Article
Plant Sciences
Alexander P. Sukhorukov, Maya V. Nilova, Maria Kushunina, Yuri Mazei, Cornelia Klak
Summary: The family Aizoaceae is a diverse group of plants, with around 1880 species, particularly in arid areas of southern Africa. These plants have evolved special reproductive adaptations to survive in harsh climatic conditions. The study focused on the anatomical features, evolutionary trends, and ecological significance of the seeds of 132 species from 61 genera. Several diagnostic characters were identified and added to the list of characteristics distinguishing major clades within the family.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Otorhinolaryngology
Mina N. Le, Beverly R. Wuertz, Merrill A. Biel, Rachel L. Thompson, Frank G. Ondrey
Summary: This study found that photodynamic therapy (PDT) with methylene blue can downregulate matrix metalloproteinases (MMPs) related to oral carcinoma. These results suggest that methylene blue PDT could be a clinically significant and cost-effective treatment for oral leukoplakia and carcinoma.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Joice Maely Souza da Silva, Adriana de Oliveira Camargo Gomes, Hilton Justino da Silva, Silvio Jose de Vasconcelos, Maria das Gracas Wanderley de Sales Coriolano, Zulina Souza de Lira
Summary: The flexible resonance tube vocal technique improved voice quality in individuals with PD and showed correlation with vocal intensity and frequency parameters.
Article
Dentistry, Oral Surgery & Medicine
Jin-Young Park, Kyu-Jin Hong, Kyung-A Ko, Jae-Kook Cha, Reinhard Gruber, Jung-Seok Lee
Summary: This study demonstrates that the use of PRF in bone regeneration performs comparably to the established GBR procedure in terms of the consolidation of DPBM.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Otorhinolaryngology
Ignacio Javier Fernandez, Federico Spagnolo, Leonardo Roncadi, Giulia Molinari, Daniele Marchioni, Livio Presutti, Daniela Lucidi
Summary: Primary mucosal melanoma of the larynx is a rare type of head and neck cancer. The optimal treatment for this disease is still debated, with surgery and systemic therapy showing some efficacy, but the prognosis remains poor.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Oncology
Andrea Costantino, Claudio Sampieri, Francesca Pirola, Da Hee Kim, Kyuin Lee, Young Min Park, Armando De Virgilio, Se-Heon Kim
Summary: This retrospective cohort study aimed to determine if positive and close surgical margins are associated with worse prognosis in patients who underwent transoral robotic surgery after neoadjuvant chemotherapy. The results showed that positive margins were not independently predictive of tumor control and survival. A threshold of 1.25 mm was identified as the most appropriate to define close margins, but no difference was measured between close and wide negative margins.
Article
Biology
Casey Paquola, Jessica Royer, Lindsay B. Lewis, Claude Lepage, Tristan Glatard, Konrad Wagstyl, Jordan DeKraker, Paule-J Toussaint, Sofie L. Valk, Louis Collins, Ali R. Khan, Katrin Amunts, Alan C. Evans, Timo Dickscheid, Boris Bernhardt
Summary: This paper introduces a toolbox called "BigBrainWarp" aimed at simplifying the workflow of integrating histological atlases of the human brain with multi-modal neuroimaging and promoting the adoption of best practices. The toolbox provides a simple wrapper function for users to easily map data between BigBrain and standard MRI spaces, automatically pulling specialized transformation procedures based on a wide collaborative network of researchers to support multi-scale brain organization investigations.
Review
Biochemistry & Molecular Biology
Claudio Tana, David Garcia Azorin, Francesco Cinetto, Cesare Mantini, Marco Tana, Massimo Caulo, Fabrizio Ricci, Paolo Martelletti, Francesco Cipollone, Maria Adele Giamberardino
Summary: Migraine and sarcoidosis may share some common biological and clinical pathways. Both conditions involve inflammation and immune system dysregulation. Migraine is a common comorbidity in sarcoidosis patients, and there have been reports of individuals with neurosarcoidosis experiencing migraines. The exact relationship between the two disorders is still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Multidisciplinary Sciences
Orsolya Barabas, Phoebe A. A. Rice
Summary: CRISPR-Cas is a bacterial defense system that can either protect host cells by attacking invading DNA or assist in the safe insertion of DNA into the genome. The structures of this specific type of CRISPR-Cas system have been successfully visualized.
Editorial Material
Multidisciplinary Sciences
Felicia Kuperwaser, Itai Yanai
Summary: A comprehensive cell atlas of gene expression and regulation in human embryos has provided a unique opportunity for innovative investigation of development through multi-organ and multi-modal analysis.
Editorial Material
Multidisciplinary Sciences
Fahad Rashid, James Berger
Summary: High-resolution structures of bacterial Rho protein in complex with an RNA polymerase enzyme and partner proteins confirm the long-held model of Rho's role in gene transcription termination.
Article
Medicine, Research & Experimental
Craig A. Bollig, Christopher I. Newberry, Tabitha L. I. Galloway, Robert P. Zitsch, Elyse K. Hanly, Vivian L. Zhu, Nitin Pagedar, Rohit Nallani, Andres M. Bur, William C. Spanos, Jeffrey B. Jorgensen
Summary: The site and pattern of distant metastasis were found to impact overall survival in head and neck cancer patients, with bone and polymetastatic disease associated with poorer prognosis.
Editorial Material
Multidisciplinary Sciences
Pavel V. Baranov, John F. Atkins
Summary: Messenger RNA has 64 possible codons, three of which usually stop protein synthesis. However, certain organisms can utilize all codons to determine amino acids, partially due to an unexpected characteristic of transfer RNA.
Editorial Material
Multidisciplinary Sciences
Leonid A. Mirny
Summary: The study reveals that loop extrusion, essential for chromosome folding and function, also plays a crucial part in repairing double-strand DNA breaks.
Review
Immunology
Malgorzata Wierzbicka, Jens Peter Klussmann, Michel R. San Giorgi, Nora Wuerdemann, Frederik G. Dikkers
Summary: Oral and laryngeal HPV infection occurs in majority of sexually active individuals at least once; difficulties in identifying asymptomatic carriers; specific sexual behavior increases risk for oropharyngeal cancer.
Article
Otorhinolaryngology
Xavier Leon, Maria del Prado Venegas, Maria Casasayas, Camilo Rodriguez, Eduard D. Neumann, Anna Holgado, Miquel Quer
Summary: This study found that the nodal yield in elective neck dissections in patients without evidence of lymph node disease had prognostic capacity depending on the location of the primary tumor, with significant impact on disease-specific mortality for tumors located in the oral cavity, oropharynx, and hypopharynx. However, for tumors located in the larynx, the number of dissected nodes did not significantly influence the prognosis.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Joan Lop, Maria del Prado Venegas, Albert Pujol, Blanca Sauter, Rosselin Vasquez, Maria Casasayas, Miquel Quer, Xavier Leon
Summary: Patients with head and neck squamous cell carcinoma (HNSCC) face long-term mortality risks post-treatment, with causes of death including the primary tumor, second or successive neoplasms, and non-cancer reasons. Mortality shifts from primary tumor-related to competing causes over time during follow-up. Understanding how patient characteristics impact mortality patterns can help optimize clinical management protocols.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Xavier Leon, Jacinto Garcia, Albert Pujol, Julia de Juan, Rosselin Vasquez, Miquel Quer, Mercedes Camacho
Summary: This study analyzed the relationship between the transcriptional expression of PIM-1 and local response to radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC). The results showed that patients with elevated transcriptional expression levels of PIM-1 had a significantly higher risk of local recurrence after radiotherapy.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Maria Casasayas, Jacinto Garcia-Lorenzo, Beatriz Gomez-Anson, Victoria Medina, Alejandro Fernandez, Miquel Quer, Xavier Leon
Summary: This study demonstrated that assessing skeletal muscle mass (SMM) from the computed tomography image of the 3rd cervical vertebra (C3) can predict the risk of pharyngocutaneous fistula (PCF) formation after total laryngectomy (TL). Low SMM was significantly associated with a higher risk of PCF, and sarcopenia was more common in underweight patients, those undergoing extended surgeries, or presenting preoperative anemia or hypoalbuminemia.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Oncology
Elisa Rioja-Blanco, Irene Arroyo-Solera, Patricia Alamo, Isolda Casanova, Alberto Gallardo, Ugutz Unzueta, Naroa Serna, Laura Sanchez-Garcia, Miquel Quer, Antonio Villaverde, Esther Vazquez, Xavier Leon, Lorena Alba-Castellon, Ramon Mangues
Summary: Novel therapeutic strategies are urgently needed for HNSCC patients with therapy resistance. T22-PE24-H6 and T22-DITOX-H6 nanotoxins show promising potential for the treatment of HNSCC by specifically targeting CXCR4-overexpressing cells and triggering caspase-3/GSDME-dependent pyroptosis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Otorhinolaryngology
M. Casasayas, A. Sansa, J. Garcia-Lorenzo, M. del Prado Venegas, M. Quer, X. Leon
Summary: This study found that there were no significant differences in the pharyngocutaneous fistula rate after total laryngectomy depending on the previous treatment with radiotherapy or chemoradiotherapy, or depending on the interval between radiotherapy treatment and surgery. Patients who received chemoradiotherapy required surgical repair more frequently.
JOURNAL OF LARYNGOLOGY AND OTOLOGY
(2022)
Article
Pharmacology & Pharmacy
Elisa Rioja-Blanco, Irene Arroyo-Solera, Patricia Alamo, Isolda Casanova, Alberto Gallardo, Ugutz Unzueta, Naroa Serna, Laura Sanchez-Garcia, Miquel Quer, Antonio Villaverde, Esther Vazquez, Ramon Mangues, Lorena Alba-Castellon, Xavier Leon
Summary: This study validates the potential use of T22-GFP-H6 as a nanocarrier to selectively deliver drugs to CXCR4(+) tumors in HNSCC, showing promising therapeutic effects without causing histological alterations in normal organs.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Medicine, Research & Experimental
Fernando Lopez, Jatin P. Shah, Jonathan J. Beitler, Carl H. Snyderman, Valerie Lund, Cesare Piazza, Antti A. Makitie, Orlando Guntinas-Lichius, Juan P. Rodrigo, Luiz P. Kowalski, Miquel Quer, Ashok Shaha, Akihiro Homma, Alvaro Sanabria, Renata Ferrarotto, Anne W. M. Lee, Victor H. F. Lee, Alessandra Rinaldo, Alfio Ferlito
Summary: Endoscopic endonasal surgery is an effective treatment for selected cases of sinonasal cancers, but there is still debate in some cases. Based on the available literature, this surgery allows for safe resection of selected lesions with decreased morbidity, but when contraindicated, craniofacial and transfacial approaches remain the best option.
ADVANCES IN THERAPY
(2022)
Article
Pharmacology & Pharmacy
Elisa Rioja-Blanco, Alberto Gallardo, Irene Arroyo-Solera, Patricia Alamo, Isolda Casanova, Ugutz Unzueta, Naroa Serna, Laura Sanchez-Garcia, Miquel Quer, Antonio Villaverde, Esther Vazquez, Xavier Leon, Lorena Alba-Castellon, Ramon Mangues
Summary: This study developed a novel protein nanoparticle, T22-DITOX-H6, which selectively delivers the diphtheria toxin cytotoxic domain to CXCR4(+) HNSCC cells. The nanoparticles effectively blocked tumor metastasis and recurrence without causing off-target toxicity.
Review
Otorhinolaryngology
Carlos M. Chiesa-Estomba, Jose A. Gonzalez-Garcia, Eric M. Genden, Cesare Piazza, Orlando Guntinas-Lichius, Vincent Vander-Poorten, Luiz P. Kowalski, Fernando Lopez, Miquel Quer, Juan P. Rodrigo, Alvaro Sanabria, Veronica Fernandez-Alvarez, Carlos Suarez, Oded Cohen, Remco de Bree, Ashok R. Shaha, Antti A. Makitie, Alfio Ferlito
Summary: This study systematically reviewed and qualitatively analyzed methods for vascular perfusion assessment in Head and Neck microsurgical reconstruction. The results indicated that Cook-Swartz IDP is a safe and effective device. Further detailed prospective registration is needed to accurately evaluate results and complications.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Xavier Leon, Gerard Pujals, Blanca Sauter, Eduard Neumann, Albert Pujol, Miquel Quer
Summary: This study aimed to analyze the differential characteristics of HNSCC patients without a history of toxic substance consumption. Through a retrospective study of 4,694 HNSCC patients treated in our center from 1985 to 2019, it was found that 7.7% of patients did not report a history of toxic substance consumption. Patients without a toxic history were older, had a higher proportion of women, a higher frequency of cases located in the oral cavity, a higher proportion of early-stage diagnoses, and a lower incidence of second neoplasms. The overall survival of patients without a history of toxic substance consumption was significantly higher than that of patients with toxic substance use.
ACTA OTORRINOLARINGOLOGICA ESPANOLA
(2023)
Article
Otorhinolaryngology
Aina Sansa, Cristina Valero, Anna Holgado, Rosselin Vasquez, Miquel Quer, Snehal G. Patel, Xavier Leon
Summary: This study validates the prognostic capacity of the H-index in patients with HNSCC, regardless of the primary tumor location, disease extent, or treatment performed.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Biochemistry & Molecular Biology
Noemi Tomsen, Omar Ortega, Daniel Alvarez-Berdugo, Laia Rofes, Pere Clave
Summary: This study compared the effects of increasing bolus viscosity and using TRPV1, TRPA1, or TRPM8 agonists on the swallow response in patients with oropharyngeal dysphagia (OD). The results showed that fluid thickening and substances like capsaicin and piperine significantly improved swallow safety and speed, providing potential candidates for the development of new pharmacological strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Otorhinolaryngology
O. Laccourreye, H. Mirghani, S. Guiquerro, M. Quer, P. Giraud
Summary: This study evaluated the perception of the survival/laryngeal preservation trade-off in advanced T-stage laryngeal cancer. The findings showed that some patients had difficulty making a decision between treatment options, while others preferred to prioritize laryngeal preservation over survival. Factors such as patient status, occupation, and treatment data were found to influence the perception of trade-off.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2023)
Article
Oncology
Mercedes Camacho, Xavier Leon, Albert Pujol, Laura Montezuma, Miquel Quer, Jacinto Garcia
Summary: This study found a significant association between the transcriptional expression of the FNDC4 gene and prognosis in head and neck cancer patients. Patients with elevated FNDC4 expression had lower disease-specific survival rates.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
