4.5 Review

Dietary non-nutrients in the prevention of non-communicable diseases: Potentially related mechanisms

Journal

NUTRITION
Volume 66, Issue -, Pages 22-28

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2019.03.016

Keywords

Polyphenols; Phytosterols; Saponins; Phytates; Food intake; Mechanisms

Funding

  1. Foundation for Research Support of the State of Minas Gerais, (FAPEMIG, Minas Gerais State, Brazil) [CDS - APQ - 02425-15]
  2. CNPq (Ministry of Science, Technology and Innovation, Brazil)
  3. CAPES Foundation (Ministry of Education, Brazil)

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Among the 10 leading causes of death in developed countries are chronic non-communicable diseases (NCDs). The effect of these multifactorial diseases on public health has stimulated considerable research aimed at investigating their primary risk factors (genetic factors, stress, food intake, and amount of physical exercise). Thus, healthful foods (e.g., fruits, vegetables, oils, grains, and seeds) are sources of bioactive compounds that promote good health and disease prevention. Among their components are non-caloric substances identified as non nutrients (polyphenols, phytosterols, saponins, and phytates), which have been found to have a role in modulating metabolic pathways, maintaining health, and preventing NCDs. The aim of this study is to demonstrate and review the performance of some non-nutrients, such as their antioxidant and anti-inflammatory action, modulation of the antiatherogenic lipid profile (higher high-density lipoprotein cholesterol, lower oxidized low-density lipoprotein, and triacylglycerols), reduction of glucose and fat intestinal absorption, increase in insulin sensitivity, and stimulation of nitic oxide synthesis. (C) 2019 Elsevier Inc. All rights reserved.

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