Review
Chemistry, Multidisciplinary
Emmanuel Oheix, Edmond Gravel, Eric Doris
Summary: Research on decontaminating sulfur mustard chemical warfare agent aims to neutralize ammunition, clean affected areas, and develop protective equipment. Different chemical routes, including catalytic procedures, are used to convert sulfur mustard into harmless products.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Inorganic & Nuclear
Beitong Zhu, Ruilong Sheng, Tianhong Chen, Joao Rodrigues, Qin-Hua Song, Xichao Hu, Lintao Zeng
Summary: This review comprehensively summarizes the recent innovations regarding reaction sites, working mechanisms, and sensing properties of various molecular engineered optical probes for chemical warfare agents (CWAs). It emphasizes the fundamental principles and strategies for designing sensitive and selective optical probes and proposes future directions for molecular engineered probes in sensing CWAs.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Analytical
Wei Feng, Hao Li, Min-Jie Xue, Qiao-Li Zhang, Shi-Lei Liu, Qin-Hua Song
Summary: In this study, four quinoline-2-thiones were developed as fluorescent probes for the rapid and sensitive detection of sulfur mustard gas and its analogues. The probes exhibited high sensitivity and selectivity, showing potential application in the field detection of mustard gas.
ANALYTICA CHIMICA ACTA
(2021)
Article
Engineering, Environmental
Tobias Kloeffel, Diana Gordon, Stanislaw Popiel, Jakub Nawala, Bernd Meyer, Pawel Rodziewicz
Summary: After World War II, the Baltic Sea became highly polluted with unused sulfur mustard and chemical warfare agents, posing a significant environmental threat. This study combines experimental and theoretical methods to investigate the reactivity of sulfur mustard in water, focusing on hydrolysis, a key reaction for its neutralization. Molecular dynamics simulations and gas chromatography-mass spectrometry experiments are used to understand the formation of sulfonium cations and the decomposition of sulfur mustard in water solution.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)
Article
Chemistry, Analytical
Mei Li, Shuang Wang, Chuting Xu, Huiwen Ruan, Weiguo Wang, Chuang Chen, Haiyang Li
Summary: A parallel coupling apparatus combining ion mobility spectrometry and ion trap MS (p-IMS-ITMS) was developed to enhance the detection rate and time response capability of a stand-alone ITMS system for efficient chemical tracking.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Hafiz Ali Rizwan, Muhammad Usman Khan, Abdul Hamid, Junaid Yaqoob, Riaz Hussain, Saeed Ahmed, Manawwer Alam
Summary: This research investigates the efficiency of nanostructured Al24N24 as a sensor for rapid detection and sensing of phosgene and mustard chemical warfare agents. Analysis of adsorption capabilities of Al(24)N(24-)nanocage using various techniques reveals that it has the strongest adsorption energy for mustard gas. The study of Frontier molecular orbitals shows that adsorption of phosgene and mustard gas reduces the energy gap of Al24N24 nanocage. Furthermore, the adsorption of phosgene results in a better sensing response and quicker recovery time.
COMPUTATIONAL AND THEORETICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Min-Jie Xue, Xiu-Zhi Wei, Wei Feng, Zhong-Fang Xing, Shi-Lei Liu, Qin-Hua Song
Summary: Two fluorescent probe molecules have been developed for rapid and sensitive detections of mustard gas and its analogues in both solutions and gas phase. The method can quickly detect mustard gas at 60 degrees Celsius with high sensitivity and excellent stability in the detection systems.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Analytical
Xiangui Ma, Mengmeng Lv, Fangxin Du, Cunqi Wu, Baohua Lou, Abdallah M. Zeid, Guobao Xu
Summary: Mustard compounds are both highly toxic chemical warfare agents and potential anticancer drugs. Therefore, the development of fast, selective, and sensitive detection methods for mustards is crucial for both public security and cancer therapy. In this study, the dimeric G4 DNA was used as a selective probe for ultrasensitive fluorescence detection of nitrogen mustard (NM).
ANALYTICAL CHEMISTRY
(2022)
Article
Spectroscopy
Fredrik Kullander, Lars Landstroem
Summary: UV Raman spectroscopy was used to measure the spectra of low volatile chemical warfare agents on silicon surfaces, with emphasis on the ratio of Raman scattering to laser excitation. The results show potential for increased efficiency and enhanced detection using UV excitation.
JOURNAL OF RAMAN SPECTROSCOPY
(2022)
Article
Nanoscience & Nanotechnology
Victoria G. Snider, Rawan Alshehri, Rachel M. Slaugenhaupt, Craig L. Hill
Summary: This article presents a system for catalytic removal of the HD simulant CEES in air, using HCPs to sequester CEES and an oxidation system to catalyze its conversion to a less-toxic sulfoxide.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Pharmacology & Pharmacy
Christopher M. Timperley, Jonathan E. Forman, Mohammad Abdollahi, Abdullah Saeed Al-Amri, Augustin Baulig, Djafer Benachour, Veronica Borrett, Flerida A. Carino, Christophe Curty, Michael Geist, David Gonzalez, William Kane, Zrinka Kovarik, Roberto Martinez-Alvarez, Nicia Maria Fusaro Mourao, Slawomir Neffe, Syed K. Raza, Valentin Rubaylo, Alejandra Graciela Suarez, Koji Takeuchi, Cheng Tang, Ferruccio Trifiro, Francois Mauritz van Straten, Paula S. Vanninen, Slavica Vucinic, Volodymyr Zaitsev, Muhammad Zafar-Uz-Zaman, Mongia Said Zina, Stian Holen, Wesam S. Alwan, Vivek Suri, Peter J. Hotchkiss, Mostafa Ghanei
Summary: The article summarizes the damage caused by blister agents to the skin, eyes, and mucous membranes, as well as the toxicological properties of sulfur mustard and its treatments. This information should be helpful for medical personnel and emergency responders who may encounter sulfur mustard exposure.
Article
Materials Science, Biomaterials
Siyuan Zhou, Yi Chen, Jie Xu, Yongfei Yin, Jianqing Yu, Wei Liu, Shigui Chen, Lu Wang
Summary: In this study, a supramolecular antidote to nitrogen mustard (NM) was developed by complexation of NM with carboxylatopillar[5]arene potassium salts (CP[5]AK). The results showed that CP[5]AK could effectively encapsulate NM and its toxic intermediate, providing protection against DNA and protein damage caused by NM. Both in vitro and in vivo experiments demonstrated that CP[5]AK had a good therapeutic effect on NM-induced skin injuries.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Nankai Song, Xuan Zhang, Yang Si, Jianyong Yu, Bin Ding
Summary: A scalable strategy was reported to fabricate chemical protective fabric (CPF) with a biomimetic extracellular matrix (ECM) barrier layer. The resulting CPF exhibited superior waterproofness, breathability, recoverable deformation, high-cycle fatigue resistance, and superior barrier performance. This research provides an important foundation for developing chemical protective clothing in the future.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Ophthalmology
Patrick McNutt
Summary: Sulfur mustard (SM) is a highly dangerous chemical weapon that can cause mass casualties through liquid or vapor exposure. The cornea is particularly sensitive to SM toxicity, and even low vapor doses can result in incapacitating acute injuries. Despite extensive research, there are currently no specific treatments for acute or persistent ocular SM injuries.
EXPERIMENTAL EYE RESEARCH
(2023)
Review
Chemistry, Applied
Xichao Hu, Yingjun Ke, Huan Ye, Beitong Zhu, Joao Rodrigues, Ruilong Sheng
Summary: In this review, the recent progress of various fluorescent probes for phosgene and mustard gas detection is introduced, including recognition sites, sensing mechanisms, and structure-function relationships. Furthermore, the challenges and perspectives of fluorescent probes for chemical warfare agents are briefly stated. We hope this review will provide constructive information for the development of the most advanced fluorescent probes towards CWAs.
Article
Environmental Sciences
Marzieh Daniali, Maryam Baeeri, Ramtin Farhadi, Mahdi Gholami, Shokoufeh Hassani, Mona Navaei-Nigjeh, Mahban Rahimifard, Mohammad Abdollahi
Summary: This study demonstrates the potential role of metformin in alleviating the adverse effects of CPF toxicity on the nervous system. Metformin shows protective potential in modulating inflammation, oxidative stress, gene expression, and histological analysis.
Article
Engineering, Biomedical
Mona Navaei-Nigjeh, Soheyl Mirzababaei, Mohammad Adel Ghiass, Kaveh Roshanbinfar, Mahdi Gholami, Mohammad Abdollahi
Summary: Islet-laden fibers generated with microfluidic technology can protect pancreatic islet cells from the immune response. Adding mesenchymal stromal cells (MSCs) improves cell function and suppresses the immune response in diabetic rats, leading to better treatment outcomes.
Review
Pharmacology & Pharmacy
Taraneh Mousavi, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: With the rise in aging population and chronic diseases, the use and abuse of opioids have increased worldwide, leading to an increase in opioid-related adverse events, specifically opioid-induced bowel dysfunction. This calls for a rational clinical management strategy.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Mahban Rahimifard, Maryam Baeeri, Taraneh Mousavi, Asaad Azarnezhad, Hamed Haghi-Aminjan, Mohammad Abdollahi
Summary: Gastric cancer is a medical dilemma with a high economic and global burden. Conventional chemotherapy regimens containing cisplatin have limited effectiveness and cause adverse drug reactions. This study tested the biological efficacy of the cisplatin-resveratrol combination.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Mahmood Alizadeh Sani, Gholamreza Jahed-Khaniki, Ali Ehsani, Nabi Shariatifar, Mohammad Hadi Dehghani, Mohammad Hashemi, Hedayat Hosseini, Mohammad Abdollahi, Shokoufeh Hassani, Zahra Bayrami, David Julian McClements
Summary: A simple, label-free, and ultra-sensitive fluorescent platform based on a metal-organic framework (MOF) was developed to detect melamine in milk powder. The fluorescence sensor was fabricated from sensitized terbium (Tb)@NH2-MIL-253 (Al) MOF using a hydrothermal method. It showed high accuracy, sensitivity, and reproducibility compared to the high-performance liquid chromatography (HPLC) method. The sensor had a linear range and lower limit of detection (LLOD) much lower than the maximum residual level (MRL) for melamine detection in infant formula and other foods/feeds.
Article
Engineering, Environmental
Farzaneh Kefayati, Atoosa Karimi Babaahmadi, Taraneh Mousavi, Mahshid Hodjat, Mohammad Abdollahi
Summary: Environmental toxicants can regulate gene expression through epigenetic mechanisms. This article discusses the impact of three epigenetic modifications on seven important categories of diseases and the influence of eleven main environmental factors on epigenetic modifications. These epigenetic-related mechanisms play a crucial role in the development of common diseases, aiding in diagnosis and treatment, as well as predicting transgenerational and intergenerational effects. However, more well-designed research is needed to determine the precise role of environmentally-induced epigenetic alterations in disease etiology.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2023)
Article
Toxicology
Marzieh Daniali, Mona Navaei-Nigjeh, Maryam Baeeri, Soheyl Mirzababaei, Mahdi Gholami, Mahban Rahimifard, Mohammad Abdollahi
Summary: In this study, the protective effects of Levosimendan (LEVO) on pancreatic islets exposed to sodium arsenite (NaAsO2) were investigated. The results showed that LEVO improved the viability and functionality of pancreatic islets and modulated oxidative stress and inflammatory biomarkers.
Review
Toxicology
Sara Mostafalou, Mohammad Abdollahi
Summary: This article reviews the role of organophosphorus (OP) compounds in the development of neurological disorders and explores how genetic variations can affect susceptibility to OP pesticide neurotoxicity. It discusses the various neurological disorders associated with OP compound exposure and the pathological mechanisms involved. Specific genetic polymorphisms have been found to increase the risk of developing OP-related neurological disorders.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shilan Mozaffari, Taraneh Mousavi, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: Polypharmacy is common among elderly patients and can lead to severe drug interactions, posing significant challenges to healthcare providers. Understanding the underlying mechanisms of these interactions and designing personalized treatment plans is crucial.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Review
Pharmacology & Pharmacy
Taraneh Mousavi, Mohammadhossein Sharifnia, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: Acute gastrointestinal cramping pain (GICP) is a common condition that significantly affects people's quality of life. This article explores the treatment options for GICP and discusses the use of antispasmodics as the primary treatment.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Review
Toxicology
Nader Rahimi Kakavandi, Taraneh Mousavi, Tayebeh Asadi, Ayda Moradi, Mahta Esmaeili, Ahmad Habibian Sezavar, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: This study conducted a systematic review and dose-response meta-analysis on the association between arsenic exposure and the risk of type 2 diabetes. The results showed that arsenic in drinking water and urine were significantly associated with the risk of type 2 diabetes.
TOXICOLOGY LETTERS
(2023)
Review
Endocrinology & Metabolism
Marzieh Daniali, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: This study compares diabetes management between pediatric and adult patients and identifies treatment challenges and gaps. Research shows children have lower insulin sensitivity, clearance, and beta cell function than adults. Personalized and precise approaches are crucial in managing diabetes in pediatrics, and more research is necessary to assess the safety and efficacy of different antidiabetic drugs and improve diabetes treatment for children and adolescents.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
(2023)
Article
Psychiatry
Ali Amirkafi, Faezeh Mohammadi, Arash Tehrani-Banihashemi, Maziar Moradi-Lakeh, Christopher J. L. Murray, Mohsen Naghavi, Ali H. Mokdad
Summary: The study investigates drug use disorders as a significant contributor to Disability Adjusted Life Years (DALYs) in the Eastern Mediterranean Region (EMR). The findings reveal a significant increase in the prevalence of drug use disorders since 1990, with opioid use being the most prevalent disorder. United Arab Emirates, Libya, and Iran are among the countries most affected by drug use disorders in the region.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Chemistry, Applied
Maryam Keykhaee, Mahban Rahimifard, Alireza Najafi, Maryam Baeeri, Mohammad Abdollahi, Fatemeh Mottaghitalab, Mehdi Farokhi, Mehdi Khoobi
Summary: The study proposes a novel approach using a multifunctional hydrogel to manage diabetic foot ulcers (DFUs). The hydrogel, made from a combination of alginate and gum arabic, is enhanced with nerve growth factor (NGF) immobilized in specially designed mesoporous silica nanoparticles (MSN). The hydrogel shows sustained release of NGF and significantly improves wound healing. The hydrogel also reduces inflammation, increases angiogenesis, and improves tissue pathology. This newly developed composite system holds promise as a potential treatment for non-healing diabetic wounds.
CARBOHYDRATE POLYMERS
(2023)
Article
Medicine, General & Internal
Group Author Only
Summary: Based on the data analysis of GBD 2019, the global population of older adults has increased since 1990, and overall mortality rates have decreased for both men and women. However, mortality rates due to falls have increased during the same period. The probability of death among people aged 70-90 has decreased, mainly due to reductions in non-communicable diseases. Globally, disability burden is mainly driven by functional decline, vision and hearing loss, and symptoms of pain. Life expectancy at age 70 (LE-70) and healthy life expectancy at age 70 (HALE-70) have shown continuous increases since 1990, with regional disparities. Higher LE-70 results in higher HALE-70 and slightly increased proportion of years in ill health at age 70 (PYIH-70). Sociodemographic factors, healthcare access and quality indices are positively correlated with HALE-70 and LE-70. Limited data are available for various dietary, environmental or occupational, and metabolic risks.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
