Article
Biochemistry & Molecular Biology
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu'uhevaha J. Kaitu'u-Lino, Susan P. Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Lisa Hui, Natalie J. Hannan
Summary: Elevated levels of OLAH in the placenta may be associated with placental dysfunction in pregnancies complicated by preterm preeclampsia and fetal growth restriction. Further research is required to understand the role of OLAH in the placenta, and whether these changes are a maternal adaptation or consequence of disease.
Article
Environmental Sciences
Hua-Long Zhu, Xue-Ting Shi, Xiao-Feng Xu, Yong-Wei Xiong, Song-Jia Yi, Guo-Xiang Zhou, Wei-Bo Liu, Miao-Miao Huang, Lan Gao, Cheng Zhang, Ling-Li Zhao, De-Xiang Xu, Hua Wang
Summary: The study found that environmental cadmium exposure can lead to fetal growth restriction by activating PERK-regulated placental mitophagy and inhibiting P4 synthesis. Additionally, placental mitophagy is associated with reduced progesterone levels and all-cause fetal growth restriction.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Developmental Biology
Zhongmei Yang, Xiaofang Luo, Biao Huang, Xiaoyan Jia, Xiaojin Luan, Nan Shan, Zhongling An, Jinfeng Cao, Hongbo Qi
Summary: Fetal growth restriction (FGR) is a common complication of pregnancy, and lipid metabolism may play a role in its development. However, the metabolic mechanisms of FGR are not well understood. This study used metabolomic profiling and gene analysis to identify metabolic profiles and potential genes and signaling pathways associated with FGR. The results showed that fatty acids accumulated in the placenta and decreased in fetal blood in FGR cases compared to controls, and linoleic acid metabolism was the focus of differential metabolite and gene enrichment analysis in the placenta.
Article
Environmental Sciences
Hao Zhang, Xiaoyun Liu, Yi Zheng, Xia Zha, Mabrouk Elsabagh, Ying Zhang, Yi Ma, Juan J. Loor, Mengzhi Wang, Hongrong Wang
Summary: This study aimed to explore the protective effect of melatonin against cadmium-induced fetal growth restriction (FGR) and analyze its mechanism through modulation of the gut microbiota. The results showed that melatonin relieved placental barrier injury, endoplasmic reticulum stress (ERS), and mitophagy, and reversed gut microbiota dysbiosis. The gut microbiota played an important role in cadmium-induced placental injury, ERS, and mitophagy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Ruth Opoku, Jenna DeCata, Charlotte L. Phillips, Laura C. Schulz
Summary: This study examined the effect of reducing maternal myostatin on the metabolomes of both maternal and fetal serum, as well as the placental metabolome. The results showed distinct differences in the metabolomes of fetal and maternal serum, confirming the impact of maternal myostatin reduction on the fetal metabolic environment.
Article
Biochemistry & Molecular Biology
Dayuan Shi, Xinyao Zhou, Luyao Cai, Xing Wei, Luye Zhang, Qianqian Sun, Fenhe Zhou, Luming Sun
Summary: Changes in placental DNA methylation patterns in sFGR may have functional implications for differentially methylated genes and regulatory regions. The study validates the presence of abnormally methylated CYP11A1 gene in the placenta of sFGR.
Article
Environmental Sciences
Yu-Feng Zhang, Hua-Long Zhu, Xiao-Feng Xu, Jin Zhang, Qing Ling, Shuang Zhang, Wei Chang, Yong-Wei Xiong, De-Xiang Xu, Hua Wang
Summary: This study investigates the role of placental lipophagy in cadmium-induced fetal growth restriction (FGR) through a case-control study, animal experiments, and primary human placental trophoblast cell cultures. The findings suggest an association between placental lipophagy and FGR. Additionally, exposure to cadmium during pregnancy induces FGR and placental lipophagy. Inhibition of placental lipophagy exacerbates cadmium-induced FGR, while activation of placental lipophagy alleviates FGR. Activation of Atg5-dependent placental lipophagy degrades lipid droplets to produce free cholesterol and promotes placental progesterone synthesis, which can reverse cadmium-induced FGR.
ENVIRONMENTAL POLLUTION
(2023)
Article
Cell Biology
Stephanie S. Chassen, Karin Zemski-Berry, Stefanie Raymond-Whish, Camille Driver, John C. Hobbins, Theresa L. Powell
Summary: Fetal growth restriction (FGR) leads to small birth weight and abnormal fetal blood flow. This study found that triglyceride concentrations increase in placentas of FGR pregnancies, while important complex lipids decrease in cord plasma. These changes are correlated with ultrasound Doppler indices.
Article
Pharmacology & Pharmacy
Lewis J. Renshall, Frances Beards, Angelos Evangelinos, Susan L. Greenwood, Paul Brownbill, Adam Stevens, Colin P. Sibley, John D. Aplin, Edward D. Johnstone, Tambet Teesalu, Lynda K. Harris
Summary: This study demonstrates the potential of using EGF-loaded, peptide-decorated liposomes to improve placental function. GPS-decorated liposomes containing EGF significantly increased amino acid transporter activity in healthy placental tissues, but were ineffective in those from pregnancies with FGR. Targeted liposomes represent a safe and useful tool for developing new therapies for placental dysfunction.
Article
Environmental Sciences
Guangquan Chen, Shiyi Xiong, Qiao Jing, Cornelis A. M. van Gestel, Nico M. van Straalen, Dick Roelofs, Luming Sun, Hao Qiu
Summary: This study investigated the effects of polystyrene nanoplastics (PS-NPs) on fetal development and cholesterol metabolism in mice. The exposure to PS-NPs led to a decline in fetal weights and abnormal cell morphologies in the placenta and fetus. Transcriptomic and metabolomic analyses revealed disturbances in cholesterol metabolism and other pathways, offering new insights into the mechanisms underlying the detrimental effects of PS-NPs on placenta and fetus.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Emily S. Barrett, Zorimar Rivera-Nunez, Kylie Getz, Pamela Ohman-Strickland, Ranran Zhang, Danielle Kozlosky, Cathleen L. Doherty, Brian T. Buckley, Jessica Brunner, Richard K. Miller, Thomas G. O'Connor, Lauren M. Aleksunes
Summary: This study assessed the protective role of the BCRP gene in prenatal cadmium exposure. It was found that individuals with a reduced function polymorphism in the BCRP gene were more vulnerable to higher cadmium exposure in the placenta, which adversely affected fetal growth. This suggests that reduced function of the BCRP gene may increase the risk of smaller placental and fetal size associated with maternal cadmium exposure.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Hao Zhang, Yi Zheng, Xiaoyun Liu, Xia Zha, Mabrouk Elsabagh, Yi Ma, Honghua Jiang, Hongrong Wang, Mengzhi Wang
Summary: This study investigated the potential relationship between oxidative stress, autophagy, and apoptosis in pregnant ewes exposed to BPA. The results showed that BPA exposure led to placental insufficiency, fetal growth restriction, autophagy, endoplasmic reticulum stress, mitochondrial dysfunction, oxidative stress, and apoptosis. Additionally, the study revealed that autophagy could alleviate BPA-induced apoptosis, mitochondrial dysfunction, and oxidative stress.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Immunology
Huan Yang, Jie He, Shuai Huang, Hongbing Yang, Qingjie Yi, Yuelan Tao, Miaomiao Chen, Xuemei Zhang, Hongbo Qi
Summary: The study identified a large number of eccDNAs/ecDNAs in FGR, highlighting their potential association with factors such as gestational age. These molecules were found to be mainly enriched in immune-related functions and pathways, overlapping with non-coding RNAs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Developmental Biology
A. Arias, J. A. Schander, M. Bariani, F. Correa, A. P. Dominguez Rubio, M. Cella, C. B. Cymeryng, M. L. Wolfson, A. M. Franchi, J. Aisemberg
Summary: Maternal dexamethasone administration during late gestation results in fetal and placental growth restriction, potentially due to altered placental angiogenesis.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
R. Aughwane, N. Mufti, D. Flouri, K. Maksym, R. Spencer, M. Sokolska, G. Kendall, D. Atkinson, A. Bainbridge, J. Deprest, T. Vercauteren, S. Ourselin, A. L. David, A. Melbourne
Summary: The study found that MRI technique can reveal differences in feto-placental oxygen saturation between normal and early-onset fetal growth restriction (FGR) pregnancies, and this difference is associated with disease severity.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Environmental Sciences
Chenyang Ji, Chang Yu, Siqing Yue, Quan Zhang, Yilun Yan, Jun Fan, Meirong Zhao
Article
Environmental Sciences
Jianqiang Zhu, Yuan Kong, Jie Yu, Shuai Shao, Manfei Mao, Meirong Zhao, Siqing Yue
ENVIRONMENTAL POLLUTION
(2019)
Article
Engineering, Environmental
Chenyang Ji, Lu Yan, Yuanchen Chen, Siqing Yue, Qiaoxiang Dong, Jiangfei Chen, Meirong Zhao
JOURNAL OF HAZARDOUS MATERIALS
(2019)
Article
Chemistry, Medicinal
Lihong Chai, Shujing Ji, Shubin Zhang, Haiying Yu, Meirong Zhao, Li Ji
CHEMICAL RESEARCH IN TOXICOLOGY
(2020)
Article
Engineering, Environmental
Siqing Yue, Yuan Kong, Qiqi Shen, Qingmiao Cui, Yuanchen Chen, Meirong Zhao
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2020)
Article
Chemistry, Medicinal
Jinping Gu, Yafei Cheng, Chenyang Ji, Ying Tao, Meirong Zhao
CHEMICAL RESEARCH IN TOXICOLOGY
(2020)
Article
Environmental Sciences
Chenyang Ji, Qin Song, Yuanchen Chen, Zhiqiang Zhou, Peng Wang, Jing Liu, Zhe Sun, Meirong Zhao
ENVIRONMENT INTERNATIONAL
(2020)
Article
Environmental Sciences
Hangbiao Jin, Lingling Mao, Jiahui Xie, Meirong Zhao, Xiaoxia Bai, Jie Wen, Tao Shen, Pengfei Wu
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Chemistry, Medicinal
Chenyang Ji, Chang Yu, Jianqiang Zhu, Yafei Cheng, Tian Tian, Bingqi Zhou, Jinping Gu, Jun Fan, Meirong Zhao
Article
Engineering, Environmental
Chenyang Ji, Jason T. Magnuson, Wen Zhang, Meirong Zhao
Summary: The study revealed that Cypermethrin enantiomers induce different cytotoxic responses and the enantioselective toxicity may be related to differential expression of cell cycle and apoptosis-related genes.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Environmental
Nan Zhao, Hongmei Hu, Meirong Zhao, Weiping Liu, Hangbiao Jin
Summary: This study identified the amount of BPs present in conjugated forms in marine organisms for the first time, providing valuable insights into the occurrence of BPs in organisms.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Lingling Mao, Shuhong Fang, Meirong Zhao, Weiping Liu, Hangbiao Jin
Summary: This study utilized metabolomics to examine the metabolic changes in rat plasma following exposure to BPA or BPS, revealing distinct alterations in metabolome and the up-regulation/down-regulation of specific metabolites in the different exposure groups. Pathway analysis also highlighted significant disruptions in metabolic pathways associated with BPA and BPS exposure.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Engineering, Environmental
Quan Zhang, Lili Fu, Tao Cang, Tao Tang, Mingcheng Guo, Bingbing Zhou, Guohua Zhu, Meirong Zhao
Summary: With the increasing demand for pollinating services, the wellness of honeybees has received widespread attention. Research has shown that S-dinotefuran is more toxic than rac-dinotefuran and R-dinotefuran by 114 times, and that the Eastern honeybee is more susceptible to the highly toxic enantiomer S-dinotefuran.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Sijia Gu, Lili Fu, Jing Wang, Xiaohui Sun, Ximing Wang, Jianlin Lou, Meirong Zhao, Cui Wang, Quan Zhang
Summary: This study investigated the association between urinary neonicotinoid and relative mitochondrial DNA copy number (RmtDNAcn) in oral epithelial cells. Results showed a significant correlation between urinary neonicotinoid and RmtDNAcn, indicating potential dose-dependent mitochondrial damage. In vitro assays confirmed that neonicotinoid exposure led to inhibition of mitochondrial oxidative phosphorylation genes and increased reactive oxygen species production.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Siqing Yue, Qixian Yuan, Qiqi Shen, Yaqi Xu, Ping Wang, Min Si, Meirong Zhao
Summary: The present study focused on the toxicological effects of Cypermethrin (CP) at environmentally relevant concentrations in pubertal male rats and found histopathological and organosomatic alterations in the liver, brain, and epididymis. Multiomics network analysis revealed the involvement of specific gut microbiota in CP-induced hepatic lipid accumulation and brain neurotoxicity. The study provides important insights into CP-induced toxicity and highlights the potential for targeted interventions to mitigate the adverse effects of environmental toxins through the gut-organ axis.
JOURNAL OF HAZARDOUS MATERIALS
(2023)