Article
Pharmacology & Pharmacy
Kim Henriksen, Karen Broekhuizen, Wadim M. de Boon, Morten A. Karsdal, Asger R. Bihlet, Claus Christiansen, Marlous R. Dillingh, Marieke de Kam, Raj Kumar, Jacobus Burggraaf, Ingrid M. C. Kamerling
Summary: The study confirmed that doses up to 40 micrograms of KBP-042 were safe, although tolerability was not present at the highest doses. Target receptor engagement was observed at the studied doses.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
K. V. Andreassen, A. T. Larsen, N. Sonne, K. E. Mohamed, M. A. Karsdal, K. Henriksen
Summary: The study demonstrates that acylated DACRA KBP-066A shows significantly improved in vivo efficacy compared to its non-acylated variant, leading to significant improvements in weight loss and glycemic control in rat models.
MOLECULAR METABOLISM
(2021)
Article
Neurosciences
Aarti Patel, Ryoichi Kimura, Wen Fu, Rania Soudy, David MacTavish, David Westaway, Jing Yang, Rachel A. Davey, Jeffrey D. Zajac, Jack H. Jhamandas
Summary: The study suggests that amylin receptor may modulate the pathogenesis of Alzheimer's disease. By using compound transgenic AD mice models, it was found that deficiency of amylin receptors could improve hippocampal long-term potentiation response and spatial memory, while reducing amyloid plaque burden and neuroinflammation markers.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Neurosciences
Aimilia Lydia Kalafateli, Tugce Munise Satir, Daniel Vallof, Henrik Zetterberg, Elisabet Jerlhag
Summary: Alcohol activates reward-processing brain areas causing stimulatory behavioral responses, while sCT attenuates alcohol-mediated behaviors when infused into the laterodorsal, ventral tegmental, and nucleus accumbens regions, indicating an inhibitory effect on alcohol-induced behaviors.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Anna Thors o Larsen, Simone A. Melander, Nina Sonne, Emma Bredtoft, Mays Al-Rubai, Morten A. Karsdal, Kim Henriksen
Summary: Dual amylin and calcitonin receptor agonists (DACRAs) have shown significant effects on weight loss and improvement in glucose control and insulin action in rats. However, it is still unclear to what extent DACRAs affect insulin sensitivity beyond weight loss and their impact on tissue-specific glucose uptake.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Obstetrics & Gynecology
Anna Katri, Ditte Reker, Morten A. Karsdal, Anne-Christine Bay-Jensen, Kim Henriksen
Summary: In a model driven by unhealthy diet, age, and menopause, treatment with KBPs significantly reduces body weight, improves fat depot size, and enhances glucose tolerance in rats.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
Article
Endocrinology & Metabolism
Melissa K. Thomas, Amir Nikooienejad, Ross Bray, Xuewei Cui, Jonathan Wilson, Kevin Duffin, Zvonko Milicevic, Axel Haupt, Deborah A. Robins
Summary: Tirzepatide demonstrated significantly greater improvements in insulin sensitivity and beta-cell function compared to dulaglutide, with only partial contributions from weight loss. The dual receptor agonism of tirzepatide may confer distinct mechanisms of glycemic control beyond just weight reduction.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, Research & Experimental
Liu Yang, Xian-Tao Lei, Qi Huang, Ting Wang, Hong-Bin Sun, He-Yao Wang
Summary: The study revealed that LXT34, a potent and selective GPR120 agonist, significantly improved glucose tolerance and insulin resistance, while reducing inflammation in the liver and adipose tissues of db/db mice.
Article
Endocrinology & Metabolism
Sriram Gubbi, Ranganath Muniyappa, Susmeeta T. Sharma, Shivraj Grewal, Raven McGlotten, Lynnette K. Nieman
Summary: Short-term administration of mifepristone improved adipose and hepatic insulin sensitivity in obese individuals with hyperglycemia but without hypercortisolism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Madeleine M. Fletcher, Peter Keov, Tin T. Truong, Grace Mennen, Caroline A. Hick, Peishen Zhao, Sebastian G. B. Furness, Thomas Kruse, Trine R. Clausen, Denise Wootten, Patrick M. Sexton
Summary: The study found that agonists targeting AMYRs may have improved efficacy for treating obesity, with AM833 showing a unique pharmacological profile across receptor binding, activation, and regulation.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Fangluo Chen, Dylan C. Sarver, Muzna Saqib, Mingqi Zhou, Susan Aja, Marcus M. Seldin, G. William Wong
Summary: The protein CTRPl3 is found to play a role in regulating insulin secretion and metabolism. It has been shown to improve glucose metabolism and triglyceride clearance, reduce obesity and inflammation when deficient. Genetic variation of CTRP13 expression in humans may be associated with metabolic syndrome.
MOLECULAR METABOLISM
(2023)
Article
Food Science & Technology
Wenzhe Yu, Lida Fan, Mingfu Wang, Bin Cao, Xiaoqian Hu
Summary: This study demonstrated that PTE effectively reduced the accumulation of AGEs in the body, alleviated AGEs-associated diabetes symptoms, and improved glucose sensitivity, making it a promising nutritional intervention agent.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Physiology
Zhenguo Wang, Xiaojing Gao, Qingrun Li, Hongwen Zhu, Xiangjie Zhao, Minerva Garcia-Barrio, Jifeng Zhang, Yanhong Guo, Y. Eugene Chen, Rong Zeng, Jia-Rui Wu, Lin Chang
Summary: This study highlights the critical role of CLK1 in regulating browning of adipose tissue and insulin sensitivity, with the CLK1-THRAP3-PPARγ axis identified as a key mechanism involved in controlling energy expenditure.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hye-Jeong Yang, Ting Zhang, Xuan-Gao Wu, Min-Jung Kim, Young-Ho Kim, Eun-Suk Yang, Yeong-Seok Yoon, Sunmin Park
Summary: The study found that blackcurrant extracts can improve glucose metabolism and insulin sensitivity in non-obese type 2 diabetic animals, reduce inflammation and oxidative stress, and increase the diversity of gut microbiota.
Article
Medicine, Research & Experimental
Rodrigo Martins Pereira, Kellen Cristina da Cruz Rodrigues, Marcella Ramos Sant'Ana, Guilherme Francisco Peruca, Chadi Pellegrini Anaruma, Thais Dantis Pereira de Campos, Raphael dos Santos Canciglieri, Diego Gomes de Melo, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Leandro Pereira de Moura
Summary: The study showed that short-term combined training can reduce glucose levels and fatty liver, improve hepatic insulin sensitivity, and reduce complications caused by fatty liver.
Article
Transplantation
Nadja Sparding, Federica Genovese, Daniel Guldager Kring Rasmussen, Morten Asser Karsdal, Michaela Neprasova, Dita Maixnerova, Veronika Satrapova, Doubravka Frausova, Mads Hornum, Lenka Bartonova, Eva Honsova, Marek Kollar, Helena Koprivova, Zdenka Hruskova, Vladimir Tesar
Summary: This study found that levels of circulating and excreted ETP are associated with kidney function, CKD severity, and the extent of interstitial fibrosis, gradually increasing with higher fibrotic burden. ETP outperformed the known fibrosis biomarker Dickkopf-3 in discriminating patients with high fibrotic burden.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Orthopedics
V. B. Kraus, M. A. Karsdal
Summary: This article provides an overview of biomarkers for osteoarthritis (OA) and aims to equip non-specialists with a toolbox to understand and utilize biomarkers in the field of OA. Although the importance of molecular biomarkers in OA has been increasingly recognized, no OA-related biomarkers have been widely adopted in clinical practice. However, there is a growing compendium of OA-related biomarkers that could facilitate drug development for OA. The use of appropriate biomarkers is crucial for OA diagnosis, prognosis, drug development, and treatment.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Rheumatology
Salome Kristensen, Signe Holm Nielsen, Erik Berg Schmidt, Anne Christine Bay-Jensen, Morten A. Karsdal, Jeppe Hagstrup Christensen
Summary: The study found that there was no significant correlation between the content of fatty acids in granulocytes and disease activity in patients with psoriatic arthritis (PsA). However, marine n-3 PUFA was positively correlated with collagen degradation, while n-6 PUFA was positively correlated with collagen formation. Further investigation is needed to explore the relationship between fatty acids and biomarkers of bone and soft tissue turnover.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Majken Lindholm, Antonio Di Sabatino, Tina Manon-Jensen, Giuseppe Mazza, Gunvor Madsen, Paolo Giuffrida, Massimo Pinzani, Aleksander Krag, Morten A. Karsdal, Jens Kjeldsen, Joachim H. Mortensen
Summary: The study demonstrated that serum LG1M levels were elevated in CD patients compared to healthy subjects, indicating a possible association with laminin degradation. In DSS-induced colitis rats, LG1M levels increased upon disease reversal, suggesting ongoing mucosal repair.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Endocrinology & Metabolism
Sami Qadri, Noora Ahlholm, Ida Lonsmann, Paola Pellegrini, Anni Poikola, Panu K. Luukkonen, Kimmo Porthan, Anne Juuti, Henna Sammalkorpi, Anne K. Penttila, Roberta D'Ambrosio, Giorgio Soardo, Diana J. Leeming, Morten Karsdal, Johanna Arola, Stergios Kechagias, Serena Pelusi, Mattias Ekstedt, Luca Valenti, Hannes Hagstrom, Hannele Yki-Jarvinen
Summary: This study investigated the impact of obesity on the performance of liver fibrosis biomarkers in NAFLD and found that ADAPT and FIB-4 are the best-performing biomarkers in obese patients, unaffected by body mass index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Liang-Jie Tang, Hong-Lei Ma, Mohammed Eslam, Grace Lai-Hung Wong, Pei-Wu Zhu, Sui-Dan Chen, Diana Julie Leeming, Morten Karsdal, Gang Li, Ou-Yang Huang, Howard Ho-Wai Leung, Yu-Jie Zhou, Qian Feng, Pei Jiang, Li-Mei Gao, Christopher D. Byrne, Giovanni Targher, Jacob George, Vincent Wai-Sun Wong, Ming-Hua Zheng
Summary: This study evaluated the performance of new biomarkers and algorithms for diagnosing advanced fibrosis in an Asian population. The results showed that the ADAPT score had good accuracy and sensitivity in diagnosing advanced fibrosis, and it outperformed other non-invasive fibrosis biomarkers. The ADAPT score also had good diagnostic performance in subgroup analyses.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Letter
Dermatology
Signe Holm Nielsen, Solveig Skovlund Groen, Yiqiu Yao, Astrid-Helene Ravn Jorgensen, Valdemar Wendelboe Nielsen, Morten Karsdal, Kristoffer Gehring, Anne-Christine Bay-Jensen, Simon Francis Thomsen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nina Sonne, Anna Thorso Larsen, Morten Asser Karsdal, Kim Henriksen
Summary: This study compared the effects of different dosing profiles of Dual Amylin and Calcitonin Receptor Agonists (DACRAs) on obese and diabetic rats. The results showed that dosing profiles had no impact on metabolic benefits in obese rats, while injection of KBP was superior to infusion in diabetic rats. For KBP-A, the effects of injection and infusion were similar in diabetic rats.
Article
Medicine, Research & Experimental
A. T. Larsen, K. E. Mohamed, N. Sonne, E. Bredtoft, F. Andersen, M. A. Karsdal, K. Henriksen
Summary: Cagrilintide is a novel long-acting amylin receptor agonist that induces weight loss. KBP-336, another long-acting DACRA, shows superior efficacy in weight loss and glucose control compared to cagrilintide. Both peptides activate amylin and calcitonin receptors, but KBP-336 has a bias towards calcitonin receptor activation, resulting in a different receptor activation balance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Transplantation
Daan Kremer, Firas F. Alkaff, Adrian Post, Tim J. Knobbe, Martin Tepel, Olivier Thaunat, Stefan P. Berger, Jacob van den Born, Federica Genovese, Morten A. Karsdal, Daniel G. K. Rasmussen, Stephan J. L. Bakker, Behalf Transplant Lines Investigators
Summary: This study found a strong association between plasma endotrophin and graft failure and mortality in kidney transplant recipients. The findings suggest that abnormal extracellular matrix turnover and fibrosis play a key role in the prognosis of kidney transplant recipients and highlight the need for interventional studies targeting the profibrotic state of these patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pharmacology & Pharmacy
Anna Thorso Larsen, Morten A. Karsdal, Kim Henriksen
Summary: Long-acting dual amylin and calcitonin receptor agonists (DACRAs) have potential as treatments for obesity. Switching or combining treatment with KBP-336 and semaglutide improves weight loss and glucose tolerance in obese rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mette J. Nielsen, Grace E. Dolman, Rebecca Harris, Peder Frederiksen, Jane Chalmers, Jane I. Grove, William L. Irving, Morten A. Karsdal, Keyur Patel, Diana Julie Leeming, Indra Neil Guha
Summary: This study investigated the prognostic value of the fibrogenesis marker PRO-C3 and the ALBI score in predicting clinical outcomes and mortality in two cohorts of compensated cirrhosis patients. The results showed that both PRO-C3 and ALBI were independently associated with liver-related clinical outcomes, suggesting that PRO-C3 may be a valuable predictor of treatment efficacy.
Article
Endocrinology & Metabolism
Simone Anna Melander, Alexandra Louise Moller, Khaled Elhady Mohamed, Daniel Guldager Kring Rasmussen, Federica Genovese, Morten Asser Karsdal, Kim Henriksen, Anna Thorso Larsen
Summary: This study demonstrates that long-acting DACRA treatment has potential as a therapy for T2D-related kidney complications by attenuating fibrotic alterations in the kidney ECM and improving glucose control.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Medicine, Research & Experimental
Anna Thors o Larsen, Simone A. Melander, Nina Sonne, Emma Bredtoft, Mays Al-Rubai, Morten A. Karsdal, Kim Henriksen
Summary: Dual amylin and calcitonin receptor agonists (DACRAs) have shown significant effects on weight loss and improvement in glucose control and insulin action in rats. However, it is still unclear to what extent DACRAs affect insulin sensitivity beyond weight loss and their impact on tissue-specific glucose uptake.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Morten A. Karsdal, Kate Hallsworth, Jadine Scragg, Diana J. Leeming, Ida F. Villesen, Leah Avery, Laura Haigh, Olivier Govaere, Sarah Wichmann, Guy Taylor, Sophie Cassidy, Stuart Mcpherson, Quentin M. Anstee
Summary: The amount of fibroblast activity in patients with NAFLD can be defined by circulating biomarkers of collagen formation. The high-risk, high-fibrogenesis patient endotype with greater fibroblast activity exhibited a marked reduction in collagen fibrogenesis with a very low-calorie diet intervention, while fibrogenesis remained unchanged in the low activity group. The quantification of fibrogenesis biomarkers at baseline can predict the likelihood of treatment response.
HEPATOLOGY COMMUNICATIONS
(2023)