Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 214, Issue -, Pages 339-347Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2019.02.068
Keywords
Fluorescence; Chemosensor; Viscosity; NIR; Cell imaging
Categories
Funding
- National Natural Science Foundation of China [81672508, 61505076]
- Jiangsu Provincial Foundation for Distinguished Young Scholars [BK20170041]
- China-Sweden Joint Mobility Project [51811530018, 51661145021]
- National Postdoctoral Program for Innovative Talents [BX201700119]
- China Postdoctoral Science Foundation Funded Project [2018M632293]
- Natural Science Foundation of Guangdong Province [2017A030313299]
- Key University Science Research Project of Jiangsu Province [16KJA180004]
Ask authors/readers for more resources
Developing near-infrared (NIR) fluorescence probes for detection of intracellular viscosity is still sufficiently challenging. In thiswork, three kinds of D-A-D type naphthyl and 2,1,3-benzoxadiazol hybrid NIR dyes functionalized with amino (NY1), N-methylamino (NY2) and N,N-dimethylamino (NY3) groups for intracellular micro-viscosity detection were designed and synthesized. All the probes exhibited very weak NIR emission in low viscosity environment and obvious fluorescence enhancementwith the increased viscosity. Different substituent groups had a high impact on the photophysical properties and response sensitive of the probes to viscosity. The structure-property relationships were systematic investigated. The results showed that stronger electron-donating ability and larger steric effect of N,N-dimethylamino led to a narrower energy gap and more sensitive to viscosity environment. Therefore, NY3 exhibited higher signal noise ratio for viscosity detection and was successfully applied for imaging the changes of intracellular micro-viscosity. This work provides an efficient way to design powerful NIR fluorescence probes for viscosity detection. (C) 2019 Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available