Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.714357
Keywords
neutrophil extracellular trap; cancer; neutrophil; immunity; inflammation
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Funding
- Ministry of Science and Technology of the Peoples Republic of China [2016YFC1303600]
- General Hospital of the Chinese Peoples Liberation Army [2018ZD-006, 2018MS-012]
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Neutrophil extracellular traps (NETs) play a vital role in the immune response, combating microbial infections and influencing the pathogenesis of various diseases. This review highlights the biological characteristics of NETs and their mechanisms in cancer, providing insights into potential therapeutic targets.
Neutrophils are vital components of innate and adaptive immunity. It is widely acknowledged that in various pathological conditions, neutrophils are activated and release condensed DNA strands, triggering the formation of neutrophil extracellular traps (NETs). NETs have been shown to be effective in fighting against microbial infections and modulating the pathogenesis and progression of diseases, including malignant tumors. This review describes the current knowledge on the biological characteristics of NETs. Additionally, the mechanisms of NETs in cancer are discussed, including the involvement of signaling pathways and the crosstalk between other cancer-related mechanisms, including inflammasomes and autophagy. Finally, based on previous and current studies, the roles of NET formation and the potential therapeutic targets and strategies related to NETs in several well-studied types of cancers, including breast, lung, colorectal, pancreatic, blood, neurological, and cutaneous cancers, are separately reviewed and discussed.
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