Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response

The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168

(2018) Xiaoduo Xie et al.   NATURE CELL BIOLOGY

Methylation dependent down-regulation of G0S2 leads to suppression of invasion and improved prognosis of IDH1-mutant glioma

(2018) Takanori Fukunaga et al.   PLoS One

Lipid sensing by mTOR complexes viade novosynthesis of phosphatidic acid

(2017) Deepak Menon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program

(2016) C. Y. Yim et al.   CANCER RESEARCH

Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis

(2016) F. Geng et al.   CLINICAL CANCER RESEARCH

Deletion of the putative tumor suppressor gene, G0s2, does not affect progression of Eμ-Myc driven lymphomas in mice

(2016) Rachid Zagani et al.   LEUKEMIA RESEARCH

SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial–mesenchymal transition and invasion in mice and humans

(2016) L Zhang et al.   ONCOGENE

DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity

(2015) Henning Willers et al.   SEMINARS IN RADIATION ONCOLOGY

Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells

(2015) Rachid Zagani et al.   Oncotarget

The Polyamine Catabolic Enzyme SAT1 Modulates Tumorigenesis and Radiation Response in GBM

(2014) A. Brett-Morris et al.   CANCER RESEARCH

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis

(2014) Haizhong Feng et al.   JOURNAL OF CLINICAL INVESTIGATION

Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma

(2014) Olivier L. Chinot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of 53BP1 Protein Stability by RNF8 and RNF168 Is Important for Efficient DNA Double-Strand Break Repair

(2014) Yiheng Hu et al.   PLoS One

UbcH7 regulates 53BP1 stability and DSB repair

(2014) Xiangzi Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

G0S2 inhibits the proliferation of K562 cells by interacting with nucleolin in the cytosol

(2013) Takeshi Yamada et al.   LEUKEMIA RESEARCH

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

Strategies for optimizing the response of cancer and normal tissues to radiation

(2013) Everett J. Moding et al.   NATURE REVIEWS DRUG DISCOVERY

Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation

(2013) H. Kioka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

(2013) M. Di Virgilio et al.   SCIENCE

53BP1 Is a Haploinsufficient Tumor Suppressor and Protects Cells from Radiation Response in Glioma

(2012) M. Squatrito et al.   CANCER RESEARCH

The Cytosolic Protein G0S2 Maintains Quiescence in Hematopoietic Stem Cells

(2012) Takeshi Yamada et al.   PLoS One

SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans

(2011) Kun-Wei Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

RAD51 can inhibit PDGF-B–induced gliomagenesis and genomic instability

(2011) Ulrica K. Westermark et al.   NEURO-ONCOLOGY

The G0/G1 Switch Gene 2 Regulates Adipose Lipolysis through Association with Adipose Triglyceride Lipase

(2010) Xingyuan Yang et al.   Cell Metabolism

Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists

(2009) Masashi Kusakabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of a Protein, G0S2, That Lacks Bcl-2 Homology Domains and Interacts with and Antagonizes Bcl-2

(2009) C. Welch et al.   CANCER RESEARCH

H2AX: functional roles and potential applications

(2009) Jennifer S. Dickey et al.   CHROMOSOMA

Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches

(2009) Masashi Kusakabe et al.   INTERNATIONAL JOURNAL OF CANCER

Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma

(2008) Anastasia Murat et al.   JOURNAL OF CLINICAL ONCOLOGY