Article
Nutrition & Dietetics
Zalina Abu Zaid, May Kay Neoh, Zulfitri Azuan Mat Daud, Nor Baizura Md Yusop, Zuriati Ibrahim, Zuwariah Abdul Rahman, Norshariza Jamhuri, Aishah Zafirah Abdul Azim
Summary: This study aimed to evaluate the weight loss during and post-treatment among head and neck cancer patients. The study found that the average weight loss during treatment was 7.4%, and post-treatment weight loss was 2.1%. One month after treatment completion, patients showed significant improvements in nutrition status and muscle mass, but there was a decrease in oral nutritional supplement intake.
Article
Psychology, Multidisciplinary
Melissa Henry, Justine G. Albert, Saul Frenkiel, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Martin Black, Christina MacDonald, Keith Richardson, Marco Mascarella, Gregoire B. Morand, Gabrielle Chartier, Nader Sadeghi, Christopher Lo, Zeev Rosberger
Summary: This longitudinal study identifies patients who are more susceptible to experience body image disturbance following head and neck cancer. It emphasizes the importance of clinicians paying attention to body image concerns upon cancer diagnosis, physical symptom burden, and neuroticism, and suggests targeting these factors in future preventive interventions.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Oncology
Mohammed I. Quraishi
Summary: Precision oncology utilizes molecular profiling to guide therapeutic interventions, and radiomic analysis can depict molecular mechanisms and correlate with genetic alterations. Combining these two approaches can be beneficial in the management of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Oncology
Linda Sharp, Laura-Jayne Watson, Liya Lu, Sam Harding, Katrina Hurley, Steve J. Thomas, Joanne M. Patterson
Summary: This study investigated cancer-related fatigue (CRF) in head and neck cancer patients using data from the Head and Neck 5000 prospective clinical cohort. The findings revealed a high prevalence of CRF, indicating the need for additional interventions and supports for affected patients.
Article
Oncology
Leonie W. Wahjudi, Stephan Bernhardt, Khalid Abnaof, Peter Horak, Simon Kreutzfeldt, Christoph Heining, Simone Borgoni, Corinna Becki, Daniela Berg, Daniela Richter, Barbara Hutter, Sebastian Uhrig, Katrin Pfuetze, Jonas Leichsenring, Hanno Glimm, Benedikt Brors, Christof von Kalle, Albrecht Stenzinger, Ulrike Korf, Stefan Froehling, Stefan Wiemann
Summary: The study demonstrates that integrated analysis of DNA, RNA, and protein data can optimize the therapeutic stratification of individual patients, potentially increasing the success rate of precision cancer therapy. Prospective validation studies are necessary to further incorporate proteomic analysis into precision oncology.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Nabil F. F. Saba, Saagar Pamulapati, Bhamini Patel, Mayur Mody, Primoz Strojan, Robert Takes, Antti A. A. Maekitie, Oded Cohen, Pia Pace-Asciak, Jan B. B. Vermorken, Carol Bradford, Arlene Forastiere, Yong Teng, Andreas Wieland, Alfio Ferlito
Summary: Head and neck cancer (HNC) is a common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) being the majority of cases. The incidence of HPV-related OPSCC, caused by human papillomavirus (HPV), is increasing rapidly. Immunotherapy has shown promise in managing recurrent and metastatic HNC, leading to interest in its application for HPV-related OPSCC. This review focuses on the immune characteristics and potential for immunotherapy in this virus-driven cancer.
Article
Behavioral Sciences
Raul Alfaro, Sylvia Crowder, Kalika P. Sarma, Anna E. Arthur, Marta Yanina Pepino
Summary: The study found that survivors of head and neck squamous cell cancers have difficulty identifying low concentrations of bitter, sweet, or salty stimuli on the tongue tip, indicating possible persistent and subtle localized damage to taste perception due to radiotherapy.
Article
Behavioral Sciences
Raul Alfaro, Sylvia Crowder, Kalika P. Sarma, Anna E. Arthur, Marta Yanina Pepino
Summary: Survivors of head and neck squamous cell cancers (HNSCC) often experience taste dysfunction long after radiation therapy, possibly due to localized damage in the chorda tympani or taste buds on the tongue tip. Compared to healthy controls, HNSCC survivors had difficulty identifying low concentrations of bitter, sweet, or salty stimuli on the tongue tip, suggesting ongoing sensory issues despite completing radiotherapy.
Article
Biochemistry & Molecular Biology
Ruishan Liu, James Zou
Summary: An analysis of genomic data and medical records from over 40,000 cancer patients has identified hundreds of mutations that can predict how patients will respond to specific cancer therapies. These predictive biomarkers could provide guidance for personalized treatment planning.
Article
Health Care Sciences & Services
Damian P. P. Kotevski, Robert I. I. Smee, Matthew Field, Kathryn Broadley, Claire M. M. Vajdic
Summary: This study investigated the completeness and accuracy of routinely collected head and neck cancer data from an oncology information system (OIS) for research purposes. The OIS data was found to be less complete and accurate compared to the research dataset. This highlights the need for improved data collection practices to advance patient care.
JOURNAL OF MEDICAL SYSTEMS
(2023)
Review
Genetics & Heredity
Hoi-Lam Ngan, Chun-Ho Law, Yannie Chung Yan Choi, Jenny Yu-Sum Chan, Vivian Wai Yan Lui
Summary: The MAPK pathway plays a central role in cell proliferation, differentiation and senescence. Defects in this pathway can contribute to developmental and congenital head and neck disorders in humans, and a significant portion of head and neck squamous cell carcinoma cases have MAPK pathway mutations. Recent clinical evidence suggests that targeted therapies can be effective in treating these patients, and there is also potential for precision immunotherapy based on the effects of MAPK aberrations on immune cell recruitment.
NPJ GENOMIC MEDICINE
(2022)
Article
Oncology
Joanne M. Patterson, Liya Lu, Laura-Jayne Watson, Sam Harding, Andy R. Ness, Steve Thomas, Andrea Waylen, Miranda Pring, Tim Waterboer, Linda Sharp
Summary: The study found significant associations between markers of social functioning and depression and health-related quality of life among head and neck cancer survivors. Difficulty with social eating and contact was positively correlated with depression and negatively correlated with quality of life. Effective interventions addressing social eating and contact are crucial for improving outcomes for survivors.
Review
Biochemistry & Molecular Biology
Stuart L. Rulten, Richard P. Grose, Susanne A. Gatz, J. Louise Jones, Angus J. M. Cameron
Summary: Our understanding of cancer has advanced rapidly, recognizing the variation between patients and leading to precision medicines that promise maximum efficacy, safety, and reduced costs. However, many patients still lack access to these personalized treatments, highlighting the need for new disease characteristics, accurate diagnosis, better clinical trials, and global accessibility to targeted therapies. This review discusses current technological trends and multidisciplinary efforts to ensure wider implementation of precision oncology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Peter Weber, Axel Kunstner, Julia Hess, Kristian Unger, Sebastian Marschner, Christian Idel, Julika Ribbat-Idel, Philipp Baumeister, Olivier Gires, Christoph Walz, Sibylle Rietzler, Laura Valeanu, Timm Herkommer, Lisa Kreutzer, Olena Klymenko, Guido Drexler, Thomas Kirchner, Cornelius Maihofer, Ute Ganswindt, Axel Walch, Michael Sterr, Heiko Lickert, Martin Canis, Dirk Rades, Sven Perner, Mauricio Berriel Diaz, Stefan Herzig, Kirsten Lauber, Barbara Wollenberg, Hauke Busch, Claus Belka, Horst Zitzelsberger
Summary: There is a high degree of genetic and transcriptional heterogeneity between primary and recurrent head and neck squamous cell carcinomas (HNSCC). Treatment decisions should be based on the genetic and transcriptional characteristics of recurrent tumors to enable personalized treatment strategies.
CLINICAL CANCER RESEARCH
(2022)
Correction
Biotechnology & Applied Microbiology
Sergei Yakneen, Sebastian M. Waszak, Michael Gertz, Jan O. Korbel, Brice Aminou, Javier Bartolome, Keith A. Boroevich, Rich Boyce, Angela N. Brooks, Alex Buchanan, Ivo Buchhalter, Adam P. Butler, Niall J. Byrne, Andy Cafferkey, Peter J. Campbell, Zhaohong Chen, Sunghoon Cho, Wan Choi, Peter Clapham, Brandi N. Davis-Dusenbery, Francisco M. De La Vega, Jonas Demeulemeester, Michelle T. Dow, Lewis Jonathan Dursi, Juergen Eils, Roland Eils, Kyle Ellrott, Claudiu Farcas, Francesco Favero, Nodirjon Fayzullaev, Vincent Ferretti, Paul Flicek, Nuno A. Fonseca, Josep Ll. Gelpi, Gad Getz, Bob Gibson, Robert L. Grossman, Olivier Harismendy, Allison P. Heath, Michael C. Heinold, Julian M. Hess, Oliver Hofmann, Jongwhi H. Hong, Thomas J. Hudson, Barbara Hutter, Carolyn M. Hutter, Daniel Hubschmann, Seiya Imoto, Sinisa Ivkovic, Seung-Hyup Jeon, Wei Jiao, Jongsun Jung, Rolf Kabbe, Andre Kahles, Jules N. A. Kerssemakers, Hyung-Lae Kim, Hyunghwan Kim, Jihoon Kim, Youngwook Kim, Kortine Kleinheinz, Michael Koscher, Antonios Koures, Milena Kovacevic, Chris Lawerenz, Ignaty Leshchiner, Jia Liu, Dimitri Livitz, George L. Mihaiescu, Sanja Mijalkovic, Ana Mijalkovic Lazic, Satoru Miyano, Naoki Miyoshi, Hardeep K. Nahal-Bose, Hidewaki Nakagawa, Mia Nastic, Steven J. Newhouse, Jonathan Nicholson, Brian D. O'Connor, David Ocana, Kazuhiro Ohi, Lucila Ohno-Machado, Larsson Omberg, B. F. Francis Ouellette, Nagarajan Paramasivam, Marc D. Perry, Todd D. Pihl, Manuel Prinz, Montserrat Puiggros, Petar Radovic, Keiran M. Raine, Esther Rheinbay, Mara Rosenberg, Romina Royo, Gunnar Ratsch, Gordon Saksena, Matthias Schlesner, Solomon I. Shorser, Charles Short, Heidi J. Sofia, Jonathan Spring, Lincoln D. Stein, Adam J. Struck, Grace Tiao, Nebojsa Tijanic, David Torrents, Peter Van Loo, Miguel Vazquez, David Vicente, Jeremiah A. Wala, Zhining Wang, Sebastian M. Waszak, Joachim Weischenfeldt, Johannes Werner, Ashley Williams, Youngchoon Woo, Adam J. Wright, Qian Xiang, Liming Yang, Denis Yuen, Christina K. Yung, Junjun Zhang, Jan O. Korbel
NATURE BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
J. Loske, J. Roehmel, S. Lukassen, S. Stricker, Vg Magalhaes, J. Liebig, Rl Chua, L. Thurmann, M. Messingschlager, A. Seegebarth, B. Timmermann, S. Klages, M. Ralser, B. Sawitzki, Le Sander, Vm Corman, C. Conrad, S. Laudi, M. Binder, S. Trump, R. Eils, M. A. Mall, I Lehmann
Summary: Children exhibit higher basal expression of relevant pattern recognition receptors in airway immune cells, resulting in stronger early innate antiviral responses to SARS-CoV-2 infection compared to adults. Unique immune cell subpopulations, including cytotoxic T cells and memory CD8+ T cells, predominantly occur in children.
NATURE BIOTECHNOLOGY
(2022)
Review
Computer Science, Information Systems
Mikael Beyene, Philipp A. Toussaint, Scott Thiebes, Matthias Schlesner, Benedikt Brors, Ali Sunyaev
Summary: This review uncovers the current state of research on the application of Distributed Ledger Technology (DLT) in genomics, identifying focal research themes and directions for future research. The analysis resulted in 7 themes, including data economy and sharing, data management, data protection, and ethical implications. The review also presents 7 future research directions, such as exploring alternative consensus mechanisms and investigating data storage models appropriate for DLT.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2022)
Article
Oncology
Roman C. Maron, Achim Hekler, Sarah Haggenmueller, Christof von Kalle, Jochen S. Utikal, Verena Mueller, Maria Gaiser, Friedegund Meier, Sarah Hobelsberger, Frank F. Gellrich, Mildred Sergon, Axel Hauschild, Lars E. French, Lucie Heinzerling, Justin G. Schlager, Kamran Ghoreschi, Max Schlaak, Franz J. Hilke, Gabriela Poch, Soren Korsing, Carola Berking, Markus Heppt, Michael Erdmann, Sebastian Haferkamp, Dirk Schadendorf, Wiebke Sondermann, Matthias Goebeler, Bastian Schilling, Jakob N. Kather, Stefan Froehling, Daniel B. Lipka, Eva Krieghoff-Henning, Titus J. Brinker
Summary: This study investigates the performance of model soups for skin cancer classification and finds that they improve generalization, robustness, and calibration.
EUROPEAN JOURNAL OF CANCER
(2022)
Letter
Oncology
Paurnima Patil, Umut H. Toprak, Julian Seufert, Till Braun, Stephan H. Bernhart, Laura Wiehle, Annika Mueller, Matthias Schlesner, Marco Herling, Peter Lichter, Stephan Stilgenbauer, Reiner Siebert, Marc Zapatka
LEUKEMIA & LYMPHOMA
(2022)
Article
Oncology
Ruth Meier, Gabriele Greve, Dennis Zimmer, Helena Bresser, Bettina Berberich, Ralitsa Langova, Julia Stomper, Anne Rubarth, Lars Feuerbach, Daniel B. Lipka, Joschka Hey, Bjoern Gruening, Benedikt Brors, Justus Duyster, Christoph Plass, Heiko Becker, Michael Luebbert
Summary: The combination of DAC and ATRA shows cooperative antileukemic effects in AML, leading to the derepression of commonly regulated transcripts and changes in overall chromatin accessibility. This synergy is demonstrated through gene expression studies and transcriptional induction, as well as derepression of transposable elements resulting in a viral mimicry response.
BLOOD CANCER JOURNAL
(2022)
Article
Oncology
Anna Ricarda Gruending, Marc A. Schneider, Sarah Richtmann, Mark Kriegsmann, Hauke Winter, Beatriz Martinez-Delgado, Sarai Varona, Bin Liu, David S. DeLuca, Julia Held, Sabine Wrenger, Thomas Muley, Michael Meister, Tobias Welte, Sabina Janciauskiene
Summary: The accumulation of lipid droplets (LDs) and high expression of SREBF1 are associated with drug resistance and poor prognosis in cancer. The sensitivity of lung cancer cells to chemotherapeutics cisplatin and etoposide was assessed in this study. While both drugs reduced SREBF1 expression, it did not parallel with LD formation and cell sensitivity to chemotherapeutics. However, lower SREBF1 expression in tumors correlated with better overall survival in non-small-cell lung cancer patients.
Article
Pathology
Moritz Jesinghaus, Melanie Boxberg, Maxime Schmitt, Mark Kriegsmann, Alexander Harms, Corinna Lang, Thomas Muley, Hauke Winter, Katharina Kriegsmann, Arne Warth, Albrecht Stenzinger, Carsten Denkert, Hans Hoffmann, Seyer Safi, Wilko Weichert
Summary: Cellular dissociation grading (CDG) based on tumor budding and cell nest size can be used on biopsies of pulmonary squamous cell carcinoma (pSCC) and has a significant impact on disease prognosis.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Dania Riegel, Elena Romero-Fernandez, Malte Simon, Akinbami Raphael Adenugba, Katrin Singer, Roman Mayr, Florian Weber, Mark Kleemann, Charles D. Imbusch, Marina Kreutz, Benedikt Brors, Ines Ugele, Jens M. Werner, Peter J. Siska, Christian Schmidl
Summary: By integrating single-cell chromatin accessibility and RNA-seq data, we identified the heterogeneous functional and dysfunctional states of CD8+ tumor-infiltrating lymphocytes and revealed common chromatin remodeling and key regulatory factors involved in this process.
Article
Biochemistry & Molecular Biology
Rita Casadonte, Mark Kriegsmann, Katharina Kriegsmann, Helene Streit, Rolf Ruediger Meliss, Cornelia S. L. Mueller, Joerg Kriegsmann
Summary: This study used proteomic technology to compare the molecular profiles of BRAF and NRAS mutated and wildtype melanoma patients' tissue samples. The results showed molecular differences between BRAF and NRAS mutated melanoma, and accurate identification was possible with an accuracy of 87-89% and 76-79% depending on the classification method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Rita Casadonte, Joerg Kriegsmann, Mark Kriegsmann, Katharina Kriegsmann, Roberta Torcasio, Maria Eugenia Gallo Cantafio, Giuseppe Viglietto, Nicola Amodio
Summary: Appropriate sample preparation is critical for the analysis of cell cultures with mass spectrometry. In this study, two different sample preparation procedures for proteomic analysis of multiple myeloma (MM) cells were evaluated using imaging mass spectrometry (IMS). The results showed that cytospin preparation resulted in better signal-to-noise ratios compared to formalin fixation and paraffin embedding. IMS technology holds the potential to stratify different cell lines and identify differentially expressed proteins.
Article
Infectious Diseases
Fridolin Steinbeis, Charlotte Thibeault, Sarah Steinbrecher, Yvonne Ahlgrimm, Ira An Haack, Dietrich August, Beate Balzuweit, Carla Bellinghausen, Sarah Berger, Irina Chaplinskaya-Sobol, Oliver Cornely, Patrick Doeblin, Matthias Endres, Claudia Fink, Carsten Finke, Sandra Frank, Sabine Hanss, Tim Hartung, Johannes Christian Hellmuth, Susanne Herold, Peter Heuschmann, Jan Heyckendorf, Ralf Heyder, Stefan Hippenstiel, Wolfgang Hoffmann, Sebastian Ulrich Kelle, Philipp Knape, Philipp Koehler, Lucie Kretzler, David Manuel Leistner, Jasmin Lienau, Roberto Lorbeer, Bettina Lorenz-Depiereux, Constanze Dorothea Luettke, Knut Mai, Uta Merle, Lil Antonia Meyer-Arndt, Olga Miljukov, Maximilian Muenchhoff, Moritz Mueller-Plathe, Julia Neuhann, Hannelore Neuhauser, Alexandra Nieters, Christian Otte, Daniel Pape, Rafaela Maria Pinto, Christina Pley, Annett Pudszuhn, Philipp Reuken, Siegberg Rieg, Petra Ritter, Gernot Rohde, Maria Roennefarth, Michael Ruzicka, Jens Schaller, Anne Schmidt, Sein Schmidt, Verena Schwachmeyer, Georg Schwanitz, Werner Seeger, Dana Stahl, Nicole Stobaeus, Hans Christian Stubbe, Norbert Suttorp, Bettina Temmesfeld, Sylvia Thun, Paul Triller, Frederik Trinkmann, Istvan Vadasz, Heike Valentin, Maria Vehreschild, Christof von Kalle, Marie von Lilienfeld-Toal, Joachim Weber, Tobias Welte, Christian Wildberg, Robert Wizimirski, Saskia Zvork, Leif Erik Sander, Janne Vehreschild, Thomas Zoller, Florian Kurth, Martin Witzenrath
Summary: The NAPKON-HAP study is a multi-centered observational study aimed at providing comprehensive data and biospecimen collection for the investigation of the pathophysiology and pathology of COVID-19. It will contribute significant scientific insights and high-quality data to aid researchers in understanding the acute and long-term outcomes of the disease.
Article
Urology & Nephrology
Frederik Wessels, Max Schmitt, Eva Krieghoff-Henning, Malin Nientiedt, Frank Waldbillig, Manuel Neuberger, Maximilian C. Kriegmair, Karl-Friedrich Kowalewski, Thomas S. Worst, Matthias Steeg, Zoran V. Popovic, Timo Gaiser, Christof von Kalle, Jochen S. Utikal, Stefan Frohling, Maurice S. Michel, Philipp Nuhn, Titus J. Brinker
Summary: A interpretable deep learning model, DINO-ViT, was developed and validated to predict overall and disease-specific survival in ccRCC. The model achieved significant risk stratification and showed good interpretability by extracting image features from nuclei, cytoplasm, and peritumoural stroma.
WORLD JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Oncology
Kendra K. Maass, Pitithat Puranachot, Paulina S. Schad, Agnes M. E. Finster, Barbara Jones, Tatjana Wedig, Nathalie Schwarz, Petra Fiesel, Gnanaprakash Balasubramanian, Jochen Meyer, Felix Sahm, Stefanie Zimmermann, David T. W. Jones, Benedikt Brors, Stefan M. Pfister, Kristian W. Pajtler
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Meeting Abstract
Oncology
H. Bresser, R. Meier, G. Greve, D. Zimmer, B. Berberich, R. Langova, J. Stomper, A. Rubarth, L. Feuerbach, D. B. Lipka, J. Hey, B. Gruening, B. Brors, J. Duyster, C. Plass, H. Becker, M. Luebbert
ONCOLOGY RESEARCH AND TREATMENT
(2022)