Tetramethylpyrazine Nitrone Reduces Oxidative Stress to Alleviate Cerebral Vasospasm in Experimental Subarachnoid Hemorrhage Models

A review on the management of cerebral vasospasm following aneurysmal subarachnoid haemorrhage

(2019) Kenny Li et al.   World Neurosurgery

Salvinorin A ameliorates cerebral vasospasm through activation of endothelial nitric oxide synthase in a rat model of subarachnoid hemorrhage

(2018) Juan Sun et al.   MICROCIRCULATION

Tetramethylpyrazine Protects Against Early Brain Injury and Inhibits the PERK/Akt Pathway in a Rat Model of Subarachnoid Hemorrhage

(2018) Zhengkai Shao et al.   NEUROCHEMICAL RESEARCH

Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy

(2018) Gaoxiao Zhang et al.   NEUROMOLECULAR MEDICINE

Fasudil, a Rho-Kinase Inhibitor, Exerts Cardioprotective Function in Animal Models of Myocardial Ischemia/Reperfusion Injury: A Meta-Analysis and Review of Preclinical Evidence and Possible Mechanisms

(2018) Yue-yue Huang et al.   Frontiers in Pharmacology

Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia

(2017) Tao Zhang et al.   NEUROPHARMACOLOGY

Emerging Markers of Early Brain Injury and Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage

(2017) Fawaz Al-Mufti et al.   World Neurosurgery

Resveratrol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage via Inhibition of NLRP3 Inflammasome Activation

(2017) Xiangsheng Zhang et al.   Frontiers in Neuroscience

Safety and effectiveness of microsurgical clipping, endovascular coiling, and stent assisted coiling for unruptured anterior communicating artery aneurysms: a systematic analysis of observational studies

(2016) Anthea H O'Neill et al.   Journal of NeuroInterventional Surgery

Tetramethylpyrazine Nitrone Improves Neurobehavioral Functions and Confers Neuroprotection on Rats with Traumatic Brain Injury

(2016) Gaoxiao Zhang et al.   NEUROCHEMICAL RESEARCH

Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage])

(2016) Daniel Hänggi et al.   STROKE

Paeonol and danshensu combination attenuates apoptosis in myocardial infarcted rats by inhibiting oxidative stress: Roles of Nrf2/HO-1 and PI3K/Akt pathway

(2016) Hua Li et al.   Scientific Reports

Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy

(2016) Zaijun Zhang et al.   Scientific Reports

Methazolamide improves neurological behavior by inhibition of neuron apoptosis in subarachnoid hemorrhage mice

(2016) Mingchang Li et al.   Scientific Reports

Hydrogen Sulfide Ameliorates Early Brain Injury Following Subarachnoid Hemorrhage in Rats

(2015) Yonghua Cui et al.   MOLECULAR NEUROBIOLOGY

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

The role of rosiglitazone in the proliferation of vascular smooth muscle cells after experimental subarachnoid hemorrhage

(2014) Mao-Feng Cheng et al.   ACTA NEUROCHIRURGICA

Cysteamine Alleviates Early Brain Injury Via Reducing Oxidative Stress and Apoptosis in a Rat Experimental Subarachnoid Hemorrhage Model

(2014) Zong-yong Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Melatonin attenuates inflammatory response-induced brain edema in early brain injury following a subarachnoid hemorrhage: a possible role for the regulation of pro-inflammatory cytokines

(2014) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

Astaxanthin Activates Nuclear Factor Erythroid-Related Factor 2 and the Antioxidant Responsive Element (Nrf2-ARE) Pathway in the Brain after Subarachnoid Hemorrhage in Rats and Attenuates Early Brain Injury

(2014) Qi Wu et al.   Marine Drugs

Therapeutic Effects of Multifunctional Tetramethylpyrazine Nitrone on Models of Parkinson’s Disease in Vitro and in Vivo

(2013) Baojian Guo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Signaling pathways involved in the H2O2-induced vasoconstriction of rat coronary arteries

(2013) Elvira Santiago et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage

(2013) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

Delayed neurological deterioration after subarachnoid haemorrhage

(2013) R. Loch Macdonald   Nature Reviews Neurology

Subarachnoid Hemorrhage International Trialists Data Repository (SAHIT)

(2013) R. Loch Macdonald et al.   World Neurosurgery

Early Brain Injury, an Evolving Frontier in Subarachnoid Hemorrhage Research

(2013) Mutsumi Fujii et al.   Translational Stroke Research

Neuroprotective effects of anti-tumor necrosis factor-alpha antibody on apoptosis following subarachnoid hemorrhage in a rat model

(2012) Yong Jiang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Therapeutic effects of tetramethylpyrazine nitrone in rat ischemic stroke models

(2012) Yewei Sun et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Recombinant human erythropoietin (rhEPO) alleviates early brain injury following subarachnoid hemorrhage in rats: Possible involvement of Nrf2–ARE pathway

(2010) Jian Zhang et al.   CYTOKINE

Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following subarachnoid hemorrhage in rats

(2008) Cheng Gao et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke

(2008) Yewei Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mitochondrial dynamics and apoptosis

(2008) D.-F. Suen et al.   GENES & DEVELOPMENT

A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model

(2007) Takashi Sugawara et al.   JOURNAL OF NEUROSCIENCE METHODS