Article
Nanoscience & Nanotechnology
Jian Liu, Nan Lu, Jie Guan, Yaowu Hu
Summary: This study introduces diversified strain modes through nano-twist manufacturing by laser shock process, providing a convenient fabrication process for strain engineering and twistronics fields.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Hyung-Joon Park, Hyunsik Hong, Ramar Thangam, Min-Gyo Song, Ju-Eun Kim, Eun-Hae Jo, Yun-Jeong Jang, Won-Hyoung Choi, Min-Young Lee, Heemin Kang, Kyu-Back Lee
Summary: Cells in the biological microenvironment interact with the extracellular matrix (ECM) and are influenced by its physical and chemical properties. Efficient strategies for modulating cellular responses have become crucial in various scientific fields. Biomaterials have been extensively studied due to their ability to mimic cellular modulation. Recent research focuses on dynamic biomimetic modulation, considering both physical and chemical factors.
Article
Polymer Science
Lorenzo Bonetti, Luigi De Nardo, Silvia Fare
Summary: The study successfully prepared thermoresponsive methylcellulose (MC) hydrogels using a crosslinking strategy based on citric acid (CA) and demonstrated their potential as substrates in cell sheet engineering. The hydrogels showed improved mechanical performance and cell adhesion, allowing for easy detachment of cell sheets for regenerative purposes.
Article
Biotechnology & Applied Microbiology
Rowoon Park, Jung Won Yoon, Jin-Ho Lee, Suck Won Hong, Jae Ho Kim
Summary: Researchers have developed an ultrathin cell-culture platform with potential-responsive nanoscale biointerfaces for monitoring mesenchymal stem cells (MSCs). The platform allows for highly ordered organization and spontaneous differentiation of MSCs, providing a robust strategy for directing stem cells and differentiation.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Chiara Spezzati, Zhenyun Lan, Ivano E. Castelli
Summary: This study investigates the photo-electrochemical response of InSnO2N under strain using Density Functional Theory (DFT) calculations. The results show that strain can reduce the reaction overpotentials, especially when combined with polarization switching and dynamic strain changes.
JOURNAL OF CATALYSIS
(2022)
Article
Materials Science, Multidisciplinary
S. J. Chen, Y. L. Tang, F. H. Gong, J. H. Wang, X. D. Lv, R. J. Jiang, S. Z. Liu, Y. J. Wang, Y. L. Zhu, X. L. Ma
Summary: Strain engineering in low dimensional ferroelectrics has made significant progress in the discovery of various ferroelectric topologies. However, the difficulty in preparing high-quality single-crystal substrates has hindered the exploration of these structures. This study proposes a practical method to prepare REScO3 buffer layers using precision pulsed laser deposition and controlled post-annealing. The obtained PrScO3 films exhibit high quality, and periodic flux-closure arrays in PbTiO3 layers have been successfully achieved on the PrScO3-buffered SrTiO3 substrates.
Article
Chemistry, Multidisciplinary
Sebastian A. Howard, Egor Evlyukhin, Galo Paez Fajardo, Hanjong Paik, Darrell G. Schlom, Louis F. J. Piper
Summary: This study successfully demonstrated the tuning of the metal-to-insulator transition (MIT) temperature of VO2 using MgF2 substrates and epitaxial films. By optimizing growth parameters, different orientations of VO2/MgF2 films were synthesized with transition temperatures controlled precisely through strain engineering.
ADVANCED MATERIALS INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Benedikt Diepold, Steffen Neumeier, Annalena Meermeier, Heinz Werner Hoeppel, Torsten Sebald, Mathias Goeken
Summary: The study found that 316L stainless steel manufactured using SLM technology exhibits higher compressive strength at high temperatures, but experiences a loss in ductility between 300 and 627 degrees Celsius. Alloying elements cause serrated yielding in the affected temperature range, while dynamic strain aging is identified as the cause for reduced ductility.
ADVANCED ENGINEERING MATERIALS
(2021)
Article
Engineering, Civil
Ju Dong Lee
Summary: This study fills the research gap on the understanding of concrete tensile properties in moment-curvature analysis for prestressed concrete. It proposes a simple model capturing the concrete tensile stress-strain relationship and investigates the effect of prestressing force on concrete tension stiffening.
ENGINEERING STRUCTURES
(2022)
Article
Chemistry, Multidisciplinary
Jun Zhang, Patrick Byers, Amelie Erben, Christine Frank, Levin Schulte-Spechtel, Michael Heymann, Denitsa Docheva, Heinz P. Huber, Stefanie Sudhop, Hauke Clausen-Schaumann
Summary: The laser-based bioprinting approach allows for the precise selection and positioning of individual mammalian cells with single cell resolution, while also enabling the generation of complex 3D structures with high cell viability.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Engineering, Environmental
Bingbing Yu, Yang Liu, Zhiyin Li, Yanan Liu, Pinhua Rao, Guanghui Li
Summary: This paper reviews the latest research progress in the combination of water-stable MOFs with durable substrates in the field of water treatment. It analyzes the advantages of durable substrates in terms of structure and species, discusses the methods for preparing MOFs on substrates, and analyzes the modification methods to improve the binding stability of MOFs to durable substrates. In addition, a series of engineering strategies, including controllable distribution of MOFs on substrates, regulation of MOFs morphology and size, regulation of surface wettability and design of synergistic effects, are summarized. The water treatment applications of MOFs, such as adsorption, oil-water separation, catalytic degradation, and desalination, are introduced. Finally, insights and prospects for future challenges are presented.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Peter B. Mozhaev, Alexey Khoryushin, Jorn Bindslev Hansen, Claus S. Jacobsen
Summary: Thin films of Y:ZrO2 (YSZ) were grown on vicinal NdGaO3 substrates by pulsed laser deposition with smooth surfaces and step-flow growth mode detected for small tilt angles. The films showed good graphoepitaxial matching with the substrates for all studied tilt angles and exhibited a contracted lattice constant normal to the (110) plane with increasing film thickness, reaching a characteristic thickness for exponential saturation of rocking curves. The relaxation of substrate-induced strain with thickness likely involves the generation of dislocations.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Article
Biotechnology & Applied Microbiology
Zhe Chu, Qi Ren, Wenjie Su, Wei Cui, Jie Wu
Summary: The curvature radius of the anterior corneal surface is an independent influencing factor for the stress-strain index (SSI) in addition to the axial length (AL). The relationship between SSI and AL is more complex due to the effect of corneal curvature.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Coatings & Films
M. F. H. Abd El-Kader, M. K. Ahmed, M. T. Elabbasy, M. Afifi, A. A. Menazea
Summary: The study focused on developing innovative biomaterial compositions for hard tissue regeneration using pulsed laser deposition (PLD) technique. Results showed changes in surface morphology, roughness, and mechanical properties of hydroxyapatite (HAP) sputtered on alumina substrates at different exposure times. The attachment behavior of human osteoblasts towards the obtained scaffolds demonstrated cell proliferation and coverage, suggesting the potential for innovative scaffold design based on tailored bioactive material depositions on inert biomaterials.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Isabel Verit, Laura Gemini, Julie Preterre, Pierre Pfirmann, Hugo Bakis, Jean-Christophe Fricain, Rainer Kling, Claire Rigothier
Summary: Research investigates the formation of intra-volume channels within three-dimensional collagen microfibers using laser-induced cavitation to address the lack of efficient vascularization systems for organ transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jose Garcia-Calvo, Javier Lopez-Andarias, Jimmy Maillard, Vincent Mercier, Chloe Roffay, Aurelien Roux, Alexandre Fuerstenberg, Naomi Sakai, Stefan Matile
Summary: HydroFlippers are fluorescent membrane tension probes that report on both membrane compression and hydration. Different cellular membranes show varied responses to tension-induced decompression and hydration. The mechanical compression is independent of the nature of the membrane of interest (MOI), while the response to hydration depends on the intrinsic order of the MOI.
Article
Biochemistry & Molecular Biology
Lea Assies, Vincent Mercier, Javier Lopez-Andarias, Aurelien Roux, Naomi Sakai, Stefan Matile
Summary: This study reveals that primary ammonium cations with higher pK(a) efficiently label early endosomes and Golgi networks. Guanidinium cations with higher pK(a) selectively label the plasma membrane in endocytosis. It is also found that guanidinium cations can self-assemble into micelles and penetrate mitochondria unidirectionally.
Article
Cell Biology
Caterina Tomba, Valeriy Luchnikov, Luca Barberi, Carles Blanch-Mercader, Aurelien Roux
Summary: This study developed self-rolling substrates to investigate the adaptation of flat epithelial cell monolayers to rapid anisotropic changes in curvature. The primary response was found to be an active and transient osmotic swelling of cells, triggered by a drop in membrane tension and actin depolymerization. These findings suggest that epithelial cells are unique in their ability to transiently and actively swell while adapting to changes in curvature.
DEVELOPMENTAL CELL
(2022)
Article
Multidisciplinary Sciences
Nebojsa Jukic, Alma P. Perrino, Frederic Humbert, Aurelien Roux, Simon Scheuring
Summary: In this study, the authors used high-speed AFM to investigate the characteristics of Snf7, the major component of ESCRT-III, on nano-patterned and soft supports. They found that loaded Snf7 spiral springs are curvature sensitive and deform membranes.
NATURE COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Mathilde Grosjean, Sidzigui Ouedraogo, Stephane Dejean, Xavier Garric, Valeriy Luchnikov, Arnaud Ponche, Noelle Mathieu, Karine Anselme, Benjamin Nottelet
Summary: In this study, biodegradable self-rolling tubes that exhibit spontaneous and rapid actuation in water were designed. The use of specific materials and interface properties enabled fast self-rolling. The results confirm the potential of such materials in the field of temporary medical devices.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cell Biology
Ilaria Di Meglio, Anastasiya Trushko, Pau Guillamat, Carles Blanch-Mercader, Shada Abuhattum, Aurelien Roux
Summary: This study reveals that epithelia growing under confinement accumulate pressure that inhibits cell proliferation, but when the pressure exceeds a threshold, cell proliferation can be reactivated within folds. This reactivation is correlated with the reactivation of the mechano-sensing pathway YAP/TAZ.
Article
Biochemical Research Methods
Xiuyun Jiang, Lena Harker-Kirschneck, Christian Vanhille-Campos, Anna-Katharina Pfitzner, Elene Lominadze, Aurelien Roux, Buzz Baum, Andela Saric
Summary: ESCRT-III filaments can constrict and cut cell membranes from the inside, and undergo composition and geometry changes in the presence of an ATP-consuming enzyme. Researchers developed a model to simulate the depolymerization process and found that changes in filament composition can trigger membrane deformation, leading to the release of cargo-loaded vesicles.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Biology
Dawn M. Wenzel, Douglas R. Mackay, Jack J. Skalicky, Elliott L. Paine, Matthew S. Miller, Katharine S. Ullman, Wesley Sundquist, Aurelien Roux
Summary: In this study, the interactions between human MIT domains and ESCRT-III tails were comprehensively mapped and quantified. Several new interactions were discovered, and the structure of the SPASTIN MIT domain in complex with the IST1 C-terminal tail was reported. The study also revealed the localization and functions of three MIT enzymes in cytokinetic abscission.
Article
Chemistry, Multidisciplinary
Valeriy A. Luchnikov, Yukie Saito, Luc Delmotte, Joseph Dentzer, Emmanuel Denys, Vincent Malesys, Ludovic Josien, Laurent Simon, Simon Gree
Summary: Under Ar atmosphere with trace amounts of oxygen, graphitized hollow filaments are resistively heated to 1800-2400 degrees C, forming regular hexagonal arrays of microscopic pyramids consisting of soot nanoparticles on the surface. The height and width of these pyramids depend on the temperature, and they can function as field emission point sources.
Article
Biophysics
Maksim Eremchev, David Roesel, Chetan S. Poojari, Aurelien Roux, Jochen S. Hub, Sylvie Roke
Summary: In biology, the release of Ca2+ ions in the cytosol is crucial for cell functions, and calcium signaling depends on membrane permeability to Ca2+. This study investigates the impact of varying the hydrophobic core of bilayer membranes on Ca2+ translocation. The results suggest that ion transport occurs through transient pores, which require membrane restructuring, and the hydrophobic structure of lipids plays a more sophisticated regulating role than previously thought.
BIOPHYSICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Navin Gopaldass, Maria Giovanna De Leo, Thibault Courtellemont, Vincent Mercier, Christin Bissig, Aurelien Roux, Andreas Mayer
Summary: Proteins exit from endosomes through retromer-coated tubular carriers, which affects cellular signaling, lysosomal biogenesis, and various diseases. The coat formation requires overcoming membrane tension. In this study, we investigated the dynamics and driving force of this process using yeast retromer, BAR-domain sorting nexins Vps5 and Vps17, and synthetic lipid tubules. The results showed that the coat forms a static tubular structure by bidirectional oligomerization, and high concentrations of sorting nexins constrict the membrane tubes. However, retromer oligomers are needed to drive constriction at lower concentrations.
Editorial Material
Cell Biology
Markku Hakala, Aurelien Roux
Summary: The authors discuss a novel ESCRT-III structure discovered in migrating macrophages and dendritic cells, suggesting a new, cell type-specific function for this complex.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Roxane Petrot, Thibaut Devillers, Olivier Stephan, Orphee Cugat, Caterina Tomba
Summary: Two-photon polymerization enables precise 3D printing at a micrometer scale and the creation of remotely actuable micro-structures. By combining it with magnetic materials, a magnetically deformable 3D culture substrate was created to study cells in an environment that mimics the properties of tissues in vivo. The structure was actuated by an external magnetic field and showed promising results in preliminary cell culture trials.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Cell Biology
Anna-Katharina Pfitzner, Henry Zivkovic, Cesar Bernat-Silvestre, Matt West, Tanner Peltier, Frederic Humbert, Greg Odorizzi, Aurelien Roux
Summary: This study demonstrates that functionally distinct ESCRT-III polymers are formed by Vps60 and Snf7, and the increase in ESCRT-III subunit diversity may enable the acquisition of new cellular functions.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xiao-Xiao Chen, Rosa M. Gomila, Juan Manuel Garcia-Arcos, Maxime Vonesch, Nerea Gonzalez-Sanchis, Aurelien Roux, Antonio Frontera, Naomi Sakai, Stefan Matile
Summary: We have developed a new design paradigm for fluorescent flipper probes, which allows for rapid screening and targeting of membrane tension in living cells.