Knockout of apolipoprotein A‐I decreases parenchymal and vascular β‐amyloid pathology in the Tg2576 mouse model of Alzheimer's disease

Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain

(2019) Roxana Aldea et al.   Frontiers in Aging Neuroscience

Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells

(2018) Martina Zandl-Lang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Intraventricular infusion of clusterin ameliorated cognition and pathology in Tg6799 model of Alzheimer’s disease

(2018) Xue-Mei Qi et al.   BMC NEUROSCIENCE

Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease

(2018) David C. Hondius et al.   Acta Neuropathologica Communications

Apolipoprotein C-III is an Amyloid-β-Binding Protein and an Early Marker for Alzheimer's Disease

(2018) Yao-Hsiang Shih et al.   JOURNAL OF ALZHEIMERS DISEASE

Apolipoprotein A1 in Cerebrospinal Fluid and Plasma and Progression to Alzheimer’s Disease in Non-Demented Elderly

(2017) Rosalinde E.R. Slot et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Apolipoprotein E and Alzheimer’s disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins

(2017) Tien-Phat V. Huynh et al.   JOURNAL OF LIPID RESEARCH

Overexpression of apolipoprotein A-I alleviates endoplasmic reticulum stress in hepatocytes

(2017) Qing Guo et al.   Lipids in Health and Disease

Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later

(2017) Katarina Nägga et al.   NEUROLOGY

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

(2017) Aleksandra M. Wojtas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The clinical significance of plasma clusterin and Aβ in the longitudinal follow-up of patients with Alzheimer’s disease

(2017) Jung-Lung Hsu et al.   Alzheimers Research & Therapy

Clusterin protects neurons against intracellular proteotoxicity

(2017) Jenna M. Gregory et al.   Acta Neuropathologica Communications

Central Nervous System LipoproteinsHighlights

(2016) Robert W. Mahley   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ

(2016) J. Scott Miners et al.   BRAIN PATHOLOGY

Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases

(2016) Erik N. T. P. Bakker et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Modulation of Amyloid-β1–40 Transport by ApoA1 and ApoJ Across an in vitro Model of the Blood-Brain Barrier

(2016) Cristina Merino-Zamorano et al.   JOURNAL OF ALZHEIMERS DISEASE

Clusterin Binds to Aβ1–42Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation

(2016) Marten Beeg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Systems proteomic analysis reveals that clusterin and tissue inhibitor of metalloproteinases 3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy

(2016) A. Manousopoulou et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Prenatal high-fat diet alters the cerebrovasculature and clearance ofβ-amyloid in adult offspring

(2015) Cheryl A Hawkes et al.   JOURNAL OF PATHOLOGY

Expression and Purification of Chaperone-Active Recombinant Clusterin

(2014) Rebecca A. Dabbs et al.   PLoS One

Clusterin/Apolipoprotein J Attenuates Angiotensin II-Induced Renal Fibrosis

(2014) Gwon-Soo Jung et al.   PLoS One

Secreted clusterin (sCLU) regulates cell proliferation and chemosensitivity to cisplatin by modulating ERK1/2 signals in human osteosarcoma cells

(2014) Hai Huang et al.   World Journal of Surgical Oncology

Intravenously Injected Human Apolipoprotein A‐I Rapidly Enters the Central Nervous System via the Choroid Plexus

(2014) Sophie Stukas et al.   Journal of the American Heart Association

Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain

(2013) Cheryl A. Hawkes et al.   AGING CELL

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Interaction of Clusterin and Matrix Metalloproteinase-9 and Its Implication for Epithelial Homeostasis and Inflammation

(2012) Shinwu Jeong et al.   AMERICAN JOURNAL OF PATHOLOGY

Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

(2012) Cheryl A. Hawkes et al.   PLoS One

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

(2011) Cheryl A. Hawkes et al.   ACTA NEUROPATHOLOGICA

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

(2011) Amy R. Wyatt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide

(2011) Priyanka Narayan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease

(2011) M. Sano et al.   NEUROLOGY

Paraoxonase 2 (PON2) in the mouse central nervous system: A neuroprotective role?

(2011) Gennaro Giordano et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

HDLs inhibit endoplasmic reticulum stress and autophagic response induced by oxidized LDLs

(2010) C Muller et al.   CELL DEATH AND DIFFERENTIATION

Apolipoproteins in the brain: implications for neurological and psychiatric disorders

(2010) David A Elliott et al.   Clinical Lipidology

Apolipoprotein A-I Deficiency Increases Cerebral Amyloid Angiopathy and Cognitive Deficits in APP/PS1ΔE9 Mice

(2010) Iliya Lefterov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of Human Apolipoprotein A-I Preserves Cognitive Function and Attenuates Neuroinflammation and Cerebral Amyloid Angiopathy in a Mouse Model of Alzheimer Disease

(2010) Terry L. Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

(2010) H. H. Feldman et al.   NEUROLOGY

Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer’s disease

(2009) Alex E. Roher et al.   BIOMARKERS

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later

(2009) Alina Solomon et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Pravastatin and cognitive function in the elderly. Results of the PROSPER study

(2009) Stella Trompet et al.   JOURNAL OF NEUROLOGY

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

The Atorvastatin/Donepezil in Alzheimer’s Disease Study (LEADe): Design and baseline characteristics

(2008) Roy W. Jones et al.   Alzheimers & Dementia

Human apolipoprotein A–I binds amyloid-β and prevents Aβ-induced neurotoxicity

(2008) Andréa C. Paula-Lima et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Modulation of paraoxonase 1 and 3 expression after moderate exercise training in the rat

(2008) Rita Romani et al.   JOURNAL OF LIPID RESEARCH

Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity

(2007) Mark R. Wilson et al.   Molecular BioSystems