Journal
CHEMICAL RESEARCH IN TOXICOLOGY
Volume 34, Issue 6, Pages 1578-1587Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrestox.1c00018
Keywords
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Funding
- Natural Science Foundation of China [21806139, U20A20134]
- Natural Science Foundation of Zhejiang Province [YQ 202043985]
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This study utilized metabolomics to examine the metabolic changes in rat plasma following exposure to BPA or BPS, revealing distinct alterations in metabolome and the up-regulation/down-regulation of specific metabolites in the different exposure groups. Pathway analysis also highlighted significant disruptions in metabolic pathways associated with BPA and BPS exposure.
Toxic effects induced upon exposure to low-dose bisphenol A (BPA) or bisphenol S (BPS) remains controversial. In this study, metabolomics was used to examine the metabolomic perturbation arising from 28 days of exposure to BPA or BPS at 50 mu g/kg bw/day in Sprague-Dawley (SD) rats. Endogenous metabolite profiling revealed a clear discrimination of metabolome in the rat plasma among BPA-treatment, BPS-treatment, and control groups. BPA exposure induced the up-regulation of 19 metabolites and down-regulation of 32 metabolites in plasma of SD rats, compared with the control. BPS exposure induced the up-regulation of 15 metabolites and the down-regulation of 33 metabolites in the plasma of SD rats, compared with the control. Joint pathway analysis suggested marked perturbations in the citrate cycle, butanoate metabolism, and alanine, aspartate, and glutamate metabolism for BPA-exposed rats as well as glycerophospholipid metabolism for BPS-exposed rats. These findings provide novel insights into associations between the metabolomic perturbation and phenotypic changes arising from BPA and BPS exposure.
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