Article
Nutrition & Dietetics
Zalina Abu Zaid, May Kay Neoh, Zulfitri Azuan Mat Daud, Nor Baizura Md Yusop, Zuriati Ibrahim, Zuwariah Abdul Rahman, Norshariza Jamhuri, Aishah Zafirah Abdul Azim
Summary: This study aimed to evaluate the weight loss during and post-treatment among head and neck cancer patients. The study found that the average weight loss during treatment was 7.4%, and post-treatment weight loss was 2.1%. One month after treatment completion, patients showed significant improvements in nutrition status and muscle mass, but there was a decrease in oral nutritional supplement intake.
Article
Psychology, Multidisciplinary
Melissa Henry, Justine G. Albert, Saul Frenkiel, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Martin Black, Christina MacDonald, Keith Richardson, Marco Mascarella, Gregoire B. Morand, Gabrielle Chartier, Nader Sadeghi, Christopher Lo, Zeev Rosberger
Summary: This longitudinal study identifies patients who are more susceptible to experience body image disturbance following head and neck cancer. It emphasizes the importance of clinicians paying attention to body image concerns upon cancer diagnosis, physical symptom burden, and neuroticism, and suggests targeting these factors in future preventive interventions.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Oncology
Mohammed I. Quraishi
Summary: Precision oncology utilizes molecular profiling to guide therapeutic interventions, and radiomic analysis can depict molecular mechanisms and correlate with genetic alterations. Combining these two approaches can be beneficial in the management of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Oncology
Linda Sharp, Laura-Jayne Watson, Liya Lu, Sam Harding, Katrina Hurley, Steve J. Thomas, Joanne M. Patterson
Summary: This study investigated cancer-related fatigue (CRF) in head and neck cancer patients using data from the Head and Neck 5000 prospective clinical cohort. The findings revealed a high prevalence of CRF, indicating the need for additional interventions and supports for affected patients.
Article
Oncology
Leonie W. Wahjudi, Stephan Bernhardt, Khalid Abnaof, Peter Horak, Simon Kreutzfeldt, Christoph Heining, Simone Borgoni, Corinna Becki, Daniela Berg, Daniela Richter, Barbara Hutter, Sebastian Uhrig, Katrin Pfuetze, Jonas Leichsenring, Hanno Glimm, Benedikt Brors, Christof von Kalle, Albrecht Stenzinger, Ulrike Korf, Stefan Froehling, Stefan Wiemann
Summary: The study demonstrates that integrated analysis of DNA, RNA, and protein data can optimize the therapeutic stratification of individual patients, potentially increasing the success rate of precision cancer therapy. Prospective validation studies are necessary to further incorporate proteomic analysis into precision oncology.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Nabil F. F. Saba, Saagar Pamulapati, Bhamini Patel, Mayur Mody, Primoz Strojan, Robert Takes, Antti A. A. Maekitie, Oded Cohen, Pia Pace-Asciak, Jan B. B. Vermorken, Carol Bradford, Arlene Forastiere, Yong Teng, Andreas Wieland, Alfio Ferlito
Summary: Head and neck cancer (HNC) is a common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) being the majority of cases. The incidence of HPV-related OPSCC, caused by human papillomavirus (HPV), is increasing rapidly. Immunotherapy has shown promise in managing recurrent and metastatic HNC, leading to interest in its application for HPV-related OPSCC. This review focuses on the immune characteristics and potential for immunotherapy in this virus-driven cancer.
Article
Behavioral Sciences
Raul Alfaro, Sylvia Crowder, Kalika P. Sarma, Anna E. Arthur, Marta Yanina Pepino
Summary: The study found that survivors of head and neck squamous cell cancers have difficulty identifying low concentrations of bitter, sweet, or salty stimuli on the tongue tip, indicating possible persistent and subtle localized damage to taste perception due to radiotherapy.
Article
Behavioral Sciences
Raul Alfaro, Sylvia Crowder, Kalika P. Sarma, Anna E. Arthur, Marta Yanina Pepino
Summary: Survivors of head and neck squamous cell cancers (HNSCC) often experience taste dysfunction long after radiation therapy, possibly due to localized damage in the chorda tympani or taste buds on the tongue tip. Compared to healthy controls, HNSCC survivors had difficulty identifying low concentrations of bitter, sweet, or salty stimuli on the tongue tip, suggesting ongoing sensory issues despite completing radiotherapy.
Article
Biochemistry & Molecular Biology
Ruishan Liu, James Zou
Summary: An analysis of genomic data and medical records from over 40,000 cancer patients has identified hundreds of mutations that can predict how patients will respond to specific cancer therapies. These predictive biomarkers could provide guidance for personalized treatment planning.
Article
Health Care Sciences & Services
Damian P. P. Kotevski, Robert I. I. Smee, Matthew Field, Kathryn Broadley, Claire M. M. Vajdic
Summary: This study investigated the completeness and accuracy of routinely collected head and neck cancer data from an oncology information system (OIS) for research purposes. The OIS data was found to be less complete and accurate compared to the research dataset. This highlights the need for improved data collection practices to advance patient care.
JOURNAL OF MEDICAL SYSTEMS
(2023)
Review
Genetics & Heredity
Hoi-Lam Ngan, Chun-Ho Law, Yannie Chung Yan Choi, Jenny Yu-Sum Chan, Vivian Wai Yan Lui
Summary: The MAPK pathway plays a central role in cell proliferation, differentiation and senescence. Defects in this pathway can contribute to developmental and congenital head and neck disorders in humans, and a significant portion of head and neck squamous cell carcinoma cases have MAPK pathway mutations. Recent clinical evidence suggests that targeted therapies can be effective in treating these patients, and there is also potential for precision immunotherapy based on the effects of MAPK aberrations on immune cell recruitment.
NPJ GENOMIC MEDICINE
(2022)
Article
Oncology
Joanne M. Patterson, Liya Lu, Laura-Jayne Watson, Sam Harding, Andy R. Ness, Steve Thomas, Andrea Waylen, Miranda Pring, Tim Waterboer, Linda Sharp
Summary: The study found significant associations between markers of social functioning and depression and health-related quality of life among head and neck cancer survivors. Difficulty with social eating and contact was positively correlated with depression and negatively correlated with quality of life. Effective interventions addressing social eating and contact are crucial for improving outcomes for survivors.
Review
Biochemistry & Molecular Biology
Stuart L. Rulten, Richard P. Grose, Susanne A. Gatz, J. Louise Jones, Angus J. M. Cameron
Summary: Our understanding of cancer has advanced rapidly, recognizing the variation between patients and leading to precision medicines that promise maximum efficacy, safety, and reduced costs. However, many patients still lack access to these personalized treatments, highlighting the need for new disease characteristics, accurate diagnosis, better clinical trials, and global accessibility to targeted therapies. This review discusses current technological trends and multidisciplinary efforts to ensure wider implementation of precision oncology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Peter Weber, Axel Kunstner, Julia Hess, Kristian Unger, Sebastian Marschner, Christian Idel, Julika Ribbat-Idel, Philipp Baumeister, Olivier Gires, Christoph Walz, Sibylle Rietzler, Laura Valeanu, Timm Herkommer, Lisa Kreutzer, Olena Klymenko, Guido Drexler, Thomas Kirchner, Cornelius Maihofer, Ute Ganswindt, Axel Walch, Michael Sterr, Heiko Lickert, Martin Canis, Dirk Rades, Sven Perner, Mauricio Berriel Diaz, Stefan Herzig, Kirsten Lauber, Barbara Wollenberg, Hauke Busch, Claus Belka, Horst Zitzelsberger
Summary: There is a high degree of genetic and transcriptional heterogeneity between primary and recurrent head and neck squamous cell carcinomas (HNSCC). Treatment decisions should be based on the genetic and transcriptional characteristics of recurrent tumors to enable personalized treatment strategies.
CLINICAL CANCER RESEARCH
(2022)
Correction
Biotechnology & Applied Microbiology
Sergei Yakneen, Sebastian M. Waszak, Michael Gertz, Jan O. Korbel, Brice Aminou, Javier Bartolome, Keith A. Boroevich, Rich Boyce, Angela N. Brooks, Alex Buchanan, Ivo Buchhalter, Adam P. Butler, Niall J. Byrne, Andy Cafferkey, Peter J. Campbell, Zhaohong Chen, Sunghoon Cho, Wan Choi, Peter Clapham, Brandi N. Davis-Dusenbery, Francisco M. De La Vega, Jonas Demeulemeester, Michelle T. Dow, Lewis Jonathan Dursi, Juergen Eils, Roland Eils, Kyle Ellrott, Claudiu Farcas, Francesco Favero, Nodirjon Fayzullaev, Vincent Ferretti, Paul Flicek, Nuno A. Fonseca, Josep Ll. Gelpi, Gad Getz, Bob Gibson, Robert L. Grossman, Olivier Harismendy, Allison P. Heath, Michael C. Heinold, Julian M. Hess, Oliver Hofmann, Jongwhi H. Hong, Thomas J. Hudson, Barbara Hutter, Carolyn M. Hutter, Daniel Hubschmann, Seiya Imoto, Sinisa Ivkovic, Seung-Hyup Jeon, Wei Jiao, Jongsun Jung, Rolf Kabbe, Andre Kahles, Jules N. A. Kerssemakers, Hyung-Lae Kim, Hyunghwan Kim, Jihoon Kim, Youngwook Kim, Kortine Kleinheinz, Michael Koscher, Antonios Koures, Milena Kovacevic, Chris Lawerenz, Ignaty Leshchiner, Jia Liu, Dimitri Livitz, George L. Mihaiescu, Sanja Mijalkovic, Ana Mijalkovic Lazic, Satoru Miyano, Naoki Miyoshi, Hardeep K. Nahal-Bose, Hidewaki Nakagawa, Mia Nastic, Steven J. Newhouse, Jonathan Nicholson, Brian D. O'Connor, David Ocana, Kazuhiro Ohi, Lucila Ohno-Machado, Larsson Omberg, B. F. Francis Ouellette, Nagarajan Paramasivam, Marc D. Perry, Todd D. Pihl, Manuel Prinz, Montserrat Puiggros, Petar Radovic, Keiran M. Raine, Esther Rheinbay, Mara Rosenberg, Romina Royo, Gunnar Ratsch, Gordon Saksena, Matthias Schlesner, Solomon I. Shorser, Charles Short, Heidi J. Sofia, Jonathan Spring, Lincoln D. Stein, Adam J. Struck, Grace Tiao, Nebojsa Tijanic, David Torrents, Peter Van Loo, Miguel Vazquez, David Vicente, Jeremiah A. Wala, Zhining Wang, Sebastian M. Waszak, Joachim Weischenfeldt, Johannes Werner, Ashley Williams, Youngchoon Woo, Adam J. Wright, Qian Xiang, Liming Yang, Denis Yuen, Christina K. Yung, Junjun Zhang, Jan O. Korbel
NATURE BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marina Laplana, Matthias Bieg, Christian Faltus, Svitlana Melnik, Olga Bogatyrova, Zuguang Gu, Thomas Muley, Michael Meister, Hendrik Dienemann, Esther Herpel, Christopher Amos, Matthias Schlesner, Roland Eils, Christoph Plass, Angela Risch
Summary: This study utilized a targeted sequencing approach to investigate DNA methylation changes in NSCLC patients, identifying differential methylation regions and confirming potential regulatory elements. The research contributes to understanding the mechanisms of lung cancer initiation and progression, and offers new potential targets for cancer treatment.
Review
Oncology
Katja Hauser, Alexander Kurz, Sarah Haggenmueller, Roman C. Maron, Christof von Kalle, Jochen S. Utikal, Friedegund Meier, Sarah Hobelsberger, Frank F. Gellrich, Mildred Sergon, Axel Hauschild, Lars E. French, Lucie Heinzerling, Justin G. Schlager, Kamran Ghoreschi, Max Schlaak, Franz J. Hilke, Gabriela Poch, Heinz Kutzner, Carola Berking, Markus Heppt, Michael Erdmann, Sebastian Haferkamp, Dirk Schadendorf, Wiebke Sondermann, Matthias Goebeler, Bastian Schilling, Jakob N. Kather, Stefan Froehling, Daniel B. Lipka, Achim Hekler, Eva Krieghoff-Henning, Titus J. Brinker
Summary: This study investigates the application of explainable artificial intelligence (XAI) in skin cancer detection. It found that XAI is commonly used during the development of new deep neural networks (DNNs), but there is a lack of systematic and rigorous evaluation of its usefulness in this scenario.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Cleo-Aron Weis, Kian R. Weihrauch, Katharina Kriegsmann, Mark Kriegsmann
Summary: This study explored the feasibility of using unsupervised learning concepts for segmentation in Pathomics projects, but the results showed that unsupervised training combined with subsequent supervised training did not offer any benefits for histological images.
APPLIED SCIENCES-BASEL
(2022)
Article
Oncology
Stephanie J. Yaung, Corinna Woestmann, Christine Ju, Xiaoju Max Ma, Sandeep Gattam, Yiyong Zhou, Liu Xi, Subrata Pal, Aarthi Balasubramanyam, Nalin Tikoo, Claus Peter Heussel, Michael Thomas, Mark Kriegsmann, Michael Meister, Marc A. Schneider, Felix J. Herth, Birgit Wehnl, Maximilian Diehn, Ash A. Alizadeh, John F. Palma, Thomas Muley
Summary: Monitoring early changes in ctDNA levels using liquid biopsies may help identify treatment responders and guide personalized therapy for advanced non-small-cell lung cancer patients, leading to improved patient outcomes.
Article
Biochemistry & Molecular Biology
Benjamin Sobol, Osama Azzam Nieto, Emily Lara Eberlein, Anna-Lena Scherr, Lars Ismail, Annika Kessler, Luisa Nader, Maximilian Schwab, Paula Hoffmeister, Nathalie Schmitt, Dirk Jaeger, Stefan Welte, Katharina Seidensaal, Petros Christopoulos, Christoph Heilig, Katharina Kriegsmann, Stefan Froehling, Mark Kriegsmann, Jochen Hess, Bruno Christian Koehler
Summary: This study evaluates the effects of highly specific inhibitors for Bcl-x(L) (WEHI-539), Bcl-2 (ABT-199) and Mcl-1 (S63845) as radiosensitizers. The results suggest that targeting Bcl-x(L) may be an effective strategy to overcome radioresistance in HNSCC, synovial sarcoma and NSCLC in vitro. Mcl-1 may also be a potential therapeutic target in NSCLC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jason A. Carter, Leonie Stroemich, Matthew Peacey, Sarah R. Chapin, Lars Velten, Lars M. Steinmetz, Benedikt Brors, Sheena Pinto, Hannah Meyer
Summary: This study reveals the transcriptomic diversity of mTECs in the thymus and establishes a web portal for querying their transcriptome, which may aid in identifying the drivers of autoimmune diseases.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Damian T. Rieke, Till de Bortoli, Peter Horak, Mario Lamping, Manuela Benary, Ivan Jelas, Gina Rueter, Johannes Berger, Marit Zettwitz, Niklas Kagelmann, Andreas Kind, Falk Fabian, Dieter Beule, Hanno Glimm, Benedikt Brors, Albrecht Stenzinger, Stefan Froehling, Ulrich Keilholz
Summary: The study compared the clinical interpretation of WES and RNA-Seq data by two independent molecular tumor boards, finding that reproducible clinical interpretation of high-dimensional molecular data is feasible. Challenges still exist in interpreting molecular aberrations beyond single nucleotide variants, clinically validated biomarkers, and combination therapies.
Article
Oncology
Christoph E. Heilig, Andreas Lassmann, Sadaf S. Mughal, Andreas Mock, Sebastian Pirmann, Veronica Teleanu, Marcus Renner, Carolin Andresen, Bruno C. Kohler, Bogac Aybey, Sebastian Bauer, Jens T. Siveke, Rainer Hamacher, Gunnar Folprecht, Stephan Richter, Evelin Schrock, Christian H. Brandts, Marit Ahrens, Peter Hohenberger, Gerlinde Egerer, Thomas Kindler, Melanie Boerries, Anna L. Illert, Nikolas von Bubnoff, Leonidas Apostolidis, Philipp J. Jost, C. Benedikt Westphalen, Wilko Weichert, Ulrich Keilholz, Frederick Klauschen, Katja Beck, Ulrike Winter, Daniela Richter, Lino Mohrmann, Michael Bitzer, Klaus Schulze-Osthoff, Benedikt Brors, Gunhild Mechtersheimer, Simon Kreutzfeldt, Christoph Heining, Daniel B. Lipka, Albrecht Stenzinger, Richard F. Schlenk, Peter Horak, Hanno Glimm, Daniel Hubschmann, Stefan Frohling
Summary: The expression levels of NTRK3, IGF1R, and KDR genes are associated with progression-free survival in patients with sarcoma treated with pazopanib. A pazopanib efficacy predictor can be developed based on the expression levels of these genes to accurately predict treatment outcomes for patients.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Dania Riegel, Elena Romero-Fernandez, Malte Simon, Akinbami Raphael Adenugba, Katrin Singer, Roman Mayr, Florian Weber, Mark Kleemann, Charles D. Imbusch, Marina Kreutz, Benedikt Brors, Ines Ugele, Jens M. Werner, Peter J. Siska, Christian Schmidl
Summary: By integrating single-cell chromatin accessibility and RNA-seq data, we identified the heterogeneous functional and dysfunctional states of CD8+ tumor-infiltrating lymphocytes and revealed common chromatin remodeling and key regulatory factors involved in this process.
Article
Biochemistry & Molecular Biology
Rita Casadonte, Mark Kriegsmann, Katharina Kriegsmann, Helene Streit, Rolf Ruediger Meliss, Cornelia S. L. Mueller, Joerg Kriegsmann
Summary: This study used proteomic technology to compare the molecular profiles of BRAF and NRAS mutated and wildtype melanoma patients' tissue samples. The results showed molecular differences between BRAF and NRAS mutated melanoma, and accurate identification was possible with an accuracy of 87-89% and 76-79% depending on the classification method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Rita Casadonte, Joerg Kriegsmann, Mark Kriegsmann, Katharina Kriegsmann, Roberta Torcasio, Maria Eugenia Gallo Cantafio, Giuseppe Viglietto, Nicola Amodio
Summary: Appropriate sample preparation is critical for the analysis of cell cultures with mass spectrometry. In this study, two different sample preparation procedures for proteomic analysis of multiple myeloma (MM) cells were evaluated using imaging mass spectrometry (IMS). The results showed that cytospin preparation resulted in better signal-to-noise ratios compared to formalin fixation and paraffin embedding. IMS technology holds the potential to stratify different cell lines and identify differentially expressed proteins.
Article
Infectious Diseases
Fridolin Steinbeis, Charlotte Thibeault, Sarah Steinbrecher, Yvonne Ahlgrimm, Ira An Haack, Dietrich August, Beate Balzuweit, Carla Bellinghausen, Sarah Berger, Irina Chaplinskaya-Sobol, Oliver Cornely, Patrick Doeblin, Matthias Endres, Claudia Fink, Carsten Finke, Sandra Frank, Sabine Hanss, Tim Hartung, Johannes Christian Hellmuth, Susanne Herold, Peter Heuschmann, Jan Heyckendorf, Ralf Heyder, Stefan Hippenstiel, Wolfgang Hoffmann, Sebastian Ulrich Kelle, Philipp Knape, Philipp Koehler, Lucie Kretzler, David Manuel Leistner, Jasmin Lienau, Roberto Lorbeer, Bettina Lorenz-Depiereux, Constanze Dorothea Luettke, Knut Mai, Uta Merle, Lil Antonia Meyer-Arndt, Olga Miljukov, Maximilian Muenchhoff, Moritz Mueller-Plathe, Julia Neuhann, Hannelore Neuhauser, Alexandra Nieters, Christian Otte, Daniel Pape, Rafaela Maria Pinto, Christina Pley, Annett Pudszuhn, Philipp Reuken, Siegberg Rieg, Petra Ritter, Gernot Rohde, Maria Roennefarth, Michael Ruzicka, Jens Schaller, Anne Schmidt, Sein Schmidt, Verena Schwachmeyer, Georg Schwanitz, Werner Seeger, Dana Stahl, Nicole Stobaeus, Hans Christian Stubbe, Norbert Suttorp, Bettina Temmesfeld, Sylvia Thun, Paul Triller, Frederik Trinkmann, Istvan Vadasz, Heike Valentin, Maria Vehreschild, Christof von Kalle, Marie von Lilienfeld-Toal, Joachim Weber, Tobias Welte, Christian Wildberg, Robert Wizimirski, Saskia Zvork, Leif Erik Sander, Janne Vehreschild, Thomas Zoller, Florian Kurth, Martin Witzenrath
Summary: The NAPKON-HAP study is a multi-centered observational study aimed at providing comprehensive data and biospecimen collection for the investigation of the pathophysiology and pathology of COVID-19. It will contribute significant scientific insights and high-quality data to aid researchers in understanding the acute and long-term outcomes of the disease.
Article
Urology & Nephrology
Frederik Wessels, Max Schmitt, Eva Krieghoff-Henning, Malin Nientiedt, Frank Waldbillig, Manuel Neuberger, Maximilian C. Kriegmair, Karl-Friedrich Kowalewski, Thomas S. Worst, Matthias Steeg, Zoran V. Popovic, Timo Gaiser, Christof von Kalle, Jochen S. Utikal, Stefan Frohling, Maurice S. Michel, Philipp Nuhn, Titus J. Brinker
Summary: A interpretable deep learning model, DINO-ViT, was developed and validated to predict overall and disease-specific survival in ccRCC. The model achieved significant risk stratification and showed good interpretability by extracting image features from nuclei, cytoplasm, and peritumoural stroma.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Oncology
Edwin Cuppen, Olivier Elemento, Richard Rosenquist, Svetlana Nikic, Maarten IJzerman, Isabelle Durand Zaleski, Geert Frederix, Lars-Ake Levin, Charles G. Mullighan, Reinhard Buettner, Trevor J. Pugh, Sean Grimmond, Carlos Caldas, Fabrice Andre, Ilse Custers, Elias Campo, Hans van Snellenberg, Anna Schuh, Hidewaki Nakagawa, Christof von Kalle, Torsten Haferlach, Stefan Froehling, Vaidehi Jobanputra
Summary: The combination of whole-genome and transcriptome sequencing (WGTS) is a comprehensive precision diagnostic test that is expected to transform diagnosis and treatment for cancer patients. However, there are barriers to the implementation and widespread adoption of this test, including considerations of utility in different cancer types, cost-effectiveness and affordability.
JCO PRECISION ONCOLOGY
(2022)