NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

(2018) Joana Catarina Macedo et al.   Nature Communications

Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number

(2018) Katherine I. Farley-Barnes et al.   Cell Reports

Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism

(2017) Daniel D. Scott et al.   NUCLEIC ACIDS RESEARCH

The G-patch protein NF-κB-repressing factor mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis

(2017) Indira Memet et al.   NUCLEIC ACIDS RESEARCH

The nuclear mitotic apparatus protein NuMA controls rDNA transcription and mediates the nucleolar stress response in a p53-independent manner

(2017) Swaathi Jayaraman et al.   NUCLEIC ACIDS RESEARCH

Human NF-κB repressing factor acts as a stress-regulated switch for ribosomal RNA processing and nucleolar homeostasis surveillance

(2017) Marta Coccia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleolar expansion and elevated protein translation in premature aging

(2017) Abigail Buchwalter et al.   Nature Communications

TGFβ/Activin signalling is required for ribosome biogenesis and cell growth inDrosophilasalivary glands

(2017) Torcato Martins et al.   Open Biology

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

(2016) Andreas C. Joerger et al.   Annual Review of Biochemistry

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks

(2016) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

Small nucleoli are a cellular hallmark of longevity

(2016) Varnesh Tiku et al.   Nature Communications

The Evolution of the Ribosomal Protein–MDM2–p53 Pathway

(2016) Chad Deisenroth et al.   Cold Spring Harbor Perspectives in Medicine

The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy

(2015) Simone J. Woods et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation

(2015) Kazuho Nishimura et al.   Cell Reports

Connecting the nucleolus to the cell cycle and human disease

(2014) Robert Y. L. Tsai et al.   FASEB JOURNAL

Transient Activation of p53 in G2 Phase Is Sufficient to Induce Senescence

(2014) Lenno Krenning et al.   MOLECULAR CELL

The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA

(2014) K. E. Sloan et al.   RNA

An overview of pre-ribosomal RNA processing in eukaryotes

(2014) Anthony K. Henras et al.   Wiley Interdisciplinary Reviews-RNA

Nucleolar stress with and without p53

(2014) Allison James et al.   Nucleus

p53 Acts as a Safeguard of Translational Control by Regulating Fibrillarin and rRNA Methylation in Cancer

(2013) Virginie Marcel et al.   CANCER CELL

The nucleolar protein Viriato/Nol12 is required for the growth and differentiation progression activities of the Dpp pathway during Drosophila eye development

(2013) Joana Marinho et al.   DEVELOPMENTAL BIOLOGY

Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing

(2013) Katherine E. Sloan et al.   JOURNAL OF CELL BIOLOGY

5S Ribosomal RNA Is an Essential Component of a Nascent Ribosomal Precursor Complex that Regulates the Hdm2-p53 Checkpoint

(2013) Giulio Donati et al.   Cell Reports

The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress

(2013) Katherine E. Sloan et al.   Cell Reports

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression

(2012) S. Sadasivam et al.   GENES & DEVELOPMENT

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

(2012) S. Bursac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOL11, Implicated in the Pathogenesis of North American Indian Childhood Cirrhosis, Is Required for Pre-rRNA Transcription and Processing

(2012) Emily F. Freed et al.   PLoS Genetics

p53 -Dependent and -Independent Nucleolar Stress Responses

(2012) Karl Holmberg Olausson et al.   Cells

Mdm2–p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin

(2011) Hugh S. Gannon et al.   DEVELOPMENTAL BIOLOGY

Assembly ofSaccharomyces cerevisiae60S ribosomal subunits: role of factors required for 27S pre-rRNA processing

(2011) Aarti Sahasranaman et al.   EMBO JOURNAL

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assembly and disassembly of the nucleolus during the cell cycle

(2011) Danièle Hernandez-Verdun   Nucleus

Specific activation of the p53 pathway by low dose actinomycin D: A new route to p53 based cyclotherapy

(2010) Meng Ling Choong et al.   CELL CYCLE

The Drosophila Nol12 homologue viriato is a dMyc target that regulates nucleolar architecture and is required for dMyc-stimulated cell growth

(2010) J. Marinho et al.   DEVELOPMENT

Perturbation of 60 S Ribosomal Biogenesis Results in Ribosomal Protein L5- and L11-dependent p53 Activation

(2010) Xiao-Xin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

Growth control and ribosome biogenesis

(2009) Harri Lempiäinen et al.   CURRENT OPINION IN CELL BIOLOGY

Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression

(2009) Arne Lindqvist et al.   EMBO JOURNAL

What the nucleolus says to a tumour pathologist

(2009) Massimo Derenzini et al.   HISTOPATHOLOGY

Rrp17p Is a Eukaryotic Exonuclease Required for 5′ End Processing of Pre-60S Ribosomal RNA

(2009) Marlene Oeffinger et al.   MOLECULAR CELL

Depletion of nucleophosmin leads to distortion of nucleolar and nuclear structures in HeLa cells

(2008) Mohammed Abdullahel Amin et al.   BIOCHEMICAL JOURNAL

Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway

(2008) H F Horn et al.   ONCOGENE