ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine

Calmodulin-dependent protein kinase II (CaMKII) mediates radiation-induced mitochondrial fission by regulating the phosphorylation of dynamin-related protein 1 (Drp1) at serine 616

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Dynamin-related protein 1-mediated mitochondrial fission contributes to IR-783-induced apoptosis in human breast cancer cells

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MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells

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Molecular machinery underlying the autophagic regulation by MDA-9/Syntenin leading to anoikis resistance of tumor cells

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Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells

(2018) Hong-Wei Zhang et al.   Scientific Reports

Autophagy and its potent modulators from phytochemicals in cancer treatment

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Autophagy in Cancer: Regulation by Small Molecules

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Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

(2017) Go J. Yoshida   Journal of Hematology & Oncology

Calmodulin kinases: essential regulators in health and disease

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Autophagy inhibition reduces chemoresistance and tumorigenic potential of human ovarian cancer stem cells

(2017) Anna Pagotto et al.   Cell Death & Disease

c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death

(2017) Lujun Zhou et al.   Cell Death & Disease

Silibinin sensitizes TRAIL-mediated apoptosis by upregulating DR5 through ROS-induced endoplasmic reticulum stress-Ca2+-CaMKII-Sp1 pathway

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An overview of the effective combination therapies for the treatment of breast cancer

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Drp1, Mff, Fis1, and MiD51 are coordinated to mediate mitochondrial fission during UV irradiation–induced apoptosis

(2016) Zhenzhen Zhang et al.   FASEB JOURNAL

CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation

(2016) Shangcheng Xu et al.   Nature Communications

Chasing cardiac physiology and pathology down the CaMKII cascade

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Comparing the metabolism of quercetin in rats, mice and gerbils

(2015) Shu-Lan Yeh et al.   EUROPEAN JOURNAL OF NUTRITION

Oxidant stress promotes disease by activating CaMKII

(2015) Mark E. Anderson   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen-activated protein kinase kinase signaling pathways

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Autophagy inhibition enhances isorhamnetin-induced mitochondria-dependent apoptosis in non-small cell lung cancer cells

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The Ca2+-calmodulin-Ca2+/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes

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Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers

(2014) Sylvain Lefort et al.   Autophagy

CaMKII oxidative activation and the pathogenesis of cardiac disease

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Oxidative activation of the Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates vascular smooth muscle migration and apoptosis

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Chemopreventive Activity of Plant Flavonoid Isorhamnetin in Colorectal Cancer Is Mediated by Oncogenic Src and  -Catenin

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Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c

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Ezrin dephosphorylation/downregulation contributes to ursolic acid-mediated cell death in human leukemia cells

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Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors

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Detection of reactive oxygen species derived from the family of NOX NADPH oxidases

(2012) Ghassan J. Maghzal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Isorhamnetin Inhibits Proliferation and Invasion and Induces Apoptosis through the Modulation of Peroxisome Proliferator-activated Receptor γ Activation Pathway in Gastric Cancer

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GSK3beta-Mediated Drp1 Phosphorylation Induced Elongated Mitochondrial Morphology against Oxidative Stress

(2012) Chia-Hua Chou et al.   PLoS One

Isorhamnetin Suppresses Skin Cancer through Direct Inhibition of MEK1 and PI3-K

(2011) J.-E. Kim et al.   Cancer Prevention Research

Reactive Oxygen Species–Activated Ca/Calmodulin Kinase IIδ Is Required for Late I Na Augmentation Leading to Cellular Na and Ca Overload

(2011) Stefan Wagner et al.   CIRCULATION RESEARCH

Permeabilization of the Mitochondrial Outer Membrane by Bax/Truncated Bid (tBid) Proteins as Sensitized by Cardiolipin Hydroperoxide Translocation

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Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization

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A Chemical Inhibitor of DRP1 Uncouples Mitochondrial Fission and Apoptosis

(2008) Atsushi Tanaka et al.   MOLECULAR CELL

Bax- or Bak-Induced Mitochondrial Fission Can Be Uncoupled from Cytochrome c Release

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