Suppressing nNOS Enzyme by Small-Interfering RNAs Protects SH-SY5Y Cells and Nigral Dopaminergic Neurons from 6-OHDA Injury

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

The 200-year journey of Parkinson disease: Reflecting on the past and looking towards the future

(2018) Stanley Fahn   PARKINSONISM & RELATED DISORDERS

Delivery of miRNA-Targeted Oligonucleotides in the Rat Striatum by Magnetofection with Neuromag®

(2018) Simoneide Titze de Almeida et al.   MOLECULES

Gene-silencing technology gets first drug approval after 20-year wait

(2018) Heidi Ledford   NATURE

Therapeutic Oligonucleotides: State of the Art

(2018) C.I. Edvard Smith et al.   Annual Review of Pharmacology and Toxicology

The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

(2017) Helena Xicoy et al.   Molecular Neurodegeneration

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market

(2017) Ricardo Titze-de-Almeida et al.   PHARMACEUTICAL RESEARCH

Inhibition by Multifunctional Magnetic Nanoparticles Loaded with Alpha-Synuclein RNAi Plasmid in a Parkinson's Disease Model

(2017) Shuiqin Niu et al.   Theranostics

Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson’s Disease

(2017) Christin Helmschrodt et al.   Molecular Therapy-Nucleic Acids

An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons

(2017) Lotta Agholme et al.   JOURNAL OF ALZHEIMERS DISEASE

Chemical and structural modifications of RNAi therapeutics

(2016) Sook Hee Ku et al.   ADVANCED DRUG DELIVERY REVIEWS

RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?

(2016) Maggie L. Bobbin et al.   Annual Review of Pharmacology and Toxicology

An Update on the Role of Nitric Oxide in the Neurodegenerative Processes of Parkinson's Disease

(2016) Félix Jiménez-Jiménez et al.   CURRENT MEDICINAL CHEMISTRY

Therapeutic approaches in Parkinson's disease and related disorders

(2016) Elvira Valera et al.   JOURNAL OF NEUROCHEMISTRY

Antidyskinetic Effect of 7-Nitroindazole and Sodium Nitroprusside Associated with Amantadine in a Rat Model of Parkinson’s Disease

(2016) Mariza Bortolanza et al.   NEUROTOXICITY RESEARCH

The Presence of the Neuronal Nitric Oxide Synthase Isoform in the Intervertebral Disk

(2016) Vitor Castania et al.   NEUROTOXICITY RESEARCH

Preclinical Safety Evaluation in Rats of a Polymeric Matrix Containing an siRNA Drug Used as a Local and Prolonged Delivery System for Pancreatic Cancer Therapy

(2016) Yuval Ramot et al.   TOXICOLOGIC PATHOLOGY

Suppression of the Eag1 potassium channel sensitizes glioblastoma cells to injury caused by temozolomide

(2016) Thais Torquato Sales et al.   Oncology Letters

Localized RNAi Therapeutics of Chemoresistant Grade IV Glioma Using Hyaluronan-Grafted Lipid-Based Nanoparticles

(2015) Zvi R. Cohen et al.   ACS Nano

Convection-enhanced delivery to the central nervous system

(2015) Russell R. Lonser et al.   JOURNAL OF NEUROSURGERY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Enduring high-efficiency in vivo transfection of neurons with non-viral magnetoparticles in the rat visual cortex for optogenetic applications

(2015) Cristina Soto-Sánchez et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nitric oxide synthase inhibition decreases l-DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3−/− aphakia mice

(2015) Oscar Solís et al.   NEUROBIOLOGY OF DISEASE

Effects of prolonged neuronal nitric oxide synthase inhibition on the development and expression of l-DOPA-induced dyskinesia in 6-OHDA-lesioned rats

(2015) Fernando Eduardo Padovan-Neto et al.   NEUROPHARMACOLOGY

Post-lesion administration of 7-NI attenuated motor and non-motor deficits in 6-OHDA induced bilaterally lesioned female rat model of Parkinson’s disease

(2015) Rita Kumari et al.   NEUROSCIENCE LETTERS

Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain

(2014) Paramita Mukherjee et al.   CHEMICAL SOCIETY REVIEWS

Interferon Gamma Potentiates the Injury Caused by MPP(+) on SH-SY5Y Cells, Which is Attenuated by the Nitric Oxide Synthases Inhibition

(2014) Simoneide S. Titze-de-Almeida et al.   NEUROCHEMICAL RESEARCH

Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson’s Disease

(2014) Georgia S. Gaki et al.   NEUROMOLECULAR MEDICINE

Anti-dyskinetic effect of the neuronal nitric oxide synthase inhibitor is linked to decrease of FosB/DeltaFosB expression

(2013) Fernando Eduardo Padovan-Neto et al.   NEUROSCIENCE LETTERS

Counteraction by Nitric Oxide Synthase Inhibitor of Neurochemical Alterations of Dopaminergic System in 6-OHDA-Lesioned Rats Under l-DOPA Treatment

(2013) Elaine Del-Bel et al.   NEUROTOXICITY RESEARCH

Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis

(2012) Petra Dunkel et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Cellular models to investigate biochemical pathways in Parkinson’s disease

(2012) Tiziana Alberio et al.   FEBS Journal

Retinoic acid protects against proteasome inhibition associated cell death in SH-SY5Y cells via the AKT pathway

(2012) Benxu Cheng et al.   NEUROCHEMISTRY INTERNATIONAL

Role of Nitric Oxide in Motor Control: Implications for Parkinson's Disease Pathophysiology and Treatment

(2011) Elaine Del-Bel et al.   CURRENT PHARMACEUTICAL DESIGN

New Strategies in Neuroprotection and Neurorepair

(2011) Marta C. Antonelli et al.   NEUROTOXICITY RESEARCH

Relationships between age and late progression of Parkinson's disease: a clinico-pathological study

(2010) P. A. Kempster et al.   BRAIN

Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies

(2010) Fernanda Martins Lopes et al.   BRAIN RESEARCH

Nitric oxide and neuronal death

(2010) Guy C. Brown   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

siRNAs: their potential as therapeutic agents – Part I. Designing of siRNAs

(2009) Praveensingh B. Hajeri et al.   DRUG DISCOVERY TODAY

Delivery of small-interfering RNA (siRNA) to the brain

(2009) Saroj P Mathupala   EXPERT OPINION ON THERAPEUTIC PATENTS

Nitric oxide synthase inhibition attenuates l-DOPA-induced dyskinesias in a rodent model of Parkinson's disease

(2009) F.E. Padovan-Neto et al.   NEUROSCIENCE

Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical implications

(2009) Li Zhou et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Identification of Novel Reference Genes Using Multiplatform Expression Data and Their Validation for Quantitative Gene Expression Analysis

(2009) Mi Jeong Kwon et al.   PLoS One

A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway

(2008) Margarete Zanardo Gomes et al.   BRAIN RESEARCH

7-nitroindazole attenuates 6-hydroxydopamine-induced spatial learning deficits and dopamine neuron loss in a presymptomatic animal model of Parkinson's disease.

(2008) Kristi L. Haik et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research

(2008) Yuen-Ting Cheung et al.   NEUROTOXICOLOGY