A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix
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Title
A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix
Authors
Keywords
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Journal
Science Translational Medicine
Volume 11, Issue 489, Pages eaar4953
Publisher
American Association for the Advancement of Science (AAAS)
Online
2019-04-25
DOI
10.1126/scitranslmed.aar4953
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Note: Only part of the references are listed.- Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk vs. tip cell competence
- (2017) Andreas Benn et al. FASEB JOURNAL
- Clinical application of bone morphogenetic proteins for bone healing: a systematic review
- (2017) Gopal Shankar Krishnakumar et al. INTERNATIONAL ORTHOPAEDICS
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- (2017) Eric A. Barcak et al. ORTHOPEDIC CLINICS OF NORTH AMERICA
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- (2017) Guang Bin Zheng et al. Spine Journal
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- (2016) M. Ki onaite et al. BIOCHEMICAL JOURNAL
- BMP signaling is required for adult skeletal homeostasis and mediates bone anabolic action of parathyroid hormone
- (2016) Mohd Parvez Khan et al. BONE
- BMPs in bone regeneration: Less is more effective, a paradigm-shift
- (2016) Katharina Schmidt-Bleek et al. CYTOKINE & GROWTH FACTOR REVIEWS
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- (2016) Elisa Migliorini et al. CYTOKINE & GROWTH FACTOR REVIEWS
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- (2016) David Yadin et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders
- (2016) Maurizio Pacifici et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Specification of osteoblast cell fate by canonical Wnt signaling requiresBmp2
- (2016) Valerie S. Salazar et al. DEVELOPMENT
- Radiographic, biomechanical, and histological evaluation of rhBMP-2 in a 3-level intertransverse process spine fusion: an ovine study
- (2016) Jeffrey M. Toth et al. JOURNAL OF NEUROSURGERY-SPINE
- Bone Morphogenetic Proteins
- (2016) Takenobu Katagiri et al. Cold Spring Harbor Perspectives in Biology
- A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives
- (2016) Jonathan W. Lowery et al. Stem Cells International
- ACVR1 R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A
- (2015) Sarah J. Hatsell et al. Science Translational Medicine
- An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2
- (2014) Byung-Hak Yoon et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development
- (2013) Alisha Holtzhausen et al. FASEB JOURNAL
- Antisense-Oligonucleotide Mediated Exon Skipping in Activin-Receptor-Like Kinase 2: Inhibiting the Receptor That Is Overactive in Fibrodysplasia Ossificans Progressiva
- (2013) SongTing Shi et al. PLoS One
- Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds
- (2012) Sungsoo S. Lee et al. BIOMATERIALS
- Periosteal BMP2 activity drives bone graft healing
- (2012) Vivianne Chappuis et al. BONE
- Co-expression of BMPs and BMP-inhibitors in human fractures and non-unions
- (2012) Peter Kloen et al. BONE
- BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system
- (2012) Karen Ruschke et al. CELL AND TISSUE RESEARCH
- rhBMP-2/Calcium Phosphate Matrix Induces Bone Formation While Limiting Transient Bone Resorption in a Nonhuman Primate Core Defect Model
- (2012) Howard J. Seeherman et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- Human Recombinant Type I Collagen Produced in Plants
- (2012) Oded Shoseyov et al. TISSUE ENGINEERING PART A
- Bone Morphogenetic Proteins: A critical review
- (2010) Beth Bragdon et al. CELLULAR SIGNALLING
- rhBMP-2 Induces Transient Bone Resorption Followed by Bone Formation in a Nonhuman Primate Core-Defect Model
- (2010) Howard J. Seeherman et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- Bone Morphogenetic Protein-2 and -6 Heterodimer Illustrates the Nature of Ligand-Receptor Assembly
- (2010) Michael J. Isaacs et al. MOLECULAR ENDOCRINOLOGY
- Production of Bioactive, Post-Translationally Modified, Heterotrimeric, Human Recombinant Type-I Collagen in Transgenic Tobacco†
- (2009) Hanan Stein et al. BIOMACROMOLECULES
- Receptor oligomerization and beyond: a case study in bone morphogenetic proteins
- (2009) Kai Heinecke et al. BMC BIOLOGY
- Immunolocalization of BMPs, BMP antagonists, receptors, and effectors during fracture repair
- (2009) Yan Yiu Yu et al. BONE
- Design of second generation therapeutic recombinant bone morphogenetic proteins
- (2009) Moulay Hicham Alaoui-Ismaili et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Intricacies of BMP receptor assembly
- (2009) Joachim Nickel et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Clinical and Radiographic Analysis of an Optimized rhBMP-2 Formulation as an Autograft Replacement in Posterolateral Lumbar Spine Arthrodesis
- (2009) John R Dimar et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- Transcriptional Analysis of Fracture Healing and the Induction of Embryonic Stem Cell–Related Genes
- (2009) Manish Bais et al. PLoS One
- BMP-2/4 and BMP-6/7 Differentially Utilize Cell Surface Receptors to Induce Osteoblastic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells
- (2008) Karen Lavery et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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