Article
Nutrition & Dietetics
Hwa-Young Lee, Geum-Hwa Lee, Hwa-Jin Kim, Young Jae Lim, Bo Mi Ko, Do-Sung Kim, Tae Won Kim, Hye Kyung Kim, Tae Young Kim, Dae Il Hwang, Ha Kyoung Choi, Seon Min Ju, Kyung Hyun Min, Han-Jung Chae
Summary: Activating brown adipose tissue and stimulating white adipose tissue browning is a potential method for obesity treatment. Plant-derived dietary components are the most effective approach to achieve this in rodents. This study found that a combination of Panax ginseng and Diospyros kaki leaf extract can inhibit adipogenesis and induce browning in adipocytes through the AMPK/SIRT1 axis. These findings suggest that the use of Panax ginseng and Diospyros kaki leaf extract may be an important strategy for obesity management.
Article
Endocrinology & Metabolism
D. Halbgebauer, J. Roos, J. B. Funcke, H. Neubauer, B. S. Hamilton, E. Simon, E. Z. Amri, K. M. Debatin, M. Wabitsch, P. Fischer-Posovszky, D. Tews
Summary: This study provides evidence that LTBP3, through TGFI32, plays an important role in promoting brown adipogenesis by modulating UCP1 expression and mitochondrial oxygen consumption. Furthermore, the LTBP3-TGFI32 axis is also implicated in regulating the browning of white adipose tissue.
MOLECULAR METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Hye-Young Joung, Jung-Mi Oh, Min-Suk Song, Young-Bae Kwon, Sungkun Chun
Summary: Obesity is a serious health problem associated with various chronic diseases. Increased MAO activity has been found in the adipose tissue of obese individuals. In this study, the anti-obesity effect of selegiline, a selective MAO-B inhibitor, was investigated using animal models. The results showed that selegiline reduced body weight and fat accumulation, improved glucose metabolism, and increased energy expenditure by promoting browning of white adipose tissue. These findings suggest that selegiline has the potential to be an anti-obesity treatment by inhibiting MAO-B activity.
Review
Nutrition & Dietetics
Danielle L. Avila, Nubia A. M. Nunes, Paulo H. R. F. Almeida, Juliana A. S. Gomes, Carla O. B. Rosa, Jacqueline Alvarez-Leite
Summary: Capsaicin shows promise as an anti-obesity agent, potentially acting through TRPV1 activation and involvement of PPAR pathways. Studies have demonstrated various beneficial effects in obesity models, but further research is needed to elucidate the mechanisms of action.
ADVANCES IN NUTRITION
(2021)
Article
Biology
Seul Gi Lee, Dong Se Kim, Jongbeom Chae, Eunbi Lee, Dongyup Hahn, Il-Kwon Kim, Chang-Jun Kim, Moon Bo Choi, Ju-Ock Nam
Summary: This study provides the first evidence of the anti-obesity effects of Nidus vespae, showing that it can inhibit adipose tissue expansion and preadipocyte differentiation, which could be valuable for the development of new drugs for obesity prevention and treatment.
Article
Nutrition & Dietetics
Do-Sung Kim, Hwa-Young Lee, Hwa-Jin Kim, Geum-Hwa Lee, Young Jae Lim, Bo Mi Ko, Ji-Hyun Kim, Tae Won Kim, Hye Kyung Kim, Tae Young Kim, Dae Il Hwang, Ha Kyoung Choi, Seon Min Ju, Myung Ja Chung, Han-Jung Chae
Summary: This study aims to investigate the synergistic effects and mechanisms of Mori Folium (Morus alba leaf) and Mori Cortex Radicis (Morus alba root cortex) in the treatment of obesity. The results showed that a combination of MF and MR enhanced the expression of brown adipocyte-specific genes and regulated adipocytic dysmetabolism. In vivo experiments confirmed that MF/MR supplementation significantly inhibited weight gain, reduced plasma cholesterol, and improved adipocyte morphology.
Review
Pharmacology & Pharmacy
Xuelian Zhang, Bin Zhang, Chenyang Zhang, Guibo Sun, Xiaobo Sun
Summary: The increasing prevalence of obesity worldwide has led to limited options for effective and safe anti-obesity drugs. Notoginsenosides, derived from traditional Chinese medicine Panax notoginseng, show potential in treating obesity by reducing lipid synthesis and improving insulin sensitivity. Further research is still needed to fully understand the effects and mechanisms of notoginsenosides in combating obesity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Pim P. van Krieken, Timothy S. Odermatt, Marcela Borsigova, Matthias Bluher, Stephan Wueest, Daniel Konrad
Summary: The study investigates the role of gp130 cytokine signaling in white adipose tissue browning in obesity, revealing the regulatory mechanism of gp130 cytokines on Ucp1 expression, providing a new insight for the treatment of obesity.
MOLECULAR METABOLISM
(2021)
Article
Medicine, Research & Experimental
Hui-Chen Ku, Tsai-Yun Chan, Jia-Fang Chung, Yung-Hsi Kao, Ching-Feng Cheng
Summary: The study found that the ATF3 inducer ST32db effectively reduced obesity by inhibiting adipogenesis, activating lipolysis and browning pathways, and reducing fat accumulation in adipocytes. This suggests the therapeutic potential of ST32db in combating obesity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Xionggao Han, Sun-Il Choi, Xiao Men, Se-Jeong Lee, Heegu Jin, Hyun-Ji Oh, Eunjin Kim, Jongwook Kim, Boo-Yong Lee, Ok-Hwan Lee
Summary: The study evaluated the anti-obesity effect of ESETM extract and found that it can inhibit adipogenesis and lipid accumulation, reducing weight change. The results suggest that ESETM may regulate weight through adipogenesis, lipogenesis, lipolysis, and thermogenesis pathways.
APPLIED SCIENCES-BASEL
(2022)
Article
Cell Biology
Joo-Hui Han, Keun-Woo Jang, Min-Ho Park, Chang-Seon Myung
Summary: This study demonstrated thatGarcinia cambogiaextract inhibited mitotic clonal expansion (MCE) by regulating p90RSK, Stat3, and cell cycle proteins, leading to G(0)/G(1) arrest. These findings provide new insight into the mechanism by whichG.cambogiasuppresses adipocyte differentiation and show that p90RSK is critical for adipogenesis as a new molecular target.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ummul Fathima Shaik Mohamed Sayed, Said Moshawih, Hui Poh Goh, Nurolaini Kifli, Gaurav Gupta, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua, Andi Hermansyah, Hooi Leng Ser, Long Chiau Ming, Bey Hing Goh
Summary: Obesity affects more than 10% of the adult population globally. Natural products have the potential to serve as attractive sources for anti-obesity agents because of their ability to alter metabolic processes, stimulate thermogenesis, regulate appetite, inhibit the production of enzymes involved in fat accumulation, enhance insulin sensitivity, and induce adipocyte apoptosis. Research on the mechanisms of action of natural products in energy balance, thermogenesis, and white adipose tissue browning has identified several proteins and pathways that play crucial roles in lipolysis and adipose tissue browning.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Luis Felipe Galvao Valdivia, Erique Castro, Rosangela Aparecida dos Santos Eichler, Mayara Franzoi Moreno, Erica de Sousa, Giovanna Freitas Rodrigues Jardim, Albert Souza Peixoto, Maria Nathalia Moraes, Ana Maria de Lauro Castrucci, Jan Nedergaard, Natasa Petrovic, William T. Festuccia, Patricia Reckziegel
Summary: This study found that cold acclimation and PPARγ agonism combined have additive effects in increasing UCP1 content and thermogenic capacity in brown and beige adipocytes, but do not increase basal energy expenditure.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Multidisciplinary Sciences
Lucas Massier, Jutta Jalkanen, Merve Elmastas, Jiawei Zhong, Tongtong Wang, Pamela A. Nono A. Nankam, Scott Frendo-Cumbo, Jesper Backdahl, Narmadha Subramanian, Takuya Sekine, Alastair G. G. Kerr, Ben T. P. Tseng, Jurga Laurencikiene, Marcus Buggert, Magda Lourda, Karolina Kublickiene, Nayanika Bhalla, Alma Andersson, Armand Valsesia, Arne Astrup, Ellen E. E. Blaak, Patrik L. L. Stahl, Nathalie Viguerie, Dominique Langin, Christian Wolfrum, Matthias Blueher, Mikael Ryden, Niklas Mejhert
Summary: Single-cell studies are conducted on human white adipose tissue (WAT) to understand the different cell types in the tissue. By analyzing multiple datasets, the authors create a comprehensive cellular map of white adipose tissue that includes over 60 subpopulations of adipocytes, fibroblast and adipogenic progenitors, vascular, and immune cells. They also discover associations between specific cell subtypes and metabolic states such as insulin resistance, dyslipidemia, adipocyte volume, and lipolysis. Overall, this meta-map provides valuable information about the cellular and microarchitectural landscape of human WAT.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Chien-Hsieh Chiang, Ching-Yuan Cheng, Yi-Ting Lien, Kuo-Chin Huang, Wan-Wan Lin
Summary: This study demonstrates that P2X7 enhances lipid accumulation during adipogenesis by suppressing the expression of sirtuin-3/5 and the browning genes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Wei Sun, Tao Nie, Kuai Li, Wenjie Wu, Qiaoyun Long, Tianshi Feng, Liufeng Mao, Yuan Gao, Qing Liu, Xuefei Gao, Dewei Ye, Kaixuan Yan, Ping Gu, Yong Xu, Xuemei Zhao, Kang Chen, Kerry Martin Loomes, Shaoqiang Lin, Donghai Wu, Xiaoyan Hui
Summary: This study reveals that deficiency of hepatic CPT1A protects against high-fat diet-induced liver damage and enhances adipose browning. Activation of the peroxisome proliferator-activated receptor alpha-fibroblast growth factor 21 (FGF21) axis in the liver contributes to the improved metabolic state.
Review
Biochemistry & Molecular Biology
Yue Qi, Xiaoyan Hui
Summary: Adipose tissue plays a crucial role in obesity-related pathologies through regulating systemic immunometabolism. It exhibits remarkable plasticity during obesity, affecting tissue morphology, extracellular matrix composition, angiogenesis, immunometabolic balance, and circadian rhythmicity. Dysregulation in these features escalates the pathogenesis caused by adipose tissue. The potential to be reprogrammed appears to be a target for the treatment of obesity and its associated comorbidities.
BIOSCIENCE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Zhiwu Jiang, Lin Cheng, Zhiping Wu, Linfu Zhou, Haitao Wang, Qilan Hong, Qiting Wu, Youguo Long, Yunlin Huang, Gaoqi Xu, Yao Yao, Zhaoyang Tang, Zhenfeng Zhang, Lili Yang, Wei Luo, Jie Yang, Likun Gong, Pentao Liu, Xinwen Chen, Shuzhong Cui, Qi Zhang, Yinxiong Li, Peng Li
Summary: The lack of in vivo models has hindered our understanding of hepatocellular carcinoma (HCC) development. In this study, we used genetic screening in an immunodeficient mouse model to identify oncogenes highly expressed in induced HCC (iHCC) samples. Overexpression of these genes transformed primary human hepatocytes into iHCC. The iHCC model recapitulates histological architecture and gene expression characteristics of clinical HCC samples, providing a biological basis for studying HCC initiation and identifying diagnostic biomarkers and targets for cellular immunotherapy.
Article
Chemistry, Multidisciplinary
Huige Lin, Lin Wang, Zhuohao Liu, Kekao Long, Mengjie Kong, Dewei Ye, Xi Chen, Kai Wang, Kelvin K. L. Wu, Mengqi Fan, Erfei Song, Cunchuan Wang, Ruby L. C. Hoo, Xiaoyan Hui, Philip Hallenborg, Hailong Piao, Aimin Xu, Kenneth K. Y. Cheng
Summary: The E3 ubiquitin ligase MDM2 controls MAFLD by blocking TG-VLDL secretion and targeting ApoB for proteasomal degradation. Inhibition of the MDM2-ApoB interaction may represent a potential therapeutic approach for MAFLD treatment.
Article
Immunology
Diwei Zheng, Xindong Wang, Lin Cheng, Le Qin, Zhiwu Jiang, Ruocong Zhao, Yao Li, Jingxuan Shi, Qiting Wu, Youguo Long, Suna Wang, Zhaoyang Tang, Wei Wei, Jie Yang, Yangqiu Li, Hongsheng Zhou, Qifa Liu, Pentao Liu, Xinwen Chen, Yao Yao, LiHua Yang, Peng Li
Summary: Anti-CCR8 CAR T cells demonstrate potent antitumor activity against ATLL and CCR8(+) tumors, providing a promising therapeutic approach for ATLL and CCR8(+) tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Zhiwu Jiang, Le Qin, Yuou Tang, Rui Liao, Jingxuan Shi, Bingjia He, Shanglin Li, Diwei Zheng, Yuanbin Cui, Qiting Wu, Youguo Long, Yao Yao, Zhihui Wei, Qilan Hong, Yi Wu, Yuanbang Mai, Shixue Gou, Xiaoping Li, Robert Weinkove, Sam Norton, Wei Luo, Weineng Feng, Hongsheng Zhou, Qifa Liu, Jiekai Chen, Liangxue Lai, Xinwen Chen, Duanqing Pei, Thomas Graf, Xingguo Liu, Yangqiu Li, Pentao Liu, Zhenfeng Zhang, Peng Li
Summary: Researchers successfully reprogrammed human T cells into induced T-to-natural killer cells (ITNKs) by inactivating the BCL11B gene. ITNKs showed selective killing of cancer cells and inhibited the growth of solid tumors. Preliminary clinical study demonstrated that autologous administration of ITNKs was well tolerated and led to tumor stabilization in advanced solid tumor patients.
BIOMARKER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yingying Li, Hai Wang, Huangyao Chen, Yuan Liao, Shixue Gou, Quanmei Yan, Zhenpeng Zhuang, Hao Li, Jiaowei Wang, Yangyang Suo, Ting Lan, Yang Liu, Yu Zhao, Qingjian Zou, Tao Nie, Xiaoyan Hui, Liangxue Lai, Donghai Wu, Nana Fan
Summary: Obesity is a strong risk factor for type 2 diabetes. This study found that the CREBRF variant is associated with obesity and reduced risk of T2D in people of Pacific ancestry. By introducing the CREBRF variant into the porcine genome, researchers observed that the variant led to significantly increased fat deposition, mainly in subcutaneous adipose tissue. The variant also promoted preadipocyte differentiation, resulting in a greater number but smaller size of adipocytes in subcutaneous adipose tissue. Additionally, the variant pigs showed reduced oxidative stress in adipose tissue, indicating a relative metabolic protection despite their obesity.
Article
Multidisciplinary Sciences
Le Qin, Yuanbin Cui, Tingjie Yuan, Dongmei Chen, Ruocong Zhao, Shanglin Li, Zhiwu Jiang, Qiting Wu, Youguo Long, Suna Wang, Zhaoyang Tang, Huixia Pan, Xiaoping Li, Wei Wei, Jie Yang, Xuequn Luo, Zhenfeng Zhang, Qiannan Tang, Pentao Liu, Robert Weinkove, Yao Yao, Dajiang Qin, Jean Paul Thiery, Peng Li
Summary: Co-expression of PD-L1-specific chimeric switch receptors (CSRs) improves the antitumor effects of CAR T cells by promoting their differentiation into central memory-like cells.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Tianshi Feng, Xuemei Zhao, Ping Gu, Wah Yang, Cunchuan Wang, Qingyu Guo, Qiaoyun Long, Qing Liu, Ying Cheng, Jin Li, Cynthia Kwan Yui Cheung, Donghai Wu, Xinyu Kong, Yong Xu, Dewei Ye, Shuang Hua, Kerry Loomes, Aimin Xu, Xiaoyan Hui
Summary: Adipocyte tissue macrophages (ATM) are recruited and activated in obesity. Adipocytes release lactate as a signal of inflammation, which can enhance obesity-associated inflammation through direct binding with PHD2. This study reveals the critical role of adipocyte-derived lactate in promoting the pro-inflammatory microenvironment in adipose tissue and identifies PHD2 as a direct sensor of lactate, linking chronic inflammation and energy metabolism.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Shanglin Li, Ruocong Zhao, Diwei Zheng, Le Qin, Yuanbin Cui, Yao Li, Zhiwu Jiang, Mengjun Zhong, Jingxuan Shi, Ming Li, Xindong Wang, Zhaoyang Tang, Qiting Wu, Youguo Long, Duo Hu, Suna Wang, Yao Yao, Shuang Liu, Li-Hua Yang, Zhenfeng Zhang, Qiannan Tang, Pentao Liu, Yangqiu Li, Peng Li
Summary: A novel dual-targeting system utilizing DAP10 chimeric receptor and anti-GPC3 scFv was designed to enhance the efficacy of CAR-T cells against solid tumors, showing successful elimination of heterogeneous cancer cells in vitro and in vivo.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Endocrinology & Metabolism
Ping Gu, Kai Ding, Lei Lu, Yu Zhang, Wei Wang, Qingyu Guo, Yannian Liao, Bingjie Yang, Tiantian Wang, Changsheng Zhou, Bin Lu, Alice P. S. Kong, Alfred S. Cheng, Hannah Xiaoyan Hui, Jiaqing Shao
Summary: This study investigated the expressions of major brown adipose markers in white adipose tissue (WAT) of different ages and their associations with metabolic parameters and key adipokines. The findings suggest that UCP1 and PRDM16 have differential clinical correlations with metabolic features in human WAT in an age-dependent manner. UCP1 and PRDM16 may participate in the pathogenesis of ageing-related metabolic diseases with distinct mechanisms.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shiting Zhao, Tao Nie, Lei Li, Qiaoyun Long, Ping Gu, Yuwei Zhang, Wei Sun, Zexin Lin, Qing Liu, Yue Qi, Wei Wang, Mengyuan Xie, Kerry Loomes, Chenleng Cai, Donghai Wu, Hannah Xiaoyan Hui
Summary: PRDM16 is a dominant activator of brown and beige adipocytes. The regulation of PRDM16 expression is not fully understood. Androgen receptor (AR) is negatively correlated with PRDM16 expression. Sex differences in PRDM16 mRNA expression are observed in human WAT, with females having higher expression than males. Androgen-AR signaling inhibits PRDM16 expression and beige adipocyte browning. AR directly binds to the intronic region of PRDM16, but not to Ucp1 and other browning-related genes. Adipocyte-specific deletion of Ar promotes beige cell biogenesis, while adipocyte-specific overexpression of AR attenuates white adipose beiging.
Article
Multidisciplinary Sciences
Qing Liu, Qiaoyun Long, Jiayu Zhao, Wenjie Wu, Zexin Lin, Wei Sun, Ping Gu, Tuo Deng, Kerry Martin Loomes, Donghai Wu, Alice P. S. Kong, Jingying Zhou, Alfred S. Cheng, Hannah Xiaoyan Hui
Summary: Through transcriptomic profiling at the single-cell and single-nucleus resolution, we reconstructed the cellular atlas in mouse subcutaneous white adipose tissue and revealed the transcriptomes and intercellular cross-talks during brown remodeling. Our findings identified subpopulations in mature adipocytes, adipose stem and progenitor cells, and endothelial cells, and uncovered their interconversion and reprogramming in response to cold. Our data unveil fundamental changes during cold-evoked adipose browning.
Review
Biochemistry & Molecular Biology
Yue Qi, Xiaoyan Hannah Hui
Summary: This review summarizes and evaluates the use of single-cell transcriptomics in the study of cellular plasticity and intercellular crosstalk in thermogenic adipose tissue.
MOLECULES AND CELLS
(2022)
Article
Biochemistry & Molecular Biology
Liufeng Mao, Lijie Peng, Xiaomei Ren, Yi Chu, Tao Nie, Wanhua Lin, Andrew Libby, Yong Xu, Yu Chang, Chong Lei, Kerry Loomes, Na Wang, Jinsong Liu, Moshe Levi, Donghai Wu, Xiaoyan Hui, Ke Ding
Summary: Nonalcoholic fatty liver disease is a prevalent chronic liver disease linked to insulin resistance and reduced fatty acid oxidation. The orphan nuclear receptor ERRa has been identified as a master regulator in energy homeostasis, and improving its function may provide a new option for NAFLD management.
ACS BIO & MED CHEM AU
(2022)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.