Article
Biophysics
Sojin Song, Jong Uk Lee, Myeong Jin Jeon, Soohyun Kim, Sang Jun Sim
Summary: An advanced plasmonic biosensor based on DNA-assembled nanoarchitecture has been developed for accurate detection of exosomal miRNAs in human serum, which can differentiate Alzheimer's disease patients from healthy controls by measuring the levels of exosomal miRNA-125b and miRNA-361.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Medicine, Research & Experimental
Chuanyun Li, Tong Zhou, Jing Chen, Rong Li, Huan Chen, Shumin Luo, Dexi Chen, Cao Cai, Weihua Li
Summary: Exosomal miRNAs play a critical role in regulating genes and their altered expression is associated with almost all human cancers. They modulate processes that interfere with cancer immunity and microenvironment, and significantly impact tumor growth, invasion, metastasis, angiogenesis, and drug resistance. Understanding the detailed mechanisms of miRNAs in cancer development could contribute to both cancer treatment and prevention of malignant diseases. This review highlights recent advances in cancer-derived exosomal miRNAs, including their sorting and delivery mechanisms, as well as their potential as diagnostic and prognostic markers and in detecting cancer resistance to therapeutic agents.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biophysics
Junbeom Kim, Ji Sung Shim, Bo Hoon Han, Hye Jin Kim, Jaesung Park, Il-Joo Cho, Sung Gu Kang, Ji Yoon Kang, Ki Wan Bong, Nakwon Choi
Summary: Urinary exosomal miRNAs are potential biomarkers, but limited by low concentration and small volume. Hydrogel-based HCR technique shows high amplification and enhanced detection limits for miRNA in urine samples, with potential for clinical diagnosis applications in differentiating prostate cancer patients from healthy controls.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Medical Laboratory Technology
Xinlei Zou, Ziyue Huang, Canghai Guan, Wujiang Shi, Jianjun Gao, Jiangang Wang, Yunfu Cui, Mei Wang, Yi Xu, Xiangyu Zhong
Summary: Pancreatic cancer (PC) is highly aggressive with a poor prognosis. The tumor microenvironment (TME) of PC is complex and diverse. Various cellular components in the microenvironment secrete different substances that promote tumor development. These substances can be released via exosomes, which are abundant extracellular vesicles (EVs) capable of carrying factors and enabling intercellular communication. MiRNAs are involved in regulating pathological and physiological processes and can be transported by exosomes to regulate the TME. Exosomal miRNAs hold promise as future targets for PC diagnosis and prognosis, offering potential new treatment strategies.
CLINICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Meng-Shin Shiao, Jia-Ming Chang, Arb-Aroon Lertkhachonsuk, Naparat Rermluk, Natini Jinawath
Summary: Early detection of EOC is crucial for improving survival rates. Exosomal miRNAs show promise as non-invasive biomarkers for early cancer detection, but stability, sensitivity, and selection of endogenous reference miRNAs are important considerations. Current clinical trials using miRNAs for EOC detection suggest their potential utility in the future.
Review
Oncology
Ya-Ting Chuang, Jen-Yang Tang, Jun-Ping Shiau, Ching-Yu Yen, Fang-Rong Chang, Kun-Han Yang, Ming-Feng Hou, Ammad Ahmad Farooqi, Hsueh-Wei Chang
Summary: Cancer cells produce exosomes to regulate cell functions for tumor progression, and the modulation of exosome processing by natural products is not well understood. This review focuses on the organization of cancer-derived exosomal miRNAs and their processing and cell functions modulation by natural products. It provides a comprehensive understanding of the potential mechanisms and targets for exosome processing and cancer cell functions by natural products.
Article
Biochemistry & Molecular Biology
Giulia Furesi, Antonio Miguel de Jesus Domingues, Dimitra Alexopoulou, Andreas Dahl, Matthias Hackl, Johannes R. Schmidt, Stefan Kalkhof, Thomas Kurth, Hanna Taipaleenmaeki, Stefanie Conrad, Christine Hofbauer, Martina Rauner, Lorenz C. Hofbauer
Summary: Prostate cancer communicates with bone progenitor cells through extracellular vesicles, promoting vitality and proliferation of the progenitor cells while decreasing mineral deposition. Additionally, small RNAs released by prostate cancer cells may play a critical role in suppressing the activity of bone progenitor cells. These findings reveal an important communication mechanism between prostate cancer and bone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Tejveer Singh, Mahesh Kaushik, Lokesh Chandra Mishra, Chesta Behl, Vijay Singh, Hardeep Singh Tuli
Summary: Breast cancer is a heterogeneous disease with a high degree of diversity between and within tumors. Various factors influence its prevalence, and early diagnosis and optimal management are crucial for reducing mortality. Nanotechnology, specifically the use of nanomaterial properties for drug delivery mechanisms, is showing promise in breast cancer treatment. Exosomes, a type of nanovesicles, are emerging as novel tools for diagnosing and treating breast cancer.
FRONTIERS IN GENETICS
(2023)
Article
Biophysics
Dongsheng Mao, Mengmeng Zheng, Wenxing Li, Yi Xu, Chengguang Wang, Qiuling Qian, Shuainan Li, Guifang Chen, Xiaoli Zhu, Xianqiang Mi
Summary: In this study, a three-dimensional molecular beacon based on cubic DNA nanocage was constructed, which successfully enabled the detection of miRNA in exosomes. By overcoming the unexpected fluorescence quenching and FRET phenomena in confined space, this molecular beacon significantly improved the sensitivity of fluorescence signal detection.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Oncology
L. Zhu, L. Zhao, Q. Wang, S. Zhong, X. Guo, Y. Zhu, J. Bao, K. Xu, S. Liu
Summary: miRNAs are small non-coding ribonucleic acids that play key roles in cancer development and can be encapsulated in exosomes released into the circulatory system. Circulating exosome-derived miRNAs have the potential to replace conventional biomarkers for early cancer diagnosis.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tahani Bakhsh, Safiah Alhazmi, Najla Ali Alburae, Ali Farsi, Faisal Alzahrani, Hani Choudhry, Ahmed Bahieldin
Summary: Colorectal cancer is a common type of cancer worldwide, and early diagnosis is crucial for effective treatment. Current blood biomarkers for CRC diagnosis are not accurate enough. Studies have found that specific miRNAs in extracellular vesicles can be used as noninvasive biomarkers for the screening and diagnosis of CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Wenwen Chen, Zhongyu Li, Pengwei Deng, Zhengnan Li, Yuhai Xu, Hongjing Li, Wentao Su, Jianhua Qin
Summary: Breast cancer is a common malignancy in women worldwide, but its exact etiology remains unclear. Exosomal miRNAs play a significant role in the development and diagnosis of breast cancer.
Review
Oncology
Ya-Ting Chuang, Jun-Ping Shiau, Jen-Yang Tang, Ammad Ahmad Farooqi, Fang-Rong Chang, Yi-Hong Tsai, Ching-Yu Yen, Hsueh-Wei Chang
Summary: Cancer cells release exosomes containing tumor-promoting effects, and natural products can block exosome processing and inhibit cancer progression. However, the correlation between exosomal lncRNAs and natural product treatments is not well understood. By using bioinformatics, this study fills the gap by exploring the interaction between exosomal lncRNAs, miRNAs, and exosomal processing genes, and summarizes their roles in cancer progression and the anticancer effects of natural products.
Review
Biochemistry & Molecular Biology
Mahsa Salehi, Asma Vafadar, Seyyed Hossein Khatami, Mortaza Taheri-Anganeh, Omid Vakili, Amir Savardashtaki, Babak Negahdari, Parisa Naeli, Hamid Behrouj, Hassan Ghasemi, Ahmad Movahedpour
Summary: Exosomal miRNAs play crucial roles in drug resistance of GI cancer cells by facilitating cell-to-cell communication through transferring various cargos, providing new insights into understanding the mechanism of drug resistance in GI cancers.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Katiusse Alves dos Santos, Isabelle Cristina Clemente dos Santos, Carollyne Santos Silva, Heriks Gomes Ribeiro, Igor de Farias Domingos, Vivian Nogueira Silbiger
Summary: Colorectal cancer is a common malignant tumor in the gastrointestinal tract, involving multiple factors such as environmental, genetic, and lifestyle factors. The lack of specific and sensitive biomarkers leads to late diagnosis and poor prognosis for CRC patients. Exosomal miRNAs are considered potential biomarkers for the diagnosis and prognosis of CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
