Review
Immunology
Xiaoxue Li, Ying Wang, Haiyuan Yang, Yifan Dai
Summary: Liver diseases affect a significant portion of the Chinese population, and the lack of donors is a major problem. Porcine xenotransplantation of liver and hepatocytes has the potential to provide therapeutic benefits and alleviate the shortage of donors for patients with severe liver diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
News Item
Biotechnology & Applied Microbiology
Asher Mullard
Summary: The FDA's supplemental approval of Novo Nordisk's semaglutide for weight loss may signal a significant shift in the development of anti-obesity drugs.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Editorial Material
Medicine, General & Internal
Clifford J. Rosen, Julie R. Ingelfinger
Summary: Obesity is a chronic disease that can lead to complications such as type 2 diabetes, posing a serious threat to people's health, especially impacting certain specific populations.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Immunology
Arthur A. Cross-Najafi, Kevin Lopez, Abdulkadir Isidan, Yujin Park, Wenjun Zhang, Ping Li, Sezai Yilmaz, Sami Akbulut, Burcin Ekser
Summary: Recent studies on pig-to-nonhuman primate liver xenotransplantation have shown progress in achieving longer survival times. However, there are still challenges of thrombocytopenia and coagulation dysregulation. The current research aims to understand the biological mechanisms behind these issues and explore genetic modifications as potential solutions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Psychology, Multidisciplinary
Rachel Colla, Paige Williams, Lindsay G. Oades, Jesus Camacho-Morles
Summary: The review highlights the significant impact of hope theory on advancing our understanding of thriving characterized by hope, while also identifying limitations that can impede future growth. An interdisciplinary approach is advocated to expand theoretical and methodological horizons, enabling a more dynamic systems approach to the study of hope emergence. This research agenda aims to provide alternative methodologies to address current limitations in hope research and accelerate the next wave of research and practice in positive psychology.
FRONTIERS IN PSYCHOLOGY
(2022)
Editorial Material
Optics
Ji-Xin Cheng
Summary: A hybrid optical parametrically-oscillating laser at 1930 nm has been developed for photoacoustic mapping of water content in deep tissue, providing good sensitivity and high spatial resolution.
LIGHT-SCIENCE & APPLICATIONS
(2022)
Article
Computer Science, Information Systems
Xuechen Luo, Ling Ge, Chong (Alex) Wang
Summary: This study investigates the impact of prosocial crowdfunding on traditional microfinance institutions (MFIs). Combining multiple data sources, the study finds that joining an online crowdfunding platform improves MFI sustainability and decreases interest rates, mainly through efficiency enhancement.
Article
Engineering, Biomedical
Zahra Aliakbar Ahovan, Zahra Esmaeili, Behnaz Sadat Eftekhari, Sadjad Khosravimelal, Morteza Alehosseini, Gorka Orive, Alireza Dolatshahi-Pirouz, Narendra Pal Singh Chauhan, Paul A. Janmey, Ali Hashemi, Subhas C. Kundu, Mazaher Gholipourmalekabadi
Summary: This research critically reviews the recent pre-clinical and clinical advances in using smart hydrogels against skin wound infections and proposes the next best thing for future trends. It aims to provide a pathway for producing new biomaterials with clinical applications.
MATERIALS TODAY BIO
(2022)
Review
Cell Biology
Ming Yang, Kwok-Fai So, Wai-Ching Lam, Amy Cheuk Yin Lo
Summary: Retinitis pigmentosa (RP) is a genetic retinal degenerative disease with more than 60 gene mutations. Recent studies have suggested a potential involvement of ferroptosis, a novel form of programmed cell death characterized by iron overload and lipid peroxidation, in the pathogenesis of RP. This finding may open up new avenues for research and novel therapeutic targets for RP.
Review
Neurosciences
Hong-Xia Fan, Shuo Sheng, Feng Zhang
Summary: There is a strong connection between gut microbiota and Parkinson's disease, as changes in gut microbiota may affect the pathogenesis and treatment of PD.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Immunology
Amber N. Carrier, Anjali Verma, Muhammad Mohiuddin, Manuel Pascual, Yannick D. Muller, Alban Longchamp, Chandra Bhati, Leo H. Buhler, Daniel G. Maluf, Raphael P. H. Meier
Summary: Organ allotransplantation is hindered by the limited supply of human donor organs. Xenotransplantation has the potential to address this shortage by using organs from pigs with gene editing. Recent research progress in the United States includes successful trials of pig-to-human heart and kidney xenotransplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Hematology
Yi Zhang
Summary: Thangavelu et al have developed a novel pharmacological approach to inhibit graft-versus-host disease (GVHD) by activating retinoid X receptor (RXR) in donor T cells in this issue of Blood.
Review
Multidisciplinary Sciences
Shanu Bhardwaj, Kavindra Kumar Kesari, Mahesh Rachamalla, Shalini Mani, Ghulam Md Ashraf, Saurabh Kumar Jha, Pravir Kumar, Rashmi K. Ambasta, Harish Dureja, Hari Prasad Devkota, Gaurav Gupta, Dinesh Kumar Chellappan, Sachin Kumar Singh, Kamal Dua, Janne Ruokolainen, Mohammad Amjad Kamal, Shreesh Ojha, Niraj Kumar Jha
Summary: This review discusses the role of CRISPR/Cas9 gene editing in the management of Alzheimer's disease. The technology has significant potential for correcting undesired gene mutations associated with AD, leading to better therapeutic and diagnostic approaches.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Haidi Chen, Qifeng Zhuo, Zeng Ye, Xiaowu Xu, Shunrong Ji
Summary: Pancreatic cancer is a rapidly progressing disease with a poor prognosis, and there are still many questions regarding its pathogenesis, early diagnosis, and precise treatment. Organoids, a rapidly emerging technology, can simulate the characteristics of pancreatic tumors and offer insights for guiding clinical practice and improving patient prognosis. This review introduces the development of organoids, compares them with other preclinical models, and discusses their current status in basic research and clinical applications for pancreatic cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Cell Biology
Tan-Jun Zhao, Neng Zhu, Ya-Ning Shi, Yu-Xiang Wang, Chan-Juan Zhang, Chang-Feng Deng, Duan-Fang Liao, Li Qin
Summary: High-density lipoprotein is closely related to the risk of various cancers and plays a crucial role in tumorigenesis and cancer development by influencing the tumor microenvironment and immune response, suggesting a potential strategy for cancer therapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
