Article
Pharmacology & Pharmacy
Ling Chen, Xiao-lin Zhong, Wen-yu Cao, Ming-li Mao, Dan-dan Liu, Wen-jia Liu, Xu-yu Zu, Jiang-hua Liu
Summary: In this study, the role and mechanism of IGF2 in ulcerative colitis were investigated using a mouse model. The results showed that IGF2 can alleviate colon injury and inflammation caused by ulcerative colitis by downregulating the cGAS-Sting pathway, thus maintaining colonic stemness and barrier integrity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Xin Li, Kaibin Mo, Ge Tian, Jiaxin Zhou, Jiongzhou Gong, Li Li, Xianhui Huang
Summary: This study investigated the effects of shikimic acid (SA) on intestinal inflammation using a mouse colitis model. The results showed that SA could slow down weight loss, reduce disease activity, enhance intestinal barrier function, inhibit key protein phosphorylation in MAPK and NF-kappa B signaling pathways, and decrease the expression of inflammatory factors. In addition, SA treatment altered the gut microbiota composition and richness. These findings suggest that SA has therapeutic potential in improving intestinal inflammation and enhancing intestinal immunity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Hye-Jung Moon, Youn-Soo Cha, Kyung-Ah Kim
Summary: This study investigated the protective effects of blackcurrant (BC) on ulcerative colitis (UC) in mice. BC powder relieved symptoms of colitis, reduced the production of pro-inflammatory cytokines, regulated the NF-kappa B signaling pathway and gut barrier function related genes, and modulated the gut microbiota composition.
Article
Pharmacology & Pharmacy
Yongfu Wang, Jingjing Liu, Ziwei Huang, Yucui Li, Yuanyuan Liang, Chaodan Luo, Chen Ni, Jianhui Xie, Ziren Su, Jiannan Chen, Cailan Li
Summary: Coptisine has demonstrated therapeutic effects on ulcerative colitis by maintaining the integrity of the intestinal epithelial barrier, inhibiting apoptosis, and inflammatory response.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Plant Sciences
Taoxiu Xiong, Xiang Zheng, Ke Zhang, Hansong Wu, Yingjie Dong, Fuchen Zhou, Bingbing Cheng, Linzi Li, Wanfeng Xu, Jie Su, Jiahui Huang, Zetian Jiang, Bo Li, Beibei Zhang, Guiyuan Lv, Suhong Chen
Summary: The study found that Ganluyin (GLY) exerts an anti-ulcerative colitis (UC) effect by improving the colonic mucosal barrier, inhibiting the enteric-origin lipopolysaccharide (LPS)/toll-like receptor (TLR)4/nuclear factor-kappa B (NF-κB) inflammatory pathway, and restoring the homeostasis of the intestinal flora in UC mice. These findings lay a strong foundation for GLY as a potential treatment for UC.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shengjie Li, Aoxiang Zhuge, Kaicen Wang, Longxian Lv, Xiaoyuan Bian, Liya Yang, Jiafeng Xia, Xianwan Jiang, Wenrui Wu, Shuting Wang, Qiangqiang Wang, Lanjuan Li
Summary: Ketogenic diet worsens DSS-induced colitis in mice by increasing inflammation, disrupting the intestinal barrier, and modulating gut microbiota and metabolism.
Article
Biochemistry & Molecular Biology
Kwang-Youn Kim, Jae Dong Son, Su-Jin Hwang, Jong Kwang Lee, Jae Young Park, Kwang Il Park, Tae Woo Oh
Summary: Fermented glutinous rice can improve ulcerative colitis by regulating the expression of tight junction proteins, reducing inflammation, and inhibiting apoptosis. The treatment with fermented glutinous rice can protect the intestinal barrier function, suppress inflammation, and prevent apoptosis, making it a potential candidate for treating and preventing inflammatory bowel disease.
Article
Agriculture, Multidisciplinary
Mengqi Li, Qi Ge, Hanting Du, Pengfei Jiang, Zhijie Bao, Dong Chen, Songyi Lin
Summary: The study demonstrated that peptides derived from Tricholoma matsutake alleviate colitis symptoms by regulating TJ protein expression and suppressing pro-inflammatory cytokine production.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Medicine, General & Internal
Zhi-Yu Li, Lan-Hui Lin, He-Jun Liang, Ya-Qi Li, Fu-Qian Zhao, Ting-Yi Sun, Zi-Yu Liu, Jing-Yi Zhu, Feng Gu, Jia-Ning Xu, Qi-Yuan Hao, De-Shan Zhou, Hui-Hong Zhai
Summary: This study found that Lycium barbarum polysaccharides (LBP) have a protective effect on intestinal barrier function and intestinal microbiota in mice with chronic ulcerative colitis (UC). LBP can alleviate UC by regulating inflammatory cytokines and tight junction proteins. Moreover, LBP promotes the growth of probiotics, suppresses conditional pathogens, and increases the production of short-chain fatty acids (SCFAs).
ANNALS OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Zuoting Yu, Dinggang Li, Hongxiang Sun
Summary: This study investigated the protective effect of Herba Origani on dextran sodium sulfate (DSS)-induced ulcerative colitis in mice. The results showed that Herba Origani alleviated colitis symptoms, inflammation, and pathological injury, and repaired intestinal barrier function. It also restored gut microbiota dysbiosis, regulated bile acids metabolism, and adjusted short-chain fatty acids (SCFAs). These findings suggest that Herba Origani has the potential to be used for the treatment of inflammatory intestinal diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Food Science & Technology
Yingyin Xu, Huiyu Feng, Zhiyuan Zhang, Qian Zhang, Jie Tang, Jie Zhou, Yong Wang, Weihong Peng
Summary: This study investigated the mechanisms by which polysaccharides derived from Scorias spongiosa contribute to the integrity of the intestinal barrier. The results revealed that these polysaccharides enhanced intestinal barrier integrity, mitigated oxidative stress and inflammation, and reshaped the intestinal microbiome. The protective effects of Scorias spongiosa polysaccharides against colitis were mediated through the regulation of the NF-kappa B-STAT1-MAPK axis.
Article
Pharmacology & Pharmacy
Abdullah Glil Alkushi, Sara T. Elazab, Ahmed Abdelfattah-Hassan, Hala Mahfouz, Gamal A. Salem, Nagwa I. Sheraiba, Eman A. A. Mohamed, Mai S. Attia, Eman S. El-Shetry, Ayman A. Saleh, Naser A. ElSawy, Doaa Ibrahim
Summary: This study demonstrates that incorporating multi-strain probiotics into nanomaterials can enhance their therapeutic efficacy in treating inflammatory bowel disease. The use of nanomaterials as a carrier ensures the viability and targeted release of probiotics, leading to reduced colonic damage and improved intestinal epithelium healing. Additionally, the nanomaterial carrier promotes the restoration of beneficial gut microbiota.
Article
Agriculture, Multidisciplinary
Zhiyong Xie, Ziqi Zeng, Guijie Chen, Wei Dong, Yujia Peng, Weiqi Xu, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
Summary: The intracellular polysaccharides of Aspergilluscristatus (IPSs) from Fuzhuan brick tea have been found to improve immune function and modulate gut microbiota. In this study, it was demonstrated that the purified fraction of IPSs (IPSs-2) can protect against colitis in mice induced by dextran sulfate sodium (DSS) through various mechanisms, including reducing inflammation, repairing intestinal barrier function, and modulating gut microbiota.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Meng-Meng Niu, Huan-Xin Guo, Jun-Wu Cai, Xiang-Chen Meng
Summary: This study explores the intestinal barrier repair mechanisms of Bifidobacterium breve (B. breve) strains H4-2 and H9-3 with different exopolysaccharide (EPS) production in mice with colitis. The results demonstrate that both strains of B. breve can regulate cytokine levels and repair intestinal damage caused by colitis. H4-2, with higher EPS output, is more effective at repair than H9-3. These findings are important for clinical applications and the development of probiotic products for colitis treatment.
Article
Biochemistry & Molecular Biology
Junhong Tao, Zhihua Huang, Yudan Wang, Yaping Liu, Tianrui Zhao, Yifen Wang, Lei Tian, Guiguang Cheng
Summary: The research found that Pteris wallichiana J. Agardh extract can alleviate DSS-induced ulcerative colitis in mice through various mechanisms, including reducing the production of inflammatory factors, alleviating oxidative stress, improving intestinal barrier, and suppressing intestinal inflammation.
Article
Biochemistry & Molecular Biology
Jin-Wang Li, Bing Fang, Guo-Fang Pang, Ming Zhang, Fa-Zheng Ren
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Yanxiong Huo, Xuhong Lu, Xiaoyu Wang, Xifan Wang, Lingli Chen, Huiyuan Guo, Ming Zhang, Yixuan Li
Article
Biotechnology & Applied Microbiology
Yuanyuan Dong, Jun Zhu, Ming Zhang, Shaoyang Ge, Liang Zhao
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2020)
Article
Food Science & Technology
Yuanyuan Dong, Ruijia Li, Yajie Zheng, Ming Zhang
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2020)
Article
Nutrition & Dietetics
Xiaomei Zhang, Shanbin Chen, Ming Zhang, Fazheng Ren, Yimei Ren, Yixuan Li, Ning Liu, Yan Zhang, Qi Zhang, Ran Wang
Summary: This study investigated the effect of Lacticaseibacillus paracasei strain Shirota on constipation and depression symptoms in patients with specific etiology and gut microbiota. The results showed that LcS could alleviate certain symptoms of constipation and depression, regulate intestinal microbiota related to mental illness, and significantly decrease IL-6 levels.
Article
Food Science & Technology
Yajie Zheng, Fang Wu, Ming Zhang, Bing Fang, Liang Zhao, Lijie Dong, Xiaojuan Zhou, Shaoyang Ge
Summary: The study found that camel milk supplement has positive effects in reducing blood glucose, cholesterol, and increasing GLP-1, indicating improvement in adipose tissue and skeletal muscle. Camel milk powder can be used as a functional food to treat type 2 diabetes.
FOOD SCIENCE & NUTRITION
(2021)
Article
Nutrition & Dietetics
Fang Wu, Bing Fang, Guna Wuri, Liang Zhao, Fudong Liu, Ming Zhang
Summary: The study found that Lactobacillus paracasei L9 and Bifidobacterium animalis A6 can alleviate the symptoms of periodontitis by regulating oral microbiota. They can inhibit inflammatory response, increase the expression of anti-inflammatory cytokines, reduce the proportion of pathogenic bacteria, and inhibit the levels of bacterial virulence factors related to periodontitis. These results suggest that A6 and L9 may be promising prophylactic and therapeutic agents for periodontitis.
Article
Biochemistry & Molecular Biology
Zhi Zhao, Jianmin Wu, Zhe Sun, Jinbo Fan, Fudong Liu, Wen Zhao, Wei-Hsien Liu, Ming Zhang, Wei-Lian Hung
Summary: The study evaluates the effects of L. paracasei ET-22 on the formation of S. mutans biofilms. Results show that both live bacteria and its postbiotics have inhibitory effects on the formation of S. mutans biofilm, suggesting their potential as promising biological anticariogenic agents.
Article
Food Science & Technology
Fang Wu, Guna Wuri, Bing Fang, Mengxuan Shi, Ming Zhang, Liang Zhao
Summary: This study found that BAA6 alleviated symptoms of ulcerative colitis in a mouse model. It increased levels of butyric acid and activated the butyric acid-FFAR pathway, while suppressing excessive inflammatory response and protecting the function of the colon epithelial barrier.
FOOD SCIENCE & NUTRITION
(2023)
Article
Food Science & Technology
Zhe Sun, Zhi Zhao, Bing Fang, Weilian Hung, Haina Gao, Wen Zhao, Hanglian Lan, Mingkun Liu, Liang Zhao, Ming Zhang
Summary: Inactivation is a crucial step in the production of postbiotics, and excessive heating can diminish the antioxidant activity and alter the chemical composition of postbiotics. However, mild heating does not affect the antioxidant and anti-inflammatory properties of postbiotics. The findings highlight the importance of carefully controlling the heating temperature in the production of postbiotics.
Article
Food Science & Technology
Tengteng Ji, Bing Fang, Ming Zhang, Yaqiong Liu
Summary: Succinate supplementation can reduce fat deposition and adipocyte size, enhance lipolysis in adipose tissue, and increase the activity of brown adipose tissue in obese mice.
Article
Food Science & Technology
Taojun Wang, Huiyuan Guo, Hao Zhang, Fazheng Ren, Ming Zhang, Shaoyang Ge, Hailing Luo, Liang Zhao
FOOD SCIENCE OF ANIMAL RESOURCES
(2019)
