Article
Biochemistry & Molecular Biology
Shriyansh Srivastava, Shubham Yadav, Gaaminepreet Singh, Shamsher Singh Bajwa
Summary: This study investigated the cardioprotective effects of Wnt/β-catenin inhibition on isoproterenol-induced cardiotoxicity. The results showed that inhibiting the Wnt/β-catenin pathway can alleviate pathological manifestations and has antioxidant, anti-inflammatory, and anti-fibrotic effects.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Agriculture, Dairy & Animal Science
Ziqiang Feng, Ichraf Mabrouk, Petunia Msuthwana, Yuxuan Zhou, Yupu Song, Haizhou Gong, Shengyi Li, Changguo Min, Anqi Ju, Aoyi Duan, Jiangting Niu, Jinhong Fu, Xiaomin Yan, Xiaohui Xu, Chuanghang Li, Yongfeng Sun
Summary: This study found that activating the Wnt/beta-catenin signaling pathway can promote the morphogenesis and development of feather follicles in a chick embryo model, and increase the expression of the downstream target LEF1.
Article
Physiology
Sergey N. Arkhipov, D'Anna L. Potter, Regina F. Sultanova, Daria V. Ilatovskaya, Peter C. Harris, Tengis S. Pavlov
Summary: This study found that the development of autosomal dominant polycystic kidney disease (ADPKD) is associated with abnormal expression of Pannexin-1 protein in cystic epithelial cells. Treatment with probenecid, which can inhibit the function of Pannexin-1, improves renal function and slows cyst formation in ADPKD.
PHYSIOLOGICAL REPORTS
(2023)
Article
Oncology
Hui Zhang, Yonghong Wang, Hao Yang, Zhenglan Huang, Xin Wang, Wenli Feng
Summary: TCF7 plays a crucial role in CML imatinib-resistant cells, with its silencing reducing the proliferation of resistant cells. The upregulation of the Wnt/β-catenin and ABC transporter signaling pathways in imatinib-resistant cells can be neutralized by TCF7 knockdown, suggesting that targeting TCF7 may be an effective strategy to overcome imatinib resistance.
Article
Oncology
Xuefang Lin, Yan Chen, Xiabin Ye, Xuemei Xia
Summary: Circular RNA ABCB10 (circ-ABCB10) promotes cell proliferation and invasion, and inhibits apoptosis in epithelial ovarian cancer (EOC) by regulating the miR-1271-mediated Capn4/Wnt/beta-catenin signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Urology & Nephrology
Qiankun Zhang, Hang Fang, Zaihua Zhu
Summary: This study demonstrated that NRBP1 inhibition played an essential role in attenuating hyperuricemia and gout by upregulation of ABCG2 via the Wnt/β-catenin signaling pathway in HK-2 cells.
Article
Urology & Nephrology
Qiankun Zhang, Hang Fang, Zaihua Zhu
Summary: The study demonstrates that NRBP1 inhibition plays a crucial role in reducing hyperuricemia and gout by upregulating ABCG2 through the Wnt/β-catenin signaling pathway.
Article
Cell Biology
Daniel Nouri-Nejada, Brooke L. O'Donnell, Chetan S. Patil, Rafael E. Sanchez-Pupo, Danielle Johnston, Samar Sayedyahossein, Kristina Jurcic, Rebecca Lau, Laszlo Gyenis, David W. Litchfield, Michael F. Jackson, Gregory B. Gloor, Silvia Penuela
Summary: This study investigated the effects of single amino acid changes in various PANX1 domains, revealing a highly conserved ancestral allele and another mutated form found in a melanoma patient tumor, providing insights into the impact of PANX1 on the structure and function of tumor cells.
MOLECULAR BIOLOGY OF THE CELL
(2021)
Article
Cell Biology
Luke T. G. Harland, Claire S. Simon, Anna D. Senft, Ita Costello, Lucas Greder, Ivan Imaz-Rosshandler, Berthold Gottgens, John C. Marioni, Elizabeth K. Bikoff, Catherine Porcher, Marella F. T. R. de Bruijn, Elizabeth J. Robertson
Summary: The study shows that the T-box transcription factor Eomes influences chromatin accessibility at SCL-bound enhancers in the extra-embryonic mesoderm, regulating erythropoiesis and Runx1 expression. Eomes governs the haemogenic competency of ExM and is essential for the normal development of haemogenic endothelium. The findings suggest that haemogenic competence is established earlier during embryonic development than previously thought, with Eomes playing a crucial role in the transcriptional hierarchy of early blood formation.
NATURE CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Samar Sayedyahossein, Kenneth Huang, Zhigang Li, Christopher Zhang, Alexandra M. Kozlov, Danielle Johnston, Daniel Nouri-Nejad, Lina Dagnino, Dean H. Betts, David B. Sacks, Silvia Penuela
Summary: The study revealed a direct interaction between PANX1 and beta-catenin to modulate growth and metabolism in melanoma cells, providing mechanistic insight into melanoma progression. This interaction may be a new component of the Wnt signaling pathway in various contexts.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
C. Brent Wakefield, Vanessa R. Lee, Danielle Johnston, Parastoo Boroumand, Nicolas J. Pillon, Samar Sayedyahossein, Brooke L. O'Donnell, Justin Tang, Rafael E. Sanchez-Pupo, Kevin J. Barr, Robert Gros, Lauren Flynn, Nica M. Borradaile, Amira Klip, Frank Beier, Silvia Penuela
Summary: PANX3 expression in male adult mouse adipose tissue may regulate adipocyte numbers, influencing fat accumulation and inflammation. Male KO mice fed a chow diet had lower body weight and lower fat mass, reduced to the same extent as WT mice with forced exercise, suggesting a potential role of PANX3 in regulating body weight. Additionally, KO mice exhibited a more anti-inflammatory phenotype on a high-fat diet compared to WT mice, with significantly lower expression of multiple pro-inflammatory genes in white adipose tissue.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Abigail G. Wolpe, Melissa A. Luse, Scott R. Johnstone, Jianxiang Xue, Vikram Sabapathy, Brent Wakefield, Rahul Sharma, Kevin Barr, Frank Beier, Dale Laird, Stefanie Redemann, Linda Columbus, Silvia Penuela, Brant E. Isakson
Article
Biochemistry & Molecular Biology
Louise Thines, Laetitia Gorisse, Zhigang Li, Samar Sayedyahossein, David B. Sacks
Summary: The Hippo signaling pathway regulates tissue growth and cell fate, and calmodulin has been identified to promote Hippo signaling by directly interacting with LATS1 and YAP, which activates the Hippo kinase cascade and inhibits YAP activity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Rafael E. Sanchez-Pupo, Brooke L. O'Donnell, Danielle Johnston, Laszlo Gyenis, David W. Litchfield, Silvia Penuela
Summary: Pannexins (PANX) are a family of membrane glycoproteins expressed in the skin. This study found that one variant of PANX2 is abundantly expressed in the skin and plays a role in cell differentiation and cell death.
MOLECULAR BIOLOGY OF THE CELL
(2022)
Article
Multidisciplinary Sciences
Samar Sayedyahossein, Jessica Smith, Elena Barnaeva, Zhigang Li, Jun Choe, Michael Ronzetti, Christopher Dextras, Xin Hu, Juan Marugan, Noel Southall, Bolormaa Baljinnyam, Louise Thines, Andy D. Tran, Marc Ferrer, David B. Sacks
Summary: Small molecules that inhibit the binding between Cdc42 and IQGAP1 have been identified, which could potentially lead to the development of chemotherapeutic agents.
SCIENTIFIC REPORTS
(2022)
Review
Physiology
Brent Wakefield, Silvia Penuela
Summary: Pannexins, expressed in the cardiovascular and musculoskeletal system, play important roles in cell signaling through the release of nucleotides and calcium channel activation. Exercise training has been shown to influence pannexin expression and may have implications in certain diseases.
JOURNAL OF VASCULAR RESEARCH
(2023)
Article
Dermatology
Brooke L. O'Donnell, Rafael E. Sanchez-Pupo, Samar Sayedyahossein, Mehdi Karimi, Mehrnoosh Bahmani, Christopher Zhang, Danielle Johnston, John J. Kelly, C. Brent Wakefield, Kevin Barr, Lina Dagnino, Silvia Penuela
Summary: PANX3 plays crucial roles in maintaining skin architecture, barrier function, keratinocyte differentiation, and inflammatory responses during skin aging.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Proceedings Paper
Acoustics
Mahsa Bataghva, Student Member, Danielle Johnston, Nicholas Power, Aaron Ward, Silvia Penuela, James C. Lacefield
Summary: This study assesses the usefulness of perfusion parameters from different ultrasound images in classifying the anti-angiogenic tumor treatment response. The results indicate that the model with selected parameters from SVD-filtered PD images outperforms other models and can be used as a supplement to conventional PD and CEUS analysis.
2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS)
(2022)