Article
Immunology
Mahvash Sadeghi, Sajad Dehnavi, Tannaz Jamialahmadi, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Numerous studies suggest that neutrophils play a crucial role in the development of systemic autoimmune diseases through the formation of neutrophil extracellular traps (NET), production of pro-inflammatory cytokines, and tissue damage. The components of NET released into the extracellular spaces act as autoantigens, leading to the breakdown of self-tolerance and the development of autoimmune responses. Imbalance between NET formation and degradation can contribute to prolonged exposure of the immune system to modified autoantigens and exacerbate tissue damage. This review discusses the generation and clearance of NET, as well as the role of NETosis in the pathogenesis of various autoimmune disorders.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Yuning Ma, Mengyan Wang, Jinchao Jia, Jianfen Meng, Jialin Teng, Dehao Zhu, Hui Shi, Yue Sun, Yutong Su, Honglei Liu, Xiaobing Cheng, Junna Ye, Huihui Chi, Tingting Liu, Xia Chen, Liyan Wan, Zhuochao Zhou, Fan Wang, Dongyi He, Chengde Yang, Qiongyi Hu
Summary: This study found that type I interferons play important roles in the pathogenesis of adult-onset Still's disease through their promotion of neutrophil extracellular trap formation, characterized by enhanced release of oxidized mitochondrial DNA.
JOURNAL OF AUTOIMMUNITY
(2022)
Review
Biochemistry & Molecular Biology
Joanna Czerwinska, Agnieszka Owczarczyk-Saczonek
Summary: Neutrophil extracellular traps (NETs) play a significant role in the pathogenesis of psoriasis by involving neutrophils, lymphocytes, dendritic cells and keratinocytes. This comprehensive review aims to clarify the field of NET research in psoriasis and identify potential targets for new therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ji-Won Kim, Mi-Hyun Ahn, Ju-Yang Jung, Chang-Hee Suh, Hyoun-Ah Kim
Summary: Neutrophils are crucial immune cells that defend against pathogens through mechanisms such as phagocytosis and formation of neutrophil extracellular traps (NETs). While NETs can kill pathogens, they may also cause toxic effects in hosts and trigger autoimmune responses in susceptible individuals, contributing to various inflammatory autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ramiz S. Ahmad, Timothy D. Eubank, Slawomir Lukomski, Brian A. Boone
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a dense, fibrotic stroma, which acts as a barrier to cancer treatment and promotes PDAC progression. The interactions between immune cells and pancreatic stellate cells play a crucial role in the pathogenesis of PDAC.
Review
Oncology
Qian Chen, Lu Zhang, Xiang Li, Wei Zhuo
Summary: This article reviews the crucial roles of neutrophil extracellular traps (NETs) in the cascade of tumor metastasis. It also highlights the potential of NETs as a cancer prognostic biomarker and therapeutic target.
Article
Oncology
Yanze Yin, Huijuan Dai, Xicheng Sun, Zhifeng Xi, Jiang Zhang, Yixiao Pan, Yongxin Huang, Xueyun Ma, Qiang Xia, Kang He
Summary: This study reveals that liver cancer promotes tumor lung metastasis by regulating neutrophil recruitment and NETs formation in the metastatic microenvironment through reducing HRG secretion. The findings of this study will contribute to the development of possible strategies for treating metastases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Anderson dos Santos Ramos, Giovana Cristina Santana Viana, Marcelo de Macedo Brigido, Juliana Franco Almeida
Summary: Neutrophils, particularly their ability to form extracellular traps (NETs), play a significant role in the pathophysiology of inflammatory bowel disease (IBD). Studies have shown increased levels of NETs in tissue and serum samples from IBD patients, indicating their involvement in disease progression. This highlights the potential of targeting NETs as a therapeutic strategy to expand the current spectrum of IBD therapies.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Jiawei Liu, Shuang Zhang, Yunnan Jing, Wei Zou
Summary: Intracerebral hemorrhage is a common neurological disease with a complex pathological mechanism. Neutrophils, as the first recruited leukocyte subtype after intracerebral hemorrhage, play a crucial role in tissue damage. Previous beliefs regarded neutrophils' functions to be phagocytosis, chemotaxis, and degranulation. However, recent studies have revealed that neutrophils also secrete extracellular traps, which are fibrous structures consisting of chromatin and granular proteins, and play an important role in innate immunity. These extracellular traps have been found in abundance in hematoma samples, plasma samples, and drainage samples after intracerebral hemorrhage. This paper summarizes the mechanisms of neutrophil extracellular traps and the resulting injury following intracerebral hemorrhage and suggests that inhibiting their formation or promoting their dissolution can effectively alleviate the pathological damage caused by intracerebral hemorrhage.
METABOLIC BRAIN DISEASE
(2023)
Article
Neurosciences
Leon C. D. Smyth, Helen C. Murray, Madison Hill, Eve van Leeuwen, Blake Highet, Nicholas J. Magon, Mahyar Osanlouy, Sophie N. Mathiesen, Bruce Mockett, Malvindar K. Singh-Bains, Vanessa K. Morris, Andrew N. Clarkson, Maurice A. Curtis, Wickliffe C. Abraham, Stephanie M. Hughes, Richard L. M. Faull, Anthony J. Kettle, Mike Dragunow, Mark B. Hampton
Summary: This study found that neutrophil accumulation in Alzheimer's disease is associated with cognitive impairment. The oxidant-generating enzyme myeloperoxidase (MPO) expressed in neutrophils could be a potential therapeutic target for AD. Vascular changes may drive neutrophil adhesion and NETosis.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Review
Oncology
Leonardo Cristinziano, Luca Modestino, Alessandro Antonelli, Gianni Marone, Hans-Uwe Simon, Gilda Varricchi, Maria Rosaria Galdiero
Summary: Neutrophils, in addition to their well-known functions in the acute phases of the immune response, play important roles in tumor initiation and progression through the release of various mediators. Neutrophil extracellular traps (NETs), composed of DNA and decorating proteins, not only trap and kill extracellular pathogens, but also have both pro-inflammatory and anti-inflammatory effects in cancer-related inflammation. This review focuses on the mechanisms underlying the emerging effects of NETs in cancer initiation and progression.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Oncology
Bo-Zong Shao, Yi Yao, Jin-Ping Li, Ning-Li Chai, En-Qiang Linghu
Summary: Neutrophil extracellular traps (NETs) play a vital role in the immune response, combating microbial infections and influencing the pathogenesis of various diseases. This review highlights the biological characteristics of NETs and their mechanisms in cancer, providing insights into potential therapeutic targets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Min Liu, Siyi Liu, Lin Liu, Jingya Xiu, Tian Zhang, Dawei Chen, Mingxi Qiao, Haiyang Hu, Jiulong Zhang, Xiuli Zhao
Summary: Rheumatoid arthritis (RA) is characterized by inflammation outbreak and joint destruction. Neutrophils play a crucial role in RA by releasing excess neutrophil extracellular traps (NETs), but preventing NETs formation is still challenging. In this study, a method using sivelestat-conjugated bovine serum albumin nanoparticles (BTST NPs) was established to selectively inhibit neutrophil elastase (NE) and prevent NETs production. Additionally, the BTST NPs were loaded with dexamethasone palmitate (DP) for synergistic treatment of RA. The results showed that DP/BTST NPs could effectively target inflamed neutrophils, hinder NETs generation, and improve RA symptoms.
Review
Immunology
Chuting Liang, Ni Lian, Min Li
Summary: Fungal infections are significant global public health problems, and modulating the antifungal capacity of the host immune system through neutrophil extracellular traps (NETs) is an effective way to combat these infections. This review summarizes the interactions between fungal pathogens and NETs, as well as the molecular mechanisms of fungi-induced NETs formation and defensive strategies used by fungi.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Hiroto Tsuboi, Seiji Segawa, Mizuki Yagishita, Hirofumi Toko, Fumika Honda, Ayako Kitada, Haruka Miki, Ayako Ohyama, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
Summary: Adult onset Still disease (AOSD) is a systemic inflammatory disorder characterized by skin rash, spiking fever, arthritis, sore throat, lymphadenopathy, and hepatosplenomegaly. Both innate and acquired immune responses contribute to the pathogenesis of AOSD, involving hyperactivation of macrophages, neutrophils, Thi and Th17 cells, and low activation of NK cells and regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Rheumatology
Ji-Won Kim, Ju-Yang Jung, Chang-Hee Suh, Hyoun-Ah Kim
Summary: This study reports a case of a 49-year-old female who experienced a flare of adult-onset Still's disease (AOSD) after receiving the first dose of BNT162b2 mRNA COVID-19 vaccination. The patient presented with fever and nausea 4 days after vaccination and was ultimately treated with steroid pulse therapy. The study also discusses possible mechanisms linking vaccination with a flare of AOSD.
CLINICAL RHEUMATOLOGY
(2022)
Article
Oncology
Ji-Won Kim, Eunyoung A. Lee, Hyoun-Ah Kim, Chang-Hee Suh, Ju-Yang Jung
Summary: This study aimed to analyze the clinical features, outcomes, and reasons for discontinuing TNF inhibitor therapy in older patients with ankylosing spondylitis (AS). Data from a nationwide registry were used to compare clinical variables and outcomes. The study found that older patients had a higher incidence of hypertension and diabetes, and lower drug retention rates. However, improvements in disease activity and manifestations were comparable between older and younger patients.
Article
Medicine, General & Internal
Ju-Yang Jung, Hyun-Young Lee, Eunyoung Lee, Hyoun-Ah Kim, Dukyong Yoon, Chang-Hee Suh
Summary: This study identified three clusters of patients with systemic lupus erythematosus (SLE) based on their initial laboratory findings. These clusters had different laboratory characteristics, but did not differ significantly in terms of damage and mortality rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Sun-Kyung Lee, Kichul Shin, Ju-Yang Jung, Chang-Hee Suh, Ji-Won Kim, Hyoun-Ah Kim
Summary: This study aimed to evaluate the long-term retention and safety of bDMARDs and tsDMARDs in patients with RA-ILD and identify factors associated with drug withdrawal. The study found that patients with RA-ILD had lower drug retention rates compared to those without ILD, and Janus kinase inhibitors had the highest retention rate in the RA-ILD group. Factors associated with drug withdrawal included current smoking and concomitant corticosteroid use.
Article
Biochemistry & Molecular Biology
Ju-Yang Jung, Ji-Won Kim, Sang-Won Lee, Wook-Young Baek, Hyoun-Ah Kim, Chang-Hee Suh
Summary: This study evaluates the clinical value of Immunoglobulin gamma-3 chain C (IGHG3) by measuring and comparing its levels in different body fluids of patients with systemic lupus erythematosus (SLE). The levels of IGHG3 in saliva, serum, and urine were measured and analyzed in patients with SLE and healthy controls. It was found that IGHG3 levels were increased in the saliva, serum, and urine of patients with SLE, and correlated with certain clinical characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ye-Ji Kim, Jeein Oh, Soohan Jung, Chan Johng Kim, Jinyong Choi, Yoon Kyung Jeon, Hyun Jik Kim, Ji-Won Kim, Chang-Hee Suh, Yoontae Lee, Sin-Hyeog Im, Shane Crotty, Youn Soo Choi
Summary: Communication between CD4 T cells and cognate B cells is crucial for the maturation of GC-TFH cells and the induction of CD4 T cell-dependent humoral immune response. Mef2d regulates the formation of B:T synapse and the production of IL-21, thus controlling the differentiation of CD4 T cells into GC-TFH cells and the antibody production by B cells. The expression of MEF2D gene is inversely correlated with autoimmune parameters in SLE patients.
SCIENCE IMMUNOLOGY
(2023)
Article
Rheumatology
Wook-Young Baek, Sung-Min Lee, Sang-Won Lee, Chang-Hee Suh
Summary: This study aimed to evaluate the effect of rosuvastatin on inflammatory responses in lupus-prone mice. The results showed that rosuvastatin can decrease serum cholesterol levels and reduce the expression of inflammatory cytokines in lymphoid organs and kidneys. However, it did not improve clinical manifestations, autoantibody titres, or renal histopathology.
JOURNAL OF RHEUMATIC DISEASES
(2023)
Letter
Endocrinology & Metabolism
Chang-Hee Suh
OSTEOPOROSIS AND SARCOPENIA
(2023)
Article
Medicine, General & Internal
Ji-Won Kim, Wook-Young Baek, Ju-Yang Jung, Hyoun-Ah Kim, Cheong In Yang, Seung-Ju Kim, Chang-Hee Suh
Summary: This study found that seasonal vitamin D levels are correlated with clinical manifestations and disease activity in lupus patients. Adequate vitamin D levels are important for achieving a low disease activity state in both winter and summer.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Ji-Won Kim, Ju-Yang Jung, Chang -Hee Suh, Young-Min Ye, Hyoun-Ah Kim
Summary: This study compared the occurrence of adverse events and disease flares after COVID-19 and influenza vaccination in patients with autoimmune rheumatic diseases (ARDs). The results showed that the rates of adverse events and disease flares were significantly higher after COVID-19 vaccination than after influenza vaccination. Previous allergic reactions to other vaccines were the only factor associated with the occurrence of adverse events. There was no difference in the post-vaccine response between mixed and matched vaccines.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Rheumatology
Ju-Yang Jung, Eunyoung Lee, Ji-Won Kim, Chang-Hee Suh, Kichul Shin, Jinhyun Kim, Hyoun-Ah Kim
Summary: Despite treatment with b/tsDMARDs, patients with D2T RA experience higher disease activity and have a higher rate of drug withdrawal due to inefficacy. Effective therapeutic strategies are needed to improve disease control and treatment outcomes for this unique patient population.
ARTHRITIS RESEARCH & THERAPY
(2023)