Article
Chemistry, Analytical
Mengren Wu, Yuan Gao, Amirreza Ghaznavi, Weiqi Zhao, Jie Xu
Summary: Efficient mixing of fluids is crucial for various biomedical and biochemical applications in lab-on-a-chip devices. This study explores electroosmosis micromixing in a lab-on-a-foil microfluidic device, achieving efficient micromixing using tooth-shaped planar electrodes. The study evaluates the mixing performance through intensity measurement and investigates the effects of frequency, flow rate, voltage amplitude, and number of electrode tooth pairs. The research demonstrates the potential for optimizing mixing performance in EOF-based micromixers and the fabrication of low-cost flexible electric microfluidic devices.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Manufacturing
Ketki M. Lichade, Yayue Pan
Summary: This study successfully integrates acoustic patterning with the TPP process to print nanoparticle-polymer composite microstructures with spatially varied nanoparticle compositions. Experimental results validate the feasibility of the developed acoustic field-assisted TPP process for printing anisotropic composites with spatially controlled material compositions.
JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING-TRANSACTIONS OF THE ASME
(2021)
Article
Polymer Science
Martyna Durko-Maciag, Gilles Ulrich, Julien Massue, Jaroslaw Mysliwiec, Konrad Cyprych
Summary: This work demonstrates the successful application of Excited-State Intramolecular Proton Transfer (ESIPT) fluorophores as photoinitiators for microfabrication. The influence of chemical structure on this application was investigated, followed by analysis of two-photon polymerization. The study determined the quality of fabricated structures and polymerization thresholds, with one of the chromophores having an impressively low value of 11 nJ.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Chemistry, Analytical
Federico Sala, Carlotta Ficorella, Roberto Osellame, Josef A. Kaes, Rebeca Martinez Vazquez
Summary: Understanding cell migration is crucial for unraveling physiological phenomena and predicting pathologies like cancer metastasis. Microfluidic devices have been used to investigate cellular migration response by engineering mechanical and spatial stimuli. This review discusses the existing technologies, such as soft lithography and femtosecond laser micromachining, used in microfluidic cellular migration assays. It highlights the different geometrical configurations employed and envisions future developments in in vitro migration studies under spatial confinement in microfluidic devices.
Article
Engineering, Manufacturing
Ketki M. Lichade, Shan Hu, Yayue Pan
Summary: A new microfabrication strategy, acoustic streaming-assisted two-photon polymerization (AS-TPP), was proposed for fabricating miniaturized devices with locally-controlled multimaterial patterns. The AS-TPP technique utilizes acoustic streaming integrated with TPP to pattern hydrophilic nanoparticles with micro/nanoscale resolutions within a hydrophobic polymer. Experimental results validate the high-resolution multimaterial manufacturing capability of the AS-TPP process and its potential applications in microfluidics, surface engineering, and biomedical engineering.
ADDITIVE MANUFACTURING
(2023)
Article
Materials Science, Coatings & Films
Hua-Feng Pang, Ran Tao, Jingting Luo, Xiaosong Zhou, Jian Zhou, Glen McHale, Julien Reboud, Hamdi Torun, Desmond Gibson, Kai Tao, Honglong Chang, Yong-Qing Fu
Summary: In this study, large-area and uniformly inclined piezoelectric ZnO films were successfully fabricated using a glancing angle deposition method. The films exhibited dual-mode surface acoustic waves, including Rayleigh waves and shear-horizontal waves. The Rayleigh waves enabled efficient acoustofluidic functions, while the shear-horizontal waves were utilized for biosensing. These findings are significant for lab-on-a-chip applications.
SURFACE & COATINGS TECHNOLOGY
(2022)
Review
Engineering, Chemical
Zahra Ghorbani Kharaji, Morteza Bayareh, Vali Kalantar
Summary: Acoustic field-driven micromixers utilize vibration induced by sound waves to improve mixing performance, with air bubbles acting as an external energy source and inducing friction forces at the interface between the bubble and liquid, leading to circulatory flows.
INTERNATIONAL JOURNAL OF CHEMICAL REACTOR ENGINEERING
(2021)
Article
Optics
Heming Wei, Zhangli Wu, Yan Wei, Chen Wang, Haiyan Zhang, Fufei Pang, Carlos Marques, Christophe Caucheteur, Xuehao Hu
Summary: This study demonstrates a fiber-tip based acoustic probe sensor that is printed directly on an optical fiber tip using 3D printing technology and assembled with a glass horn structure. The sensor shows high sensitivity and wide bandwidth, making it suitable for detecting weak acoustic waves.
OPTICS AND LASER TECHNOLOGY
(2024)
Article
Chemistry, Multidisciplinary
Filipe A. Couto, Marcelo B. Andrade, Adriano J. G. Otuka, Sebastiao Pratavieira, Sergio R. Muniz, Cleber R. Mendonca
Summary: In this study, we demonstrated a method to incorporate fluorescent nanodiamonds into engineered microstructures using two-photon polymerization. The results show the feasibility of fabricating microstructures embedded within fluorescent nanodiamonds via this method for photonics and quantum technology applications.
Review
Chemistry, Analytical
Zhaoxin Lao, Neng Xia, Shijie Wang, Tiantian Xu, Xinyu Wu, Li Zhang
Summary: Microactuators can convert external stimuli into mechanical motion at microscale and have wide applications. Compared to traditional 2D MEMS devices, 3D microactuators offer a new platform for stimuli-responsive functional devices. 3D laser printing is a promising technique for creating smart devices due to its versatility and flexibility.
Article
Polymer Science
Yulia E. Begantsova, Roman Zvagelsky, Evgeny Baranov, Dmytro A. Chubich, Yuri Chechet, Danila A. Kolymagin, Anastasia Pisarenko, Alexey G. Vitukhnovsky, Sergey A. Chesnokov
Summary: Three imidazole-containing compounds were used as initiators of two-photon polymerization for the first time, and one compound containing phenanthroline combined with triethanolamine showed the best performance in terms of fabrication window, degree of conversion, and two-photon polymerization threshold. This photocomposition was proposed as an effective photoresist for 3D two-photon polymerization, resulting in the fabrication of sub-micron and cell-like polymer structures.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Thomas Wloka, Michael Gottschaldt, Ulrich S. Schubert
Summary: This review focuses on the class of two-photon photo initiators (2PI) used for radical polymerization in two-photon polymerization (2PP) technique. It summarizes the absorption behavior, two-photon cross sections, and polymerization efficiency of different 2PIs. Different design approaches are explored to improve the efficiency of 2PIs.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Yusheng Zhang, Yuming Su, Yi Zhao, Zhiye Wang, Cheng Wang
Summary: This study demonstrates the technology of two-photon polymerization inside a metal-organic framework crystal. Complex microstructures are built in the porous crystal to create a hybrid of crystal and microstructure. The metal-organic framework can be removed by acid treatment to release the printed structure. This technology has potential applications in MOF sensor device fabrication and data storage.
Article
Engineering, Mechanical
Wenjun Li, Pengfei Zhang, Siyong Yang, Shenling Cai, Kai Feng
Summary: This study presents a novel two-dimensional non-contact platform based on Near-field Acoustic Levitation (NFAL), which can realize both one-dimensional and two-dimensional transportation. Numerical and experimental results prove the feasibility and ease of this method.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2024)
Article
Nanoscience & Nanotechnology
Andrea Ottomaniello, Paolo Vezio, Omar Tricinci, Frank M. Den Hoed, Paul Dean, Alessandro Tredicucci, Virgilio Mattoli
Summary: The continuously increasing interest in flexible and integrated photonics has led to the development of new strategies for manufacturing devices on complex surfaces and with small sizes. Terahertz (THz) technology can greatly benefit from this advancement to create compact systems for emitting, detecting, and manipulating THz radiation. This research presents a novel fabrication method that uses polymeric nanomembranes and direct laser writing to create conformable terahertz metasurfaces. By using new flexible dielectric materials with low absorption and permittivity, this work also enables the realization of ultra-thin, flexible hybrid or all-dielectric devices, expanding the application of THz technologies and flexible photonics.
Article
Biochemical Research Methods
Yuan Gao, Mengren Wu, Qiyue Luan, Ian Papautsky, Jie Xu
Summary: The study presents an acoustic bubble-based system for the isolation, trapping, rotation, and culture of circulating tumor cells (CTCs). The system utilizes microcavities and culture chambers to simplify the process and improve the efficiency of CTC processing. The controlled acoustic bubble allows continuous trapping and rotation of CTCs, enabling downstream analysis and personalized drug testing.
Article
Chemistry, Analytical
Amirreza Ghaznavi, Yang Lin, Mark Douvidzon, Adam Szmelter, Alannah Rodrigues, Malik Blackman, David Eddington, Tal Carmon, Lev Deych, Lan Yang, Jie Xu
Summary: This study reports a microfluidic droplet generator that can produce single and compound droplets using a 3D printing process. The device's performance was successfully verified, and various emulsions were generated. The study also demonstrated the capability of generating bio emulsions using this device.
Article
Chemistry, Multidisciplinary
Dmitry Gritsenko, Roberto Paoli, Jie Xu
Summary: In this paper, a fluid dynamics approach is proposed to theoretically model the separation force in constrained-surface-based stereolithography. The study demonstrates the possibility of reducing the separation force by accelerating the movement of the printing platform. The approach involves deceleration and acceleration stages and provides analytical solutions for switching between the stages without a noticeable increase in separation force.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Analytical
Pedro Mesquita, Liyuan Gong, Yang Lin
Summary: This paper proposes a low-cost 3D printed device for the identification of microplastics by combining low-cost plastic staining technologies with microfluidics. The device shows comparable performance to conventional staining processes and offers continuous recognition for long-term environmental monitoring.
Article
Nanoscience & Nanotechnology
Stanislav Kreps, Vladimir Shuvayev, Mark Douvidzon, Baheej Bathish, Tom Lenkiewicz Abudi, Amirreza Ghaznavi, Jie Xu, Yang Lin, Lev Deych, Tal Carmon
Summary: In this work, optical modes of photonic molecules - clusters of optically coupled spherical resonators are studied both theoretically and experimentally. Unlike previous studies, optical tweezers are used instead of stems to maintain the desired structures. Coupled resonators are excited using a tapered fiber and observed as resonances with a high quality factor. Families of coupled modes with similar spatial and spectral shapes are observed using the fluorescent mapping technique. The experimental results are compared with numerical simulations based on a multi-sphere Mie theory, demonstrating the potential for developing large arrays of coupled high-Q spherical resonators.
Article
Chemistry, Analytical
Yanfang Guan, Lei Liu, Shaobo Yu, Feng Lv, Mingshuo Guo, Qing Luo, Shukai Zhang, Zongcai Wang, Lan Wu, Yang Lin, Guangyu Liu
Summary: Diabetes is a major threat to human health, and current detection methods are invasive, cumbersome, and time-consuming. In this study, a novel noninvasive and low-cost biosensor based on enzyme-based electrodes was proposed to detect glucose in human sweat for point-of-care use. Experimental results showed that the electrode had a short response time and a strong correlation.
Article
Engineering, Environmental
Yanfang Guan, Yansheng Liu, Qilong Wang, Hao Geng, Tangyong Cui, Yuang Hu, Qing Luo, Aonan Li, Wujie Li, Yang Lin, Lin Zhang, Guangyu Liu, Jingyuan Fan, Lan Wu
Summary: Soft robots are widely used due to their flexible movement and adaptability. Magnetic actuation has become important as it allows for penetration, rapid response, and non-destructive performance. However, soft composite films often lack toughness and flexibility. To solve this problem, a composite film composed of PDMS, EGaIn and NdFeB (PEN) was designed with exceptional properties including an elastic modulus of 1.17 MPa and tearing energy of 7.36 KJ/m2. The developed inchworm-like robot based on the PEN material exhibited exceptional deformation, flexibility, velocity, and magnetic controllability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemical Research Methods
Mengren Wu, Yuan Gao, Qiyue Luan, Ian Papautsky, Xiaolin Chen, Jie Xu
Summary: A simple and low-cost 3D lab-on-a-foil microfluidic device is developed for dielectrophoretic separation of circulating tumor cells. By using xurography and rapid inkjet printing, disposable thin films and microelectrode arrays are fabricated. The device enables the spatial movement study of CTCs and RBCs under dielectrophoresis and achieves high capture rate of CTCs. This device not only opens the possibility for 3D high-throughput cell separation but also allows for future developments in 3D cell manipulation through rapid and low-cost fabrication.
Article
Chemistry, Multidisciplinary
Sai Siva Kare, Pradeep Kumar Ramkumar, Yuan Gao, Jie Xu, John Desmond Finan
Summary: This study presents a new connected droplet shape analysis (CDSA) technique that simplifies flow rate and zeta potential quantification in thin electroosmotic flow (EOF) micropumps. It is also found that a pair of droplets connected by an EOF pump can function as a tunable convex lens system (TCLS). The CDSA technique is a simple low-cost method for EOF rate and zeta potential measurement, and a pair of droplets connected by an EOF micropump can function as a TCLS without any moving parts.
Review
Biophysics
Liyuan Gong, Andrew Cretella, Yang Lin
Summary: Microfluidic technology offers a promising tool for various applications and provides advantages such as contactless operation, label-free detection, high accuracy, good sensitivity, and minimal reagent requirements. However, the release and recovery efficiency of trapped particles have often been overlooked. This review highlights the importance of both capture and release mechanisms in microfluidic systems and assesses their effectiveness.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Mechanics
Zhengxin Tang, Francois Yaya, Ethan Sun, Lubna Shah, Jie Xu, Annie Viallat, Emmanuele Helfer, Zhangli Peng
Summary: We derived equations and closed-form solutions for the transit time of a viscous droplet passing through a small circular pore with a finite length at microscale under constant pressures. Our analysis is motivated by the importance of understanding the processes of biological cells passing through small pores and droplets passing through pores in microfluidics. We found that the transit time is dependent on pressure, viscosity, pore/droplet dimensions, and surface tension, and the relationship between transit time and surface tension is nonmonotonic. Our results provide valuable insights for designing droplet microfluidics and understanding cell flow through constrictions.
Article
Chemistry, Analytical
Amirreza Ghaznavi, Jie Xu, Seth A. A. Hara
Summary: Three-dimensional printing technology is used in microfluidic mold fabrication for its advantages such as design freedom, speed, and low-cost. In this paper, we propose a non-sacrificial approach using Stereolithography (SLA) printers to assemble modular microfluidic molds, which simplifies the mold fabrication process and addresses the limitations in fabricating complex and time-consuming micro/mesoscale devices. The paper discusses the process flow, optimization of print time and feature resolution, alignments of modular devices, and the advantages and limitations of the proposed technique.
Article
Engineering, Electrical & Electronic
Weiqi Zhao, Amirreza Ghaznavi, Yuan Gao, Mengren Wu, Jie Xu
Summary: In this study, a high-sensitivity pH sensor was developed using a functionalized single-wall carbon nanotube graphene (FSWCNT/G) composite. The sensor consisted of Cr/Au electrodes and FSWCNT/G sealed in a PDMS microchannel on a glass substrate. The fabricated composite sensor exhibited superior performance compared to a pristine graphene sensor, as confirmed by field-effect transistor (FET), linear sweep voltammetry (LSV), and response time measurements. The composite nanosensor demonstrated a high potentiometric gradient of 98.75 mV/pH within the pH range of 4-10 and showed potential for label-free cancer cell detection with a concentration detection range of 5 x 106 to 2.5 x 105 cells/mL.
ACS APPLIED ELECTRONIC MATERIALS
(2023)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
