Article
Oncology
Ryusuke Nakamoto, Jialin Zhuo, Kip E. Guja, Heying Duan, Stephanie L. Perkins, Christoph Leuze, Bruce L. Daniel, Benjamin Lewis Franc
Summary: This study demonstrates the accurate localization of targets in the head and neck region using 3D augmented reality (AR) visualization of single-photon emission computed tomography (SPECT)/computed tomography (CT) data. The results show that wearing an AR headset significantly reduces the time required for target detection and provides high localization accuracy.
Article
Medicine, General & Internal
Marco Rubatto, Franco Picciotto, Giovenale Moirano, Enrico Fruttero, Virginia Caliendo, Silvia Borriello, Nadia Sciamarrelli, Paolo Fava, Rebecca Senetta, Adriana Lesca, Anna Sapino, Desiree Deandreis, Simone Ribero, Pietro Quaglino
Summary: This study evaluated the characteristics of patients with head and neck melanoma who underwent sentinel lymph node biopsy and found that scalp melanomas are more aggressive than non-scalp melanomas. The status of the sentinel lymph node is the strongest predictor for recurrence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Otorhinolaryngology
Ilyes Berania, Sharon Tzelnick, John R. de Almeida, Gregory McKinnon, David P. Goldstein
Summary: An international survey found that nearly half of head and neck surgeons would recommend completion lymph node dissection (CLND) for head and neck melanomas, which contrasts with current practice patterns for melanoma in other anatomical locations. Surgeons with access to immunotherapy treatment were less likely to recommend CLND. Further investigation is needed to understand the reasons for these practice variations.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Editorial Material
Oncology
Amanda W. Lund
Summary: An objective approach was used to study the sentinel lymph node landscape in patients with stage I-III cutaneous melanoma, revealing that micrometastasis is associated with progressive immune dysfunction. Tumor-induced lymph node dysfunction may lead to new hypotheses for neoadjuvant therapy that aims to reinvigorate the body's own anti-tumor immunity.
CLINICAL CANCER RESEARCH
(2022)
Article
Otorhinolaryngology
Jamie R. Oliver, Omar A. Karadaghy, Scott N. Fassas, Zack Arambula, Andres M. Bur
Summary: This study demonstrates that machine learning algorithms can accurately identify head and neck melanoma patients with very low risk of nodal metastasis, potentially reducing the need for sentinel lymph node biopsy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Madalina Costea, Alexandra Zlate, Anne-Agathe Serre, Severine Racadot, Thomas Baudier, Sylvie Chabaud, Vincent Gregoire, David Sarrut, Marie -Claude Biston
Summary: This study investigates the performance of four atlas-based and two deep learning solutions for automatic segmentation of head-and-neck elective nodes on CT images. The results show that the deep learning solutions outperform the atlas-based methods, with the multi-centric deep learning method being preferred by physicians. Manual corrections are still necessary to avoid underdosage of the elective target volume.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yanfeng Dai, Xiang Yu, Yuehong Leng, Xingzhou Peng, Junjie Wang, Yifan Zhao, Juan Chen, Zhihong Zhang
Summary: We report a melittin-loaded and hyaluronic acid (HA)-conjugated high-density lipoprotein (HDL) mimic phospholipid scaffold nanoparticle (MLT-HA-HPPS) that targets both breast cancer and its metastasis to lymph nodes. This nanoparticle effectively delivers the melittin peptide to breast cancer cells and inhibits their growth. Moreover, the delivery of MLT-HA-HPPS to lymph nodes can be monitored by NIR fluorescence imaging, which is beneficial for prognosis and treatment of lymph node metastasis in breast cancer.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Otorhinolaryngology
Neide Lira Bonachela, Luiz Paulo Kowalski, Andre Bandiera de Oliveira Santos
Summary: This study evaluated the technical aspects, positivity, and prognostic impact of cervicofacial sentinel lymph node biopsy in patients with head and neck cutaneous melanoma. The results showed a lower frequency of positive sentinel lymph node biopsy and highlighted the importance of the mitotic index in predicting prognosis.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2021)
Article
Oncology
Susan B. Kesmodel, Joshua P. Kronenfeld, Wei Zhao, Tulay Koru-Sengul, Neha Goel, Daniel N. Weingrad, Leonel Hernandez-Aya, Jose Lutzky, Lynn Feun, Mary Garland-Kledzik, Jessica S. Crystal
Summary: This study found no difference in overall survival between patients with head and neck melanoma who underwent sentinel lymph node biopsy (SLNB) only and those who underwent SLNB with completion lymph node dissection (CLND). Further research is needed to determine the role of CLND.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Katherine M. Marsh, Courtney M. Lattimore, Christopher L. Cramer, Craig L. Slingluff, Lynn T. Dengel
Summary: This study reports cases of primary melanoma draining to subcostal lymph nodes and provides characterization of the locations of these nodes. The study found that subcostal nodes are typically located under ribs 10-12 and have size limitations.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gianni Gerlini, Paola Di Gennaro, Nicola Pimpinelli, Serena Sestini, Lorenzo Borgognoni
Summary: Langerhans cells (LCs) are important regulators of anti-cancer immune responses, but cancer can alter their functions, leading to immune tolerance. In this study, IDO1 expression was investigated in LCs from sentinel lymph nodes (SLNs) of melanoma patients. The results showed that a subset of Langerin(+) LCs in the T cell-rich area of SLNs expressed IDO1. The expression of IDO1 did not significantly differ between SLNs with or without metastases, but was higher in SLN LCs of patients with mitotic rate > 1 in primary melanoma. Immature SLN LCs could be induced to mature after in vitro stimulation by inflammatory cytokines. These findings provide new insights for immunotherapy targeting LCs in melanoma patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Kavitha Yaddanapudi, Bryce F. Stamp, Priyanka B. Subrahmanyam, Andrei Smolenkov, Sabine J. Waigel, Rahul Gosain, Michael E. Egger, Robert C. G. Martin, Robert Buscaglia, Holden T. Maecker, Kelly M. McMasters, Jason A. Chesney
Summary: The study identified immunologic changes in the sentinel lymph nodes of melanoma patients that may impact melanoma treatment. These changes include a potential activation of immune response, as well as a decrease in NK cells and an increase in cells with low melanoma killing capabilities.
CLINICAL CANCER RESEARCH
(2022)
Article
Chemistry, Analytical
Wilson T. Fonseca, Fernando H. Cincotto, Bruna C. Lourencao, Sthefane de Almeida, Fernando C. Moraes, Orlando Fatibello-Filho, Ana C. de Carvalho, Andre L. Carvalho, Matias E. Melendez, Ronaldo C. Faria
Summary: A fast and simple magnetogenoassay was proposed for diagnosis of metastatic lymph nodes in HNSCC patients. The method involved constructing a disposable electrochemical sensor to detect miRNA-203, using magnetic particles and gold nanoparticles for biomarker detection without amplification steps. The developed molecular test offers an effective, simple, and fast alternative for cancer diagnosis based on detecting microRNAs as biomarkers.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Danique M. S. Berger, Nynke S. van den Berg, Vincent van der Noort, Bernies van der Hiel, Renato A. Valdes Olmos, Tessa A. Buckle, Gijs H. KleinJan, Oscar R. Brouwer, Lenka Vermeeren, Baris Karakullukcu, Michiel W. M. van den Brekel, Bart A. van de Wiel, Omgo E. Nieweg, Alfons J. M. Balm, Fijs W. B. van Leeuwen, W. Martin C. Klop
Summary: The study evaluated the impact of technological evolution on sentinel lymph node biopsy in head and neck melanoma patients and found that the use of advanced detection technologies can increase the number of identified sentinel lymph nodes without increasing overall operation time. The operation time per harvested node decreased, while the false negative rate remained at 11.9% and the postoperative complication rate did not significantly change.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Immunology
Aleksey K. Molodtsov, Nikhil Khatwani, Jennifer L. Vella, Kathryn A. Lewis, Yanding Zhao, Jichang Han, Delaney E. Sullivan, Tyler G. Searles, Nicholas K. Preiss, Tamer B. Shabaneh, Peisheng Zhang, Aaron R. Hawkes, Brian T. Malik, Fred W. Kolling, Edward J. Usherwood, Sandra L. Wong, Joseph D. Phillips, Keisuke Shirai, Christina Angeles, Shaofeng Yan, Tyler J. Curiel, Yina H. Huang, Chao Cheng, Mary Jo Turk
Summary: The study revealed that tumor-specific Trm cells persist in lymph nodes, restraining the development of metastatic cancer and providing long-term protection against melanoma seeding. These findings suggest that Trm cells play a crucial role in preventing the spread of melanoma.