Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
You Lee Son, Takayoshi Ubuka, Kazuyoshi Tsutsui
Summary: Under stressful conditions, the GnIH neuropeptide may play a key role in regulating reproductive function. Different types and durations of stress can modulate the GnIH system, impacting the activity of the HPG axis. GnIH appears to be a potential novel mediator responsible for stress-induced reproductive dysfunction.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pin-Yu Huang, Yu-Chih Yang, Chun- Wang, Pei-Wen Hsiao, Hsin- Chiang, Ting-Wen Chen
Summary: This study profiled gut microbiota composition in prostate cancer-bearing mice and control mice, revealing significant differences in microbial taxa and identifying bacteria families associated with responses to immunotherapy. The findings provide valuable insights into longitudinal microbiota alterations during cancer development, highlighting potential links between certain bacteria families and cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Shoichiro Kameoka, Daisuke Motooka, Satoshi Watanabe, Ryuichi Kubo, Nicolas Jung, Yuki Midorikawa, Natsuko O. Shinozaki, Yu Sawai, Aya K. Takeda, Shota Nakamura
Summary: The study compared 192 Japanese volunteers' fecal 16S analysis data using modified V1-V2 and standard V3-V4 primers. Results showed that the bacterial composition derived from the V34 region might differ from the actual abundance, suggesting that the modified V12 primer set is more desirable for analyzing the Japanese gut microbiota.
Article
Immunology
Xiaolin Liu, Nina van Beek, Aleksa Cepic, Nadia A. Andreani, Cecilia J. Chung, Britt M. Hermes, Kaan Yilmaz, Sandrine Benoit, Kossara Drenovska, Sascha Gerdes, Regine Glaeser, Matthias Goebeler, Claudia Guenther, Anabelle von Georg, Christoph M. Hammers, Maike M. Holtsche, Franziska Huebner, Dimitra Kiritsi, Franziska Schauer, Beke Linnenmann, Laura Huilaja, Kaisa Tasanen-Maatta, Snejina Vassileva, Detlef Zillikens, Christian D. Sadik, Enno Schmidt, Saleh Ibrahim, John F. Baines
Summary: Bullous pemphigoid patients have altered gut microbiota composition and function, with decreased microbial diversity and overall changed microbial community. Disease-associated gut microbial features, including reduced Faecalibacterium prausnitzii and increased pathways related to gamma-aminobutyric acid metabolism, are observed in BP patients. These findings suggest that gut microbiota alterations may play a role in the development of bullous pemphigoid.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Wisdom Alemya Akurugu, Carel Jacobus Van Heerden, Nicola Mulder, Ekkehard Werner Zollner
Summary: This study found that some SNPs of the CRHR1 and NR3C1 genes are associated with HPAS in asthmatic children, with the C allele of rs41423247 potentially having a protective effect on HPAS, and the CC genotype being associated with the highest PMTP ACTH response.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Yehan Bian, Heidi Hahn, Anja Uhmann
Summary: Hedgehog signaling plays essential roles in embryonic development, adult homeostasis, and tumorigenesis. Despite its close connection with pituitary embryonic development, the engagement of Hedgehog signaling in the pituitary gland has been underestimated. Dysfunction of this signaling pathway during pituitary development leads to gland malformation. Recent research also suggests a regulatory role of Hedgehog signaling in the adult pituitary, affecting homeostasis, hormone production, and possibly formation of neoplasms. Targeting this pathway with therapeutic strategies shows promise in treating pituitary diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Yanyan Que, Man Cao, Jianquan He, Qiang Zhang, Qiongyun Chen, Changsheng Yan, Aiqiang Lin, Luxi Yang, Zezhen Wu, Dan Zhu, Fengwu Chen, Zhangran Chen, Chuanxing Xiao, Kaijian Hou, Bangzhou Zhang
Summary: Research shows significant differences in microbial diversity between individuals with type 2 diabetes mellitus (T2DM) and controls, but not in microbial alpha diversity. Various operational taxonomic units (OTUs) and bacterial genera with significant odds ratios for T2DM were identified. The microbial characteristics of T2DM can be applied to other studies, improving detection accuracy and disease specificity for T2DM through training on multiple research studies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Li Xi, Yumin Song, Xinxi Qin, Jincheng Han, Yung-Fu Chang
Summary: By comparing the gut microbial composition of healthy and diarrheic giraffes, this study found that diarrhea significantly impacts the diversity and composition of the gut microbiota by increasing the proportion of pathogenic bacteria and decreasing beneficial bacteria. It also identified specific changes in bacterial phyla and genera, providing insights for establishing prevention and treatment strategies for diarrhea in giraffes.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Casey T. Finnicum, Zahraa Rahal, Maya Hassane, Warapen Treekitkarnmongkol, Ansam Sinjab, Rhiannon Morris, Yuejiang Liu, Elizabeth L. Tang, Sarah Viet, Jason L. Petersen, Philip L. Lorenzi, Lin Tan, Joseph Petrosino, Kristi L. Hoffman, Junya Fujimoto, Seyed Javad Moghaddam, Humam Kadara
Summary: Research has shown that exposure to tobacco carcinogens leads to significant changes in the gut and lung microbiomes, which are associated with the development of lung adenocarcinoma (LUAD) and immunotherapeutic response in human lung cancer patients. Loss of the bacterial growth inhibitor Lcn2 also results in widespread changes in the gut and lung microbiomes. These findings shed light on the role of microbial phenotypes in the development of tobacco-associated LUAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Stefanie Brezina, Martin Borkovec, Andreas Baierl, Fabienne Bastian, Andreas Futschik, Nikolaus Gasche, Thomas Gruenberger, Michael Hallas, Christian Jannsen, Gernot Leeb, Rebecca Lutz, Barbara Sladek, Andrea Gsur
Summary: The study evaluated the usability of FIT cartridges for microbiome analysis and compared it to Stool Collection and Preservation Tubes. The FIT and Preservation Tube samples had highly similar microbiome profiles, with minor differences between abundances of some bacterial taxa. The results indicate that FIT cartridges are suitable for gut microbiome analysis within CRC screening programs.
Article
Agriculture, Dairy & Animal Science
Ming -Han Li, Jin-Xin Meng, Wei Wang, Ma He, Zi-Yu Zhao, Ning Ma, Qing-Bo Lv, Yi-Feng Qin, Quan Zhao, Hong -Bo Ni, Xiao-Xuan Zhang
Summary: This study examined the diversity of bacteria and fungi in the gut microbiota of commercial broilers raised in cages. The results showed that the composition of the gut microbiota was influenced by age, with increasing richness and diversity as the broilers grew older. The gut microbiota had a unique structure in the early days after birth, and then underwent significant changes during periods of rapid growth and weight gain. Furthermore, certain bacteria and fungi played key roles in the gut microbiota of broilers, and their loss may impact the intestinal homeostasis of broilers.
Article
Immunology
Jie Huang, Shanshan Wei, Chuanhao Jiang, Zijun Xiao, Jian Liu, Weijun Peng, Bikui Zhang, Wenqun Li
Summary: This study reveals that an imbalance in the composition and function of the gut microbiota may be one of the etiological mechanisms underlying Doxorubicin-induced cardiotoxicity (DIC). The gut microbiota may serve as new targets for the treatment of cardiotoxicity and cardiovascular diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Martin Werdermann, Ilona Berger, Laura D. Scriba, Alice Santambrogio, Pia Schlinkert, Heike Brendel, Henning Morawietz, Andreas Schedl, Mirko Peitzsch, Aileen J. F. King, Cynthia L. Andoniadou, Stefan R. Bornstein, Charlotte Steenblock
Summary: This study investigated the impact of metabolic diseases on progenitor cells in the hypothalamic-pituitary-adrenal axis, showing that insulin enhances proliferation and differentiation of these cells, while chronic metabolic stress leads to hyperactivation of the axis. This suggests a potential link between early life stress and the development of metabolic syndrome in adulthood.
MOLECULAR METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Cheng Zhou, Wenji Zhang, Hui Lin, Luyun Zhang, Fan Wu, Yan Wang, Susu Yu, Xinyue Peng, Wenli Cheng, Min Li, Xiaoying Pan, Zhenrui Huang, Wenjuan Zhang
Summary: TF3, a polyphenol compound extracted from black tea, has shown potential therapeutic mechanisms in protecting against nonalcoholic fatty liver disease (NAFLD). The study revealed that TF3 may regulate lipid metabolism through the Fads1/PPAR delta/Fabp4 axis and gut microbiota, thereby preventing the development of NAFLD symptoms.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yun Chen, Ming Zhang, Fazheng Ren
Article
Biochemistry & Molecular Biology
Yanxiong Huo, Xuhong Lu, Xiaoyu Wang, Xifan Wang, Lingli Chen, Huiyuan Guo, Ming Zhang, Yixuan Li
Article
Biotechnology & Applied Microbiology
Yuanyuan Dong, Jun Zhu, Ming Zhang, Shaoyang Ge, Liang Zhao
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2020)
Article
Food Science & Technology
Yuanyuan Dong, Ruijia Li, Yajie Zheng, Ming Zhang
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2020)
Article
Nutrition & Dietetics
Xiaomei Zhang, Shanbin Chen, Ming Zhang, Fazheng Ren, Yimei Ren, Yixuan Li, Ning Liu, Yan Zhang, Qi Zhang, Ran Wang
Summary: This study investigated the effect of Lacticaseibacillus paracasei strain Shirota on constipation and depression symptoms in patients with specific etiology and gut microbiota. The results showed that LcS could alleviate certain symptoms of constipation and depression, regulate intestinal microbiota related to mental illness, and significantly decrease IL-6 levels.
Article
Food Science & Technology
Yajie Zheng, Fang Wu, Ming Zhang, Bing Fang, Liang Zhao, Lijie Dong, Xiaojuan Zhou, Shaoyang Ge
Summary: The study found that camel milk supplement has positive effects in reducing blood glucose, cholesterol, and increasing GLP-1, indicating improvement in adipose tissue and skeletal muscle. Camel milk powder can be used as a functional food to treat type 2 diabetes.
FOOD SCIENCE & NUTRITION
(2021)
Article
Nutrition & Dietetics
Fang Wu, Bing Fang, Guna Wuri, Liang Zhao, Fudong Liu, Ming Zhang
Summary: The study found that Lactobacillus paracasei L9 and Bifidobacterium animalis A6 can alleviate the symptoms of periodontitis by regulating oral microbiota. They can inhibit inflammatory response, increase the expression of anti-inflammatory cytokines, reduce the proportion of pathogenic bacteria, and inhibit the levels of bacterial virulence factors related to periodontitis. These results suggest that A6 and L9 may be promising prophylactic and therapeutic agents for periodontitis.
Article
Biochemistry & Molecular Biology
Zhi Zhao, Jianmin Wu, Zhe Sun, Jinbo Fan, Fudong Liu, Wen Zhao, Wei-Hsien Liu, Ming Zhang, Wei-Lian Hung
Summary: The study evaluates the effects of L. paracasei ET-22 on the formation of S. mutans biofilms. Results show that both live bacteria and its postbiotics have inhibitory effects on the formation of S. mutans biofilm, suggesting their potential as promising biological anticariogenic agents.
Article
Food Science & Technology
Fang Wu, Guna Wuri, Bing Fang, Mengxuan Shi, Ming Zhang, Liang Zhao
Summary: This study found that BAA6 alleviated symptoms of ulcerative colitis in a mouse model. It increased levels of butyric acid and activated the butyric acid-FFAR pathway, while suppressing excessive inflammatory response and protecting the function of the colon epithelial barrier.
FOOD SCIENCE & NUTRITION
(2023)
Article
Food Science & Technology
Zhe Sun, Zhi Zhao, Bing Fang, Weilian Hung, Haina Gao, Wen Zhao, Hanglian Lan, Mingkun Liu, Liang Zhao, Ming Zhang
Summary: Inactivation is a crucial step in the production of postbiotics, and excessive heating can diminish the antioxidant activity and alter the chemical composition of postbiotics. However, mild heating does not affect the antioxidant and anti-inflammatory properties of postbiotics. The findings highlight the importance of carefully controlling the heating temperature in the production of postbiotics.
Article
Food Science & Technology
Tengteng Ji, Bing Fang, Ming Zhang, Yaqiong Liu
Summary: Succinate supplementation can reduce fat deposition and adipocyte size, enhance lipolysis in adipose tissue, and increase the activity of brown adipose tissue in obese mice.
Article
Food Science & Technology
Taojun Wang, Huiyuan Guo, Hao Zhang, Fazheng Ren, Ming Zhang, Shaoyang Ge, Hailing Luo, Liang Zhao
FOOD SCIENCE OF ANIMAL RESOURCES
(2019)