Article
Polymer Science
Na Ni, Tiantang Fan, Wuyou Ye, Qi Xia, Dongyang Liu, Jingwen Qin, Zhongyong Fan, Qing Liu
Summary: This study developed biodegradable PTLG terpolymers with improved mechanical performance and processed them into peripheral vascular stents using a novel 3D 4-axial printing technology. The crystallinity and mechanical properties of the PTLG terpolymers varied with degradation rate depending on the chain sequence structure and the component contents. Compared with laser-engraved stents, the 3D printed PTLG terpolymer-based stents exhibited a finer structure and smoother surface. The addition of the PTMC segment effectively improved the flexibility of the PTLG terpolymer stent and the 3D printed stent, and the stents showed good biocompatibility.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Polymer Science
Evaldas Bolskis, Erika Adomaviciute, Egidijus Griskonis
Summary: The aim of this research is to investigate the formation of biodegradable melt-spun multifilament Poly(lactic acid) (PLA) yarns with different contents of natural material-rosin. The presence of rosin in multifilament yarns decreased the mechanical properties of the yarns and increased absorbance in the UV region spectra.
Article
Engineering, Biomedical
Mohamad Nageeb Hassan, Mohammed Ahmed Yassin, Ahmed Maher Eltawila, Ahmed Emad Aladawi, Samih Mohamed-Ahmed, Salwa Suliman, Sherif Kandil, Kamal Mustafa
Summary: The study evaluated the osteoconductivity of 3D-printed PLATMC templates for bone tissue engineering, comparing them to widely used 3D-printed PCL templates. PLATMC showed greater wettability, strength, degradation, and promoted osteogenic differentiation of hBMSCs, with superior osteoconductivity compared to PCL. In vivo, PLATMC demonstrated unique contact osteogenesis and significantly higher amounts of new bone regeneration, showing its potential advantage in bone tissue engineering.
BIOMATERIALS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Guojun Hu, Yanwei Wang, Yaorong Wang, Xuehua Zhu, Dan Yuan, Yingming Yao
Summary: Two amino-bridged bis(phenolate) neodymium complexes were synthesized and used as efficient initiators for the copolymerization of TMC and L-LA under mild conditions, resulting in the formation of random copolymers. NMR monitoring experiments confirmed the generation of a TMC/LA random copolymer through random copolymerization.
CHEMICAL COMMUNICATIONS
(2023)
Article
Polymer Science
Lihuang Wu, Zixiang Wu, Yuqi Wang, Lu Han, Hongli Mao, Zhongwei Gu
Summary: In this study, the enzymatic degradation and in vivo degradation of PTLA with different chemical compositions were investigated. The degradation behavior of PTLA changed from surface degradation to bulk degradation with the increase of lactide content within a certain range, and followed typical bulk degradation behaviors for lactide content > 30 mol%.
POLYMER DEGRADATION AND STABILITY
(2022)
Article
Polymer Science
Magdalena Rzepna, Jaroslaw Sadlo, Grazyna Przybytniak, Anna Iuliano
Summary: The study investigated the effect of ionizing radiation on polylactide (PLA) and poly(trimethylene carbonate) (PTMC) statistical copolymers using EPR spectroscopy, revealing that PLA radicals dominate in copolymers with ratios of 30:70 and 70:30 PLA and PTMC components. The results showed compatibility and miscibility between the components in both non-irradiated and irradiated samples, with chain scission predominantly over cross-linking in PLA and PLA-rich copolymers.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Materials Science, Biomaterials
Lu Han, Yuqi Wang, Lihuang Wu, Zixiang Wu, Yiyan He, Hongli Mao, Zhongwei Gu
Summary: Smart materials, specifically biodegradable shape memory polymers (SMPs), have significant potential in various biomedical applications such as surgical sutures, implants, and stents. Poly(DL-lactide-co-trimethylene carbonate) (PDLLTC) is a promising SMP widely used in the field, but the relationship between its shape memory property and chemical structure requires further investigation. In this study, different compositions of PDLLTC copolymers were synthesized and their shape memory properties were studied. The results showed that the shape memory property is influenced by the chemical composition and polymeric chain segments. PDLLTC copolymer with a DLLA/TMC ratio of 75:25 (PDLLTC7525) exhibited excellent shape fixation and recovery ratio at human body temperature. Furthermore, PDLLTC7525-based self-morphing small-diameter vascular scaffolds, incorporating electrospun aligned gelatin/hyaluronic acid (Gel/HA) nanofibers on the inner layer, showed great potential for facilitating endothelial cell proliferation and adhesion. Thus, PDLLTC with customizable shape memory properties holds promise for SMP development and small-diameter vascular scaffold construction.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Nikola Toshikj, Jean-Jacques Robin, Michel Ramonda, Sylvain Catrouillet, Sebastien Blanquer
Summary: Efficient and rapid organocatalyzed ring-opening polymerization was used to synthesize PTMC-b-PCL-b-PTMC block copolymers, with controlled architectures achieved through an additional cross-linking step. The crystalline-driven phase-separated morphology predominated, and the cross-linked thin films exhibited shape-memory properties, while remaining stable with access to thermodynamic phase-separated morphologies below the poly(epsilon-caprolactone) melting point.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Polymer Science
Xiliang Liu, Song Liu, Shaomin Feng, Xin Wang, Wei Bai, Jianping Xiao, Dongliang Chen, Chengdong Xiong, Lifang Zhang
Summary: PTMC/PLCL blends exhibited excellent flexibility, mechanical strength, and biocompatibility for soft tissue applications, along with a higher degradation rate than pure PTMC. The blend can provide a promising alternative for soft tissue implants due to its suitable properties.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Polymer Science
Artur Turek, Jakub Rech, Aleksandra Borecka, Justyna Wilinska, Magdalena Kobielarz, Henryk Janeczek, Janusz Kasperczyk
Summary: This study aimed to determine the role of mechanical, structural, and thermal properties of P(l-LA:GA:TMC) with shape memory in the formulation of implantable and biodegradable rods with aripiprazole. The results showed that the proposed formulation may be administered as a delayed-release system, and EB irradiation was found to accelerate ARP release.
Article
Chemistry, Inorganic & Nuclear
Guojun Hu, Ziyue Deng, Yanwei Wang, Dan Yuan, Yong Zhang, Yingming Yao
Summary: A series of rare-earth metal complexes were synthesized and used as efficient initiators for the polymerization of trimethylene carbonate (TMC) and (L)-lactide ((L)-LA).
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Polymer Science
Zhuang-Zhuang Liang, Xiang Li, Chen-Yang Hu, Ran-Long Duan, Xian-Hong Wang, Xuan Pang, Xue-Si Chen
Summary: A new dinuclear Salen-Cr(III) complex was designed in this study, which exhibited higher efficiency for copolymerization of propylene oxide/carbon dioxide and lactide, and gradient and random copolymers of PPC-PLA were successfully synthesized.
CHINESE JOURNAL OF POLYMER SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Lee Yae Tan, Nalinthip Chanthaset, Hiroharu Ajiro
Summary: This study investigated the properties and surface coating performance of a urea-functionalized ester-free polymer PTMCM-SU. The modified polymer demonstrated higher glass transition temperature, improved wettability, and enhanced protein adsorption, suggesting its potential use as a coating surface for biomaterials.
MATERIALS ADVANCES
(2022)
Article
Biochemistry & Molecular Biology
Tiziana Fuoco, Astrid Ahlinder, Shubham Jain, Kamal Mustafa, Anna Finne-Wistrand
Article
Biochemistry & Molecular Biology
Tiziana Fuoco, Maria Cuartero, Marc Parrilla, Juan Jose Garcia-Guzman, Gaston A. Crespo, Anna Finne-Wistrand
Summary: An innovative methodology combining polymer characterization techniques and electrochemical sensors was developed to assess degradable biomedical polymers in real-time under physiological conditions. The study provided new insights into the mechanistic and kinetics aspects of the degradation process, with pH variation and L-lactate concentration serving as direct evidence of polymer resorption and chain scission extent. Linear models were found for pH and released L-lactate as a function of mass loss for the Llactide-based copolymers, indicating the potential for preclinical material evaluation and reduction of animal testing.
Article
Chemistry, Multidisciplinary
Tiziana Fuoco
Summary: The clever combination of ring-opening polymerization (ROP) and step-growth polymerization (SGP) allows for the design of a library of sequence-controlled polymers with diverse degradability functions. This strategy offers higher chemical diversity and control over primary structure, while being simple, effective, and atom-economical.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Biomaterials
Shubham Jain, Mohammed Ahmad Yassin, Tiziana Fuoco, Samih Mohamed-Ahmed, Hallvard Vindenes, Kamal Mustafa, Anna Finne-Wistrand
Summary: The study evaluates and compares five different medical-grade resorbable polyesters with varying L-lactide content to design 3D resorbable implants for adipose tissue engineering. The physical and mechanical properties of the scaffolds, influenced by copolymer compositions, play a significant role in human adipose tissue-derived stem cells proliferation and differentiation. Sterilization methods, such as electron beam and ethylene oxide, also impact the polymer properties, with ethylene oxide demonstrating better retention of physical and chemical properties for the scaffolds.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Negar Abbasi Aval, Rahmatollah Emadi, Ali Valiani, Mahshid Kharaziha, Anna Finne-Wistrand
Summary: Successful synthesis of a thermosensitive hydrogel for regeneration of central nervous system tissue, mimicking the neural extracellular matrix and showing promising tissue engineering properties.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Polymer Science
Tiziana Fuoco, Mo Chen, Shubham Jain, Xi Vincent Wang, Lihui Wang, Anna Finne-Wistrand
Summary: This article introduces the development of degradable ink for 3D printing. The ink is designed for direct-ink-writing technology, with suitable viscosity and rheological properties, and can be used to manufacture soft 3D scaffolds with no cytotoxicity and high hydration capacity.
Article
Polymer Science
Thayanithi Ayyachi, Daniela Pappalardo, Anna Finne-Wistrand
Summary: Polymethylmethacrylate is commonly used as bone cement in orthopedic and trauma surgeries. Adding linoleic acid to the formulation has shown potential to prevent adjacent vertebral fractures and improve handling properties. However, the mechanism behind these advantageous properties remains unclear, and there are concerns about the degradation of linoleic acid during sterilization.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Fika Andriani, Tiziana Fuoco
Summary: This study successfully synthesized ester bond copolymers with controllable erosion rate and susceptibility to three degradation pathways depending on the surrounding environment. By regulating the composition and microstructure of the random copolymers, diverse and more predictable degradation pathways were achieved.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Engineering, Biomedical
Tove Kivijarvi, Oyvind Goksoyr, Mohammed A. Yassin, Shubham Jain, Shuntaro Yamada, Alvaro Morales-Lopez, Kamal Mustafa, Anna Finne-Wistrand
Summary: Degradable polyester-based scaffolds provide long-term structural integrity and mechanical support in tissue engineering. However, their hydrophobic and unfunctionalized surfaces limit their tissue-mimetic quality. On the other hand, hyaluronan (HA) hydrogels act as cell-instructive materials with the ability to replicate native tissue. To address this issue, researchers developed a hybrid hydrogel material that combines the tissue-relevant properties of HA with the structural and mechanical support of PLATMC scaffolds.
MATERIALS TODAY BIO
(2022)
Article
Immunology
Salwa Suliman, Anna Mieszkowska, Justyna Folkert, Neha Rana, Samih Mohamed-Ahmed, Tiziana Fuoco, Anna Finne-Wistrand, Kai Dirscherl, Bodil Jorgensen, Kamal Mustafa, Katarzyna Gurzawska-Comis
Summary: This study demonstrates that functionalized PLCA scaffolds can modulate inflammatory responses and play a crucial role in promoting bone healing in critical-sized bone defects of aged rodents. This is significant in the field of bone tissue engineering for the development of immunomodulatory 3D scaffolds that promote osteogenesis.
INFLAMMATION AND REGENERATION
(2022)
Article
Polymer Science
Hailong Liu, Shubham Jain, Astrid Ahlinder, Tiziana Fuoco, T. Christian Gasser, Anna Finne-Wistrand
Summary: The study proposes an internal-bra-like prototype design for breast reconstruction, combining 3D-printed scaffold, knitted meshes, and electrospun nanofibers to support both breast tissue regeneration and silicone implants. Finite element analysis and mechanical testing show that introducing mesh can lower scaffold stiffness and the compressive modulus can be tailored.
Article
Polymer Science
Astrid Ahlinder, Sebastien Charlon, Tiziana Fuoco, Jeremie Soulestin, Anna Finne-Wistrand
POLYMER DEGRADATION AND STABILITY
(2020)
Article
Cell & Tissue Engineering
Shubham Jain, Mohammed Ahmad Yassin, Tiziana Fuoco, Hailong Liu, Samih Mohamed-Ahmed, Kamal Mustafa, Anna Finne-Wistrand
JOURNAL OF TISSUE ENGINEERING
(2020)
Article
Polymer Science
Tetsu Sato, Mariko Takahashi, Takeshi Saito, Masahito Toyonaga, Itsuo Tanuma, Rie Yamada, Satoru Hosoda
Summary: An automatic evaluation system for photooxidation has been developed and successfully applied to assess the photo-OIT of LDPE samples containing photooxidation stabilizers. The system allows independent setting of various measurement conditions and provides detailed information on the photooxidation process.
POLYMER DEGRADATION AND STABILITY
(2024)
Article
Polymer Science
Zongzheng Zuo, Shuxue Zhou
Summary: In this study, three fluoroalkyl trimethoxysilane (FATMS) additives with different chain lengths were incorporated into a two-component polyurethane clearcoat to improve its hydrophobic durability. The coatings modified with FATMS maintained their surface hydrophobicity under various conditions, but quickly lost it when exposed to both UV irradiation and/or high temperature with water. The results suggest that the FATMS route is more suitable for indoor applications at room temperature.
POLYMER DEGRADATION AND STABILITY
(2024)
Article
Polymer Science
Song Li, Feng Zhao, Xueya Wang, Zhihua Liu, Jingze Guo, Yutong Li, Shuangmei Tan, Zhenxiang Xin, Shuai Zhao, Lin Li
Summary: Green flame retardants have garnered attention for their environmental friendliness, but current options fall short in achieving high flame retardancy for flammable polymers and maintaining environmental protection. This study takes a two-pronged approach to address flame retardants and the flame-retardant process. An eco-friendly bio-based synergistic flame retardant (PAU), synthesized using phytic acid (PA) and urea (U), is used to create a flame retardant coating that can be directly applied to any surface shape using polydopamine as an adhesive. The resulting EPS-PAU exhibits excellent flame retardancy, smoke suppression, and light weight while only slightly increasing the density.
POLYMER DEGRADATION AND STABILITY
(2024)