Tetrahydrocurcumin Ameliorates Diabetic Cardiomyopathy by Attenuating High Glucose-Induced Oxidative Stress and Fibrosis via Activating the SIRT1 Pathway

An Aza resveratrol-chalcone derivative 6b protects mice against diabetic cardiomyopathy by alleviating inflammation and oxidative stress

(2018) Shengban You et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Andrographolide Ameliorates Diabetic Cardiomyopathy in Mice by Blockage of Oxidative Damage and NF-κB-Mediated Inflammation

(2018) Ershun Liang et al.   Oxidative Medicine and Cellular Longevity

Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway

(2018) Bin Zhang et al.   Oxidative Medicine and Cellular Longevity

Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?

(2018) Xavier Palomer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Rα-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice

(2018) Bin Lin Chen et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Tetrahydrocurcumin and octahydrocurcumin, the primary and final hydrogenated metabolites of curcumin, possess superior hepatic-protective effect against acetaminophen-induced liver injury: Role of CYP2E1 and Keap1-Nrf2 pathway

(2018) Dan-Dan Luo et al.   FOOD AND CHEMICAL TOXICOLOGY

Tetrahydrocurcumin epigenetically mitigates mitochondrial dysfunction in brain vasculature during ischemic stroke

(2018) Nandan K. Mondal et al.   NEUROCHEMISTRY INTERNATIONAL

Reactive oxygen species signalling in the diabetic heart: emerging prospect for therapeutic targeting

(2017) Adam J Wilson et al.   HEART

Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC-1β: In vivo and in vitro studies

(2017) Mengen Zhai et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis

(2017) Mengen Zhai et al.   JOURNAL OF PINEAL RESEARCH

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1

(2017) Hai-han Liao et al.   Oxidative Medicine and Cellular Longevity

SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice

(2017) Sai Ma et al.   Oxidative Medicine and Cellular Longevity

Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells

(2017) Weijin Zhang et al.   Oxidative Medicine and Cellular Longevity

Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential

(2017) Alyssa Faria et al.   PHARMACOLOGY & THERAPEUTICS

Mitochondrial NAD+/NADH Redox State and Diabetic Cardiomyopathy

(2017) Jessica M. Berthiaume et al.   ANTIOXIDANTS & REDOX SIGNALING

Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery

(2016) Chun-Yan Shen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity

(2016) Yu-Xuan Luo et al.   EUROPEAN HEART JOURNAL

Diabetes-associated cardiac fibrosis: Cellular effectors, molecular mechanisms and therapeutic opportunities

(2016) Ilaria Russo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Berberine Attenuates Myocardial Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1

(2016) Liming Yu et al.   Oxidative Medicine and Cellular Longevity

Tetrahydrocurcumin in combination with deferiprone attenuates hypertension, vascular dysfunction, baroreflex dysfunction, and oxidative stress in iron-overloaded mice

(2016) Weerapon Sangartit et al.   VASCULAR PHARMACOLOGY

Sirtuin functions and modulation: from chemistry to the clinic

(2016) Vincenzo Carafa et al.   Clinical Epigenetics

Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor

(2016) Lan Xiang et al.   Aging-US

Myocardial Metabolism in Diabetic Cardiomyopathy: Potential Therapeutic Targets

(2015) Miranda M. Sung et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress, mitochondrial damage and diabetic retinopathy

(2015) Renu A. Kowluru et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats

(2015) Mingge Ding et al.   Cardiovascular Diabetology

Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic MiceCLINICAL PERSPECTIVE

(2015) Anna Biernacka et al.   Circulation-Heart Failure

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

(2015) Stephan Winnik et al.   EUROPEAN HEART JOURNAL

Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes

(2015) Petar M. Seferović et al.   EUROPEAN HEART JOURNAL

SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism

(2015) Rong Guo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Reduced silent information regulator 1 signaling exacerbates myocardial ischemia-reperfusion injury in type 2 diabetic rats and the protective effect of melatonin

(2015) Liming Yu et al.   JOURNAL OF PINEAL RESEARCH

Heart failure in diabetes: effects of anti-hyperglycaemic drug therapy

(2015) Richard E Gilbert et al.   LANCET

Hyperglycemia and angiotensin II cooperate to enhance collagen I deposition by cardiac fibroblasts through a ROS-STAT3-dependent mechanism

(2014) Tania Fiaschi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Arachidonate 12/15-Lipoxygenase–Induced Inflammation and Oxidative Stress Are Involved in the Development of Diabetic Cardiomyopathy

(2014) Hirofumi Suzuki et al.   DIABETES

Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: role of SIRT1

(2014) Liming Yu et al.   JOURNAL OF PINEAL RESEARCH

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

(2014) Bharat Aggarwal et al.   MOLECULES

Chemopreventative effects of tetrahydrocurcumin on human diseases

(2013) Jia-Ching Wu et al.   Food & Function

Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction

(2011) Shuang Zhou et al.   CIRCULATION RESEARCH

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Hepatitis C Virus Regulates Transforming Growth Factor β1 Production Through the Generation of Reactive Oxygen Species in a Nuclear Factor κB–Dependent Manner

(2010) Wenyu Lin et al.   GASTROENTEROLOGY

A liquid chromatography–tandem mass spectrometric method for quantification of curcuminoids in cell medium and mouse plasma

(2010) U.V.R. Vijaya Saradhi et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

TIMP3 Is Reduced in Atherosclerotic Plaques From Subjects With Type 2 Diabetes and Increased by SirT1

(2009) M. Cardellini et al.   DIABETES

Human Apolipoprotein A-I Gene Transfer Reduces the Development of Experimental Diabetic Cardiomyopathy

(2008) Sophie Van Linthout et al.   CIRCULATION

Effect of tetrahydrocurcumin on insulin receptor status in type 2 diabetic rats: studies on insulin binding to erythrocytes

(2008) Pidaran Murugan et al.   JOURNAL OF BIOSCIENCES

Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease

(2008) A. N. Begum et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS