Trauma‐induced coagulopathy: The past, present, and future

Harmful or Physiologic

(2018) J. Carolina Gomez-Builes et al.   ANESTHESIA AND ANALGESIA

Platelet transfusion does not improve outcomes in patients with brain injury on antiplatelet therapy

(2018) Jeremy L Holzmacher et al.   BRAIN INJURY

Perhaps It’s Not the Platelet

(2018) Lucy Z Kornblith et al.   Journal of Trauma and Acute Care Surgery

Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial

(2018) Hunter B Moore et al.   LANCET

Relationship of Coagulopathy and Platelet Dysfunction to Transfusion Needs After Traumatic Brain Injury

(2018) Grace Martin et al.   Neurocritical Care

Hemorrhagic Shock

(2018) Jeremy W. Cannon   NEW ENGLAND JOURNAL OF MEDICINE

High-throughput measurement of human platelet aggregation under flow: application in hemostasis and beyond

(2018) Sanne L. N. Brouns et al.   PLATELETS

Endotheliopathy of Trauma is an on-Scene Phenomenon, and is Associated with Multiple Organ Dysfunction Syndrome

(2018) David N. Naumann et al.   SHOCK

Early Identification of the Patient with Endotheliopathy of Trauma by Arrival Serum Albumin

(2018) Erika Gonzalez Rodriguez et al.   SHOCK

Perhaps It’s Not the Platelet

(2018) Lucy Z Kornblith et al.   Journal of Trauma and Acute Care Surgery

Dynamic Coagulability after Injury

(2018) Joshua J. Sumislawski et al.   Journal of Trauma and Acute Care Surgery

Tranexamic Acid Administration is Associated With an Increased Risk of Post-Traumatic Venous Thromboembolism

(2018) Sara P Myers et al.   Journal of Trauma and Acute Care Surgery

Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock

(2018) Jason L. Sperry et al.   NEW ENGLAND JOURNAL OF MEDICINE

THE IMPACT OF HYPOTHERMIA ON OUTCOMES IN MASSIVELY TRANSFUSED PATIENTS

(2018) E.L.W. Lester et al.   Journal of Trauma and Acute Care Surgery

Time Course and Outcomes Associated with Transient Versus Persistent Fibrinolytic Phenotypes After Injury

(2018) Derek J. Roberts et al.   Journal of Trauma and Acute Care Surgery

Tranexamic acid is associated with increased mortality in patients with physiological fibrinolysis

(2017) Hunter B. Moore et al.   JOURNAL OF SURGICAL RESEARCH

Impact of blood products on platelet function in patients with traumatic injuries: a translational study

(2017) Hanne Hee Henriksen et al.   JOURNAL OF SURGICAL RESEARCH

Persistent Fibrinolysis Shutdown Is Associated with Increased Mortality in Severely Injured Trauma Patients

(2017) Jonathan P. Meizoso et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Syndecan-1: A Quantitative Marker for the Endotheliopathy of Trauma

(2017) Erika Gonzalez Rodriguez et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

In vitrocharacterization of SynthoPlate™ (synthetic platelet) technology and itsin vivoevaluation in severely thrombocytopenic mice

(2017) M. Shukla et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Sympathoadrenal activation and endotheliopathy are drivers of hypocoagulability and hyperfibrinolysis in trauma

(2017) Sisse R. Ostrowski et al.   Journal of Trauma and Acute Care Surgery

Characterization of distinct coagulopathic phenotypes in injury

(2017) S. Ariane Christie et al.   Journal of Trauma and Acute Care Surgery

Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator

(2017) Hunter B. Moore et al.   Journal of Trauma and Acute Care Surgery

Rotational thromboelastometry significantly optimizes transfusion practices for damage control resuscitation in combat casualties

(2017) Nicolas J. Prat et al.   Journal of Trauma and Acute Care Surgery

Targeted clinical control of trauma patient coagulation through a thrombin dynamics model

(2017) Amor A. Menezes et al.   Science Translational Medicine

Loss of Syndecan-1 Abrogates the Pulmonary Protective Phenotype Induced by Plasma After Hemorrhagic Shock

(2017) Feng Wu et al.   SHOCK

Platelet adenosine diphosphate receptor inhibition provides no advantage in predicting need for platelet transfusion or massive transfusion

(2017) Gregory R. Stettler et al.   SURGERY

Time for trauma immunology

(2017) Timothy R. Billiar et al.   PLOS MEDICINE

Sympathoadrenal activation and endotheliopathy are drivers of hypocoagulability and hyperfibrinolysis in trauma

(2017) Sisse R. Ostrowski et al.   Journal of Trauma and Acute Care Surgery

Characterization of distinct coagulopathic phenotypes in injury

(2017) S. Ariane Christie et al.   Journal of Trauma and Acute Care Surgery

Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator

(2017) Hunter B. Moore et al.   Journal of Trauma and Acute Care Surgery

Rotational thromboelastometry significantly optimizes transfusion practices for damage control resuscitation in combat casualties

(2017) Nicolas J. Prat et al.   Journal of Trauma and Acute Care Surgery

In Vivo Biosensing: Progress and Perspectives

(2017) Guoxin Rong et al.   ACS Sensors

Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy

(2016) Eduardo Gonzalez et al.   ANNALS OF SURGERY

Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va

(2016) H. Deguchi et al.   BLOOD

Effects of an acidic environment on coagulation dynamics

(2016) M. Gissel et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Modulating the endotheliopathy of trauma

(2016) Shibani Pati et al.   Journal of Trauma and Acute Care Surgery

Ex vivo recapitulation of trauma-induced coagulopathy and preliminary assessment of trauma patient platelet function under flow using microfluidic technology

(2016) Ruizhi Li et al.   Journal of Trauma and Acute Care Surgery

Inducing Acute Traumatic Coagulopathy In Vitro: The Effects of Activated Protein C on Healthy Human Whole Blood

(2016) Benjamin M. Howard et al.   PLoS One

Platelets regulate vascular endothelial stability: assessing the storage lesion and donor variability of apheresis platelets

(2016) Gyulnar Baimukanova et al.   TRANSFUSION

New understandings of post injury coagulation and resuscitation

(2016) Mitchell Jay Cohen et al.   International Journal of Surgery

Ex vivo recapitulation of trauma-induced coagulopathy and preliminary assessment of trauma patient platelet function under flow using microfluidic technology

(2016) Ruizhi Li et al.   Journal of Trauma and Acute Care Surgery

Modulating the endotheliopathy of trauma

(2016) Shibani Pati et al.   Journal of Trauma and Acute Care Surgery

Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma

(2015) John B. Holcomb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Platelet-derived HMGB1 is a critical mediator of thrombosis

(2015) Sebastian Vogel et al.   JOURNAL OF CLINICAL INVESTIGATION

Shock releases bile acidinducing platelet inhibition and fibrinolysis

(2015) Gregory Wiener et al.   JOURNAL OF SURGICAL RESEARCH

Thrombin generation and procoagulant microparticle profiles after acute trauma

(2015) Myung S. Park et al.   Journal of Trauma and Acute Care Surgery

Syndecan-1 restitution by plasma after hemorrhagic shock

(2015) Rosemary A. Kozar et al.   Journal of Trauma and Acute Care Surgery

Statistical Machines for Trauma Hospital Outcomes Research: Application to the PRospective, Observational, Multi-Center Major Trauma Transfusion (PROMMTT) Study

(2015) Sara E. Moore et al.   PLoS One

Thrombin generation and procoagulant microparticle profiles after acute trauma

(2015) Myung S. Park et al.   Journal of Trauma and Acute Care Surgery

Syndecan-1 restitution by plasma after hemorrhagic shock

(2015) Rosemary A. Kozar et al.   Journal of Trauma and Acute Care Surgery

The Natural History and Effect of Resuscitation Ratio on Coagulation After Trauma

(2014) Matthew E. Kutcher et al.   ANNALS OF SURGERY

Increasing Trauma Deaths in the United States

(2014) Peter Rhee et al.   ANNALS OF SURGERY

Toll-Like Receptor 4 Regulates Platelet Function and Contributes to Coagulation Abnormality and Organ Injury in Hemorrhagic Shock and Resuscitation

(2014) N. Ding et al.   Circulation-Cardiovascular Genetics

Measuring thrombin generation as a tool for predicting hemostatic potential and transfusion requirements following trauma

(2014) Jessica C. Cardenas et al.   Journal of Trauma and Acute Care Surgery

Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown

(2014) Hunter B. Moore et al.   Journal of Trauma and Acute Care Surgery

Fibrinogen and platelet contributions to clot formation

(2014) Lucy Z. Kornblith et al.   Journal of Trauma and Acute Care Surgery

Superactivated Platelets

(2013) Marshall Mazepa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS)

(2013) S. Gando et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Time-dependent prediction and evaluation of variable importance using superlearning in high-dimensional clinical data

(2013) Alan Hubbard et al.   Journal of Trauma and Acute Care Surgery

Platelet activation and dysfunction in a large-animal model of traumatic brain injury and hemorrhage

(2013) Martin Sillesen et al.   Journal of Trauma and Acute Care Surgery

Injuries

(2013) Robyn Norton et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of the red cell membrane in thrombin generation

(2013) Matthew F. Whelihan et al.   THROMBOSIS RESEARCH

Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes

(2012) C. ROURKE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy

(2012) Sisse R. Ostrowski et al.   Journal of Trauma and Acute Care Surgery

Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration

(2012) Bryan A. Cotton et al.   Journal of Trauma and Acute Care Surgery

Characterization of platelet dysfunction after trauma

(2012) Matthew E. Kutcher et al.   Journal of Trauma and Acute Care Surgery

Extracellular histone release in response to traumatic injury

(2012) Matthew E. Kutcher et al.   Journal of Trauma and Acute Care Surgery

Early Complementopathy After Multiple Injuries in Humans

(2012) Anne-Maud Burk et al.   SHOCK

Critical Role of Activated Protein C in Early Coagulopathy and Later Organ Failure, Infection and Death in Trauma Patients

(2011) Mitchell Jay Cohen et al.   ANNALS OF SURGERY

A Normal Platelet Count May Not Be Enough: The Impact of Admission Platelet Count on Mortality and Transfusion in Severely Injured Trauma Patients

(2011) Lisa M. Brown et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Pathophysiology of Early Trauma-Induced Coagulopathy: Emerging Evidence for Hemodilution and Coagulation Factor Depletion

(2011) Beth H. Shaz et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Clotting Factor Deficiency in Early Trauma-Associated Coagulopathy

(2011) Sandro B. Rizoli et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

High circulating adrenaline levels at admission predict increased mortality after trauma

(2011) Pär Ingemar Johansson et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Early Release of Soluble Receptor for Advanced Glycation Endproducts After Severe Trauma in Humans

(2010) Mitchell J. Cohen et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Protective Effects of Fresh Frozen Plasma on Vascular Endothelial Permeability, Coagulation, and Resuscitation After Hemorrhagic Shock Are Time Dependent and Diminish Between Days 0 and 5 After Thaw

(2010) Shibani Pati et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Angiopoietin-2, Marker and Mediator of Endothelial Activation With Prognostic Significance Early After Trauma?

(2009) Michael T. Ganter et al.   ANNALS OF SURGERY

INCREASE IN ACTIVATED PROTEIN C MEDIATES ACUTE TRAUMATIC COAGULOPATHY IN MICE

(2009) Brian B. Chesebro et al.   SHOCK

TRANSFUSION PRACTICE: Thrombin generation in trauma patients

(2009) Nancy M. Dunbar et al.   TRANSFUSION

Regulation of endothelial barrier function by reactive oxygen and nitrogen species

(2008) Adel Boueiz et al.   MICROVASCULAR RESEARCH