary: Research indicates that increasing individuals' psychological ownership of government benefits can enhance their willingness to apply for these benefits. Psychological ownership interventions outperform other common psychological interventions in stimulating interest in claiming benefits. This approach serves as an effective tool to boost individuals' interest in pursuing government benefits.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Psychiatry
Lin-xuan Xu, Lu-lu Wu, Xiao-min Geng, Zi-liang Wang, Xiang-yi Guo, Kun-ru Song, Guan-qun Liu, Lin-yuan Deng, Jin-tao Zhang, Marc N. Potenza
Summary: This systematic review focused on psychological treatments for internet addiction, highlighting interventions that target reduction of addiction-related impulsivity and craving, improvement of cognitive maladjustment, and alleviation of family problems. The study suggests that targeted domains and intervention methods are not mutually exclusive, and further research is needed to demonstrate the effective components and mechanisms of action for treatments of internet addiction. Such research will help generate more efficacious evidence-based interventions.
PSYCHIATRY RESEARCH
(2021)
Article
Psychology, Multidisciplinary
Alexander P. Landry, Eran Halperin
Summary: Social scientists have applied descriptive research to develop interventions for improving intergroup relations, which have shown significant success. However, individuals often lack motivation to engage with these interventions. This article presents a framework of approaches for delivering interventions to an unmotivated target audience and discusses implications and future directions.
AMERICAN PSYCHOLOGIST
(2023)
Review
Oncology
Elina Semenenko, Suvam Banerjee, Ian Olver, Patrick Ashinze
Summary: Cancer is a leading cause of death worldwide and has negative effects on both physical and mental health. This review aims to explore and evaluate the effectiveness of different interventions and their applications in clinical practice.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Immunology
Claudio Costantino, Walter Mazzucco, Nicole Bonaccorso, Livia Cimino, Arianna Conforto, Martina Sciortino, Gabriele Catalano, Maria Rosa D'Anna, Antonio Maiorana, Renato Venezia, Giovanni Corsello, Francesco Vitale
Summary: A study conducted in Italy found that educational interventions on maternal immunization, including counseling by healthcare professionals, significantly improved vaccination adherence among pregnant women during pregnancy.
Article
Computer Science, Cybernetics
Farzad Jahedi, Paul Fay W. Henman, Jillian C. Ryan
Summary: Personalized digital psychological interventions (DPIs) aim to provide customized solutions based on user requirements, and personalization has been shown to increase user engagement and improve treatment outcomes. However, there is a lack of research on personalized DPIs for young adults, with most studies focusing on content personalization by providers rather than users. Future research should focus on co-design and understanding users' personal preferences to enhance personalization quality and increase user engagement, leading to better clinical outcomes.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2022)
Article
Psychiatry
Rhea Daruvala, Ajit Kumar, Soumitra Shankar Datta
Summary: This review examines the effects of psychological interventions for adolescents with psychosis, finding that cognitive remediation therapy (CRT) and group psychotherapy may have positive effects on short-term memory and overall adaptation, but the evidence is of low certainty.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Multidisciplinary Sciences
Kristien Van Reeth, Anna Parys, Jose Carlos Mancera Gracia, Ivan Trus, Koen Chiers, Philip Meade, Sean Liu, Peter Palese, Florian Krammer, Elien Vandoorn
Summary: This study demonstrates that sequential vaccination with diverse H1N1 viruses in pigs induces a broad H1N1 antibody response, providing protection against multiple H1N1 strains in humans and pigs.
NATURE COMMUNICATIONS
(2023)
Review
Health Care Sciences & Services
Jacinta Jardine, Robert Bowman, Gavin Doherty
Summary: Digital interventions to enhance readiness for psychological therapy are a diverse field with potential to address the global problem of mental illness. These interventions take various forms, such as web-based programs, screening tools, videos, apps, and websites. The effectiveness and feasibility of these interventions vary and are inconclusive. The development and evaluation of digital readiness interventions should be approached with caution.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Review
Psychology, Multidisciplinary
Mauro Cavarra, Alessandra Falzone, Johannes G. Ramaekers, Kim P. C. Kuypers, Carmela Mento
Summary: Modern clinical research on psychedelics shows interesting outcomes in various clinical conditions when used in combination with psychotherapy. Individual and contextual factors seem to influence the psychedelic experience and clinical outcomes. These findings highlight the importance of investigating environmental and relational factors in therapeutic contexts.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Public, Environmental & Occupational Health
J. Hancox, K. Ayling, L. Bedford, K. Vedhara, J. F. R. Roberston, B. Young, R. das Nair, F. M. Sullivan, S. Schembri, F. S. Mair, R. Littleford, D. Kendrick
Summary: The Early CDT(R)-Lung antibody blood test has positive effects in reducing late-stage lung cancer presentation, but it also leads to some negative psychological outcomes, although these effects are short-lived and small.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
H. Knight, R. Jia, K. Ayling, H. Blake, J. R. Morling, A. M. Villalon, J. Corner, C. Denning, J. Ball, K. Bolton, G. Figueredo, D. Morris, P. Tighe, K. Vedhara
Summary: This study explored COVID-19 vaccine hesitancy in young adults in the UK and found that hesitancy declined over time. Those willing to accept the vaccine cited self-protection and pro-social reasons, while hesitant individuals expressed concerns about confidence in the vaccines and personal risk.
PERSPECTIVES IN PUBLIC HEALTH
(2023)
Article
Health Care Sciences & Services
David M. Phillippo, Sofia Dias, A. E. Ades, Mark Belger, Alan Brnabic, Daniel Saure, Yves Schymura, Nicky J. Welton
Summary: This study demonstrates the application of ML-NMR method to estimate treatment effects in different populations. The results show that ML-NMR has better fit and reduces uncertainty compared to previous methods, and the assumptions made are valid.
MEDICAL DECISION MAKING
(2023)
Article
Rheumatology
Leher Gumber, Nancy Gomez, Georgina Hopkins, Davis Tucis, Laura Bartlett, Kieran Ayling, Kavita Vedhara, Graham Steers, Mithun Chakravorty, Megan Rutter, Hannah Jackson, Patrick Tighe, Alastair Ferraro, Sheila Power, Marie-Josephe Pradere, David Onion, Peter C. Lanyon, Fiona A. Pearce, Lucy Fairclough
Summary: This study investigated the humoral and cell-mediated T cell response after the second dose of COVID-19 vaccine in RAIRD patients. The results showed that RAIRD patients had lower antibody levels and anti-SARS-CoV-2 T cell responses compared to healthy controls. In particular, the use of certain medications may reduce the immunogenicity of the vaccine.
Article
Endocrinology & Metabolism
Ru Jia, Kieran Ayling, Carol Coupland, Trudie Chalder, Adam Massey, Urs Nater, Elizabeth Broadbent, Norina Gasteiger, Wei Gao, Clemens Kirschbaum, Kavita Vedhara
Summary: This study found a positive correlation between psychological distress and cortisone levels during the COVID-19 pandemic. Individuals with a history of mental health difficulties had the highest cortisone levels, and those who reported higher stress levels early in the pandemic had the greatest changes in cortisone levels.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Respiratory System
Matthew Evison, Ross Maconachie, Toby Mercer, Caitlin H. Daly, Nicky J. Welton, Shahzeena Aslam, Doug West, Neal Navani
Summary: Chemoradiotherapy followed by surgery (CRS) provides an extended disease-free survival and improved cost-effectiveness compared to chemotherapy plus surgery (CS) and chemotherapy plus radiotherapy (CR) in potentially resectable stage III-N2 NSCLC patients.
Article
Immunology
Nancy E. Gomez, Victoria James, Kenton P. Arkill, Zubair A. Nizamudeen, David Onion, Lucy C. Fairclough
Summary: This study aimed to optimize methodologies to study immune cell-derived extracellular vesicles (EVs). Peripheral blood mononuclear cell-derived small EVs were isolated and characterized using conventional transmission electron microscopy and nanoparticle tracking analysis. They were further analyzed using imaging flow cytometry and flow cytometric multiplex bead assay. These techniques were applied to smoking-related inflammatory disease research following the Minimal Information for Studies of Extracellular Vesicle 2018 guidelines.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
David Glynn, Georgios Nikolaidis, Dina Jankovic, Nicky J. J. Welton
Summary: This article introduces a method to construct priors for randomized clinical trials (RCTs) based on previous RCTs, which can be used to aid research prioritization and trial design. The study shows that using empirically derived priors can reduce the expected value of research in value of information (VOI) analysis compared to using uninformative priors.
MEDICAL DECISION MAKING
(2023)
Article
Health Care Sciences & Services
Mathyn Vervaart, Eline Aas, Karl P. Claxton, Mark Strong, Nicky J. Welton, Torbjorn Wisloff, Anna Heath
Summary: We developed general purpose methods for simulating survival data from a probabilistic sample of survival probabilities, greatly reducing the computational burden of the EVSI data-simulation step when assuming treatment effect waning or using flexible survival models.
MEDICAL DECISION MAKING
(2023)
Article
Geriatrics & Gerontology
Claudio Di Lorito, Veronika van der Wardt, Kristian Pollock, Louise Howe, Vicky Booth, Pip Logan, John Gladman, Tahir Masud, Roshan das Nair, Sarah Goldberg, Kavita Vedhara, Rebecca O'Brien, Emma Adams, Alison Cowley, Alessandro Bosco, Jennie Hancox, Clare Burgon, Rupinder Bajwa, Juliette Lock, Annabelle Long, Maureen Godfrey, Marianne Dunlop, Rowan H. Harwood
Summary: The PrAISED study delivered an exercise and functional activity programme to participants living with dementia, but the Randomised Controlled Trial showed no measurable benefits. The process evaluation revealed that participants valued the intervention for addressing health issues and providing social contact, but factors such as cognitive impairment and the COVID-19 pandemic hindered the positive outcomes.
Editorial Material
Primary Health Care
Dhurgshaarna Shanmugavadivel, Jo-Fen Liu, Ashley Ball-Gamble, Angela Polanco, Kavita Vedhara, Paul Nathan, David Walker, Shalini Ojha
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Review
Sport Sciences
Brad S. Currier, Jonathan C. Mcleod, Laura Banfield, Joseph Beyene, Nicky J. Welton, Alysha C. D'Souza, Joshua A. J. Keogh, Lydia Lin, Giulia Coletta, Antony Yang, Lauren Colenso-Semple, Kyle J. Lau, Alexandria Verboom, Stuart M. Phillips
Summary: This study aimed to determine the effects of distinct combinations of resistance training prescription variables (load, sets, and frequency) on muscle strength and hypertrophy. A systematic review and Bayesian network meta-analysis were conducted, and it was found that higher-load, multiset, thrice-weekly training was the most effective for strength gains, while higher-load, multiset, twice-weekly training was the best for hypertrophy.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Medicine, General & Internal
Louise S. Guski, Gesche Juergens, Hugo Pedder, Niels K. G. Levinsen, Stig E. Andersen, Nicky J. Welton, Niels Graudal
Summary: This is the first network meta-analysis to assess outcomes associated with multiple conventional synthetic disease-modifying antirheumatic drugs and glucocorticoid in patients with rheumatoid arthritis. The study's results support the present role of methotrexate as the primary reference conventional synthetic disease-modifying antirheumatic drug.
Review
Primary Health Care
Nde-Eshimuni Salema, Brian G. Bell, Kate Marsden, Gill Gookey, Glen Swanwick, Mindy Bassi, Rajnikant Mehta, Nick Silcock, Anthony J. Avery, Richard Knox
Summary: This study describes the frequency and nature of prescribing problems among GPs in training and finds a high rate of prescribing errors and suboptimal prescribing. The results suggest that personalized review of prescribing may have a significant impact on patient safety and larger intervention studies are needed to evaluate its effectiveness.
Article
Psychology, Clinical
Kieran Ayling, Michaela Brown, Sophie Carlisle, Robert Bennett, Heather Buchanan, Jennifer Dumbleton, Christopher Hawkey, Katja Hoschler, Ruth H. Jack, Nguyen-Van-Tam Jonathan, Simon Royal, David Turner, Maria Zambon, Lucy Fairclough, Kavita Vedhara
Summary: This trial investigated the effects of two brief interventions on the psychological and immunological responses of older adults before receiving influenza vaccination. The interventions were successful in improving mood, but may not have a significant impact on antibody responses to highly immunogenic vaccines.